Angiopoietin-like protein 8 (ANGPTL8)/betatrophin overexpression does not increase beta cell proliferation in mice

Diabetologia

Volumn 58, Issue 7, 2015, Pages 1523-1531

  Cox, Aaron R ^a,b   Lam, Carol J ^a,b   Bonnyman, Claire W ^a,b   Chavez, Julia ^a,b   Rios, Jacqueline S ^a,b   Kushner, Jake A ^a,b  

^a BAYLOR COLLEGE OF MEDICINE   (United States)

^b TEXAS CHILDREN S HOSPITAL   (United States)

Author keywords

Ageing; ANGPTL8; Betatrophin; Lipasin; Lipid homeostasis; Pancreatic beta cell; RIFL

Indexed keywords

ANGIOPOIETIN; ANGIOPOIETIN LIKE PROTEIN 8; DNA; GREEN FLUORESCENT PROTEIN; UNCLASSIFIED DRUG; ANGIOPOIETIN-LIKE PROTEIN 8, MOUSE; GLUCOSE; LIPASIN PROTEIN, MOUSE; PEPTIDE HORMONE;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; CELL DIVISION; CELL PROLIFERATION; COHORT ANALYSIS; CONTROLLED STUDY; GENE EXPRESSION; GENETIC STRAIN; GLUCOSE HOMEOSTASIS; HYDRODYNAMICS; MALE; MOUSE; NONHUMAN; PANCREAS ISLET BETA CELL; PRIORITY JOURNAL; TAIL VEIN; AGING; ANIMAL; BIOSYNTHESIS; GENETICS; INSTITUTE FOR CANCER RESEARCH MOUSE; LIPID METABOLISM; METABOLISM; PANCREAS RESECTION; PHYSIOLOGY;

AGING; ANGIOPOIETINS; ANIMALS; CELL PROLIFERATION; DNA; GLUCOSE; INSULIN-SECRETING CELLS; LIPID METABOLISM; MALE; MICE; MICE, INBRED ICR; PANCREATECTOMY; PEPTIDE HORMONES;

EID: 84931566375     PISSN: 0012186X     EISSN: 14320428     Source Type: Journal    
DOI: 10.1007/s00125-015-3590-z     Document Type: Article

References (31)

1. Gepts W (1965) Pathologic anatomy of the pancreas in juvenile diabetes mellitus. Diabetes 14:619–633
2. Butler AE, Janson J, Bonner-Weir S et al (2003) Beta-cell deficit and increased beta-cell apoptosis in humans with type 2 diabetes. Diabetes 52:102–110
3. Kushner JA, MacDonald PE, Atkinson MA (2014) Stem cells to insulin secreting cells: two steps forward and now a time to pause? Cell Stem Cell 15:535–536
4. Dor Y, Brown J, Martinez OI, Melton DA (2004) Adult pancreatic beta-cells are formed by self-duplication rather than stem-cell differentiation. Nature 429:41–46
5. Teta M, Rankin MM, Long SY, Stein GM, Kushner JA (2007) Growth and regeneration of adult beta cells does not involve specialized progenitors. Dev Cell 12:817–826
6. Kulkarni RN, Mizrachi EB, Ocana AG, Stewart AF (2012) Human beta-cell proliferation and intracellular signaling: driving in the dark without a road map. Diabetes 61:2205–2213
7. Michael MD, Kulkarni RN, Postic C et al (2000) Loss of insulin signaling in hepatocytes leads to severe insulin resistance and progressive hepatic dysfunction. Mol Cell 6:87–97
8. Flier SN, Kulkarni RN, Kahn CR (2001) Evidence for a circulating islet cell growth factor in insulin-resistant states. Proc Natl Acad Sci U S A 98:7475–7480
9. El Ouaamari A, Kawamori D, Dirice E et al (2013) Liver-derived systemic factors drive beta cell hyperplasia in insulin-resistant states. Cell Rep 3:401–410
10. Yi P, Park JS, Melton DA (2013) Betatrophin: a hormone that controls pancreatic beta cell proliferation. Cell 153:747–758
11. Quagliarini F, Wang Y, Kozlitina J et al (2012) Atypical angiopoietin-like protein that regulates ANGPTL3. Proc Natl Acad Sci U S A 109:19751–19756
12. Zhang R (2012) Lipasin, a novel nutritionally-regulated liver-enriched factor that regulates serum triglyceride levels. Biochem Biophys Res Commun 424:786–792
13. Ren G, Kim JY, Smas CM (2012) Identification of RIFL, a novel adipocyte-enriched insulin target gene with a role in lipid metabolism. Am J Physiol Endocrinol Metab 303:E334–E351
14. Lickert H (2013) Betatrophin fuels beta cell proliferation: first step toward regenerative therapy? Cell Metab 18:5–6
15. Seymour PA, Serup P (2013) Bulking up on beta cells. N Engl J Med 369:777–779
16. Crunkhorn S (2013) Metabolic disorders: betatrophin boosts beta-cells. Nat Rev Drug Discov 12:504
17. Chen X, Lu P, He W et al (2015) Circulating betatrophin levels are increased in patients with type 2 diabetes and associated with insulin resistance. J Clin Endocrinol Metab 100:E96–E100
18. Hu H, Sun W, Yu S et al (2014) Increased circulating levels of betatrophin in newly diagnosed type 2 diabetic patients. Diabetes Care 37:2718–2722
19. Gomez-Ambrosi J, Pascual E, Catalan V et al (2014) Circulating betatrophin concentrations are decreased in human obesity and type 2 diabetes. J Clin Endocrinol Metab 99:E2004–E2009
20. Wang Y, Quagliarini F, Gusarova V et al (2013) Mice lacking ANGPTL8 (betatrophin) manifest disrupted triglyceride metabolism without impaired glucose homeostasis. Proc Natl Acad Sci U S A 110:16109–16114
21. Jiao Y, Le Lay J, Yu M, Naji A, Kaestner KH (2014) Elevated mouse hepatic betatrophin expression does not increase human beta-cell replication in the transplant setting. Diabetes 63:1283–1288
22. Stewart AF (2014) Betatrophin versus bitter-trophin and the elephant in the room: time for a new normal in beta-cell regeneration research. Diabetes 63:1198–1199
23. Gusarova V, Alexa Corey A, Na E et al (2014) ANGPTL8/betatrophin does not control pancreatic beta cell expansion. Cell 159:691–696
24. Yi P, Park J-S, Melton DA (2014) Perspectives on the activities of ANGPTL8/betatrophin. Cell 159:468
25. Liu F, Song Y, Liu D (1999) Hydrodynamics-based transfection in animals by systemic administration of plasmid DNA. Gene Ther 6:1258–1266
26. Song YK, Liu F, Zhang G, Liu D (2002) Hydrodynamics-based transfection: simple and efficient method for introducing and expressing transgenes in animals by intravenous injection of DNA. Methods Enzymol 346:92–105
27. Yant SR, Meuse L, Chiu W et al (2000) Somatic integration and long-term transgene expression in normal and haemophilic mice using a DNA transposon system. Nat Genet 25:35–41
28. Zhang G, Budker V, Wolff JA (1999) High levels of foreign gene expression in hepatocytes after tail vein injections of naked plasmid DNA. Hum Gene Ther 10:1735–1737
29. Rankin MM, Kushner JA (2009) Adaptive beta-cell proliferation is severely restricted with advanced age. Diabetes 58:1365–1372
30. Rankin MM, Wilbur CJ, Rak K et al (2013) Beta cells are not generated in pancreatic duct ligation induced injury in adult mice. Diabetes 62:1634–1645
31. Tuttle AH, Rankin MM, Teta M, Sartori DJ, Stein GM et al (2010) Immunofluorescent detection of two thymidine analogues (CldU and IdU) in primary tissue. J Vis Exp 2166