Increased cord blood betatrophin levels in the offspring of mothers with gestational diabetes

PLoS ONE

Volumn 11, Issue 5, 2016, Pages

  Xie, Xuemei ^a,b,c   Gao, Hongjie ^a   Wu, Shimin ^a   Zhao, Yue ^a   Du, Caiqi ^a   Yuan, Guandou ^b   Ning, Qin ^a   McCormick, Kenneth ^c   Luo, Xiaoping ^a  

^a HUAZHONG UNIVERSITY OF SCIENCE AND TECHNOLOGY   (China)

^b GUILIN MEDICAL UNIVERSITY   (China)

^c University of Alabama at Birmingham and Children's Hospital   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BETATROPHIN; GLUCOSE; HIGH DENSITY LIPOPROTEIN CHOLESTEROL; INSULIN; LOW DENSITY LIPOPROTEIN CHOLESTEROL; MITOCHONDRIAL DNA; REGULATOR PROTEIN; UNCLASSIFIED DRUG; GLUCOSE BLOOD LEVEL; LIPASIN PROTEIN, HUMAN; LIPID; PEPTIDE HORMONE;

ARTICLE; CLINICAL ARTICLE; CONTROLLED STUDY; CROSS-SECTIONAL STUDY; ELISA KIT; FEMALE; GLUCOSE BLOOD LEVEL; HUMAN; HUMAN TISSUE; HYPERGLYCEMIA; INSULIN BLOOD LEVEL; INSULIN RESISTANCE; MITOCHONDRION; ORAL GLUCOSE TOLERANCE TEST; PLACENTA TISSUE; PREGNANCY DIABETES MELLITUS; PROGENY; REAL TIME POLYMERASE CHAIN REACTION; UMBILICAL CORD BLOOD; ANALYSIS; BLOOD; CELL PROLIFERATION; CESAREAN SECTION; CHEMISTRY; CHINA; CYTOLOGY; FETUS BLOOD; GLUCOSE TOLERANCE TEST; METABOLISM; NUTRITIONAL SCIENCE; PANCREAS ISLET BETA CELL; PHYSIOLOGY; PLACENTA; PREGNANCY;

BLOOD GLUCOSE; CELL PROLIFERATION; CESAREAN SECTION; CHINA; CROSS-SECTIONAL STUDIES; DIABETES, GESTATIONAL; FEMALE; FETAL BLOOD; GLUCOSE TOLERANCE TEST; HUMANS; HYPERGLYCEMIA; INSULIN; INSULIN RESISTANCE; INSULIN-SECRETING CELLS; LIPIDS; MITOCHONDRIA; NUTRITIONAL SCIENCES; PEPTIDE HORMONES; PLACENTA; PREGNANCY;

EID: 84970959667     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0155646     Document Type: Article

References (54)

1. Barker DJ, Hales CN, Fall CH, Osmond C, Phipps K, Clark PM. Type 2 (non-insulin-dependent) diabetes mellitus, hypertension and hyperlipidaemia (syndrome X): relation to reduced fetal growth. Diabetologia. 1993; 36(1):62-7. Epub 1993/01/01. PMID: 8436255.
2. Hales CN, Barker DJ. Type 2 (non-insulin-dependent) diabetes mellitus: the thrifty phenotype hypothesis. Diabetologia. 1992; 35(7):595-601. Epub 1992/07/01. PMID: 1644236.
3. Sarr O, Yang K, Regnault TR. In utero programming of later adiposity: the role of fetal growth restriction. Journal of pregnancy. 2012; 2012:134758. Epub 2012/12/20. doi: 10.1155/2012/134758 PMID: 23251802; PubMed Central PMCID: PMC3518064.
4. Jiwani A, Marseille E, Lohse N, Damm P, Hod M, Kahn JG. Gestational diabetes mellitus: results from a survey of country prevalence and practices. The journal of maternal-fetal & neonatal medicine: the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstet. 2012; 25(6):600-10. Epub 2011/07/19. doi: 10.3109/14767058.2011.587921 PMID: 21762003.
5. Norman JE, Reynolds RM. The consequences of obesity and excess weight gain in pregnancy. The Proceedings of the Nutrition Society. 2011; 70(4):450-6. Epub 2011/09/02. doi: 10.1017/s0029665111003077 PMID: 21880162.
6. Clausen TD, Mathiesen ER, Hansen T, Pedersen O, Jensen DM, Lauenborg J, et al. Overweight and the metabolic syndrome in adult offspring of women with diet-treated gestational diabetes mellitus or type 1 diabetes. The Journal of clinical endocrinology and metabolism. 2009; 94(7):2464-70. Epub 2009/05/07. doi: 10.1210/jc.2009-0305 PMID: 19417040.
7. Damm P. Future risk of diabetes in mother and child after gestational diabetes mellitus. International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics. 2009; 104 Suppl 1:S25-6. Epub 2009/01/20. doi: 10.1016/j.ijgo.2008.11.025 PMID: 19150058.
8. Lawlor DA, Lichtenstein P, Langstrom N. Association of maternal diabetes mellitus in pregnancy with offspring adiposity into early adulthood: sibling study in a prospective cohort of 280,866 men from 248,293 families. Circulation. 2011; 123(3):258-65. Epub 2011/01/12. doi: 10.1161/circulationaha.110.980169 PMID: 21220735; PubMed Central PMCID: PMC4440894.
9. Zinkhan EK, Fu Q, Wang Y, Yu X, Callaway CW, Segar JL, et al. Maternal Hyperglycemia Disrupts Histone
10. Lysine 36 Trimethylation of the IGF-1 Gene. Journal of nutrition and metabolism. 2012; 2012:930364. Epub 2012/05/02. doi: 10.1155/2012/930364 PMID: 22548154; PubMed Central PMCID: PMC3324902.
11. Kousta E, Lawrence NJ, Godsland IF, Penny A, Anyaoku V, Millauer BA, et al. Insulin resistance and beta-cell dysfunction in normoglycaemic European women with a history of gestational diabetes. Clinical endocrinology. 2003; 59(3):289-97. Epub 2003/08/16. PMID: 12919151.
12. Krishnaveni GV, Hill JC, Leary SD, Veena SR, Saperia J, Saroja A, et al. Anthropometry, glucose tolerance, and insulin concentrations in Indian children: relationships to maternal glucose and insulin concentrations during pregnancy. Diabetes care. 2005; 28(12):2919-25. Epub 2005/11/25. PMID: 16306555.
13. Bush NC, Chandler-Laney PC, Rouse DJ, Granger WM, Oster RA, Gower BA. Higher maternal gestational glucose concentration is associated with lower offspring insulin sensitivity and altered beta-cell function. The Journal of clinical endocrinology and metabolism. 2011; 96(5):E803-9. Epub 2011/02/25. doi: 10.1210/jc.2010-2902 PMID: 21346075; PubMed Central PMCID: PMC3176781.
14. Page KA, Romero A, Buchanan TA, Xiang AH. Gestational diabetes mellitus, maternal obesity, and adiposity in offspring. The Journal of pediatrics. 2014; 164(4):807-10. Epub 2014/01/07. doi: 10.1016/j.jpeds.2013.11.063 PMID: 24388326; PubMed Central PMCID: PMC3962700.
15. Bunt JC, Tataranni PA, Salbe AD. Intrauterine exposure to diabetes is a determinant of hemoglobin A (1)c and systolic blood pressure in pima Indian children. The Journal of clinical endocrinology and metabolism. 2005; 90(6):3225-9. Epub 2005/03/31. doi: 10.1210/jc.2005-0007 PMID: 15797952; PubMed Central PMCID: PMC1579248.
16. Zhu JZ, Yu CH, Li YM. Betatrophin provides a new insight into diabetes treatment and lipid metabolism (Review). Biomedical reports. 2014; 2(4):447-51. Epub 2014/06/20. doi: 10.3892/br.2014.284 PMID: 24944788; PubMed Central PMCID: PMC4051489.
17. Zhang R, Abou-Samra AB. A dual role of lipasin (betatrophin) in lipid metabolism and glucose homeostasis: consensus and controversy. Cardiovascular diabetology. 2014; 13(1):133. Epub 2014/09/13. doi: 10.1186/preaccept-6310273751364807 PMID: 25212743; PubMed Central PMCID: PMC4172915.
18. Fu Z, Berhane F, Fite A, Seyoum B, Abou-Samra AB, Zhang R. Elevated circulating lipasin/betatrophin in human type 2 diabetes and obesity. Scientific reports. 2014; 4:5013. Epub 2014/05/24. doi: 10.1038/srep05013 PMID: 24852694.
19. Espes D, Martinell M, Carlsson PO. Increased circulating betatrophin concentrations in patients with type 2 diabetes. International journal of endocrinology. 2014; 2014:323407. Epub 2014/06/26. doi: 10.1155/2014/323407 PMID: 24963292; PubMed Central PMCID: PMC4055101.
20. Hu H, Sun W, Yu S, Hong X, Qian W, Tang B, et al. Increased circulating levels of betatrophin in newly diagnosed type 2 diabetic patients. Diabetes care. 2014; 37(10):2718-22. Epub 2014/07/16. doi: 10.2337/dc14-0602 PMID: 25024395.
21. Espes D, Lau J, Carlsson PO. Increased circulating levels of betatrophin in individuals with long-standing type 1 diabetes. Diabetologia. 2014; 57(1):50-3. Epub 2013/10/01. doi: 10.1007/s00125-013-3071-1 PMID: 24078058; PubMed Central PMCID: PMC3855541.
22. Rieck S, White P, Schug J, Fox AJ, Smirnova O, Gao N, et al. The transcriptional response of the islet to pregnancy in mice. Molecular endocrinology (Baltimore, Md). 2009; 23(10):1702-12. Epub 2009/07/04. doi: 10.1210/me.2009-0144 PMID: 19574445; PubMed Central PMCID: PMC2754894.
23. Alonso LC, Yokoe T, Zhang P, Scott DK, Kim SK, O'Donnell CP, et al. Glucose infusion in mice: a new model to induce beta-cell replication. Diabetes. 2007; 56(7):1792-801. Epub 2007/04/03. doi: 10.2337/db06-1513 PMID: 17400928; PubMed Central PMCID: PMC2921922.
24. Yi P, Park JS, Melton DA. Betatrophin: a hormone that controls pancreatic beta cell proliferation. Cell. 2013; 153(4):747-58. Epub 2013/04/30. doi: 10.1016/j.cell.2013.04.008 PMID: 23623304; PubMed Central PMCID: PMC3756510.
25. Gusarova V, Alexa CA, Na E, Stevis PE, Xin Y, Bonner-Weir S, et al. ANGPTL8/betatrophin does not control pancreatic beta cell expansion. Cell. 2014; 159(3):691-6. Epub 2014/11/25. doi: 10.1016/j.cell.2014.09.027 PMID: 25417115; PubMed Central PMCID: PMC4243040.
26. Wang Y, Quagliarini F, Gusarova V, Gromada J, Valenzuela DM, Cohen JC, et al. Mice lacking ANGPTL8 (Betatrophin) manifest disrupted triglyceride metabolism without impaired glucose homeostasis. Proceedings of the National Academy of Sciences of the United States of America. 2013; 110(40):16109-14. Epub 2013/09/18. doi: 10.1073/pnas.1315292110 PMID: 24043787; PubMed Central PMCID: PMC3791734.
27. Zhang R. Lipasin, a novel nutritionally-regulated liver-enriched factor that regulates serum triglyceride levels. Biochemical and biophysical research communications. 2012; 424(4):786-92. Epub 2012/07/20. doi: 10.1016/j.bbrc.2012.07.038 PMID: 22809513.
28. Mooradian AD. Dyslipidemia in type 2 diabetes mellitus. Nature clinical practice Endocrinology & metabolism. 2009; 5(3):150-9. Epub 2009/02/21. doi: 10.1038/ncpendmet1066 PMID: 19229235.
29. Li G, Kong L, Zhang L, Fan L, Su Y, Rose JC, et al. Early Pregnancy Maternal Lipid Profiles and the Risk of Gestational Diabetes Mellitus Stratified for Body Mass Index. Reproductive sciences (Thousand Oaks, Calif). 2014. Epub 2014/11/15. doi: 10.1177/1933719114557896 PMID: 25394643.
30. International Association of D, Pregnancy Study Groups Consensus P, Metzger BE, Gabbe SG, Persson B, Buchanan TA, et al. International association of diabetes and pregnancy study groups recommendations on the diagnosis and classification of hyperglycemia in pregnancy. Diabetes care. 2010; 33(3):676-82. Epub 2010/03/02. doi: 10.2337/dc09-1848 PMID: 20190296; PubMed Central PMCID: PMC2827530.
31. American Diabetes A. Standards of medical care in diabetes - 2014. Diabetes care. 2014; 37 Suppl 1: S14-80. Epub 2013/12/21. doi: 10.2337/dc14-S014 PMID: 24357209.
32. Xie X, Gao H, Zeng W, Chen S, Feng L, Deng D, et al. Placental DNA methylation of peroxisome-proliferator-activated receptor-gamma co-activator-1alpha promoter is associated with maternal gestational glucose level. Clinical science (London, England: 1979). 2015; 129(4):385-94. Epub 2015/04/16. doi: 10.1042/cs20140688 PMID: 25875376.
33. Fenzl A, Itariu BK, Kosi L, Fritzer-Szekeres M, Kautzky-Willer A, Stulnig TM, et al. Circulating betatrophin correlates with atherogenic lipid profiles but not with glucose and insulin levels in insulin-resistant individuals. Diabetologia. 2014; 57(6):1204-8. Epub 2014/03/14. doi: 10.1007/s00125-014-3208-x PMID: 24623100.
34. Xie X, Lin T, Zhang M, Liao L, Yuan G, Gao H, et al. IUGR with infantile overnutrition programs an insulin-resistant phenotype through DNA methylation of peroxisome proliferator-activated receptor-gamma coactivator-1alpha in rats. Pediatric research. 2015; 77(5):625-32. Epub 2015/02/13. doi: 10.1038/pr.2015.32 PMID: 25675425.
35. Barres R, Osler ME, Yan J, Rune A, Fritz T, Caidahl K, et al. Non-CpG methylation of the PGC-1alpha promoter through DNMT3B controls mitochondrial density. Cell metabolism. 2009; 10(3):189-98. Epub 2009/09/03. doi: 10.1016/j.cmet.2009.07.011 PMID: 19723495.
36. Reiling E, Ling C, Uitterlinden AG, Van't Riet E, Welschen LM, Ladenvall C, et al. The association of mitochondrial content with prevalent and incident type 2 diabetes. The Journal of clinical endocrinology and metabolism. 2010; 95(4):1909-15. Epub 2010/02/13. doi: 10.1210/jc.2009-1775 PMID: 20150578.
37. Gomez-Ambrosi J, Pascual E, Catalan V, Rodriguez A, Ramirez B, Silva C, et al. Circulating betatrophin concentrations are decreased in human obesity and type 2 diabetes. The Journal of clinical endocrinology and metabolism. 2014; 99(10):E2004-9. Epub 2014/07/23. doi: 10.1210/jc.2014-1568 PMID: 25050901.
38. Westgate JA, Lindsay RS, Beattie J, Pattison NS, Gamble G, Mildenhall LF, et al. Hyperinsulinemia in cord blood in mothers with type 2 diabetes and gestational diabetes mellitus in New Zealand. Diabetes care. 2006; 29(6):1345-50. Epub 2006/05/30. doi: 10.2337/dc05-1677 PMID: 16732019.
39. Luo ZC, Nuyt AM, Delvin E, Fraser WD, Julien P, Audibert F, et al. Maternal and fetal leptin, adiponectin levels and associations with fetal insulin sensitivity. Obesity (Silver Spring, Md). 2013; 21(1):210-6. Epub 2013/03/19. doi: 10.1002/oby.20250 PMID: 23505188.
40. Wang Q, Huang R, Yu B, Cao F, Wang H, Zhang M, et al. Higher fetal insulin resistance in Chinese pregnant women with gestational diabetes mellitus and correlation with maternal insulin resistance. PloS one. 2013; 8(4):e59845. Epub 2013/04/06. doi: 10.1371/journal.pone.0059845 PMID: 23560057; PubMed Central PMCID: PMC3613391.
41. Gomez-Ambrosi J, Pascual E, Catalan V, Rodriguez A, Ramirez B, Silva C, et al. Circulating Betatrophin Concentrations Are Decreased in Human Obesity and Type 2 Diabetes. The Journal of clinical endocrinology and metabolism. 2014. doi: 10.1210/jc.2014-1568 PMID: 25050901.
42. Nelissen EC, van Montfoort AP, Dumoulin JC, Evers JL. Epigenetics and the placenta. Human reproduction update. 2011; 17(3):397-417. Epub 2010/10/21. doi: 10.1093/humupd/dmq052 PMID: 20959349.
43. Colomiere M, Permezel M, Riley C, Desoye G, Lappas M. Defective insulin signaling in placenta from pregnancies complicated by gestational diabetes mellitus. European journal of endocrinology / European Federation of Endocrine Societies. 2009; 160(4):567-78. Epub 2009/01/31. doi: 10.1530/eje-09-0031 PMID: 19179458.
44. Sorenson RL, Brelje TC. Adaptation of islets of Langerhans to pregnancy: beta-cell growth, enhanced insulin secretion and the role of lactogenic hormones. Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme. 1997; 29(6):301-7. Epub 1997/06/01. doi: 10.1055/s-2007-979040 PMID: 9230352.
45. Wawrusiewicz-Kurylonek N, Telejko B, Kuzmicki M, Sobota A, Lipinska D, Pliszka J, et al. Increased Maternal and Cord Blood Betatrophin in Gestational Diabetes. PloS one. 2015; 10(6):e0131171. Epub 2015/06/27. doi: 10.1371/journal.pone.0131171 PMID: 26115519; PubMed Central PMCID: PMC4483159.
46. Trebotic LK, Klimek P, Thomas A, Fenzl A, Leitner K, Springer S, et al. Circulating Betatrophin Is Strongly Increased in Pregnancy and Gestational Diabetes Mellitus. PloS one. 2015; 10(9):e0136701. Epub 2015/09/02. doi: 10.1371/journal.pone.0136701 PMID: 26325425; PubMed Central PMCID: PMC4556632.
47. Ebert T, Kralisch S, Wurst U, Lossner U, Kratzsch J, Bluher M, et al. Betatrophin levels are increased in women with gestational diabetes mellitus compared to healthy pregnant controls. European journal of endocrinology / European Federation of Endocrine Societies. 2015; 173(1):1-7. Epub 2015/04/09. doi: 10.1530/eje-14-0815 PMID: 25850828.
48. Erol O, Ellidag HY, Ayik H, Ozel MK, Derbent AU, Yilmaz N. Evaluation of circulating betatrophin levels in gestational diabetes mellitus. Gynecological endocrinology: the official journal of the International Society of Gynecological Endocrinology. 2015:1-5. Epub 2015/08/06. PMID: 26242313.
49. Fowden AL, Hill DJ. Intra-uterine programming of the endocrine pancreas. British medical bulletin. 2001; 60:123-42. Epub 2002/01/26. PMID: 11809622.
50. Erol O, Ellidag HY, Ayik H, Ozel MK, Derbent AU, Yilmaz N. Evaluation of circulating betatrophin levels in gestational diabetes mellitus. Gynecological endocrinology: the official journal of the International Society of Gynecological Endocrinology. 2015; 31(8):652-6. Epub 2015/08/21. doi: 10.3109/09513590.2015.1056142 PMID: 26291796.
51. Handschin C, Spiegelman BM. Peroxisome proliferator-activated receptor gamma coactivator 1 coactivators, energy homeostasis, and metabolism. Endocr Rev. 2006; 27(7):728-35. Epub 2006/10/05. doi: 10.1210/er.2006-0037 PMID: 17018837.
52. Newsholme P, Haber EP, Hirabara SM, Rebelato EL, Procopio J, Morgan D, et al. Diabetes associated cell stress and dysfunction: role of mitochondrial and non-mitochondrial ROS production and activity. The Journal of physiology. 2007; 583(Pt 1):9-24. Epub 2007/06/23. doi: 10.1113/jphysiol.2007.135871 PMID: 17584843; PubMed Central PMCID: PMC2277225.
53. Chiaratti MR, Malik S, Diot A, Rapa E, Macleod L, Morten K, et al. Is Placental Mitochondrial Function a Regulator that Matches Fetal and Placental Growth to Maternal Nutrient Intake in the Mouse? PloS one. 2015; 10(7):e0130631. Epub 2015/07/02. doi: 10.1371/journal.pone.0130631 PMID: 26132581; PubMed Central PMCID: PMC4488591.
54. Duque-Guimaraes DE, Ozanne SE. Nutritional programming of insulin resistance: causes and consequences. Trends in endocrinology and metabolism: TEM. 2013; 24(10):525-35. Epub 2013/06/25. doi: 10.1016/j.tem.2013.05.006 PMID: 23791137.