Memantine potentiates hippocampal theta oscillations at a therapeutic dose in anesthetized mice: A mechanistic link to its cognitive-enhancing properties

Neuropharmacology

Volumn 62, Issue 7, 2012, Pages 2208-2218

  Guadagna, Simone ^a,b   Bundgaard, Christoffer ^a   Hovelsø, Nanna ^a   Volbracht, Christiane ^a   Francis, Paul T ^b   Egebjerg, Jan ^a   Sotty, Florence ^a  

^a H LUNDBECK A S   (Denmark)

^b KING'S COLLEGE LONDON   (United Kingdom)

Author keywords

Cognition; Hippocampus; Memantine; NMDA receptor; Theta rhythm

Indexed keywords

DIZOCILPINE; MEMANTINE; N METHYL DEXTRO ASPARTIC ACID RECEPTOR BLOCKING AGENT; URETHAN;

ANESTHESIA; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BINDING AFFINITY; BRAIN CELL; CELL SYNCHRONIZATION; COGNITION; COGNITIVE DEFECT; CONTROLLED STUDY; DOSE RESPONSE; DRUG BLOOD LEVEL; DRUG BRAIN LEVEL; DRUG CEREBROSPINAL FLUID LEVEL; DRUG DOSE COMPARISON; DRUG EFFECT; DRUG MECHANISM; DRUG MEGADOSE; DRUG RECEPTOR BINDING; EXTRACELLULAR FLUID; HIPPOCAMPUS THETA RHYTHM; HUMAN; LEARNING; LOW DRUG DOSE; MALE; MENTAL PERFORMANCE; MOUSE; NERVE CELL NETWORK; NONHUMAN; OSCILLATION; PRIORITY JOURNAL;

EID: 84859105519     PISSN: 00283908     EISSN: 18737064     Source Type: Journal    
DOI: 10.1016/j.neuropharm.2012.01.014     Document Type: Article

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