Epigenetic modulation of BDNF gene: Differences in DNA methylation between unipolar and bipolar patients

Journal of Affective Disorders

Volumn 166, Issue , 2014, Pages 330-333

  Dell'Osso, Bernardo ^a   D'Addario, Claudio ^b,c   Carlotta Palazzo, Maria ^a   Benatti, Beatrice ^a   Camuri, Giulia ^a   Galimberti, Daniela ^a   Fenoglio, Chiara ^a   Scarpini, Elio ^a   Di Francesco, Andrea ^b   MacCarrone, Mauro ^d,e   Carlo Altamura, A ^a  

^a UNIVERSITY OF MILAN   (Italy)

^b UNIVERSITY OF TERAMO   (Italy)

^c KAROLINSKA INSTITUTE   (Sweden)

^d UNIVERSITY CAMPUS BIO MEDICO   (Italy)

^e IRCCS FONDAZIONE SANTA LUCIA   (Italy)

Author keywords

Bipolar disorders; Brain derived neurotrophic factor (BDNF); Epigenetics; Major depressive disorder; Methylation

Indexed keywords

BRAIN DERIVED NEUROTROPHIC FACTOR; DNA; LITHIUM; PSYCHOTROPIC AGENT; VALPROIC ACID;

ADULT; ANALYSIS OF VARIANCE; ARTICLE; BIPOLAR DISORDER; BIPOLAR I DISORDER; BIPOLAR II DISORDER; CONTROLLED STUDY; CROSS-SECTIONAL STUDY; DNA METHYLATION; EPIGENETICS; HUMAN; MAJOR CLINICAL STUDY; MAJOR DEPRESSION; MANIA; PERIPHERAL BLOOD MONONUCLEAR CELL; POST HOC ANALYSIS; PRESCRIPTION; PRIORITY JOURNAL; PROMOTER REGION; AGED; CASE CONTROL STUDY; DEPRESSIVE DISORDER, MAJOR; FEMALE; GENETIC EPIGENESIS; GENETICS; MALE; MIDDLE AGED; MONONUCLEAR CELL;

ADULT; AGED; BIPOLAR DISORDER; BRAIN-DERIVED NEUROTROPHIC FACTOR; CASE-CONTROL STUDIES; CROSS-SECTIONAL STUDIES; DEPRESSIVE DISORDER, MAJOR; DNA METHYLATION; EPIGENESIS, GENETIC; FEMALE; HUMANS; LEUKOCYTES, MONONUCLEAR; MALE; MIDDLE AGED; PROMOTER REGIONS, GENETIC;

EID: 84902578460     PISSN: 01650327     EISSN: 15732517     Source Type: Journal    
DOI: 10.1016/j.jad.2014.05.020     Document Type: Article

References (24)

1. American Psychiatric Association Diagnostic and statistical manual of mental disorders 4th ed. 1994 American Psychiatric Press Washington, DC
2. F. Boulle, D.L. van den Hove, S.B. Jakob, B.P. Rutten, M. Hamon, J. van Os, K.P. Lesch, L. Lanfumey, H.W. Steinbusch, and G. Kenis Epigenetic regulation of the BDNF gene: implications for psychiatric disorders Mol. Psychiatry 17 6 2012 584 596
3. N. Craddock, and I. Jones Molecular genetics of bipolar disorder Br. J. Psychiatry Suppl. 178 2001 128 133 (Pubitemid 32530340)
4. R.S. Duman, J. Malberg, S. Nakagawa, and C. D'sa Neuronal plasticity and survival in mood disorders Biol. Psychiatry 48 2000 732 739
5. C. D'Addario, B. Dell'Osso, M.C. Palazzo, B. Benatti, L. Lietti, E. Cattaneo, D. Galimberti, C. Fenoglio, F. Cortini, E. Scarpini, B. Arosio, A. Di Francesco, M. Di Benedetto, P. Romualdi, S. Candeletti, D. Mari, L. Bergamaschini, N. Bresolin, M. Maccarrone, and A.C. Altamura Selective DNA methylation of BDNF promoter in bipolar disorder: differences among patients with BDI and BDII Neuropsychopharmacology 37 7 2012 1647 1655
6. C. D'Addario, B. Dell'Osso, D. Galimberti, M.C. Palazzo, B. Benatti, A. Di Francesco, E. Scarpini, A.C. Altamura, and M. Maccarrone modulation of BDNF gene in patients with major depressive disorder Biol. Psychiatry 73 2 2013 e6 e7
7. A.J. de Ruijter, A.H. van Gennip, H.N. Caron, S. Kemp, and A.B. van Kuilenburg Histone deacetylases (HDACs): characterization of the classical HDAC family Biochem. J. 370 Pt. 3 2003 737 749 (Pubitemid 36399066)
8. F. Dangond, and S.R. Gullans Differential expression of human histone deacetylase mRNAs in response to immune cell apoptosis induction by trichostatin A and butyrate Biochem. Biophys. Res. Commun. 247 3 1998 833 837 (Pubitemid 28418477)
9. M.N. Davies, M. Volta, R. Pidsley, K. Lunnon, A. Dixit, S. Lovestone, C. Coarfa, R.A. Harris, A. Milosavljevic, C. Troakes, S. Al-Sarraj, R. Dobson, L.C. Schalkwyk, and J. Mill Functional annotation of the human brain methylome identifies tissue-specific epigenetic variation across brain and blood Genome Biol. 13 6 2012 R43
10. M.B. First, M. Gibbon, R.L. Spitzer, J.B.W. Williams, and L.S. Benjamin Structured Clinical Interview for DSM-IV Axis II Personality Disorders (SCID-II) 1997 American Psychiatric Press Washington, DC
11. M.B. First, R.L. Spitzer, L. Gibbon, and J.B.V. Williams Structured Clinical Interview for DSM-IV-TR Axis I Disorders, Research Version, Non-Patient Edition (SCID-I/NP) 2002 New York State Psychiatric Institute, Biometric Research New York
12. B.S. Fernandes, C.S. Gama, K.M. Ceresér, L.N. Yatham, G.R. Fries, G. Colpo, D. de Lucena, M. Kunz, F.A. Gomes, and F. Kapczinski Brain-derived neurotrophic factor as a state-marker of mood episodes in bipolar disorders: a systematic review and meta-regression analysis J. Psychiatr. Res. 45 8 2011 995 1004
13. D.P. Gavin, and R.P. Sharma Chromatin from peripheral blood mononuclear cells as biomarkers for epigenetic abnormalities in schizophrenia Cardiovasc. Psychiatry Neurol. 2009 409562
14. K.J. Livak, and T.D. Schmittgen Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) method Methods 25 2001 402 408 (Pubitemid 34164012)
15. X. Lu, J.N. Freund, M. Muller, J. Ravey, J.P. Nicolas, J.L. Gueant, and F. Namour Differential regulation of CDX1 and CDX2 gene expression by deficiency in methyl group donors Biochimie 90 5 2008 697 704
16. P.O. McGowan, and T. Kato Epigenetics in mood disorders Environ. Health Prev. Med. 13 1 2008 16 24
17. K. Nakata, H. Ujike, A. Sakai, N. Uchida, A. Nomura, and T. Imamura Association study of the brain-derived neurotrophic factor (BDNF) gene with bipolar disorder Neurosci. Lett. 337 2003 17 20 (Pubitemid 36078301)
18. R. Pidsley, and J. Mill Research highlights: epigenetic changes to serotonin receptor gene expression in schizophrenia and bipolar disorder Epigenomics 3 5 2011 537 538
19. M. Schroeder, M.O. Krebs, S. Bleich, and H. Frieling Epigenetics and depression: current challenges and new therapeutic options Curr. Opin. Psychiatry 23 6 2010 5 88 92
20. B.D. Schanker Epigenetic regulation of brain-derived neurotrophic factor: implications in neurodevelopment and behavior Behav. Brain Sci. 35 5 2012 377 378
21. M.T. Tsuang, and S.V. Faraone The Genetics of Mood Disorders 1990 Johns Hopkins University Press Baltimore, MD
22. T. Timmuskb Multiple promoters direct tissue-specific expression of the rat BDNF gene Neuron 10 1993 475 489
23. R. Uher The implications of gene-environment interactions in depression: will cause inform cure? Mol. Psychiatry 13 2008 1070 1078
24. D.D. Zhang, L.J. Cheng, J.A. Badner, C. Chen, Q. Chen, W. Luo, D.W. Craig, M. Redman, E.S. Gershon, and C.Y. Liu Genetic control of individual differences in gene-specific methylation in human brain Am. J. Hum. Genet. 86 2010 411 419