The inflammatory cytokine response of cholesterol-enriched macrophages is dampened by stimulated pinocytosis

Journal of Leukocyte Biology

Volumn 81, Issue 2, 2007, Pages 483-491

  Li, Yankun ^a   Tabas, Ira ^a  

^a Och Spine at New York Presbyterian Hospitals   (United States)

Author keywords

Atherosclerosis; M CSF; TNF

Indexed keywords

2 MORPHOLINO 8 PHENYLCHROMONE; CHOLESTEROL; COLONY STIMULATING FACTOR 1; INTERLEUKIN 6; MITOGEN ACTIVATED PROTEIN KINASE; PHOSPHATIDYLINOSITOL 3 KINASE; TUMOR NECROSIS FACTOR ALPHA; WORTMANNIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; ATHEROSCLEROSIS; CONTROLLED STUDY; CYTOKINE RELEASE; ENDOPLASMIC RETICULUM; FEMALE; INFLAMMATION; MACROPHAGE; NONHUMAN; PINOCYTOSIS; PRIORITY JOURNAL;

ANIMALS; CELLS, CULTURED; CHOLESTEROL; DOWN-REGULATION; INFLAMMATION; LYSOSOMES; MACROPHAGE COLONY-STIMULATING FACTOR; MACROPHAGES; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; PINOCYTOSIS; STRUCTURE-ACTIVITY RELATIONSHIP; TUMOR NECROSIS FACTOR-ALPHA;

EID: 33846672726     PISSN: 07415400     EISSN: None     Source Type: Journal    
DOI: 10.1189/jlb.0806518     Document Type: Article

References (35)

1. Libby, P., Clinton, S. K. (1993) The role of macrophages in atherogenesis. Curr. Opin. Lipidol. 4, 355-363.
2. Rapp, J. H., Connor, W. E., Lin, D. S., Inahara, T., Porter, J. M. (1983) Lipids of human atherosclerotic plaques and xanthomas: clues to the mechanism of plaque progression. J. Lipid Res. 24, 1329-1335.
3. Small, D. M., Bond, M. G., Waugh, D., Prack, M., Sawyer, J. K. (1984) Physicochemical and histological changes in the arterial wall of nonhuman primates during progression and regression of atherosclerosis. J. Clin. Invest. 73, 1590-1605.
4. Kruth, H. S. (1984) Localization of unesterified cholesterol in human atherosclerotic lesions. Demonstration of filipin-positive, oil-red-O-negative particles. Am. J. Pathol. 114, 201-208.
5. Li, Y., Schwabe, R. F., DeVries-Seimon, T., Yao, P. M., Gerbod-Giannone, M. C., Tall, A. R., Davis, R. J., Flavell, R., Brenner, D. A., Tabas, I. (2005) Free cholesterol-loaded macrophages are an abundant source of tumor necrosis factor-α and interleukin-6: model of NF-κB- and MAP kinase-dependent inflammation in advanced atherosclerosis. J. Biol. Chem. 280, 21763-21772.
6. DeVries-Seimon, T., Li, Y., Yao, P. M., Stone, E., Wang, Y., Davis, R. J., Flavell, R., Tabas, I. (2005) Cholesterol-induced macrophage apoptosis requires ER stress pathways and engagement of the type A scavenger receptor. J. Cell Biol. 171, 61-73.
7. Tabas, I. (2002) Consequences of cellular cholesterol accumulation: basic concepts and physiological implications. J. Clin. Invest. 110, 905-911.
8. Tabas, I. (2004) Apoptosis and plaque destabilization: the role of macrophage apoptosis induced by cholesterol. Cell Death Differ. 11, S12-S16.
9. Kellner-Weibel, G., Jerome, W. G., Small, D. M., Warner, G. J., Stoltenborg, J. K., Kearney, M. A., Corjay, M. H., Phillips, M. C., Rothblat, G. H. (1998) Effects of intracellular free cholesterol accumulation on macrophage viability: a model for foam cell death. Arterioscler. Thromb. Vasc. Biol. 18, 423-431.
10. Schrijvers, D. M., De Meyer, G. R., Kockx, M. M., Herman, A. G., Martinet, W. (2005) Phagocytosis of apoptotic cells by macrophages is impaired in atherosclerosis. Arterioscler. Thromb. Vasc. Biol. 25, 1256-1261.
11. Tabas, I. (2005) Consequences and therapeutic implications of macrophage apoptosis in atherosclerosis: the importance of lesion stage and phagocytic efficiency. Arterioscler. Thromb. Vasc. Biol. 25, 2255-2264.
12. Chang, M-K., Bergmark, C., Laurila, A., Horkko, S., Han, K-H., Friedman, P., Dennis, E. A., Witztum, J. L. (1999) Monoclonal antibodies against oxidized low-density lipoprotein bind to apoptotic cells and inhibit their phagocytosis by elicited macrophages: evidence that oxidation-specific epitopes mediate macrophage recognition. Proc. Natl. Acad. Sci. USA 96, 6353-6358.
13. Aikawa, M., Libby, P. (2004) The vulnerable atherosclerotic plaque: pathogenesis and therapeutic approach. Cardiovasc. Pathol. 13, 125-138.
14. Kolodgie, F. D., Virmani, R., Burke, A. P., Farb, A., Weber, D. K., Kutys, R., Finn, A. V., Gold, H. K. (2004) Pathologic assessment of the vulnerable human coronary plaque. Heart 90, 1385-1391.
15. Havel, R. J., Eder, H., Bragdon, J. (1955) The distribution and chemical composition of ultracentrifugally reported lipoproteins in human serum. J. Clin. Invest. 34, 1345-1353.
16. Basu, S. K., Goldstein, J. L., Anderson, R. G. W., Brown, M. S. (1976) Degradation of cationized low density lipoprotein and regulation of cholesterol metabolism in homozygous familial hypercholesterolemia fibroblasts. Proc. Natl. Acad. Sci. USA 73, 3178-3182.
17. Ross, A. C., Go, K. J., Heider, J. G., Rothblat, G. H. (1984) Selective inhibition of acyl coenzyme A:cholesterol acyltransferase by compound 58-035. J. Biol. Chem. 259, 815-819.
18. Li, Y., Ge, M., Ciani, L., Kuriakose, G., Westover, E., Dura, M., Covey, D. F., Freed, J. H., Maxfield, F. R., Lytton, J., Tabas, I. (2004) Enrichment of endoplasmic reticulum with cholesterol inhibits SERCA2b activity in parallel with increased order of membrane lipids. Implications for depletion of ER calcium stores and apoptosis in cholesterol-loaded macrophages. J. Biol. Chem. 279, 37030-37039.
19. Li, Y., Gerbod-Giannone, M. C., Seitz, H., Cui, D., Thorp, E., Tall, A. R., Matsushima, G. K., Tabas, I. (2006) Cholesterol-induced apoptotic macrophages elicit an inflammatory response in phagocytes, which is partially attenuated by the Mer receptor. J. Biol. Chem. 281, 6707-6717.
20. Yao, P. M., Tabas, I. (2000) Free cholesterol loading of macrophages induces apoptosis involving the fas pathway. J. Biol. Chem. 275, 23807-23813.
21. Racoosin, E. L., Swanson, J. A. (1989) Macrophage colony-stimulating factor (rM-CSF) stimulates pinocytosis in bone marrow-derived macrophages. J. Exp. Med. 170, 1635-1648.
22. Kooistra, T., Lloyd, J. B. (1985) Degradation of insulin by human fibroblasts: effects of inhibitors of pinocytosis and lysosomal activity. Int. J. Biochem. 17, 805-811.
23. Tsang, A. W., Oestergaard, K., Myers, J. T., Swanson, J. A. (2000) Altered membrane trafficking in activated bone marrow-derived macrophages. J. Leukoc. Biol. 68, 487-494.
24. Murray, J., Wilson, L., Kellie, S. (2000) Phosphatidylinositol-3′ kinase-dependent vesicle formation in macrophages in response to macrophage colony stimulating factor. J. Cell Sci. 113, 337-348.
25. Araki, N., Johnson, M. T., Swanson, J. A. (1996) A role for phosphoinositide 3-kinase in the completion of macropinocytosis and phagocytosis by macrophages. J. Cell Biol. 135, 1249-1260.
26. Knight, K. R., Vairo, G., Hamilton, J. A. (1992) Regulation of pinocytosis in murine macrophages by colony-stimulating factors and other agents. J. Leukoc. Biol. 51, 350-359.
27. Racoosin, E. L., Swanson, J. A. (1992) M-CSF-induced macropinocytosis increases solute endocytosis but not receptor-mediated endocytosis in mouse macrophages. J. Cell Sci. 102, 867-880.
28. Feng, B., Yao, P. M., Li, Y., Devlin, C. M., Zhang, D., Harding, H. P., Sweeney, M., Rong, J. X., Kuriakose, G., Fisher, E. A., Marks, A. R., Ron, D., Tabas, I. (2003) The endoplasmic reticulum is the site of cholesterol-induced cytotoxicity in macrophages. Nat. Cell Biol. 5, 781-792.
29. Boullier, A., Li, Y., Quehenberger, O., Palinski, W., Tabas, I., Witztum, J. L., Miller, Y. I. (2006) Minimally oxidized LDL offsets the apoptotic effects of extensively oxidized LDL and free cholesterol in macrophages. Arterioscler. Thromb. Vasc. Biol. 26, 1169-1176.
30. Lupu, F., Danaricu, I., Simionescu, N. (1987) Development of intracellular lipid deposits in the lipid-laden cells of atherosclerotic lesions. A cytochemical and ultrastructural study. Atherosclerosis 67, 127-142.
31. Libby, P. (2002) Inflammation in atherosclerosis. Nature 420, 868-874.
32. Kruth, H. S., Jones, N. L., Huang, W., Zhao, B., Ishii, I., Chang, J., Combs, C. A., Malide, D., Zhang, W. Y. (2005) Macropinocytosis is the endocytic pathway that mediates macrophage foam cell formation with native low density lipoprotein. J. Biol. Chem. 280, 2352-2360.
33. Bergmann, C. E., Hoefer, I. E., Meder, B., Roth, H., van Royen, N., Breit, S. M., Jost, M. M., Aharinejad, S., Hartmann, S., Buschmann, I. R. (2006) Arteriogenesis depends on circulating monocytes and macrophage accumulation and is severely depressed in op/op mice. J. Leukoc. Biol. 80, 59-65.
34. Wiktor-Jedrzejczak, W., Ratajczak, M. Z., Ptasznik, A., Sell, K. W., Ahmed-Ansari, A., Ostertag, W. (1992) CSF-1 deficiency in the op/op mouse has differential effects on macrophage populations and differentiation stages. Exp. Hematol. 20, 1004-1010.
35. Umeda, S., Takahashi, K., Shultz, L. D., Naito, M., Takagi, K. (1996) Effects of macrophage colony-stimulating factor on macrophages and their related cell populations in the osteopetrosis mouse defective in production of functional macrophage colony-stimulating factor protein. Am. J. Pathol. 149, 559-574.