Discovery of 4-phenyl-2-phenylaminopyridine based TNIK inhibitors

Bioorganic and Medicinal Chemistry Letters

Volumn 23, Issue 2, 2013, Pages 569-573

  Ho, Koc Kan ^a   Parnell, K Mark ^a   Yuan, Yi ^a   Xu, Yong ^a   Kultgen, Steven G ^a   Hamblin, Steven ^a   Hendrickson, Thomas F ^a   Luo, Bai ^a   Foulks, Jason M ^a   McCullar, Michael V ^a   Kanner, Steven B ^a  

^a ASTEX PHARMACEUTICALS   (United Kingdom)

Author keywords

catenin; Phenylaminopyridine; TCF4; TNIK; Wnt signaling

Indexed keywords

4 PHENYL 2 PHENYLAMINOPYRIDINE DERIVATIVE; AMINOPYRIDINE DERIVATIVE; ANTINEOPLASTIC AGENT; BETA CATENIN; BETA LACTAMASE; ENZYME INHIBITOR; PHOSPHOTRANSFERASE; STAUROSPORINE; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR TCF4; TUMOR NECROSIS FACTOR RECEPTOR ASSOCIATED FACTOR 2 AND NCK INTERACTIVE KINASE; UNCLASSIFIED DRUG; WNT PROTEIN;

ARTICLE; CANCER CELL; CELL PROLIFERATION; CELL VIABILITY; COLORECTAL CANCER; COMPLEX FORMATION; CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME INHIBITION; GENETIC TRANSCRIPTION; MOLECULAR STABILITY; SIGNAL TRANSDUCTION;

AMINOPYRIDINES; CELL LINE, TUMOR; CELL PROLIFERATION; CELL SURVIVAL; COLORECTAL NEOPLASMS; DRUG DISCOVERY; ENZYME ACTIVATION; HUMANS; INHIBITORY CONCENTRATION 50; MODELS, MOLECULAR; MOLECULAR STRUCTURE; PROTEIN-SERINE-THREONINE KINASES; SIGNAL TRANSDUCTION;

EID: 84871718156     PISSN: 0960894X     EISSN: 14643405     Source Type: Journal    
DOI: 10.1016/j.bmcl.2012.11.013     Document Type: Article

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