Notch Inhibition Induces Cochlear Hair Cell Regeneration and Recovery of Hearing after Acoustic Trauma

Neuron

Volumn 77, Issue 1, 2013, Pages 58-69

  Mizutari, Kunio ^a,b   Fujioka, Masato ^a,b,c   Hosoya, Makoto ^c   Bramhall, Naomi ^a,b,d   Okano, Hirotaka James ^c   Okano, Hideyuki ^c   Edge, Albert S B ^a,b,d  

^a HARVARD MEDICAL SCHOOL   (United States)

^b MASSACHUSETTS EYE AND EAR INFIRMARY   (United States)

^c KEIO UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^d MASSACHUSETTS INSTITUTE OF TECHNOLOGY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BASIC HELIX LOOP HELIX TRANSCRIPTION FACTOR; N2 [2 (3,5 DIFLUOROPHENYL) 2 HYDROXYACETYL] N1 (6,7 DIHYDRO 5 METHYL 6 OXO 5H DIBENZ[B,D]AZEPIN 7 YL)ALANINAMIDE; NOTCH RECEPTOR; PROTEIN ATOH1; TRANSCRIPTION FACTOR SOX2; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL DIFFERENTIATION; CELL FATE; CELL REGENERATION; CELL STIMULATION; CELL TRANSPLANTATION; CHEMICAL LABELING; CONTROLLED STUDY; CONVALESCENCE; DRUG POTENCY; DRUG SCREENING; EVOKED BRAIN STEM RESPONSE; FEMALE; HAIR CELL; HEARING IMPAIRMENT; IN VIVO STUDY; INTRACELLULAR SIGNALING; MALE; MOUSE; NEWBORN; NOISE INJURY; NONHUMAN; PRIORITY JOURNAL; RECEPTOR BLOCKING; TREATMENT OUTCOME;

ACOUSTIC STIMULATION; ALANINE; AMYLOID PRECURSOR PROTEIN SECRETASES; ANIMALS; ANIMALS, NEWBORN; AZEPINES; COCHLEA; FEMALE; HAIR CELLS, AUDITORY; HEARING; HEARING LOSS, NOISE-INDUCED; MALE; MICE; MICE, INBRED C57BL; MICE, TRANSGENIC; NERVE REGENERATION; ORGAN CULTURE TECHNIQUES; RECEPTORS, NOTCH; RECOVERY OF FUNCTION;

EID: 84872173335     PISSN: 08966273     EISSN: 10974199     Source Type: Journal    
DOI: 10.1016/j.neuron.2012.10.032     Document Type: Article

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