The 5-HT6 receptor antagonist idalopirdine potentiates the effects of donepezil on gamma oscillations in the frontal cortex of anesthetized and awake rats without affecting sleep-wake architecture

Neuropharmacology

Volumn 113, Issue , 2017, Pages 45-59

  Amat Foraster, Maria ^a   Leiser, Steven C ^b   Herrik, Kjartan F ^a   Richard, Nelly ^a   Agerskov, Claus ^a   Bundgaard, Christoffer ^a   Bastlund, Jesper F ^a   de Jong, Inge E M ^a  

^a H LUNDBECK A S   (Denmark)

^b LUNDBECK RESEARCH USA   (United States)

Author keywords

5 HT6 receptor; Acetylcholinesterase inhibitor; Alzheimer's disease; EEG; Idalopirdine; sleep

Indexed keywords

DONEPEZIL; IDALOPIRDINE; SEROTONIN 6 ANTAGONIST; (2-(6-FLUORO-1H-INDOL-3-YL)-ETHYL)-(3-(2,2,3,3-TETRAFLUOROPROPOXY)BENZYL)AMINE; BENZYLAMINE DERIVATIVE; CHOLINESTERASE INHIBITOR; INDAN DERIVATIVE; INDOLE DERIVATIVE; PIPERIDINE DERIVATIVE; SEROTONIN 6 RECEPTOR; SEROTONIN ANTAGONIST; SEROTONIN RECEPTOR;

ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; DOSE RESPONSE; DRUG BLOOD LEVEL; DRUG BRAIN LEVEL; DRUG POTENTIATION; ELECTROSTIMULATION; FRONTAL CORTEX; GAMMA RHYTHM; MALE; MEDIAL PREFRONTAL CORTEX; NONHUMAN; NONREM SLEEP; NUCLEUS PONTIS ORALIS; POLYSOMNOGRAPHY; PONTINE NUCLEUS; PRIORITY JOURNAL; RAT; REM SLEEP; SLEEP WAKING CYCLE; WAKEFULNESS; ALZHEIMER DISEASE; ANIMAL; BRAIN STEM; DRUG EFFECTS; ELECTROENCEPHALOGRAPHY; FRONTAL LOBE; PATHOPHYSIOLOGY; PHYSIOLOGY; SLEEP STAGE; SPRAGUE DAWLEY RAT;

ALZHEIMER DISEASE; ANIMALS; BENZYLAMINES; BRAIN STEM; CHOLINESTERASE INHIBITORS; ELECTRIC STIMULATION; ELECTROENCEPHALOGRAPHY; FRONTAL LOBE; GAMMA RHYTHM; INDANS; INDOLES; MALE; PIPERIDINES; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, SEROTONIN; SEROTONIN ANTAGONISTS; SLEEP STAGES; WAKEFULNESS;

EID: 84988934530     PISSN: 00283908     EISSN: 18737064     Source Type: Journal    
DOI: 10.1016/j.neuropharm.2016.09.017     Document Type: Article

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