Structural basis for the allosteric inhibitory mechanism of human kidney-type glutaminase (KGA) and its regulation by Raf-Mek-Erk signaling in cancer cell metabolism

Proceedings of the National Academy of Sciences of the United States of America

Volumn 109, Issue 20, 2012, Pages 7705-7710

  Thangavelu, K ^a   Pan, Catherine Qiurong ^a,b   Karlberg, Tobias ^c   Balaji, Ganapathy ^a   Uttamchandani, Mahesh ^a,d   Suresh, Valiyaveettil ^a   Schüler, Herwig ^c   Low, Boon Chuan ^a,b   Sivaraman, J ^a  

^a NATIONAL UNIVERSITY OF SINGAPORE   (Singapore)

^b NATIONAL UNIVERSITY OF SINGAPORE   (Singapore)

^c KAROLINSKA INSTITUTE   (Sweden)

^d DSO NATIONAL LABORATORIES   (Singapore)

Author keywords

Crystallography; RAS MAPK; Warburg effect

Indexed keywords

GLUTAMINASE; MITOGEN ACTIVATED PROTEIN KINASE; PHOSPHOPROTEIN PHOSPHATASE 2A; RAF PROTEIN;

ALLOSTERISM; ARTICLE; CANCER CELL; CATALYSIS; CELL METABOLISM; CELL PROLIFERATION; CONFORMATIONAL TRANSITION; CONTROLLED STUDY; CRYSTAL STRUCTURE; DYNAMICS; ENERGY; ENZYME ACTIVITY; GLUCOSE METABOLISM; HUMAN; HYDROPHOBICITY; INHIBITION KINETICS; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; REGULATORY MECHANISM; SIGNAL TRANSDUCTION; STRUCTURE ANALYSIS;

ALLOSTERIC REGULATION; CELL LINE, TUMOR; CELL PROLIFERATION; CRYSTALLOGRAPHY; GLUTAMINASE; HUMANS; KIDNEY; MAP KINASE KINASE 1; MAP KINASE KINASE 2; MAP KINASE SIGNALING SYSTEM; MODELS, MOLECULAR; MUTATION; PHOSPHORYLATION; PROTEIN BINDING; PROTEIN CONFORMATION; PROTO-ONCOGENE PROTEINS C-RAF; SIGNAL TRANSDUCTION; SULFIDES; THIADIAZOLES;

EID: 84861209572     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1116573109     Document Type: Article

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