Elevated mouse hepatic betatrophin expression does not increase human β-Cell replication in the transplant setting

Diabetes

Volumn 63, Issue 4, 2014, Pages 1283-1288

  Jiao, Yang ^a   Le Lay, John ^a   Yu, Ming ^a   Naji, Ali ^a   Kaestner, Klaus H ^a  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BETATROPHIN PROTEIN; DNA; DRINKING WATER; HORMONE RECEPTOR BLOCKING AGENT; PROTEIN; S 961; UNCLASSIFIED DRUG;

ADULT; ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CELL DIVISION; CELL STIMULATION; CELLULAR DISTRIBUTION; CHILD; CONTROLLED STUDY; DIABETES MELLITUS; DNA REPLICATION; FEMALE; GENE EXPRESSION; HUMAN; HUMAN CELL; HUMAN TISSUE; KIDNEY CAPSULE; LIVER LEVEL; MALE; MIDDLE AGED; MOUSE; NONHUMAN; PANCREAS ISLET; PANCREAS ISLET BETA CELL; PANCREAS ISLET TRANSPLANTATION; PRESCHOOL CHILD; PRIORITY JOURNAL; YOUNG ADULT;

ADOLESCENT; ADULT; ANIMALS; CELL PROLIFERATION; CHILD, PRESCHOOL; FEMALE; HUMANS; INSULIN-SECRETING CELLS; ISLETS OF LANGERHANS TRANSPLANTATION; MALE; MICE; MICE, INBRED NOD; MICE, SCID; MIDDLE AGED; PEPTIDE HORMONES; PEPTIDES; RECEPTOR, INSULIN; TRANSPLANTATION, HETEROLOGOUS;

EID: 84897869437     PISSN: 00121797     EISSN: 1939327X     Source Type: Journal    
DOI: 10.2337/db13-1435     Document Type: Article

References (13)

1. Bonner-Weir S, Weir GC. New sources of pancreatic beta-cells. Nat Biotechnol 2005;23:857-861
2. Dor Y, Brown J, Martinez OI, Melton DA. Adult pancreatic beta-cells are formed by self-duplication rather than stem-cell differentiation. Nature 2004;429:41-46
3. Gupta RK, Gao N, Gorski RK, et al. Expansion of adult beta-cell mass in response to increased metabolic demand is dependent on HNF-4alpha. Genes Dev 2007;21:756-769
4. Heit JJ, Karnik SK, Kim SK. Intrinsic regulators of pancreatic beta-cell proliferation. Annu Rev Cell Dev Biol 2006;22:311-338
5. Brüning JC, Winnay J, Bonner-Weir S, Taylor SI, Accili D, Kahn CR. Development of a novel polygenic model of NIDDM in mice heterozygous for IR and IRS-1 null alleles. Cell 1997;88:561-572
6. Kido Y, Burks DJ, Withers D, et al. Tissue-specific insulin resistance in mice with mutations in the insulin receptor, IRS-1, and IRS-2. J Clin Invest 2000;105:199-205
7. Withers DJ, Gutierrez JS, Towery H, et al. Disruption of IRS-2 causes type 2 diabetes in mice. Nature 1998;391:900-904
8. Porat S, Weinberg-Corem N, Tornovsky-Babaey S, et al. Control of pancreatic b cell regeneration by glucose metabolism. Cell Metab 2011;13:440-449
9. Yi P, Park JS, Melton DA. Betatrophin: a hormone that controls pancreatic β cell proliferation. Cell 2013;153:747-758
10. Zhang R. Lipasin, a novel nutritionally-regulated liver-enriched factor that regulates serum triglyceride levels. Biochem Biophys Res Commun 2012;424:786-792
11. Quagliarini F, Wang Y, Kozlitina J, et al. Atypical angiopoietin-like protein that regulates ANGPTL3. Proc Natl Acad Sci U S A 2012;109:19751-19756
12. Schäffer L, Brand CL, Hansen BF, et al. A novel high-affinity peptide antagonist to the insulin receptor. Biochem Biophys Res Commun 2008;376:380-383
13. Kushner JA. The role of aging upon b cell turnover. J Clin Invest 2013;123:990-995