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Volumn 195, Issue 2, 2012, Pages 154-164

Quercetin modulates Nrf2 and glutathione-related defenses in HepG2 cells: Involvement of p38

Author keywords

Glutathione; Glutathione related enzymes; Nrf2; p38; Quercetin

Indexed keywords

4 (4 FLUOROPHENYL) 2 (4 METHYLSULFINYLPHENYL) 5 (4 PYRIDYL)IMIDAZOLE; GLUTAMATE CYSTEINE LIGASE; GLUTATHIONE; GLUTATHIONE PEROXIDASE; GLUTATHIONE REDUCTASE; GLUTATHIONE TRANSFERASE; MESSENGER RNA; MITOGEN ACTIVATED PROTEIN KINASE P38; QUERCETIN; TRANSCRIPTION FACTOR NRF2;

EID: 84855833029     PISSN: 00092797     EISSN: 18727786     Source Type: Journal    
DOI: 10.1016/j.cbi.2011.12.005     Document Type: Article
Times cited : (161)

References (50)
  • 1
    • 34249882770 scopus 로고    scopus 로고
    • Effects of dietary flavonoids on apoptotic pathways related to cancer chemoprevention
    • DOI 10.1016/j.jnutbio.2006.11.004, PII S0955286306002646
    • S. Ramos Effects of dietary flavonoids on apoptotic pathways related to cancer chemoprevention J. Nutr. Biochem. 18 2007 427 442 (Pubitemid 46874924)
    • (2007) Journal of Nutritional Biochemistry , vol.18 , Issue.7 , pp. 427-442
    • Ramos, S.1
  • 2
    • 0032844037 scopus 로고    scopus 로고
    • The small intestine can both absorb and glucuronidate luminal flavonoids
    • DOI 10.1016/S0014-5793(99)01160-6, PII S0014579399011606
    • J. Spencer, G. Chowrimootoo, R. Choudhury, E. Debnam, S. Srai, and C. Rice-Evans The small intestine can both absorb and glucuronidate luminal flavonoids FEBS Lett. 4582 1999 224 230 (Pubitemid 29428188)
    • (1999) FEBS Letters , vol.458 , Issue.2 , pp. 224-230
    • Spencer, J.P.E.1    Chowrimootoo, G.2    Choudhury, R.3    Debnam, E.S.4    Srai, S.K.5    Rice-Evans, C.6
  • 3
    • 0035985950 scopus 로고    scopus 로고
    • Polyphenols: Do they play a role in the prevention of human pathologies?
    • DOI 10.1016/S0753-3322(02)00178-6
    • H. Tapiero, K.D. Tew, G.N. Ba, and G. Mathe Polyphenols: do they play a role in the prevention of human pathologies? Biomed. Pharmacother. 56 2002 200 207 (Pubitemid 34628383)
    • (2002) Biomedicine and Pharmacotherapy , vol.56 , Issue.4 , pp. 200-207
    • Tapiero, H.1    Tew, K.D.2    Nguyen Ba, G.3    Mathe, G.4
  • 5
    • 33646512855 scopus 로고    scopus 로고
    • Quercetin protects human hepatoma cell line (HepG2) against oxidative stress induced by tertbutyl hydroperoxide
    • M. Alia, S. Ramos, R. Mateos, A. Granado-Serrano, L. Bravo, and L. Goya Quercetin protects human hepatoma cell line (HepG2) against oxidative stress induced by tertbutyl hydroperoxide Toxicol. Appl. Pharmacol. 212 2006 110 118
    • (2006) Toxicol. Appl. Pharmacol. , vol.212 , pp. 110-118
    • Alia, M.1    Ramos, S.2    Mateos, R.3    Granado-Serrano, A.4    Bravo, L.5    Goya, L.6
  • 6
    • 32344433333 scopus 로고    scopus 로고
    • Influence of quercetin and rutin on growth and antioxidant defense system of a human hepatoma cell line (HepG2)
    • DOI 10.1007/s00394-005-0558-7
    • M. Alia, R. Mateos, S. Ramos, E. Lecumberri, L. Bravo, and L. Goya Influence of quercetin and rutin on growth and antioxidant defense system of a human hepatoma cell line (HepG2) Eur. J. Nutr. 451 2006 19 28 (Pubitemid 43221280)
    • (2006) European Journal of Nutrition , vol.45 , Issue.1 , pp. 19-28
    • Alia, M.1    Mateos, R.2    Ramos, S.3    Lecumberri, E.4    Bravo, L.5    Goya, L.6
  • 7
    • 70449625689 scopus 로고    scopus 로고
    • Quercetin induces oxidative stress and potentiates the apoptotic action of 2-methoxyestradiol in human hepatoma cells
    • Y.-F. Chang, Y.-C. Hsu, H.-F. Hung, H.-J. Lee, W.-Y. Lui, C.-W. Chi, and J.-J. Wang Quercetin induces oxidative stress and potentiates the apoptotic action of 2-methoxyestradiol in human hepatoma cells Nutr. Cancer 61 2009 735 774
    • (2009) Nutr. Cancer , vol.61 , pp. 735-774
    • Chang, Y.-F.1    Hsu, Y.-C.2    Hung, H.-F.3    Lee, H.-J.4    Lui, W.-Y.5    Chi, C.-W.6    Wang, J.-J.7
  • 8
    • 74549159301 scopus 로고    scopus 로고
    • Inhibition of AP-1 and MAPK signaling and activation of Nrf2/ARE pathway by quercitrin
    • M. Ding, J. Zhao, L. Bowman, Y. Lu, and X. Shi Inhibition of AP-1 and MAPK signaling and activation of Nrf2/ARE pathway by quercitrin Int. J. Oncol. 36 2010 59 67
    • (2010) Int. J. Oncol. , vol.36 , pp. 59-67
    • Ding, M.1    Zhao, J.2    Bowman, L.3    Lu, Y.4    Shi, X.5
  • 10
    • 33751082422 scopus 로고    scopus 로고
    • Quercetin induces apoptosis via caspase activation, regulation of Bcl-2, and inhibition of PI-3-kinase/Akt and ERK pathways in a human hepatoma cell line (HepG2)
    • A. Granado-Serrano, M. Martín, L. Bravo, L. Goya, and S. Ramos Quercetin induces apoptosis via caspase activation, regulation of Bcl-2, and inhibition of PI-3-Kinase/Akt and ERK pathways in a human hepatoma cell line (HepG2) J. Nutr. 136 2006 2715 2721 (Pubitemid 44771763)
    • (2006) Journal of Nutrition , vol.136 , Issue.11 , pp. 2715-2721
    • Granado-Serrano, A.B.1    Martin, M.A.2    Bravo, L.3    Goya, L.4    Ramos, S.5
  • 11
    • 48649099511 scopus 로고    scopus 로고
    • Time-course regulation of quercetin on cell survival/proliferation pathways in human hepatoma cells
    • A. Granado-Serrano, M. Martin, L. Bravo, L. Goya, and S. Ramos Time-course regulation of quercetin on cell survival/proliferation pathways in human hepatoma cells Mol. Nutr. Food Res. 52 2008 457 464
    • (2008) Mol. Nutr. Food Res. , vol.52 , pp. 457-464
    • Granado-Serrano, A.1    Martin, M.2    Bravo, L.3    Goya, L.4    Ramos, S.5
  • 12
    • 77951112788 scopus 로고    scopus 로고
    • Quercetin modulates NF-κB and AP-1/JNK pathways to induce cell death in human hepatoma cells
    • A. Granado-Serrano, M. Martín, L. Bravo, L. Goya, and S. Ramos Quercetin modulates NF-κB and AP-1/JNK pathways to induce cell death in human hepatoma cells Nutr. Cancer 62 2010 390 401
    • (2010) Nutr. Cancer , vol.62 , pp. 390-401
    • Granado-Serrano, A.1    Martín, M.2    Bravo, L.3    Goya, L.4    Ramos, S.5
  • 14
    • 0031724702 scopus 로고    scopus 로고
    • The effect of the flavonoids, quercetin, myricetin and epicatechin on the growth and enzyme activities of MCF7 human breast cancer cells
    • DOI 10.1016/S0009-2797(98)00092-1, PII S0009279798000921
    • E. Rodgers, and M. Grant The effect of the flavonoids, quercetin, myricetin and epicatechin on the growth and enzyme activities of MCF7 human breast cancer cells Chem. Biol. Interact. 116 1998 213 228 (Pubitemid 28543195)
    • (1998) Chemico-Biological Interactions , vol.116 , Issue.3 , pp. 213-228
    • Rodgers, E.H.1    Grant, M.H.2
  • 15
    • 3042574709 scopus 로고    scopus 로고
    • Potential toxicity of flavonoids and other dietary phenolics: Significance for their chemopreventive and anticancer properties
    • DOI 10.1016/j.freeradbiomed.2004.04.034, PII S0891584904003806
    • G. Galati, and P.J. O'Brien Potential toxicity of flavonoids and other dietary phenolics: significance for their chemopreventive and anticancer properties Free Radic. Biol. Med. 37 2004 287 303 (Pubitemid 38833996)
    • (2004) Free Radical Biology and Medicine , vol.37 , Issue.3 , pp. 287-303
    • Galati, G.1    O'Brien, P.J.2
  • 16
    • 34247282872 scopus 로고    scopus 로고
    • Action of Nrf2 and Keap1 in ARE-mediated NQO1 expression by quercetin
    • DOI 10.1016/j.freeradbiomed.2007.02.017, PII S0891584907001487
    • S. Tanigawa, M. Fujii, and D.-X. Hou Action of Nrf2 and Keap1 in ARE-mediated NQO1 expression by quercetin Free Radic. Biol. Med. 42 2007 1690 1703 (Pubitemid 46617147)
    • (2007) Free Radical Biology and Medicine , vol.42 , Issue.11 , pp. 1690-1703
    • Tanigawa, S.1    Fujii, M.2    Hou, D.-X.3
  • 17
    • 34347392509 scopus 로고    scopus 로고
    • Quercetin protects human hepatocytes from ethanol-derived oxidative stress by inducing heme oxygenase-1 via the MAPK/Nrf2 pathways
    • DOI 10.1016/j.jhep.2007.02.008, PII S0168827807001225
    • P. Yao, A. Nussler, L. Liu, L. Hao, F. Song, A. Schirmeier, and N. Nussler Quercetin protects human hepatocytes from ethanol-derived oxidative stress by inducing heme oxygenase-1 via the MAPK/Nrf2 pathways J. Hepatol. 47 2007 253 261 (Pubitemid 47023137)
    • (2007) Journal of Hepatology , vol.47 , Issue.2 , pp. 253-261
    • Yao, P.1    Nussler, A.2    Liu, L.3    Hao, L.4    Song, F.5    Schirmeier, A.6    Nussler, N.7
  • 18
    • 25144482448 scopus 로고    scopus 로고
    • Novel mechanisms of natural antioxidant compounds in biological systems: Involvement of glutathione and glutathione-related enzymes
    • DOI 10.1016/j.jnutbio.2005.05.013, PII S095528630500152X
    • R. Masella, R. Di Benedetto, R. Vari, C. Filesi, and C. Giovannini Novel mechanisms of natural antioxidant compounds in biological systems: involvement of glutathione-related enzymes J. Nutr. Biochem. 16 2005 577 586 (Pubitemid 41338369)
    • (2005) Journal of Nutritional Biochemistry , vol.16 , Issue.10 , pp. 577-586
    • Masella, R.1    Di Benedetto, R.2    Vari, R.3    Filesi, C.4    Giovannini, C.5
  • 19
    • 33748684782 scopus 로고    scopus 로고
    • Antiproliferative and cytoprotective activities of a phenolic-rich juice in HepG2 cells
    • DOI 10.1016/j.foodres.2006.07.001, PII S0963996906000950
    • J. Garcia-Alonso, G. Ros, and M.J. Periago Antiproliferative and cytoprotective activities of a phenolic-rich juice in HepG2 cells Food Res. Int. 39 2006 982 991 (Pubitemid 44397552)
    • (2006) Food Research International , vol.39 , Issue.9 , pp. 982-991
    • Garcia-Alonso, J.1    Ros, G.2    Jesus Periago, M.3
  • 23
    • 53449101213 scopus 로고    scopus 로고
    • Molecular mechanisms of natural products in chemoprevention: Induction of cytoprotective enzymes by Nrf2
    • A.L. Eggler, K.A. Gay, and A.D. Mesecar Molecular mechanisms of natural products in chemoprevention: Induction of cytoprotective enzymes by Nrf2 Mol. Nutr. Food Res. 52 2008 S84 S94
    • (2008) Mol. Nutr. Food Res. , vol.52
    • Eggler, A.L.1    Gay, K.A.2    Mesecar, A.D.3
  • 24
    • 33644838918 scopus 로고    scopus 로고
    • Involvement of Nrf2, p38, B-Raf, and nuclear factor-κB, but not phosphatidylinositol 3-kinase, in induction of hemeoxygenase-1 by dietary polyphenols
    • C.K. Andreadi, L.M. Howells, P.A. Atherfold, and M.M. Manson Involvement of Nrf2, p38, B-Raf, and nuclear factor-kB, but not phosphatidylinositol 3-kinase, in induction of hemeoxygenase-1 by dietary polyphenols Mol. Pharmacol. 69 2006 1033 1040 (Pubitemid 43363879)
    • (2006) Molecular Pharmacology , vol.69 , Issue.3 , pp. 1033-1040
    • Andreadi, C.K.1    Howells, L.M.2    Atherfold, P.A.3    Manson, M.M.4
  • 26
    • 0034213138 scopus 로고    scopus 로고
    • P38 MAP kinases: Beyond the stress response
    • DOI 10.1016/S0968-0004(00)01595-4, PII S0968000400015954
    • A.R. Nebreda, and A. Porras p38 MAP kinases: beyond the stress response TIBS 25 2000 257 260 (Pubitemid 30333380)
    • (2000) Trends in Biochemical Sciences , vol.25 , Issue.6 , pp. 257-260
    • Nebreda, A.R.1    Porras, A.2
  • 27
    • 0037569694 scopus 로고    scopus 로고
    • Curcumin activates the haem oxygenase-1 gene via regulation of Nrf2 and the antioxidant-responsive element
    • DOI 10.1042/BJ20021619
    • E. Balogun, M. Hoque, P. Gong, E. Killeen, C. Green, J. Foresti, and R. Motterlini Curcumin activates the haem oxygenase-1 gene via regulation of Nrf2 and the antioxidant response element Biochem. J. 371 2003 887 895 (Pubitemid 36578887)
    • (2003) Biochemical Journal , vol.371 , Issue.3 , pp. 887-895
    • Balogun, E.1    Hoque, M.2    Gong, P.3    Killeen, E.4    Green, C.J.5    Foresti, R.6    Alam, J.7    Motterlini, R.8
  • 28
    • 75549090203 scopus 로고    scopus 로고
    • Epicatechin induces NF-kB, activator protein-1 (AP-1) and nuclear transcription factor erythroid 2p45-related factor-2 (Nrf2) via phosphatidylinositol-3-kinase/protein kinase B (PI3K/AKT) and extracellular regulated kinase (ERK) signalling in HepG2 cells
    • A.B. Granado-Serrano, M.A. Martin, G. Haegeman, L. Goya, L. Bravo, and S. Ramos Epicatechin induces NF-kB, activator protein-1 (AP-1) and nuclear transcription factor erythroid 2p45-related factor-2 (Nrf2) via phosphatidylinositol-3-kinase/protein kinase B (PI3K/AKT) and extracellular regulated kinase (ERK) signalling in HepG2 cells Brit. J. Nutr. 103 2010 168 179
    • (2010) Brit. J. Nutr. , vol.103 , pp. 168-179
    • Granado-Serrano, A.B.1    Martin, M.A.2    Haegeman, G.3    Goya, L.4    Bravo, L.5    Ramos, S.6
  • 29
    • 0017064979 scopus 로고
    • A fluorometric method for determination of oxidised and reduced glutathione in tissues
    • P. Hissin, and R. Hilf A fluorometric method for determination of oxidised and reduced glutathione in tissues Anal. Biochem. 74 1976 214 226
    • (1976) Anal. Biochem. , vol.74 , pp. 214-226
    • Hissin, P.1    Hilf, R.2
  • 30
    • 0016287254 scopus 로고
    • An improved coupled test procedure for glutathione peroxidase in blood
    • W. Gunzler, H. Kremers, and L. Flohe An improved coupled test procedure for glutathione peroxidase in blood Z. Klin. Chem. Klin. Biochem. 12 1974 444 448
    • (1974) Z. Klin. Chem. Klin. Biochem. , vol.12 , pp. 444-448
    • Gunzler, W.1    Kremers, H.2    Flohe, L.3
  • 31
    • 0001528839 scopus 로고
    • Glutathione reductase
    • H.V. Bergmeyer, Weinheim, Verlag-Chemie
    • D. Goldberg, and R. Spooner Glutathione reductase H.V. Bergmeyer, Methods of Enzymatic Analysis 1987 Weinheim, Verlag-Chemie 258 265
    • (1987) Methods of Enzymatic Analysis , pp. 258-265
    • Goldberg, D.1    Spooner, R.2
  • 36
    • 70349301394 scopus 로고    scopus 로고
    • Reactive oxygen species-mediated kinase activation by dihydrotanshinone in tanshinones-induced apoptosis in HepG2 cells
    • W.Y.W. Lee, K.W.K. Liu, and J.H.K. Yeung Reactive oxygen species-mediated kinase activation by dihydrotanshinone in tanshinones-induced apoptosis in HepG2 cells Cancer Lett. 285 2009 46 57
    • (2009) Cancer Lett. , vol.285 , pp. 46-57
    • Lee, W.Y.W.1    Liu, K.W.K.2    Yeung, J.H.K.3
  • 39
    • 67449135837 scopus 로고    scopus 로고
    • Inhibition and genetic deficiency of p38 MAPK up-regulates heme oxygenase-1 gene expression via Nrf2
    • S. Naidu, V. Vijayan, S. Santoso, T. Kietzmann, and S. Immenschuh Inhibition and genetic deficiency of p38 MAPK up-regulates heme oxygenase-1 gene expression via Nrf2 J. Immunol. 182 2009 7048 7057
    • (2009) J. Immunol. , vol.182 , pp. 7048-7057
    • Naidu, S.1    Vijayan, V.2    Santoso, S.3    Kietzmann, T.4    Immenschuh, S.5
  • 40
    • 33749019130 scopus 로고    scopus 로고
    • Mechanism of action of sulforaphane: Inhibition of p38 mitogen-activated protein kinase isoforms contributing to the induction of antioxidant response element-mediated heme oxygenase-1 in human hepatoma HepG2 cells
    • DOI 10.1158/0008-5472.CAN-05-3513
    • Y.-S. Keum, S. Yu, P.P. Chang, X. Yuan, J.-H. Kim, C. Xu, J. Han, A. Agarwal, and A.N. Tony Kong Mechanism of action of sulforaphane: inhibition of p38 mitogen-activated protein kinase isoforms contributing to the induction of antioxidant response element-mediated heme oxygenase-1 in human hepatoma HepG2 cells Cancer Res. 66 2006 8804 8813 (Pubitemid 44449198)
    • (2006) Cancer Research , vol.66 , Issue.17 , pp. 8804-8813
    • Keum, Y.-S.1    Yu, S.2    Chang, P.P.-J.3    Yuan, X.4    Kim, J.-H.5    Xu, C.6    Han, J.7    Agarwal, A.8    Kong, A.-N.T.9
  • 41
    • 0034623211 scopus 로고    scopus 로고
    • Mechanism of heme oxygenase-1 gene activation by cadmium in MCF-7 mammary epithelial cells. Role of p38 kinase and Nrf2 transcription factor
    • J. Alam, C. Wicks, D. Stewart, P. Gong, C. Touchard, S. Otterbeini, A.M.K. Choii, M.E. Burow, and J.S. Tou Mechanism of heme oxygenase-1 gene activation by cadmium in MCF-7 mammary epithelial cells. Role of p38 kinase and Nrf2 transcription factor J. Biol. Chem. 275 2000 27694 27702
    • (2000) J. Biol. Chem. , vol.275 , pp. 27694-27702
    • Alam, J.1    Wicks, C.2    Stewart, D.3    Gong, P.4    Touchard, C.5    Otterbeini, S.6    Choii, A.M.K.7    Burow, M.E.8    Tou, J.S.9
  • 42
    • 0033789011 scopus 로고    scopus 로고
    • The essential role of phosphatidylinositol 3-kinase and of p38 mitogen-activated protein kinase activation in the antioxidant response element mediated rGSTA2 induction by decreased glutathione in H4IIE hepatoma cells
    • K.W. Kang, J.H. Ryu, and S.G. Kim The essential role of phosphatidylinositol 3-kinase and of p38 mitogen-activated protein kinase activation in the antioxidant response element mediated rGSTA2 induction by decreased glutathione in H4IIE hepatoma cells Mol. Pharmacol. 58 2000 1017 1025
    • (2000) Mol. Pharmacol. , vol.58 , pp. 1017-1025
    • Kang, K.W.1    Ryu, J.H.2    Kim, S.G.3
  • 43
    • 33646196955 scopus 로고    scopus 로고
    • Involvement of p38 MAPK and Nrf2 in phenolic acid-induced P-form phenol sulfotransferase expression in human hepatoma HepG2 cells
    • C.T. Yeh, and G.C. Yen Involvement of p38 MAPK and Nrf2 in phenolic acid-induced P-form phenol sulfotransferase expression in human hepatoma HepG2 cells Carcinogenesis 27 2006 1008 1017
    • (2006) Carcinogenesis , vol.27 , pp. 1008-1017
    • Yeh, C.T.1    Yen, G.C.2
  • 44
    • 17644390182 scopus 로고    scopus 로고
    • Response of the antioxidant defense system to tert-butyl hydroperoxide and hydrogen peroxide in a human hepatoma cell line (HepG2)
    • DOI 10.1002/jbt.20061
    • M. Alia, S. Ramos, R. Mateos, L. Bravo, and L. Goya Response of the antioxidant defense system to tert-butyl hydroperoxide and hydrogen peroxide in a human hepatoma cell line (HepG2) J. Biochem. Mol. Toxicol. 192 2005 119 128 (Pubitemid 40571692)
    • (2005) Journal of Biochemical and Molecular Toxicology , vol.19 , Issue.2 , pp. 119-128
    • Alia, M.1    Ramos, S.2    Mateos, R.3    Bravo, L.4    Goya, L.5
  • 45
    • 0033841830 scopus 로고    scopus 로고
    • Chemopreventive activity of quercetin during carcinogenesis in cervix uteri in mice
    • DOI 10.1002/1099-1573(200008)14:5< 347::AID-PTR613>3.0.CO;2-7
    • S. De, J. Chakraborty, R.N. Chakraborty, and S. Das Chemopreventive activity of quercetin during carcinogenesis in cervix uteri in mice Phytother. Res. 14 2000 347 351 (Pubitemid 30655520)
    • (2000) Phytotherapy Research , vol.14 , Issue.5 , pp. 347-351
    • De, S.1    Chakraborty, J.2    Chakraborty, R.N.3    Das, S.4
  • 46
    • 0038647564 scopus 로고    scopus 로고
    • Enhancement of glutathione and γ-glutamylcysteine synthetase, the rate limiting enzyme of glutathione synthesis, by chemoprotective plant-derived food and beverage components in the human hepatoma cell line HepG2
    • G. Scharf, S. Prustomersky, S. Knasmuller, R. Schulte-Hermann, and W.W. Huber Enhancement of glutathione and g-glutamylcysteine synthetase, the rate limiting enzyme of glutathione synthesis, by chemoprotective plant-derived food and beverage components in the human hepatoma cell line HepG2 Nutr. Cancer 45 2003 74 83 (Pubitemid 36736894)
    • (2003) Nutrition and Cancer , vol.45 , Issue.1 , pp. 74-83
    • Scharf, G.1    Prustomersky, S.2    Knasmuller, S.3    Schulte-Hermann, R.4    Huber, W.W.5
  • 47
    • 34248186574 scopus 로고    scopus 로고
    • Curcumin activates human glutathione S-transferase P1 expression through antioxidant response element
    • DOI 10.1016/j.toxlet.2007.03.011, PII S0378427407000987
    • T. Nishinaka, Y. Ichijo, M. Ito, M. Kimura, M. Katsuyama, K. Iwata, T. Miura, T. Terada, and C. Yabe-Nishimura Curcumin activates human glutathione S-transferase P1 expression through antioxidant response element Toxicol. Lett. 170 2007 238 247 (Pubitemid 46710275)
    • (2007) Toxicology Letters , vol.170 , Issue.3 , pp. 238-247
    • Nishinaka, T.1    Ichijo, Y.2    Ito, M.3    Kimura, M.4    Katsuyama, M.5    Iwata, K.6    Miura, T.7    Terada, T.8    Yabe-Nishimura, C.9
  • 48
    • 0642374221 scopus 로고    scopus 로고
    • The role of glutathione-S transferase in anti-cancer drug resistance
    • D.M. Townsend, and K.D. Tew The role of glutathione-S transferase in anti-cancer drug resistance Oncogene 22 2003 7369 7375
    • (2003) Oncogene , vol.22 , pp. 7369-7375
    • Townsend, D.M.1    Tew, K.D.2
  • 50
    • 77954664504 scopus 로고    scopus 로고
    • Putative chemopreventive molecules can increase Nrf2-regulated cell defense in some human cancer cell lines, resulting in resistance to common cytotoxic therapies
    • L. Hu, W. Miao, M. Loignon, M. Kandouz, and G. Batist Putative chemopreventive molecules can increase Nrf2-regulated cell defense in some human cancer cell lines, resulting in resistance to common cytotoxic therapies Cancer Chemother. Pharmacol. 66 2010 467 474
    • (2010) Cancer Chemother. Pharmacol. , vol.66 , pp. 467-474
    • Hu, L.1    Miao, W.2    Loignon, M.3    Kandouz, M.4    Batist, G.5


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