Supplementation with linoleic acid-rich soybean oil stimulates macrophage foam cell formation via increased oxidative stress and diacylglycerol acyltransferase1-mediated triglyceride biosynthesis

BioFactors

Volumn 43, Issue 1, 2017, Pages 100-116

  Rom, Oren ^a   Jeries, Helana ^a,b   Hayek, Tony ^a,b   Aviram, Michael ^a  

^a TECHNION ISRAEL INSTITUTE OF TECHNOLOGY   (Israel)

^b Rambam Health Care Campus ^*  (Israel)

Author keywords

linoleic acid; macrophage foam cells; oxidative stress; soybean oil; triglycerides

Indexed keywords

CHOLESTEROL; DIACYLGLYCEROL ACYLTRANSFERASE 1; GLUCOSE; LINOLEIC ACID; MITOGEN ACTIVATED PROTEIN KINASE P38; SOYBEAN OIL; STEROL REGULATORY ELEMENT BINDING PROTEIN 1; TRIACYLGLYCEROL; DGAT1 PROTEIN, MOUSE; DIACYLGLYCEROL ACYLTRANSFERASE; REACTIVE OXYGEN METABOLITE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; ATHEROGENESIS; ATHEROSCLEROSIS; BODY WEIGHT; CHOLESTEROL BLOOD LEVEL; CONTROLLED STUDY; FOAM CELL; GENE OVEREXPRESSION; GLUCOSE BLOOD LEVEL; IN VITRO STUDY; LIPID COMPOSITION; LIPID METABOLISM; LIPID PEROXIDATION; LIPID STORAGE; MACRONUTRIENT; MALE; MOUSE; NONHUMAN; OXIDATIVE STRESS; PERITONEUM MACROPHAGE; POLYACRYLAMIDE GEL ELECTROPHORESIS; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; PROTEIN EXPRESSION; SUPPLEMENTATION; ANIMAL; BIOSYNTHESIS; C57BL MOUSE; CELL LINE; DIETARY SUPPLEMENT; DRUG EFFECTS; METABOLISM; PHYSIOLOGY; PRECLINICAL STUDY;

ANIMALS; CELL LINE; DIACYLGLYCEROL O-ACYLTRANSFERASE; DIETARY SUPPLEMENTS; DRUG EVALUATION, PRECLINICAL; FOAM CELLS; LINOLEIC ACID; LIPID PEROXIDATION; MACROPHAGES, PERITONEAL; MALE; MICE, INBRED C57BL; OXIDATIVE STRESS; P38 MITOGEN-ACTIVATED PROTEIN KINASES; REACTIVE OXYGEN SPECIES; SOYBEAN OIL; TRIGLYCERIDES;

EID: 84981340985     PISSN: 09516433     EISSN: 18728081     Source Type: Journal    
DOI: 10.1002/biof.1319     Document Type: Article

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