Cellular mechanisms of aminoglycoside ototoxicity

Current Opinion in Otolaryngology and Head and Neck Surgery

Volumn 18, Issue 5, 2010, Pages 454-458

  Warchol, Mark E ^a  

^a WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

antibiotics; cochlea; hair cell; hearing; otoprotection; vestibular

Indexed keywords

CASPASE; CYTOCHROME C; FREE RADICAL; GENTAMICIN; HEAT SHOCK PROTEIN; LOOP DIURETIC AGENT; MITOCHONDRIAL RNA; MITOGEN ACTIVATED PROTEIN KINASE; NEOMYCIN; NUCLEASE; REACTIVE OXYGEN METABOLITE; STRESS ACTIVATED PROTEIN KINASE;

APOPTOSIS; CELL DAMAGE; COCHLEA; CONFORMATIONAL TRANSITION; EAR PROTECTION; ENDOLYMPH; ENZYME ACTIVATION; HAIR CELL; HEARING IMPAIRMENT; HUMAN; MECHANOTRANSDUCTION; MITOCHONDRION; MUTATION; NONHUMAN; OTOTOXICITY; PRIORITY JOURNAL; PROTEIN CONFORMATION; PROTEIN EXPRESSION; REVIEW; RIBOSOME; TRANSPORT KINETICS;

AMINOGLYCOSIDES; ANIMALS; ANTI-BACTERIAL AGENTS; HAIR CELLS, AUDITORY; HUMANS;

EID: 77957786104     PISSN: 10689508     EISSN: None     Source Type: Journal    
DOI: 10.1097/MOO.0b013e32833e05ec     Document Type: Review

References (36)

1. Rybak LP, Talaska AE, Schacht J. Drug-induced hearing loss. In: Schacht J, Popper AN, Fay RR, editors. Auditory trauma, protection and repair. New York: Springer; 2008. pp. 219-259.
2. Matsui JI, Gale JE, Warchol ME. Critical signaling events during the amino-glycoside-induced death of sensory hair cells in vitro. J Neurobiol 2004; 61:250-266.
3. Forge A, Li L. Apoptotic death of hair cells in mammalian vestibular sensory epithelia. Hearing Res 2000; 139:97-115.
4. Matsui JI, Haque A, Huss D, et al. Caspase inhibitors promote vestibular hair cell survival and function after aminoglycoside treatment in vivo. J Neurosci 2003; 23:6111-6122.
5. Tran Ba Huy P, Bernard P, Schacht J. Kinetics of gentamicin uptake and release in the rat: comparison of inner ear tissues and fluidswith other organs. J Clin Invest 1986; 77:1492-1500.
6. Dulon D, Hiel H, Aurousseau C, et al. Pharmacokinetics of gentamicin in the sensory hair cells of the organ of Corti: rapid uptake and long term persis-tence. C R Acad Sci III 1993; 316:682-687.
7. Richardson GP, Forge A, Kros CJ, et al. Myosin VIIA is required for amino-glycoside accumulation in cochlear hair cells. J Neurosci 1997; 17:9506-9519.
8. Hashino E, Shero M. Endocytosis of aminoglycoside antibiotics in sensory haircells. Brain Res 1995; 704:135-140.
9. Marcotti W, van Netten SM, Kros CJ. The aminoglycoside antibiotic dihy-drostreptomycin enters mouseouterhaircellsthrough the mechano-electrical transducer channels. J Physiol 2005; 567:505-521.
10. Dai CF, Mangiardi D, Cotanche DA, Steyger PS. Uptake of fluorescent gentamicin by vertebrate sensory hair cells in vivo. Hearing Res 2006; 213:64-78.
11. Wang Q, Steyger PS. Trafficking of systemic fluorescent gentamicin into the cochlea and hair cells. J Assoc Res Otolaryngol 2009; 10:205-219.
12. Green SH, Altschuler RA, Miller JM. Cell death and cochlear protection. In: Schacht J, Popper AN, Fay RR, editors. Auditory trauma, protection and repair. New York: Springer; 2008. pp. 275-319.
13. Xing G, Chen Z, Cao X. Mitochondrial rRNA and tRNA and hearing function. Cell Res 2007; 17:227-239.
14. Hobbie SN, Akshay A, Kalapala SK, et al. Genetic analysisofinteractionswith eukaryotic rRNA identify the mitoribosome as target in aminoglycoside ototoxicity. Proc Natl Acad Sci USA 2008; 105:20888-20893.
15. Qian Y, Guan M-X. Interaction of aminoglycosides with human mitochondrial 12S rRNA carrying the deafness associated mutation. Antimicrob Agents Chemother 2009; 53:4612-4618.
16. Neely JG, Thompson AM, Gower DJ. Detection and localization of heat shock protein 70 in the normal guinea pig cochlea. Hearing Res 1991; 52:403-406.
17. Lim HH, Jenkins OH, Meyers MW, et al. Detection of HSP 72 synthesis after acoustic overstimulation in the rat cochlea. Hearing Res 1993; 69:146-150.
18. Yoshida N, Kristiansen A, Liberman MC. Heat stress and protection from permanent acoustic injury in mice. J Neurosci 1999; 19:10116-10124.
19. Cunningham LL, Brandon CS. Heat shock inhibits both aminoglycoside-and cisplatin-induced sensory hair cell death. J Assoc Res Otolaryngol 2006; 7:299-307.
20. Taleb M, Brandon CS, Lee F-S, et al. Hsp70 inhibits aminoglycoside- induced hair cell death and is necessary for the protective effects of heat shock. J Assoc Res Otolaryngol 2008; 9:277-289.
21. Taleb M, Brandon CS, Lee F-S, et al. Hsp70 inhibits aminoglycoside- induced hearing loss and cochlear hair cell death. Cell Stress Chaperones 2009; 14:427-437.
22. Yu Y, Szczepek AJ, Haupt H, Mazurek B. Geldanamycin induces production of heat shock protein 70 and partially attenuates ototoxicity caused by genta-micin in the organ of Corti explants. J Biomed Sci 2009; 16:79.
23. Sugahara KK, Rubel EW, Cunningham LL. JNK signaling in neomycin-induced vestibular hair cell death. Hearing Res 2006; 221:128-135.
24. Lahne M, Gale JE. Damage-induced activation of ERK1/2 in cochlear supporting cells isa haircell death-promoting signal that dependson extracellular ATP and calcium. J Neurosci 2008; 28:4918-4928.
25. Gale JE, Piassa V, Ciubotaru CD, Mammano F. A mechanism for sensing noise damage in the inner ear. Curr Biol 2004; 14:526-529.
26. Tritsch NX, Xi E, Gale JE, et al. The origin of spontaneous activity in the developing auditory system. Nature 2007; 450:50-55.
27. Wu WJ, Sha SH, Mc Laren JD, et al. Aminoglycoside ototoxicity in adult CBA, C57BL and BALB mice and the Sprague-Dawley rat. Hearing Res 2001; 158:165-178.
28. Sato E, Shick HE, Ransohoff RM, Hirose K. Expression of fractalkine receptor CX3CR1 on cochlear macrophages influences the survival of hair cells following ototoxic injury. J Assoc Res Otolaryngol 2010; 11:223-234.
29. Taylor RR, Nevill G, Forge A. Rapid hair cell loss: a mouse model for cochlear lesions. J Assoc Res Otolaryngol 2008; 9:44-64.
30. Oesterle EC, Campbell S, Taylor RR, et al. Sox2 and Jagged1 expression in normal and drug-damaged adult mouse inner ear. J Assoc Res Otolaryngol 2008; 9:65-89.
31. Harris JA, Cheng AG, Cunningham LL, et al. Neomycin-induced haircell death and rapid regeneration in the lateral line ofthezebrafish (Danio rerio). JAssoc Res Otolaryngol 2003; 4:219-234.
32. Owens KN, Cunningham DE, Mc Donald G, et al. Ultrastructural analysis of aminoglycoside-induced hair cell death in the zebrafish lateral line reveal an early mitochondrial response. J Comp Neurol 2007; 502:522-543.
33. Ou HC, Cunningham LL, Francis SP, et al. Identification of FDA-approved drugsand bioactivesthat protect haircells inthezebrafish (Daniorerio) lateral line and mouse (Mus musculus) utricle. J Assoc Res Otolaryngol 2009; 10:191-203.
34. Owens KN, Santos P, Roberts B, et al. Identification of genetic and chemical modulators of zebrafish mechanosensory hair cell death. PLoS Genet 2008; 4:e1000020.
35. Fernandez EA, Ohlemiller KK, Gagnon PM, Clark WW. Protection against noise-induced hearing loss in young CBA/J mice by low dose kanamycin. JAssoc Res Otolaryngol 2010; 11:235-244.
36. Rizzi MD, Hirose K. Aminoglycoside ototoxicity. Curr Opin Otolaryngol Head Neck Surg 2007; 15:352-357.