Serotonin: A New Hope in Alzheimer's Disease?

ACS Chemical Neuroscience

Volumn 6, Issue 7, 2015, Pages 940-943

  Claeysen, Sylvie ^a,b   Bockaert, Joël ^a,b   Giannoni, Patrizia ^a,b  

^a INSTITUT DE GÉNOMIQUE FONCTIONNELLE   (France)

^b UNIV MONTPELLIER   (France)

Author keywords

5 HT4 receptors; 5 HT6 receptors; neuroprotection; Serotonin

Indexed keywords

SEROTONIN; SEROTONIN 4 RECEPTOR; SEROTONIN 6 RECEPTOR; SEROTONIN UPTAKE INHIBITOR; AMYLOID PRECURSOR PROTEIN; APP PROTEIN, HUMAN; NOOTROPIC AGENT; SEROTONIN 4 AGONIST; SEROTONIN ANTAGONIST; SEROTONIN RECEPTOR;

ALZHEIMER DISEASE; ARTICLE; CLINICAL FEATURE; COGNITION; DISEASE COURSE; DRUG TARGETING; ENZYME ACTIVATION; HUMAN; NEUROMODULATION; NEUROTRANSMISSION; NONHUMAN; PRIORITY JOURNAL; SEROTONINERGIC SYSTEM; SIGNAL TRANSDUCTION; ANIMAL; CLINICAL TRIAL (TOPIC); METABOLISM;

ALZHEIMER DISEASE; AMYLOID BETA-PROTEIN PRECURSOR; ANIMALS; CLINICAL TRIALS AS TOPIC; HUMANS; NOOTROPIC AGENTS; RECEPTORS, SEROTONIN; RECEPTORS, SEROTONIN, 5-HT4; SEROTONIN; SEROTONIN 5-HT4 RECEPTOR AGONISTS; SEROTONIN ANTAGONISTS; SEROTONIN UPTAKE INHIBITORS;

EID: 84937043578     PISSN: None     EISSN: 19487193     Source Type: Journal    
DOI: 10.1021/acschemneuro.5b00135     Document Type: Article

References (6)

1. Cirrito, J. R., Disabato, B. M., Restivo, J. L., Verges, D. K., Goebel, W. D., Sathyan, A., Hayreh, D., D'Angelo, G., Benzinger, T., Yoon, H., Kim, J., Morris, J. C., Mintun, M. A., and Sheline, Y. I. (2011) Serotonin signaling is associated with lower amyloid-beta levels and plaques in transgenic mice and humans Proc. Natl. Acad. Sci. U.S.A. 108, 14968-14973
2. Sheline, Y. I., West, T., Yarasheski, K., Swarm, R., Jasielec, M. S., Fisher, J. R., Ficker, W. D., Yan, P., Xiong, C., Frederiksen, C., Grzelak, M. V., Chott, R., Bateman, R. J., Morris, J. C., Mintun, M. A., Lee, J. M., and Cirrito, J. R. (2014) An antidepressant decreases CSF Aβ production in healthy individuals and in transgenic AD mice Sci. Transl. Med. 6, 236re234
3. Fowler, S. W., Chiang, A. C., Savjani, R. R., Larson, M. E., Sherman, M. A., Schuler, D. R., Cirrito, J. R., Lesne, S. E., and Jankowsky, J. L. (2014) Genetic modulation of soluble Abeta rescues cognitive and synaptic impairment in a mouse model of Alzheimer's disease J. Neurosci. 34, 7871-7885
4. Giannoni, P., Gaven, F., de Bundel, D., Baranger, K., Marchetti-Gauthier, E., Roman, F. S., Valjent, E., Marin, P., Bockaert, J., Rivera, S., and Claeysen, S. (2013) Early administration of RS 67333, a specific 5-HT4 receptor agonist, prevents amyloidogenesis and behavioral deficits in the 5XFAD mouse model of Alzheimer's disease Front. Aging Neurosci. 5, 96
5. Wilkinson, D., Windfeld, K., and Colding-Jorgensen, E. (2014) Safety and efficacy of idalopirdine, a 5-HT6 receptor antagonist, in patients with moderate Alzheimer's disease (LADDER): a randomised, double-blind, placebo-controlled phase 2 trial Lancet Neurol. 13, 1092-1099
6. Lecoutey, C., Hedou, D., Freret, T., Giannoni, P., Gaven, F., Since, M., Bouet, V., Ballandonne, C., Corvaisier, S., Malzert Freon, A., Mignani, S., Cresteil, T., Boulouard, M., Claeysen, S., Rochais, C., and Dallemagne, P. (2014) Design of donecopride, a dual serotonin subtype 4 receptor agonist/acetylcholinesterase inhibitor with potential interest for Alzheimer's disease treatment Proc. Natl. Acad. Sci. U. S. A. 111, E3825-3830