The deleterious effect of cholesterol and protection by quercetin on mitochondrial bioenergetics of pancreatic β-cells, glycemic control and inflammation: In vitro and in vivo studies

Redox Biology

Volumn 9, Issue , 2016, Pages 229-243

  Carrasco Pozo, Catalina ^a,b   Tan, Kah Ni ^b   Reyes Farias, Marjorie ^a   De La Jara, Nicole ^a   Ngo, Shyuan Thieu ^b,c   Garcia Diaz, Diego Fernando ^a   Llanos, Paola ^d   Cires, Maria Jose ^a   Borges, Karin ^b  

^a UNIVERSITY OF CHILE   (Chile)

^b UNIVERSITY OF QUEENSLAND   (Australia)

^c UNIVERSITY OF QUEENSLAND   (Australia)

^d UNIVERSITY OF CHILE   (Chile)

Author keywords

Cholesterol; Glycemic control; Mitochondrial dysfunction; NF B; Quercetin; Sirtuin 1

Indexed keywords

ADENOSINE TRIPHOSPHATE; CASPASE 3; CASPASE 9; CHOLESTEROL; CYTOCHROME C; GAMMA INTERFERON; GLUCOSE; GLUTATHIONE PEROXIDASE; GRANULOCYTE MACROPHAGE COLONY STIMULATING FACTOR; HIGH DENSITY LIPOPROTEIN; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INSULIN; INTERLEUKIN 12; INTERLEUKIN 1ALPHA; INTERLEUKIN 1BETA; INTERLEUKIN 5; INTERLEUKIN 6; INTERLEUKIN 7; KERATINOCYTE DERIVED CHEMOKINE; LACTATE DEHYDROGENASE; LOW DENSITY LIPOPROTEIN; MACROPHAGE INFLAMMATORY PROTEIN 1ALPHA; MACROPHAGE INFLAMMATORY PROTEIN 2; MONOCYTE CHEMOTACTIC PROTEIN 1; QUERCETIN; SIRTUIN 1; SUPEROXIDE DISMUTASE; TUMOR NECROSIS FACTOR; VERY LOW DENSITY LIPOPROTEIN; ANTIOXIDANT; AUTACOID; CYTOKINE;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ANTIINFLAMMATORY ACTIVITY; ANTIOXIDANT ACTIVITY; APOPTOSIS; ARTICLE; BIOENERGY; CELL PROTECTION; CELL VIABILITY; CELLULAR PARAMETERS; CHOLESTEROL BLOOD LEVEL; CHOLESTEROL DIET; CONTROLLED STUDY; CYTOSOL; DRUG MECHANISM; ENZYME ACTIVATION; ENZYME INHIBITION; GLUCOSE BLOOD LEVEL; GLYCEMIC CONTROL; IN VITRO STUDY; IN VIVO STUDY; INFLAMMATION; INSULIN BLOOD LEVEL; INSULIN RELEASE; LIPID PEROXIDATION; MALE; MITOCHONDRIAL MEMBRANE POTENTIAL; MITOCHONDRIAL RESPIRATION; MITOCHONDRION; NONHUMAN; OXIDATIVE STRESS; OXYGEN CONSUMPTION RATE; PANCREAS; PANCREAS ISLET BETA CELL; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN SECRETION; RAT; WISTAR RAT; ANIMAL; BLOOD; CELL LINE; CELL SURVIVAL; DRUG EFFECTS; GENE EXPRESSION REGULATION; METABOLISM; ORGANELLE BIOGENESIS; OXIDATION REDUCTION REACTION;

ANIMALS; ANTIOXIDANTS; APOPTOSIS; BLOOD GLUCOSE; CELL LINE; CELL SURVIVAL; CHOLESTEROL; CYTOKINES; GENE EXPRESSION REGULATION; INFLAMMATION; INFLAMMATION MEDIATORS; INSULIN; INSULIN-SECRETING CELLS; MALE; MITOCHONDRIA; NF-KAPPA B; ORGANELLE BIOGENESIS; OXIDATION-REDUCTION; OXIDATIVE STRESS; QUERCETIN; RATS;

EID: 84984791558     PISSN: 22132317     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.redox.2016.08.007     Document Type: Article

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