Longitudinal associations between BDNF promoter methylation and late-life depression

Neurobiology of Aging

Volumn 36, Issue 4, 2015, Pages 1764.e1-1764.e7

  Kang, Hee Ju ^a   Kim, Jae Min ^a   Bae, Kyung Yeol ^a   Kim, Sung Wan ^a   Shin, Il Seon ^a   Kim, Hye Ran ^a   Shin, Myung Geun ^a   Yoon, Jin Sang ^a  

^a Chonnam National University Medical School   (South Korea)

Author keywords

Aged; BDNF; Depression; DNA methylation; Epigenetics

Indexed keywords

BRAIN DERIVED NEUROTROPHIC FACTOR; BIOLOGICAL MARKER;

AGED; ARTICLE; CONTROLLED STUDY; CPG ISLAND; DEPRESSION ASSESSMENT; DISEASE ASSOCIATION; DISEASE SEVERITY; DNA METHYLATION; DNA METHYLATION ASSAY; DNA POLYMORPHISM; DNA SEQUENCE; EPIGENETICS; FEMALE; FOLLOW UP; GENOTYPE; GERIATRIC DEPRESSION SCALE; GERIATRIC MENTAL STATE SCHEDULE; HUMAN; INCIDENCE; KOREAN (PEOPLE); LATE LIFE DEPRESSION; LONGITUDINAL STUDY; MAJOR CLINICAL STUDY; MALE; NUCLEOTIDE SEQUENCE; PREVALENCE; PRIORITY JOURNAL; PROMOTER REGION; SUICIDAL IDEATION; DEPRESSION; GENETIC POLYMORPHISM; GENETICS; PHYSIOLOGY; RISK FACTOR; SECRETION (PROCESS); SEVERITY OF ILLNESS INDEX; STATISTICAL MODEL;

AGED; BIOMARKERS; BRAIN-DERIVED NEUROTROPHIC FACTOR; DEPRESSION; DNA METHYLATION; FEMALE; FOLLOW-UP STUDIES; HUMANS; INCIDENCE; LOGISTIC MODELS; MALE; POLYMORPHISM, GENETIC; PROMOTER REGIONS, GENETIC; RISK FACTORS; SEVERITY OF ILLNESS INDEX;

EID: 84925297855     PISSN: 01974580     EISSN: 15581497     Source Type: Journal    
DOI: 10.1016/j.neurobiolaging.2014.12.035     Document Type: Article

References (48)

1. Alexopoulos G.S. Depression in the elderly. Lancet 2005, 365:1961-1970.
2. Alexopoulos G.S., Kelly R.E. Research advances in geriatric depression. World Psychiatry 2009, 8:140-149.
3. Belmaker R.H., Agam G. Major depressive disorder. N.Engl. J. Med. 2008, 358:55-68.
4. Chen W.G., Chang Q., Lin Y., Meissner A., West A.E., Griffith E.C., Jaenisch R., Greenberg M.E. Derepression of BDNF transcription involves calcium-dependent phosphorylation of MeCP2. Science 2003, 302:885-889.
5. Chu C.L., Liang C.K., Chou M.Y., Lin Y.T., Pan C.C., Lu T., Chen L.K., Chow P.C. Decreased plasma brain-derived neurotrophic factor levels in institutionalized elderly with depressive disorder. J.Am. Med. Dir. Assoc. 2012, 13:434-437.
6. Copeland J.R.M., Dewey M.E., Griffiths-Jones H.M. Acomputerized psychiatric diagnostic system and case nomenclature for elderly subjects: GMS and AGECAT. Psychol. Med. 1986, 16:89-99.
7. Devlin A.M., Brain U., Austin J., Oberlander T.F. Prenatal exposure to maternal depressed mood and the MTHFR C677T variant affect SLC6A4 methylation in infants at birth. PLoS One 2010, 5:e12201.
8. Diniz B.S., Reynolds C.F., Begley A., Dew M.A., Anderson S.J., Lotrich F., Erickson K.I., Lopez O., Aizenstein H., Sibille E.L., Butters M.A. Brain-derived neurotrophic factor level in late-life depression and comorbid mild cognitive impairment: a longitudinal study. J.Psychiatr. Res. 2014, 49:96-101.
9. Egan M.F., Kojima M., Callicott J.H., Goldberg T.E., Kolachana B.S., Bertolino A., Zaitsev E., Gold B., Goldman D., Dean M., Lu B., Weinberger D.R. The BDNF val66met polymorphism affects activity-dependent secretion of BDNF and human memory and hippocampal function. Cell 2003, 112:257-269.
10. Folstein M.F., Fostein S.E., McHugh P.R. "Mini-Mental State": a practical method for grading the cognitive state of patients for the clinician. J.Psychiatr. Res. 1975, 12:189-198.
11. Fuchikami M., Morinobu S., Segawa M., Okamoto Y., Yamawaki S., Ozaki N., Inoue T., Kusumi I., Koyama T., Tsuchiyama K., Terao T. DNA methylation profiles of the brain-derived neurotrophic factor (BDNF) gene as a potent diagnostic biomarker in major depression. PLoS One 2011, 6:e23881.
12. Henningsson S., Borg J., Lundberg J., Bah J., Lindström M., Ryding E., Jovanovic H., Saijo T., Inoue M., Rosén I., Träskman-Bendz L., Farde L., Eriksson E. Genetic variation in brain-derived neurotrophic factor is associated with serotonin transporter but not serotonin-1A receptor availability in men. Biol. Psychiatry 2009, 66:477-485.
13. Hochberg Z., Feil R., Constancia M., Fraga M., Junien C., Carel J.C., Boileau P., Le Bouc Y., Deal C.L., Lillycrop K., Scharfmann R., Sheppard A., Skinner M., Szyf M., Waterland R.A., Waxman D.J., Whitelaw E., Ong K., Albertsson-Wikland K. Child health, developmental plasticity, and epigenetic programming. Endocr. Rev. 2010, 32:159-224.
14. Hu Y., Russek S.J. BDNF and the diseased nervous system: a delicate balance between adaptive and pathological processes of gene regulation. J.Neurochem. 2008, 105:1-17.
15. Huang E.J., Reichardt L.F. Neutrophins: roles in neuronal development and function. Annu. Rev. Neurosci. 2001, 24:677-736.
16. Hwang J.P., Tsai S.J., Hong C.J., Yang C.H., Lirng J.F., Yang Y.M. The Val66Met polymorphism of the brain-derived neurotrophic-factor gene is associated with geriatric depression. Neurobiol. Aging 2006, 27:1834-1837.
17. Kanellopoulos D., Gunning F.M., Morimoto S.S., Hoptman M.J., Murphy C.F., Kelly R.E., Glatt C., Lim K.O., Alexopoulos G.S. Hippocampal volumes and the brain-derived neurotrophic factor val66met polymorphism in geriatric major depression. Am. J. Geriatr. Psychiatry 2011, 19:13-22.
18. Kang H.J., Kim J.M., Lee J.Y., Kim S.Y., Bae K.Y., Kim S.W., Shin I.S., Kim H.R., Shin M.G., Yoon J.S. BDNF promoter methylation and suicidal behavior in depressive patients. J.Affect. Disord. 2013, 151:679-685.
19. Kang H.J., Kim J.M., Stewart R., Kim S.Y., Bae K.Y., Kim S.W., Shin I.S., Shin M.G., Yoon J.S. Association of SLC6A4 methylation with early adversity, characteristics and outcomes in depression. Prog. Neuropsychopharmacol. Biol. Psychiatry 2013, 44:23-28.
20. Karege F., Vaudan G., Schwald M., Perroud N., La Harpe R. Neurotrophin levels in postmortem brains of suicide victims and the effects of antemortem diagnosis and psychotropic drugs. Brain Res. Mol. Brain Res. 2005, 136:29-37.
21. Keller S., Sarchiapone M., Zarrilli F., Videtic A., Ferraro A., Carli V., Sacchetti S., Lembo F., Angiolillo A., Jovanovic N., Pisanti F., Tomaiuolo R., Monticelli A., Balazic J., Roy A., Marusic A., Cocozza S., Fusco A., Bruni C.B., Castaldo G., Chiariotti L. Increased BDNF promoter methylation in the Wernicke area of suicide subjects. Arch. Gen. Psychiatry 2010, 67:258-267.
22. Kim J.M., Stewart R., Glozier N., Prince M., Kim S.-W., Yang S.-J., Shin I.-S., Yoon J.-S. Physical health, depression and cognitive function as correlates of disability in an older Korean population. Int. J. Geriatr. Psychiatry 2005, 20:160-167.
23. Kim J.M., Stewart R., Kang H.J., Kim S.Y., Kim S.W., Shin I.S., Park M.S., Kim H.R., Shin M.G., Cho K.H., Yoon J.S. Alongitudinal study of BDNF promoter methylation and genotype with poststroke depression. J.Affect. Disord. 2013, 149:93-99.
24. Kim J.M., Stewart R., Kang H.J., Kim S.W., Shin I.S., Kim H.R., Shin M.G., Kim J.T., Park M.S., Cho K.H., Yoon J.S. Alongitudinal study of SLC6A4 DNA promoter methylation and poststroke depression. J.Psychiatr. Res. 2013, 47:1222-1227.
25. Kim J.M., Stewart R., Kim S.W., Kim S.Y., Bae K.Y., Kang H.J., Jang J.E., Shin I.S., Yoon J.S. Physical health and incident late-life depression: modification by genes affecting cytokine function. Neurobiol. Aging 2013, 34:356.e1-356.e9.
26. Kim J.M., Stewart R., Kim S.W., Yang S.J., Shin I.S., Kim Y.H., Yoon J.S. Interactions between life stressors and susceptibility genes (5-HTTLPR and BDNF) on depression in Korean elders. Biol. Psychiatry 2007, 62:423-428.
27. Kim J.M., Stewart R., Prince M., Shin I.S., Yoon J.S. Diagnosing dementia in a developing nation: an evaluation of the GMS-AGECAT algorithm in an older Korean population. Int. J. Geriatr. Psychiatry 2003, 18:331-336.
28. Kinnally E.L., Capitanio J.P., Leibel R., Deng L., LeDuc C., Haghighi F., Mann J.J. Epigenetic regulation of serotonin transporter expression and behavior in infant rhesus macaques. Genes Brain Behav. 2010, 9:575-582.
29. Laske C., Banschbach S., Stransky E., Bosch S., Straten G., Machann J., Fritsche A., Hipp A., Niess A., Eschweiler G.W. Exercise-induced normalization of decreased BDNF serum concentration in elderly women with remitted major depression. Int. J. Neuropsychopharmacol. 2010, 13:595-602.
30. Lindesay J. The Guy's/Age Concern Survey: physical health and psychiatric disorder in an urban elderly community. Int. J. Geriatr. Psychiatry 1990, 5:171-178.
31. Lubin F.D., Roth T.L., Sweatt J.D. Epigenetic regulation of BDNF gene transcription in the consolidation of fear memory. J.Neurosci. 2008, 28:10576-10586.
32. Martinowich K., Hattori D., Wu H., Fouse S., He F., Hu Y., Fan G., Sun Y.E. DNA methylation related chromatin remodeling in activity-dependent BDNF gene regulation. Science 2003, 302:890-893.
33. Mill J., Petronis A. Molecular studies of major depressive disorder: the epigenetic perspective. Mol. Psychiatry 2007, 12:799-814.
34. Philibert R.A., Sandhu H., Hollenbeck N., Gunter T., Adams W., Madan A. The relationship of 5HTT (SLC6A4) methylation and genotype on mRNA expression and liability to major depression and alcohol dependence in subjects from the Iowa Adoption Studies. Am. J. Med. Genet. B Neuropsychiatr. Genet. 2008, 147B:543-549.
35. Pidsley R., Mill J. Epigenetic studies of psychosis: current findings, methodological approaches, and implications for postmortem research. Biol. Psychiatry 2011, 69:146-156.
36. Powell T.R., Smith R.G., Hackinger S., Schalkwyk L.C., Uher R., McGuffin P., Mill J., Tansey K.E. DNA methylation in interleukin-11 predicts clinical response to antidepressants in GENDEP. Transl. Psychiatry 2013, 33:e300.
37. Roth T.L., Lubin F.D., Funk A.J., Sweatt J.D. Lasting epigenetic influence of early-life adversity on the BDNF gene. Biol. Psychiatry 2009, 65:760-769.
38. Schroeder M., Krebs M.O., Bleich S., Frieling H. Epigenetics and depression: current challenges and new therapeutic options. Curr. Opin. Psychiatry 2010, 23:588-592.
39. Shi Y., You J., Yuan Y., Zhang X., Li H., Hou G. Plasma BDNF and tPA are associated with late-onset geriatric depression. Psychiatry Clin. Neurosci. 2010, 64:249-254.
40. Smith G.S., Gunning-Dixon F.M., Lotrich F.E., Taylor W.D., Evans J.D. Translational research in late-life mood disorders: implications for future intervention and prevention research. Neuropsychopharmacology 2007, 32:1857-1875.
41. Surtees P.G., Wainwright N.W., Willis-Owen S.A., Sandhu M.S., Luben R., Day N.E., Flint J. No association between the BDNF Val66Met polymorphism and mood status in a non-clinical community sample of 7389 older adults. J.Psychiatr. Res. 2007, 41:404-409.
42. Tadić A., Müller-Engling L., Schlicht K.F., Kotsiari A., Dreimüller N., Kleimann A., Bleich S., Lieb K., Frieling H. Methylation of the promoter of brain-derived neurotrophic factor exon IV and antidepressant response in major depression. Mol. Psychiatry 2014, 19:281-283.
43. Taylor W.D., McQuoid D.R., Ashley-Koch A., MacFall J.R., Bridgers J., Krishnan R.R., Steffens D.C. BDNF Val66Met genotype and 6-month remission rates in late-life depression. Pharmacogenomics J. 2011, 11:146-154.
44. Taylor W.D., Züchner S., McQuoid D.R., Steffens D.C., Speer M.C., Krishnan K.R. Allelic differences in the brain-derived neurotrophic factor Val66Met polymorphism in late-life depression. Am. J. Geriatr. Psychiatry 2007, 15:850-857.
45. Uddin M., Koenen K.C., Aiello A.E., Wildman D.E., de los Santos R., Galea S. Epigenetic and inflammatory marker profiles associated with depression in a community-based epidemiologic sample. Psychol. Med. 2011, 41:997-1007.
46. Yesavage J.A., Brink T.L., Rose T.L., Lum O., Huang V., Adey M., Leirer V.O. Development and validation of a geriatric depression scale: a preliminary report. J.Psychiatr. Res. 1982-1983, 17:37-49.
47. Zhao J., Goldberg J., Bremner J.D., Vaccarino V. Association between promoter methylation of serotonin transporter gene and depressive symptoms: a monozygotic twin study. Psychosom. Med. 2013, 75:523-529.
48. Zill P., Baghai T.C., Schüle C., Born C., Früstück C., Büttner A., Eisenmenger W., Varallo-Bedarida G., Rupprecht R., Möller H.J., Bondy B. DNA methylation analysis of the angiotensin converting enzyme (ACE) gene in major depression. PLoS One 2012, 7:e40479.