The Rise and the Fall of Betatrophin/ANGPTL8 as an Inducer of β -Cell Proliferation

Journal of Diabetes Research

Volumn 2016, Issue , 2016, Pages

  Abu Farha, Mohamed ^a   Al Madhoun, Ashraf ^a   Abubaker, Jehad ^a  

^a DASMAN DIABETES INSTITUTE   (Kuwait)

Author keywords

[No Author keywords available]

Indexed keywords

ANGPTL8 PROTEIN; BETATROPHIN; HORMONE; PROTEIN; UNCLASSIFIED DRUG;

CELL PROLIFERATION; CELL REGENERATION; HORMONE ACTION; HUMAN; INSULIN DEPENDENT DIABETES MELLITUS; LIPID METABOLISM; META ANALYSIS (TOPIC); NON INSULIN DEPENDENT DIABETES MELLITUS; NONHUMAN; PANCREAS ISLET BETA CELL; PROTEIN ANALYSIS; PROTEIN FUNCTION; REVIEW;

EID: 84988723859     PISSN: 23146745     EISSN: 23146753     Source Type: Journal    
DOI: 10.1155/2016/4860595     Document Type: Review

References (79)

1. R. A. DeFronzo, E. Ferrannini, L. Groop et al. , "Type 2 diabetes mellitus," Nature Reviews Disease Primers, vol. 1, Article ID 15019, 2015
2. J. Tuomilehto, J. Lindström, J. G. Eriksson et al. , "Prevention of type 2 diabetes mellitus by changes in lifestyle among subjects with impaired glucose tolerance," The New England Journal of Medicine, vol. 344, no. 18, pp. 1343-1350, 2001
3. S. O'Rahilly, "Human obesity and insulin resistance: lessons from experiments of nature," Biochemical Society Transactions, vol. 35, part 1, pp. 33-36, 2007
4. A. M. Ackermann and M. Gannon, "Molecular regulation of pancreatic beta-cell mass development, maintenance, and expansion," Journal of Molecular Endocrinology, vol. 38, no. 1-2, pp. 193-206, 2007
5. C. Bernard-Kargar and A. Ktorza, "Endocrine pancreas plasticity under physiological and pathological conditions," Diabetes, vol. 50, supplement 1, pp. S30-S35, 2001
6. J. Petrik, B. Reusens, E. Arany et al. , "A low protein diet alters the balance of islet cell replication and apoptosis in the fetal and neonatal rat and is associated with a reduced pancreatic expression of insulin-like growth factor-II," Endocrinology, vol. 140, no. 10, pp. 4861-4873, 1999
7. E. Montanya, V. Nacher, M. Biarnes, and J. Soler, "Linear correlation between beta-cellmass and bodyweight throughout the lifespan in Lewis rats: role of beta-cell hyperplasia and hypertrophy," Diabetes, vol. 49, no. 8, pp. 1341-1346, 2000
8. R. L. Sorenson, T. C. Brelje, and C. Roth, "Effects of steroid and lactogenic hormones on islets of langerhans: a new hypothesis for the role of pregnancy steroids in the adaptation of islets to pregnancy," Endocrinology, vol. 133, no. 5, pp. 2227-2234, 1993
9. T. C. Brelje,D. W. Scharp, P. E. Lacy et al. , "Effect of homologous placental lactogens, prolactins, and growth hormones on islet B-cell division and insulin secretion in rat, mouse, and human islets: implication for placental lactogen regulation of islet function during pregnancy," Endocrinology, vol. 132, no. 2, pp. 879-887, 1993
10. J. Domnguez-Bendala, L. Inverardi, and C. Ricordi, "Regeneration of pancreatic beta-cell mass for the treatment of diabetes," ExpertOpinion on BiologicalTherapy, vol. 12, no. 6, pp. 731-741, 2012
11. A. K. Linnemann, M. Baan, and D. B. Davis, "Pancreatic betacell proliferation in obesity," Advances in Nutrition, vol. 5, no. 3, pp. 278-288, 2014
12. J. J. Meier, A. E. Butler, Y. Saisho et al. , "beta-cell replication is the primary mechanism subserving the postnatal expansion of-cell mass in humans," Diabetes, vol. 57, no. 6, pp. 1584-1594, 2008
13. Y. Dor, J. Brown, O. I. Martinez, and D. A. Melton, "Adult pancreatic-cells are formed by self-duplication rather than stem-cell differentiation," Nature, vol. 429, no. 6987, pp. 41-46, 2004
14. S. Georgia and A. Bhushan, " cell replication is the primary mechanism for maintaining postnatal cell mass," Journal of Clinical Investigation, vol. 114, no. 7, pp. 963-968, 2004
15. T. Nir, D. A. Melton, and Y. Dor, "Recovery from diabetes in mice by beta cell regeneration," The Journal of Clinical Investigation, vol. 117, no. 9, pp. 2553-2561, 2007
16. P. Wang, N. M. Fiaschi-Taesch, R. C. Vasavada, D. K. Scott, A. Garcá-Ocaña, and A. F. Stewart, "Diabetes mellitus-advances and challenges in human-cell proliferation," Nature Reviews Endocrinology, vol. 11, no. 4, pp. 201-212, 2015
17. D. Saunders and A. C. Powers, "Replicative capacity of-cells and type 1 diabetes," Journal of Autoimmunity, vol. 71,pp. 59-68, 2016
18. S. Bonner-Weir,W. C. Li, L. Ouziel-Yahalom, L. Guo, G. C. Weir, and A. Sharma, "beta-cell growth and regeneration: replication is only part of the story," Diabetes, vol. 59, no. 10, pp. 2340-2348, 2010
19. K. Juhl, S. Bonner-Weir, and A. Sharma, "Regenerating pancreatic-cells: plasticity of adult pancreatic cells and the feasibility of in-vivo neogenesis," Current Opinion in Organ Transplantation, vol. 15, no. 1, pp. 79-85, 2010
20. S. Bonner-Weir, L. Guo, W.-C. Li et al. , "Islet neogenesis: a possible pathway for beta-cell replenishment," Review of Diabetic Studies, vol. 9, no. 4, pp. 407-416, 2012
21. M. Rovira, S. G. Scott, A. S. Liss, J. Jensen, S. P. Thayer, and S. D. Leach, "Isolation and characterization of centroacinar/terminal ductal progenitor cells in adult mouse pancreas," Proceedings of the National Academy of Sciences, vol. 107, no. 1, pp. 75-80, 2010
22. F. Delaspre, R. L. Beer, M. Rovira et al. , "Centroacinar cells are progenitors that contribute to endocrine pancreas regeneration," Diabetes, vol. 64, no. 10, pp. 3499-3509, 2015
23. X. Xiao, Z. Chen, C. Shiota et al. , "No evidence for cell neogenesis inmurine adult pancreas," Journal of Clinical Investigation, vol. 123, no. 5, pp. 2207-2217, 2013
24. M. M. Rankin, C. J. Wilbur, K. Rak, E. J. Shields, A. Granger, and J. A. Kushner, "beta-Cells are not generated in pancreatic duct ligation-induced injury in adult mice," Diabetes, vol. 62, no. 5, pp. 1634-1645, 2013
25. C. Cavelti-Weder, M. Shtessel, J. E. Reuss et al. , "Pancreatic duct ligation after almost complete-cell loss: exocrine regeneration but no evidence of-cell regeneration," Endocrinology, vol. 154, no. 12, pp. 4493-4502, 2013
26. F. Thorel, V. Népote, I. Avril et al. , "Conversion of adult pancreatic-cells to-cells after extreme-cell loss," Nature, vol. 464, no. 7292, pp. 1149-1154, 2010
27. C. Talchai, S. Xuan, H. V. Lin, L. Sussel, and D. Accili, "Pancreatic cell dedifferentiation as a mechanism of diabetic cell failure," Cell, vol. 150, no. 6, pp. 1223-1234, 2012
28. P. Collombat and A. Mansouri, "Turning on the-cell identity in the pancreas," Cell Cycle, vol. 8, no. 21, pp. 3450-3451, 2009
29. S. Kordowich, A. Mansouri, and P. Collombat, "Reprogramming into pancreatic endocrine cells based on developmental cues,"Molecular and Cellular Endocrinology, vol. 315, no. 1-2, pp. 11-18, 2010
30. L. Ye, M. A. Robertson, D. Hesselson, D. Y. Stainier, and R. M. Anderson, "Glucagon is essential for alpha cell transdifferentiation and beta cell neogenesis," Development, vol. 142, no. 8, pp. 1407-1417, 2015
31. A. Mansouri, "Development and regeneration in the endocrine pancreas," ISRN Endocrinology, vol. 2012,Article ID 640956, 12 pages, 2012
32. R. Piran, S. H. Lee, C. R. Li, A. Charbono, L. M. Bradley, and F. Levine, "Pharmacological induction of pancreatic islet cell transdifferentiation: relevance to type I diabetes," Cell Death and Disease, vol. 5, no. 7,Article ID e1357, 2014
33. J. H. Nielsen, S. Linde, B. S. Welinder, N. Billestrup, and O. D. Madsen, "Growth hormone is a growth factor for the differentiated pancreatic-cell," Molecular Endocrinology, vol. 3, no. 1, pp. 165-173, 1989
34. B. N. Friedrichsen, E. D. Galsgaard, J. H. Nielsen, and A. Møldrup, "Growth hormone-and prolactin-induced proliferation of insulinoma cells, INS-1, depends on activation of STAT5 (signal transducer and activator of transcription 5)," Molecular Endocrinology, vol. 15, no. 1, pp. 136-148, 2001
35. N. Billestrup and J. H. Nielsen, "The stimulatory effect of growth hormone, prolactin, and placental lactogen on-cell proliferation is not mediated by insulin-like growth factor-I," Endocrinology, vol. 129, no. 2, pp. 883-888, 1991
36. H. Kim, Y. Toyofuku, F. C. Lynn et al. , "Serotonin regulates pancreatic beta cell mass during pregnancy," Nature Medicine, vol. 16, no. 7, pp. 804-808, 2010
37. J. Buteau, S. Foisy, E. Joly, and M. Prentki, "Glucagon-like peptide 1 induces pancreatic-cell proliferation via transactivation of the epidermal growth factor receptor," Diabetes, vol. 52, no. 1, pp. 124-132, 2003
38. S. R. Hügl, M. F. White, and C. J. Rhodes, "Insulin-like growth factor I (IGF-I)-stimulated pancreatic-cell growth is glucosedependent synergistic activation of insulin receptor substratemediated signal transduction pathways by glucose and IGF-I in INS-1 cells," The Journal of Biological Chemistry, vol. 273, no. 28, pp. 17771-17779, 1998
39. Y. Huang and Y. Chang, "Regulation of pancreatic islet betacell mass by growth factor and hormone signaling," Progress in Molecular Biology and Translational Science, vol. 121, pp. 321-349, 2014
40. F. Zhang, A. Sjoholm, and Q. Zhang, "Growth hormone signaling in pancreatic-cells-calcium handling regulated by growth hormone," Molecular and Cellular Endocrinology, vol. 297, no. 1-2, pp. 50-57, 2009
41. C. Widmann, E. Bürki, W. Dolci, and B. Thorens, "Signal transduction by the cloned glucagon-like peptide-1 receptor: comparison with signaling by the endogenous receptors of cell lines,"Molecular Pharmacology, vol. 45, no. 5, pp. 1029-1035, 1994
42. P. N. Nair, D. T. De Armond, M. L. Adamo, W. E. Strodel, and J. W. Freeman, "Aberrant expression and activation of insulin-like growth factor-1 receptor (IGF-1R) are mediated by an induction of IGF-1R promoter activity and stabilization of IGF-1R mRNA and contributes to growth factor independence and increased survival of the pancreatic cancer cell line MIA PaCa-2," Oncogene, vol. 20, no. 57, pp. 8203-8214, 2001
43. M. Bando, H. Iwakura, H. Ariyasu et al. , "Overexpression of intraislet ghrelin enhances-cell proliferation after streptozotocin-induced-cell injury in mice,"American Journal of Physiology-Endocrinology and Metabolism, vol. 305, no. 1, pp. E140-E148, 2013
44. R. Granata, F. Settanni, L. Biancone et al. , "Acylated and unacylated ghrelin promote proliferation and inhibit apoptosis of pancreatic-cells and human islets: involvement of 3,5beta-cyclic adenosine monophosphate/protein kinase A, extracellular signal-regulated kinase 1/2, and phosphatidyl inositol 3-kinase/Akt signaling," Endocrinology, vol. 148, no. 2, pp. 512-529, 2007
45. Y. S. Oh, S. Shin, Y. Lee, E. H. Kim, H. Jun, and K. Maedler, "Betacellulin-induced beta cell proliferation and regeneration is mediated by activation of ErbB-1 and ErbB-2 receptors," PLoS ONE, vol. 6, no. 8,Article ID e23894, 2011
46. G. Ren, J. Y. Kim, and C. M. Smas, "Identification of RIFL, a novel adipocyte-enriched insulin target gene with a role in lipid metabolism," American Journal of Physiology. Endocrinology and Metabolism, vol. 303, no. 3, pp. E334-E351, 2012
47. R. Zhang and A. B. Abou-Samra, "Emerging roles of Lipasin as a critical lipid regulator," Biochemical and Biophysical Research Communications, vol. 432, no. 3, pp. 401-405, 2013
48. F. Quagliarini, Y. Wang, J. Kozlitina et al. , "Atypical angiopoietin-like protein that regulates ANGPTL3," Proceedings of the National Academy of Sciences of the United States of America, vol. 109, no. 48, pp. 19751-19756, 2012
49. P. Yi, J. Park, and D. Melton, "Betatrophin: a hormone that controls pancreatic cell proliferation," Cell, vol. 153, no. 4, pp. 747-758, 2013
50. V. Gusarova, C. Alexa, E. Na et al. , "ANGPTL8/betatrophin does not control pancreatic beta cell expansion," Cell, vol. 159, no. 3, pp. 691-696, 2014
51. D. Espes, J. Lau, and P. O. Carlsson, "Increased circulating levels of betatrophin in individuals with long-standing type 1 diabetes," Diabetologia, vol. 57, no. 1, pp. 50-53, 2014
52. M. Abu-Farha, J. Abubaker, I. Al-Khairi et al. , "Higher plasma betatrophin/ANGPTL8 level in Type 2 Diabetes subjects does not correlate with blood glucose or insulin resistance," Scientific Reports, vol. 5, article 10949, 2015
53. J. Gomez-Ambrosi, E. Pascual, V. Catalan et al. , "Circulating betatrophin concentrations are decreased in human obesity and type 2 diabetes," The Journal of Clinical Endocrinology & Metabolism, vol. 99, no. 10, pp. E2004-E2009, 2014
54. R. Zhang, "Lipasin, a novel nutritionally-regulated liverenriched factor that regulates serum triglyceride levels," Biochemical and Biophysical Research Communications, vol. 424, no. 4, pp. 786-792, 2012
55. Z. Fu, F. Yao, A. B. Abou-Samra, and R. Zhang, "Lipasin, thermoregulated in brown fat, is a novel but atypical member of the angiopoietin-like protein family," Biochemical and Biophysical Research Communications, vol. 430, no. 3, pp. 1126-1131, 2013
56. M. Abu-Farha, M. Melhem, J. Abubaker, K. Behbehani, O. Alsmadi, and N. Elkum, "ANGPTL8/Betatrophin R59Wvariant is associated with higher glucose level in non-diabetic Arabs living in Kuwaits," Lipids in Health and Disease, vol. 15, article 26, 2016
57. E. Kugelberg, "Diabetes: betatrophin-inducing-cell expansion to treat diabetes mellitus" Nature Reviews Endocrinology, vol. 9, no. 7, pp. 379-379, 2013
58. H. Lickert, "Betatrophin fuels cell proliferation: first step toward regenerative therapy" CellMetabolism, vol. 18, no. 1, pp. 5-6, 2013
59. Y. Wang, F. Quagliarini, V. Gusarova et al. , "Mice lacking ANGPTL8 (Betatrophin) manifest disrupted triglyceride metabolism without impaired glucose homeostasis," Proceedings of the National Academy of Sciences, vol. 110, no. 40, pp. 16109-16114, 2013
60. Y. Jiao, J. Le Lay, M. Yu, A. Naji, and K. H. Kaestner, "Elevated mouse hepatic betatrophin expression does not increase human-cell replication in the transplant setting," Diabetes, vol. 63, no. 4, pp. 1283-1288, 2014
61. A. F. Stewart, "Betatrophin versus bitter-trophin and the elephant in the room: time for a new normal in-cell regeneration research," Diabetes, vol. 63, no. 4, pp. 1198-1199, 2014
62. M. Abu-Farha, J. Abubaker, F. Noronha et al. , "Lack of associations between betatrophin/ANGPTL8 level and C-peptide in type 2 diabetic subjects," Cardiovascular Diabetology, vol. 14,no. 1, article 112, 2015
63. K. Guo, J. Lu, H. Yu et al. , "Serum betatrophin concentrations are significantly increased in overweight but not in obese or type 2 diabetic individuals," Obesity, vol. 23, no. 4, pp. 793-797, 2015
64. H. Hu, W. Sun, S. Yu et al. , "Increased circulating levels of betatrophin in newly diagnosed type 2 diabetic patients," Diabetes Care, vol. 37, no. 10, pp. 2718-2722, 2014
65. D. Espes, M. Martinell, and P. Carlsson, "Increased circulating betatrophin concentrations in patients with type 2 diabetes," International Journal of Endocrinology, vol. 2014, 6 pages, 2014
66. A. Fenzl, B. K. Itariu, L. Kosi et al. , "Circulating betatrophin correlates with atherogenic lipid profiles but not with glucose and insulin levels in insulin-resistant individuals," Diabetologia, vol. 57, no. 6, pp. 1204-1208, 2014
67. Z. Fu, F. Berhane, A. Fite, B. Seyoum,A. B. Abou-Samra, and R. Zhang, "Elevated circulating lipasin/betatrophin in human type 2 diabetes and obesity," Scientific Reports, vol. 4, article 5013, 2014
68. X. Chen, P. Lu, W. He et al. , "Circulating betatrophin levels are increased in patients with type 2 diabetes and associated with insulin resistance," The Journal of Clinical Endocrinology &Metabolism, vol. 100, no. 1, pp. E96-E100, 2015
69. A. R. Cox, C. J. Lam, C. W. Bonnyman, J. Chavez, J. S. Rios, and J. A. Kushner, "Angiopoietin-like protein 8 (ANGPTL8)/ betatrophin overexpression does not increase beta cell proliferation in mice," Diabetologia, vol. 58, no. 7, pp. 1523-1531, 2015
70. H. Yamada, T. Saito, A. Aoki et al. , "Circulating betatrophin is elevated in patients with type 1 and type 2 diabetes," Endocrine Journal, vol. 62, no. 5, pp. 417-421, 2015
71. M. Abu-Farha, J. Abubaker, I. Al-Khairi et al. , "Circulating angiopoietin-like protein 8 (betatrophin) association with HsCRP and metabolic syndrome," Cardiovascular Diabetology, vol. 15, no. 1, article 25, 2016
72. M. Abu-Farha, D. Sriraman, P. Cherian et al. , "Circulating ANGPTL8/betatrophin is increased in obesity and reduced after exercise training," PLoS ONE, vol. 11, no. 1, Article ID e0147367, 2016
73. S. Li, D. Liu, L. Li et al. , "Circulating betatrophininpatientswith type 2 diabetes: a meta-analysis," Journal of Diabetes Research, vol. 2016, 9 pages, 2016
74. O. Erol, H. Y. Ellidag, H. Ayk, M. K. Özel, A. U. Derbent, and N. Yilmaz, "Evaluation of circulating betatrophin levels in gestational diabetes mellitus," Gynecological Endocrinology, vol. 31, no. 8, pp. 652-656, 2015
75. L. K. Trebotic, P. Klimek, A. Thomas et al. , "Circulating betatrophin is strongly increased in pregnancy and gestational diabetes mellitus," PLoS ONE, vol. 10, no. 9, Article IDe0136701, 2015
76. N. Wawrusiewicz-Kurylonek, B. Telejko, M. Kuzmicki et al. , "Increased maternal and cord blood betatrophin in gestational diabetes," PLoS ONE, vol. 10, no. 6, Article IDe0131171, 2015
77. X. Xie, H. Gao, S. Wu et al. , "Increased cord blood betatrophin levels in the offspring of mothers with gestational diabetes," PLoS ONE, vol. 11, no. 5, Article ID e0155646, 2016
78. Z. Fu, A. B. Abou-Samra, and R. Zhang, "An explanation for recent discrepancies in levels of human circulating betatrophin," Diabetologia, vol. 57, no. 10, pp. 2232-2234, 2014
79. G. Erbag, M. Eroglu, H. Turkon et al. , "Relationship between betatrophin levels and metabolic parameters in patients with polycystic ovary syndrome," Cellular and Molecular Biology, vol. 62, no. 5, pp. 20-24, 2016.