Mechanistic basis of glutaminase activation: A key enzyme that promotes glutamine metabolism in cancer cells

Journal of Biological Chemistry

Volumn 291, Issue 40, 2016, Pages 20900-20910

  Li, Yunxing ^a   Erickson, Jon W ^a   Stalnecker, Clint A ^a   Katt, William P ^a   Huang, Qingqiu ^a   Cerione, Richard A ^a   Ramachandran, Sekar ^a  

^a Department of Obstetrics Gynecology   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACIDS; BINS; BIOCHEMISTRY; CARBON; CATALYSIS; CATALYST ACTIVITY; CELLS; CHEMICAL ACTIVATION; CRYSTALLOGRAPHY; DISEASES; ENZYME ACTIVITY; MUTAGENESIS; OLIGOMERS;

ACTIVATION LOOPS; ALLOSTERIC ACTIVATOR; CONSTITUTIVELY ACTIVES; ENZYMATIC ACTIVITIES; INORGANIC PHOSPHATES; PRODUCT RELEASE; SITE DIRECTED MUTAGENESIS; SUBSTRATE BINDING;

X RAY CRYSTALLOGRAPHY;

GLUTAMINASE; GLUTAMINE; TETRAMER; TUMOR PROTEIN;

3T3 CELL LINE; ALLOSTERISM; AMINO ACID METABOLISM; ARTICLE; BREAST CANCER CELL LINE; CANCER CELL; CATALYSIS; CONTROLLED STUDY; CRYSTAL STRUCTURE; ENZYME ACTIVATION; ENZYME ACTIVE SITE; ENZYME SUBSTRATE COMPLEX; HUMAN; HUMAN CELL; OLIGOMERIZATION; PRIORITY JOURNAL; SITE DIRECTED MUTAGENESIS; X RAY CRYSTALLOGRAPHY; ANIMAL; CHEMISTRY; ENZYMOLOGY; GENETICS; METABOLISM; MOUSE; NEOPLASM; NIH 3T3 CELL LINE; PATHOLOGY; PROTEIN MULTIMERIZATION; PROTEIN SECONDARY STRUCTURE; TUMOR CELL LINE;

ANIMALS; CELL LINE, TUMOR; ENZYME ACTIVATION; GLUTAMINASE; GLUTAMINE; HUMANS; MICE; NEOPLASM PROTEINS; NEOPLASMS; NIH 3T3 CELLS; PROTEIN MULTIMERIZATION; PROTEIN STRUCTURE, SECONDARY;

EID: 84988947515     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M116.720268     Document Type: Article

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