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Volumn 31, Issue 1, 2013, Pages 265-271

Quercetin and quercitrin protect against cytokine-induced injuries in RINm5F β-cells via the mitochondrial pathway and NF-κB signaling

Author keywords

Inflammation; Insulin producing cells; Mitochondrial apoptosis; Quercetin; Quercitrin

Indexed keywords

GAMMA INTERFERON; GLUCOSE; I KAPPA B ALPHA; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INDUCIBLE NITRIC OXIDE SYNTHASE; INSULIN; INTERLEUKIN 1BETA; NITRIC OXIDE; QUERCETIN; QUERCITRIN; REACTIVE OXYGEN METABOLITE; TUMOR NECROSIS FACTOR ALPHA;

EID: 84873103087     PISSN: 11073756     EISSN: 1791244X     Source Type: Journal    
DOI: 10.3892/ijmm.2012.1177     Document Type: Article
Times cited : (79)

References (37)
  • 1
    • 84984537489 scopus 로고    scopus 로고
    • Comparative study of quercetin and its two glycoside derivatives quercitrin and rutin against methylmercury (MeHg)-induced ROS production in rat brain slices
    • Wagner C, Vargas AP, Roos DH, et al: Comparative study of quercetin and its two glycoside derivatives quercitrin and rutin against methylmercury (MeHg)-induced ROS production in rat brain slices. Arch Toxicol 84: 89-97, 2010.
    • (2010) Arch Toxicol , vol.84 , pp. 89-97
    • Wagner, C.1    Vargas, A.P.2    Roos, D.H.3
  • 2
    • 0027504187 scopus 로고
    • Dietary antioxidant flavonoids and risk of coronary heart disease: The Zutphen Elderly Study
    • Hertog MG, Feskens EJ, Hollman PC, Katan MB and Kromhout D: Dietary antioxidant flavonoids and risk of coronary heart disease: the Zutphen Elderly Study. Lancet 342: 1007-1011, 1993.
    • (1993) Lancet , vol.342 , pp. 1007-1011
    • Hertog, M.G.1    Feskens, E.J.2    Hollman, P.C.3    Katan, M.B.4    Kromhout, D.5
  • 3
    • 84857158211 scopus 로고    scopus 로고
    • Quercitrin a bioflavonoid improves the antioxidant status in streptozotocin: Induced diabetic rat tissues
    • Babujanarthanam R, Kavitha P, Mahadeva Rao US and Pandian MR: Quercitrin a bioflavonoid improves the antioxidant status in streptozotocin: induced diabetic rat tissues. Mol Cell Biochem 358: 121-129, 2011.
    • (2011) Mol Cell Biochem , vol.358 , pp. 121-129
    • Babujanarthanam, R.1    Kavitha, P.2    Mahadeva Rao, U.S.3    Pandian, M.R.4
  • 4
    • 11144328863 scopus 로고    scopus 로고
    • Quercetin, a flavonoid antioxidant, prevents and protects streptozotocin-induced oxidative stress and beta-cell damage in rat pancreas
    • Coskun O, Kanter M, Korkmaz A and Oter S: Quercetin, a flavonoid antioxidant, prevents and protects streptozotocin-induced oxidative stress and beta-cell damage in rat pancreas. Pharmacol Res 51: 117-123, 2005.
    • (2005) Pharmacol Res , vol.51 , pp. 117-123
    • Coskun, O.1    Kanter, M.2    Korkmaz, A.3    Oter, S.4
  • 5
    • 0035856952 scopus 로고    scopus 로고
    • Beta-Cell death during progression to diabetes
    • Mathis D, Vence L and Benoist C: beta-Cell death during progression to diabetes. Nature 414: 792-798, 2001.
    • (2001) Nature , vol.414 , pp. 792-798
    • Mathis, D.1    Vence, L.2    Benoist, C.3
  • 6
    • 0442305381 scopus 로고    scopus 로고
    • Apoptotic signal transduction pathways in diabetes
    • Mandrup-Poulsen T: Apoptotic signal transduction pathways in diabetes. Biochem Pharmacol 66: 1433-1440, 2003.
    • (2003) Biochem Pharmacol , vol.66 , pp. 1433-1440
    • Mandrup-Poulsen, T.1
  • 7
    • 0034456628 scopus 로고    scopus 로고
    • Cytokines induce both necrosis and apoptosis via a common Bcl-2-inhibitable pathway in rat insulin-producing cells
    • Saldeen J: Cytokines induce both necrosis and apoptosis via a common Bcl-2-inhibitable pathway in rat insulin-producing cells. Endocrinology 141: 2003-2010, 2000.
    • (2000) Endocrinology , vol.141 , pp. 2003-2010
    • Saldeen, J.1
  • 8
    • 33644749322 scopus 로고    scopus 로고
    • Mechanisms of pancreatic beta-cell death in type 1 and type 2 diabetes: Many differences, few similarities
    • Cnop M, Welsh N, Jonas JC, Jorns A, Lenzen S and Eizirik DL: Mechanisms of pancreatic beta-cell death in type 1 and type 2 diabetes: many differences, few similarities. Diabetes 54 (Suppl 2): S97-S107, 2005.
    • (2005) Diabetes , vol.54 , Issue.SUPPL. 2
    • Cnop, M.1    Welsh, N.2    Jonas, J.C.3    Jorns, A.4    Lenzen, S.5    Eizirik, D.L.6
  • 9
    • 0037401562 scopus 로고    scopus 로고
    • Cell death regulation by the Bcl-2 protein family in the mitochondria
    • Tsujimoto Y: Cell death regulation by the Bcl-2 protein family in the mitochondria. J Cell Physiol 195: 158-167, 2003.
    • (2003) J Cell Physiol , vol.195 , pp. 158-167
    • Tsujimoto, Y.1
  • 10
    • 43049168473 scopus 로고    scopus 로고
    • Protective effects of St. John's wort extract and its component hyperforin against cytokine-induced cytotoxicity in a pancreatic beta-cell line
    • Menegazzi M, Novelli M, Beffy P, et al: Protective effects of St. John's wort extract and its component hyperforin against cytokine-induced cytotoxicity in a pancreatic beta-cell line. Int J Biochem Cell Biol 40: 1509-1521, 2008.
    • (2008) Int J Biochem Cell Biol , vol.40 , pp. 1509-1521
    • Menegazzi, M.1    Novelli, M.2    Beffy, P.3
  • 11
    • 33846353847 scopus 로고    scopus 로고
    • Protective effect of quercetin on the morphology of pancreatic beta-cells of streptozotocin-treated diabetic rats
    • Adewole SO, Caxton-Martins EA and Ojewole JA: Protective effect of quercetin on the morphology of pancreatic beta-cells of streptozotocin-treated diabetic rats. Afr J Tradit Complement Altern Med 4: 64-74, 2006.
    • (2006) Afr J Tradit Complement Altern Med , vol.4 , pp. 64-74
    • Adewole, S.O.1    Caxton-Martins, E.A.2    Ojewole, J.A.3
  • 12
    • 77957229744 scopus 로고    scopus 로고
    • Quercetin potentiates insulin secretion and protects INS-1 pancreatic beta-cells against oxidative damage via the ERK1/2 pathway
    • Youl E, Bardy G, Magous R, et al: Quercetin potentiates insulin secretion and protects INS-1 pancreatic beta-cells against oxidative damage via the ERK1/2 pathway. Br J Pharmacol 161: 799-814, 2010.
    • (2010) Br J Pharmacol , vol.161 , pp. 799-814
    • Youl, E.1    Bardy, G.2    Magous, R.3
  • 13
    • 84862521881 scopus 로고    scopus 로고
    • Effects of physiological quercetin metabolites on interleukin-1beta- induced inducible NOS expression
    • Jan 3 (Epub ahead of print)
    • Cho JM, Chang SY, Kim DB, Needs PW, Jo YH and Kim MJ: Effects of physiological quercetin metabolites on interleukin-1beta-induced inducible NOS expression. J Nutr Biochem: Jan 3, 2012 (Epub ahead of print).
    • (2012) J Nutr Biochem
    • Cho, J.M.1    Chang, S.Y.2    Kim, D.B.3    Needs, P.W.4    Jo, Y.H.5    Kim, M.J.6
  • 14
    • 77952558121 scopus 로고    scopus 로고
    • Quercitrin, a bioflavonoid improves glucose homeostasis in streptozotocin-induced diabetic tissues by altering glycolytic and gluconeogenic enzymes
    • Babujanarthanam R, Kavitha P and Pandian MR: Quercitrin, a bioflavonoid improves glucose homeostasis in streptozotocin-induced diabetic tissues by altering glycolytic and gluconeogenic enzymes. Fundam Clin Pharmacol 24: 357-364, 2010.
    • (2010) Fundam Clin Pharmacol , vol.24 , pp. 357-364
    • Babujanarthanam, R.1    Kavitha, P.2    Pandian, M.R.3
  • 16
    • 77955550149 scopus 로고    scopus 로고
    • Comparable attenuation of Abeta(25-35)-induced neurotoxicity by quercitrin and 17beta-estradiol in cultured rat hippocampal neurons
    • Rattanajarasroj S and Unchern S: Comparable attenuation of Abeta(25-35)-induced neurotoxicity by quercitrin and 17beta-estradiol in cultured rat hippocampal neurons. Neurochem Res 35: 1196-1205, 2010.
    • (2010) Neurochem Res , vol.35 , pp. 1196-1205
    • Rattanajarasroj, S.1    Unchern, S.2
  • 17
    • 20344382953 scopus 로고    scopus 로고
    • 2-induced apoptosis via anti-oxidant activity and heme oxygenase 1 gene expression in macrophages
    • 2-induced apoptosis via anti-oxidant activity and heme oxygenase 1 gene expression in macrophages. Biochem Pharmacol 69: 1839-1851, 2005.
    • (2005) Biochem Pharmacol , vol.69 , pp. 1839-1851
    • Chow, J.M.1    Shen, S.C.2    Huan, S.K.3    Lin, H.Y.4    Chen, Y.C.5
  • 18
    • 0036267006 scopus 로고    scopus 로고
    • Hyperglycemia-induced apoptosis in mouse myocardium: Mitochondrial cytochrome C-mediated caspase-3 activation pathway
    • Cai L, Li W, Wang G, Guo L, Jiang Y and Kang YJ: Hyperglycemia-induced apoptosis in mouse myocardium: mitochondrial cytochrome C-mediated caspase-3 activation pathway. Diabetes 51: 1938-1948, 2002.
    • (2002) Diabetes , vol.51 , pp. 1938-1948
    • Cai, L.1    Li, W.2    Wang, G.3    Guo, L.4    Jiang, Y.5    Kang, Y.J.6
  • 19
    • 33751082356 scopus 로고    scopus 로고
    • IL-1beta-induced iNOS expression, NO release and loss in metabolic cell viability are resistant to inhibitors of ceramide synthase and sphingomyelinase in INS 832/13 cells
    • Veluthakal R, Jangati GR and Kowluru A: IL-1beta-induced iNOS expression, NO release and loss in metabolic cell viability are resistant to inhibitors of ceramide synthase and sphingomyelinase in INS 832/13 cells. JOP 7: 593-601, 2006.
    • (2006) JOP , vol.7 , pp. 593-601
    • Veluthakal, R.1    Jangati, G.R.2    Kowluru, A.3
  • 22
    • 34347399043 scopus 로고    scopus 로고
    • Reactive oxygen species as a signal in glucose-stimulated insulin secretion
    • Pi J, Bai Y, Zhang Q, et al: Reactive oxygen species as a signal in glucose-stimulated insulin secretion. Diabetes 56: 1783-1791, 2007.
    • (2007) Diabetes , vol.56 , pp. 1783-1791
    • Pi, J.1    Bai, Y.2    Zhang, Q.3
  • 23
    • 79960364799 scopus 로고    scopus 로고
    • Polyphenolic extracts from Olea europea L. protect against cytokine-induced beta-cell damage through maintenance of redox homeostasis
    • Cumaoglu A, Ari N, Kartal M and Karasu C: Polyphenolic extracts from Olea europea L. protect against cytokine-induced beta-cell damage through maintenance of redox homeostasis. Rejuvenation Res 14: 325-334, 2011.
    • (2011) Rejuvenation Res , vol.14 , pp. 325-334
    • Cumaoglu, A.1    Ari, N.2    Kartal, M.3    Karasu, C.4
  • 24
    • 0034814670 scopus 로고    scopus 로고
    • Physiology and pathophysiology of poly(ADP-ribosyl)ation
    • Burkle A: Physiology and pathophysiology of poly(ADP-ribosyl)ation. Bioessays 23: 795-806, 2001.
    • (2001) Bioessays , vol.23 , pp. 795-806
    • Burkle, A.1
  • 25
    • 78651303018 scopus 로고    scopus 로고
    • Mcl-1 downregulation by pro-inflammatory cytokines and palmitate is an early event contributing to beta-cell apoptosis
    • Allagnat F, Cunha D, Moore F, Vanderwinden JM, Eizirik DL and Cardozo AK: Mcl-1 downregulation by pro-inflammatory cytokines and palmitate is an early event contributing to beta-cell apoptosis. Cell Death Differ 18: 328-337, 2011.
    • (2011) Cell Death Differ , vol.18 , pp. 328-337
    • Allagnat, F.1    Cunha, D.2    Moore, F.3    Vanderwinden, J.M.4    Eizirik, D.L.5    Cardozo, A.K.6
  • 26
    • 0037171446 scopus 로고    scopus 로고
    • Cytokine-induced apoptosis and necrosis are preceded by disruption of the mitochondrial membrane potential (Deltapsi(m)) in pancreatic RINm5F cells: Prevention by Bcl-2
    • Barbu A, Welsh N and Saldeen J: Cytokine-induced apoptosis and necrosis are preceded by disruption of the mitochondrial membrane potential (Deltapsi(m)) in pancreatic RINm5F cells: prevention by Bcl-2. Mol Cell Endocrinol 190: 75-82, 2002.
    • (2002) Mol Cell Endocrinol , vol.190 , pp. 75-82
    • Barbu, A.1    Welsh, N.2    Saldeen, J.3
  • 27
    • 78650518771 scopus 로고    scopus 로고
    • Modulation of Bcl-2-related protein expression in pancreatic beta cells by pro-inflammatory cytokines and its dependence on the antioxidative defense status
    • Mehmeti I, Lenzen S and Lortz S: Modulation of Bcl-2-related protein expression in pancreatic beta cells by pro-inflammatory cytokines and its dependence on the antioxidative defense status. Mol Cell Endocrinol 332: 88-96, 2011.
    • (2011) Mol Cell Endocrinol , vol.332 , pp. 88-96
    • Mehmeti, I.1    Lenzen, S.2    Lortz, S.3
  • 28
    • 32444434664 scopus 로고    scopus 로고
    • Caspases 3 and 7: Key mediators of mitochondrial events of apoptosis
    • Lakhani SA, Masud A, Kuida K, et al: Caspases 3 and 7: key mediators of mitochondrial events of apoptosis. Science 311: 847-851, 2006.
    • (2006) Science , vol.311 , pp. 847-851
    • Lakhani, S.A.1    Masud, A.2    Kuida, K.3
  • 29
    • 0037315424 scopus 로고    scopus 로고
    • Diabetes activates cell death pathway after transient focal cerebral ischemia
    • Muranyi M, Fujioka M, He Q, et al: Diabetes activates cell death pathway after transient focal cerebral ischemia. Diabetes 52: 481-486, 2003.
    • (2003) Diabetes , vol.52 , pp. 481-486
    • Muranyi, M.1    Fujioka, M.2    He, Q.3
  • 30
    • 0032403857 scopus 로고    scopus 로고
    • Crucial role of apopain in the peroxynitrite-induced apoptotic DNA fragmentation
    • Virag L, Marmer DJ and Szabo C: Crucial role of apopain in the peroxynitrite-induced apoptotic DNA fragmentation. Free Radic Biol Med 25: 1075-1082, 1998.
    • (1998) Free Radic Biol Med , vol.25 , pp. 1075-1082
    • Virag, L.1    Marmer, D.J.2    Szabo, C.3
  • 31
    • 78049461252 scopus 로고    scopus 로고
    • The glycolipid sulfatide protects insulin-producing cells against cytokine-induced apoptosis, a possible role in diabetes
    • Roeske-Nielsen A, Dalgaard LT, Mansson JE and Buschard K: The glycolipid sulfatide protects insulin-producing cells against cytokine-induced apoptosis, a possible role in diabetes. Diabetes Metab Res Rev 26: 631-638, 2010.
    • (2010) Diabetes Metab Res Rev , vol.26 , pp. 631-638
    • Roeske-Nielsen, A.1    Dalgaard, L.T.2    Mansson, J.E.3    Buschard, K.4
  • 32
    • 78751698755 scopus 로고    scopus 로고
    • Quercetin exerts a neuroprotective effect through inhibition of the iNOS/NO system and pro-inflammation gene expression in PC12 cells and in zebrafish
    • Zhang ZJ, Cheang LC, Wang MW and Lee SM: Quercetin exerts a neuroprotective effect through inhibition of the iNOS/NO system and pro-inflammation gene expression in PC12 cells and in zebrafish. Int J Mol Med 27: 195-203, 2011.
    • (2011) Int J Mol Med , vol.27 , pp. 195-203
    • Zhang, Z.J.1    Cheang, L.C.2    Wang, M.W.3    Lee, S.M.4
  • 33
    • 77949442655 scopus 로고    scopus 로고
    • Nitrosative stress as a mediator of apoptosis: Implications for cancer therapy
    • Hirst DG and Robson T: Nitrosative stress as a mediator of apoptosis: implications for cancer therapy. Curr Pharm Des 16: 45-55, 2010.
    • (2010) Curr Pharm des , vol.16 , pp. 45-55
    • Hirst, D.G.1    Robson, T.2
  • 34
    • 45249090859 scopus 로고    scopus 로고
    • Role of NF-kappaB in beta-cell death
    • Melloul D: Role of NF-kappaB in beta-cell death. Biochem Soc Trans 36: 334-339, 2008.
    • (2008) Biochem Soc Trans , vol.36 , pp. 334-339
    • Melloul, D.1
  • 35
    • 0036234459 scopus 로고    scopus 로고
    • Missing pieces in the NF-kappaB puzzle
    • Ghosh S and Karin M: Missing pieces in the NF-kappaB puzzle. Cell 109 (Suppl): S81-S96, 2002.
    • (2002) Cell , vol.109 , Issue.SUPPL.
    • Ghosh, S.1    Karin, M.2
  • 36
    • 79960751192 scopus 로고    scopus 로고
    • Quercetin, a potent suppressor of NF-κB and Smad activation in osteoblasts
    • Yamaguchi M and Weitzmann MN: Quercetin, a potent suppressor of NF-κB and Smad activation in osteoblasts. Int J Mol Med 28: 521-525, 2011.
    • (2011) Int J Mol Med , vol.28 , pp. 521-525
    • Yamaguchi, M.1    Weitzmann, M.N.2
  • 37
    • 0034491103 scopus 로고    scopus 로고
    • Quercetin 3-O-beta-glucoside is better absorbed than other quercetin forms and is not present in rat plasma
    • Morand C, Manach C, Crespy V and Remesy C: Quercetin 3-O-beta-glucoside is better absorbed than other quercetin forms and is not present in rat plasma. Free Radic Res 33: 667-676, 2000.
    • (2000) Free Radic Res , vol.33 , pp. 667-676
    • Morand, C.1    Manach, C.2    Crespy, V.3    Remesy, C.4


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