Effect of lysine to alanine mutations on the phosphate activation and BPTES inhibition of glutaminase

Neurochemistry International

Volumn 88, Issue , 2015, Pages 10-14

  McDonald, Charles J ^a   Acheff, Eric ^a   Kennedy, Ryan ^a   Taylor, Lynn ^a   Curthoys, Norman P ^a  

^a Department of Environmental and Radiological Health Sciences   (United States)

Author keywords

Alanine substitution; BPTES inhibition; Glutaminase; Lysine N acetylation; Ni+ affinity chromatography; Phosphate activation

Indexed keywords

ALANINE; ANTINEOPLASTIC AGENT; BIS 2 (5 PHENYLACETAMIDO 1,2,4 THIADIAZOL 2 YL) ETHYL SULFIDE; GLUTAMINASE; LYSINE; PHOSPHATE; UNCLASSIFIED DRUG; BIS-2-(5-PHENYLACETAMIDO-1,2,4-THIADIAZOL-2-YL)ETHYL SULFIDE; SULFIDE; THIADIAZOLE DERIVATIVE;

ACETYLATION; AFFINITY CHROMATOGRAPHY; ARTICLE; BINDING SITE; ENZYME ACTIVATION; ENZYME INHIBITION; GENE EXPRESSION; GENE MUTATION; HUMAN; MOLECULAR CLONING; OLIGOMERIZATION; PRIORITY JOURNAL; PROTEIN PURIFICATION; TRANSFORMED CELL; ANTAGONISTS AND INHIBITORS; DOSE RESPONSE; DRUG EFFECTS; GENETICS; METABOLISM; MUTATION; PHYSIOLOGY;

ALANINE; DOSE-RESPONSE RELATIONSHIP, DRUG; ENZYME ACTIVATION; GLUTAMINASE; HUMANS; LYSINE; MUTATION; PHOSPHATES; SULFIDES; THIADIAZOLES;

EID: 84939563512     PISSN: 01970186     EISSN: 18729754     Source Type: Journal    
DOI: 10.1016/j.neuint.2014.12.003     Document Type: Article

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