Diphtheria toxin-induced cell death triggers Wnt-dependent hair cell regeneration in neonatal mice

Journal of Neuroscience

Volumn 36, Issue 36, 2016, Pages 9479-9489

  Hu, Lingxiang ^a,b,c   Lu, Jingrong ^a,b,c   Chiang, Hao ^b,c   Wu, Hao ^a   Edge, Albert S B ^b,c   Shi, Fuxin ^b,c  

^a SHANGHAI JIAO TONG UNIVERSITY SCHOOL OF MEDICINE   (China)

^b HARVARD MEDICAL SCHOOL   (United States)

^c MASSACHUSETTS EYE AND EAR INFIRMARY   (United States)

Author keywords

Apoptosis; Hair cell; Necrosis; Regeneration; Wnt

Indexed keywords

BETA CATENIN; KI 67 ANTIGEN; MYOSIN VIIA; N2 [2 (3,5 DIFLUOROPHENYL) 2 HYDROXYACETYL] N1 (6,7 DIHYDRO 5 METHYL 6 OXO 5H DIBENZ[B,D]AZEPIN 7 YL)ALANINAMIDE; NEOMYCIN; NOTCH RECEPTOR; TRANSCRIPTION FACTOR SOX2; WNT PROTEIN; BENZOTHIAZOLE DERIVATIVE; DIPHTHERIA TOXIN; DNA BINDING PROTEIN; ENZYME INHIBITOR; GFI1 PROTEIN, MOUSE; HEPARIN BINDING EPIDERMAL GROWTH FACTOR; IWP-2 COMPOUND; POISON; SOX2 PROTEIN, MOUSE; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR SOX;

ANIMAL EXPERIMENT; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CELL COUNTING; CELL DEATH; CELL DIFFERENTIATION; CELL LABELING; CELL PROLIFERATION; CELL REGENERATION; CONFOCAL LASER SCANNING MICROSCOPY; CONTROLLED STUDY; DIPHTHERIA TOXIN INDUCED CELL DEATH; FEMALE; IMMUNOHISTOCHEMISTRY; INNER HAIR CELL; MALE; MOUSE; NEUROEPITHELIUM; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; RNA EXTRACTION; UPREGULATION; WNT SIGNALING PATHWAY; AGE; ANIMAL; COCHLEAR HAIR CELL; DRUG EFFECTS; GENE EXPRESSION REGULATION; GENETICS; METABOLISM; NEWBORN; REGENERATION; TRANSGENIC MOUSE;

AGE FACTORS; ANIMALS; ANIMALS, NEWBORN; APOPTOSIS; BENZOTHIAZOLES; BETA CATENIN; CELL DEATH; CELL DIFFERENTIATION; CELL PROLIFERATION; DIPHTHERIA TOXIN; DNA-BINDING PROTEINS; ENZYME INHIBITORS; GENE EXPRESSION REGULATION, DEVELOPMENTAL; HAIR CELLS, AUDITORY; HEPARIN-BINDING EGF-LIKE GROWTH FACTOR; MICE; MICE, TRANSGENIC; NEOMYCIN; POISONS; REGENERATION; SOXB1 TRANSCRIPTION FACTORS; TRANSCRIPTION FACTORS; WNT PROTEINS;

EID: 84986887489     PISSN: 02706474     EISSN: 15292401     Source Type: Journal    
DOI: 10.1523/JNEUROSCI.2447-15.2016     Document Type: Article

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