Higher plasma betatrophin/ANGPTL8 level in Type 2 Diabetes subjects does not correlate with blood glucose or insulin resistance

Scientific Reports

Volumn 5, Issue , 2015, Pages

  Abu Farha, Mohamed ^a   Abubaker, Jehad ^a   Al Khairi, Irina ^a   Cherian, Preethi ^a   Noronha, Fiona ^a   Hu, Frank B ^b   Behbehani, Kazem ^a   Elkum, Naser ^c  

^a DASMAN DIABETES INSTITUTE   (Kuwait)

^b HARVARD SCHOOL OF PUBLIC HEALTH   (United States)

^c SIDRA MEDICAL AND RESEARCH CENTER   (Qatar)

Author keywords

[No Author keywords available]

Indexed keywords

FIBRINOGEN; GLUCOSE BLOOD LEVEL; GLYCOSYLATED HEMOGLOBIN; HEMOGLOBIN A1C PROTEIN, HUMAN; INSULIN; LIPASIN PROTEIN, HUMAN; LOW DENSITY LIPOPROTEIN CHOLESTEROL; PEPTIDE HORMONE;

ADULT; AGE; AGED; BLOOD; BODY MASS; CASE CONTROL STUDY; FEMALE; GLUCOSE BLOOD LEVEL; HUMAN; INSULIN RESISTANCE; LIPID METABOLISM; MALE; METABOLISM; MIDDLE AGED; NON INSULIN DEPENDENT DIABETES MELLITUS; RISK FACTOR; WAIST HIP RATIO;

ADULT; AGE FACTORS; AGED; BLOOD GLUCOSE; BODY MASS INDEX; CASE-CONTROL STUDIES; CHOLESTEROL, LDL; DIABETES MELLITUS, TYPE 2; FEMALE; FIBRINOGEN; HEMOGLOBIN A, GLYCOSYLATED; HUMANS; INSULIN; INSULIN RESISTANCE; LIPID METABOLISM; MALE; MIDDLE AGED; PEPTIDE HORMONES; RISK FACTORS; WAIST-HIP RATIO;

EID: 84935844092     PISSN: None     EISSN: 20452322     Source Type: Journal    
DOI: 10.1038/srep10949     Document Type: Article

References (38)

1. Ashcroft, F. M. & Rorsman, P. Diabetes mellitus and the beta cell: the last ten years. Cell 148, 1160-1171, doi :S0092-8674(12)00208-5(2012).
2. Skog, O., Korsgren, S., Melhus, A. & Korsgren, O. Revisiting the notion of type 1 diabetes being a T-cell-mediated autoimmune disease. Curr Opin Endocrinol Diabetes Obes 20, 118-123, doi:10.1097/MED.0b013e32835edb89 (2013).
3. Huber, A., Menconi, F., Corathers, S., Jacobson, E. M. & Tomer, Y. Joint genetic susceptibility to type 1 diabetes and autoimmune thyroiditis: from epidemiology to mechanisms. Endocr Rev 29, 697-725, doi:er.2008-0015 (2008).
4. Bluestone, J. A., Tang, Q. & Sedwick, C. E. T regulatory cells in autoimmune diabetes: past challenges, future prospects. J Clin Immunol 28, 677-684, doi:10.1007/s10875-008-9242-z (2008).
5. Rhodes, C. J., White, M. F., Leahy, J. L. & Kahn, S. E. Direct autocrine action of insulin on beta-cells: does it make physiological sense?Diabetes 62, 2157-2163, doi:62/7/2157 (2013).
6. Johnson, R. J., et al. Sugar, uric acid, and the etiology of diabetes and obesity. Diabetes 62, 3307-3315, doi:62/10/3307 (2013).
7. Drucker, D. J. Incretin action in the pancreas: potential promise, possible perils, and pathological pitfalls. Diabetes 62, 3316-3323, doi:db13-0822 (2013).
8. Marchetti, P., Bugliani, M., Boggi, U., Masini, M. & Marselli, L. The pancreatic beta cells in human type 2 diabetes. Adv Exp Med Biol 771, 288-309 (2012).
9. Yi, P., Park, J. S. & Melton, D. A. Betatrophin: a hormone that controls pancreatic beta cell proliferation. Cell 153, 747-758, doi:S0092-8674(13)00449-2 (2013).
10. Bonner-Weir, S. & Weir, G. C. New sources of pancreatic beta-cells. Nat Biotechnol 23, 857-861, doi:nbt1115 (2005).
11. Ren, G., Kim, J. Y. & Smas, C. M. Identification of RIFL, a novel adipocyte-enriched insulin target gene with a role in lipid metabolism. Am J Physiol Endocrinol Metab 303, E334-351, doi:ajpendo.00084.2012 (2012).
12. Quagliarini, F., et al. Atypical angiopoietin-like protein that regulates ANGPTL3. Proc Natl Acad Sci U S A 109, 19751-19756, doi:1217552109 (2012).
13. Zhang, R. & Abou-Samra, A. B. Emerging roles of Lipasin as a critical lipid regulator. Biochem Biophys Res Commun 432, 401-405, doi:S0006-291X(13)00258-1 (2013).
14. Fu, Z., Yao, F., Abou-Samra, A. B. & Zhang, R. Lipasin, thermoregulated in brown fat, is a novel but atypical member of the angiopoietin-like protein family. Biochem Biophys Res Commun 430, 1126-1131, doi:S0006-291X(12)02354-6 (2013).
15. El Ouaamari, A., et al. Liver-derived systemic factors drive beta cell hyperplasia in insulin-resistant states. Cell Rep 3, 401-410, doi:S2211-1247(13)00014-4 (2013).
16. Michael, M. D., et al. Loss of insulin signaling in hepatocytes leads to severe insulin resistance and progressive hepatic dysfunction. Mol Cell 6, 87-97, doi:S1097-2765(05)00015-8 (2000).
17. Gusarova, V., et al. ANGPTL8/betatrophin does not control pancreatic beta cell expansion. Cell 159, 691-696, doi:S0092-8674(14)01176-3 (2014).
18. Yi, P., Park, J. S. & Melton, D. A. Perspectives on the activities of ANGPTL8/betatrophin. Cell 159, 467-468, doi:S0092-8674(14)01177-5 (2014).
19. Espes, D., Martinell, M. & Carlsson, P. O. Increased circulating betatrophin concentrations in patients with type 2 diabetes. Int J Endocrinol 2014, 323407, doi:10.1155/2014/323407 (2014).
20. Fu, Z., et al. Elevated circulating lipasin/betatrophin in human type 2 diabetes and obesity. Sci Rep 4, 5013, doi:srep05013 (2014).
21. Hu, H., et al. Increased Circulating Levels of Betatrophin in Newly Diagnosed Type 2 Diabetic Patients. Diabetes Care, doi:dc14-0602 (2014).
22. Abu-Farha, M., Behbehani, K. & Elkum, N. Comprehensive analysis of circulating adipokines and hsCRP association with cardiovascular disease risk factors and metabolic syndrome in Arabs. Cardiovasc Diabetol 13, 76, doi:1475-2840-13-76 (2014).
23. Abu-Farha, M., et al. Gender differences in ghrelin association with cardiometabolic risk factors in arab population. Int J Endocrinol 2014, 730472, doi:10.1155/2014/730472 (2014).
24. Elkum, N., Al-Arouj, M., Sharifi, M., Behbehani, K. & Bennakhi, A. Cardiovascular disease risk factors in the South Asian population living in Kuwait: a cross-sectional study. Diabet Med 31, 531-539, doi:10.1111/dme.12386 (2014).
25. Diagnosis and classification of diabetes mellitus. Diabetes Care 31 Suppl 1, S55-60, doi:31/Supplement-1/S55 (2008).
26. Espes, D., Lau, J. & Carlsson, P. O. Increased circulating levels of betatrophin in individuals with long-standing type 1 diabetes. Diabetologia, doi:10.1007/s00125-013-3071-1 (2013).
27. Fenzl, A., et al. Circulating betatrophin correlates with atherogenic lipid profiles but not with glucose and insulin levels in insulinresistant individuals. Diabetologia, doi:10.1007/s00125-014-3208-x (2014).
28. Fu, Z., Abou-Samra, A. B. & Zhang, R. An explanation for recent discrepancies in levels of human circulating betatrophin. Diabetologia, doi:10.1007/s00125-014-3346-1 (2014).
29. Gomez-Ambrosi, J., et al. Circulating Betatrophin Concentrations Are Decreased in Human Obesity and Type 2 Diabetes. J Clin Endocrinol Metab. jc20141568, doi:10.1210/jc.2014-1568 (2014).
30. Rankin, M. M. & Kushner, J. A. Adaptive beta-cell proliferation is severely restricted with advanced age. Diabetes 58, 1365-1372, doi:db08-1198 (2009).
31. Kassem, S. A., Ariel, I., Thornton, P. S., Scheimberg, I. & Glaser, B. Beta-cell proliferation and apoptosis in the developing normal human pancreas and in hyperinsulinism of infancy. Diabetes 49, 1325-1333 (2000).
32. Meier, J. J., et al. Beta-cell replication is the primary mechanism subserving the postnatal expansion of beta-cell mass in humans. Diabetes 57, 1584-1594, doi:db07-1369 (2008).
33. Jiao, Y., Le Lay, J., Yu, M., Naji, A. & Kaestner, K. H. Elevated mouse hepatic betatrophin expression does not increase human beta-cell replication in the transplant setting. Diabetes 63, 1283-1288, doi:db13-1435 (2014).
34. Alhyas, L., McKay, A., Balasanthiran, A. & Majeed, A. Prevalences of overweight, obesity, hyperglycaemia, hypertension and dyslipidaemia in the Gulf: systematic review. JRSM Short Rep 2, 55, doi:10.1258/shorts.2011.011019 SHORTS-11-019 (2011).
35. Alhyas, L., McKay, A. & Majeed, A. Prevalence of type 2 diabetes in the States of the co-operation council for the Arab States of the Gulf: a systematic review. PLoS One 7, e40948, doi:10.1371/journal.pone.0040948 PONE-D-11-00931 (2012).
36. Al-Quwaidhi, A. J., Pearce, M. S., Sobngwi, E., Critchley, J. A. & Oflaherty, M. Comparison of type 2 diabetes prevalence estimates in Saudi Arabia from a validated Markov model against the International Diabetes Federation and other modelling studies. Diabetes Res Clin Pract 103, 496-503, doi:S0168-8227(13)00470-1 (2014).
37. Whiting, D. R., Guariguata, L., Weil, C. & Shaw, J. IDF diabetes atlas: global estimates of the prevalence of diabetes for 2011 and 2030. Diabetes Res Clin Pract 94, 311-321, doi:S0168-8227(11)00591-2 (2011).
38. Gholap, N., Davies, M., Patel, K., Sattar, N. & Khunti, K. Type 2 diabetes and cardiovascular disease in South Asians. Prim Care Diabetes 5, 45-56, doi:S1751-9918(10)00097-5 (2011).