A novel aminothiazole KY-05009 with potential to inhibit Traf2- And Nck-Interacting Kinase (TNIK) attenuates TGF-β1-mediated epithelial-to-mesenchymal transition in human lung adenocarcinoma A549 cells

PLoS ONE

Volumn 9, Issue 10, 2014, Pages

  Kim, Jiyeon ^a   Moon, Seong Hee ^b   Kim, Bum Tae ^b   Chae, Chong Hak ^b   Lee, Joo Yun ^b   Kim, Seong Hwan ^b  

^a Eulji University   (South Korea)

^b Korea Research Institute of Chemical Technology   (South Korea)

Author keywords

[No Author keywords available]

Indexed keywords

5 (4 METHYLBENZAMIDO) 2 (PHENYLAMINO)THIAZOLE 4 CARBOXAMIDE; ADENOSINE TRIPHOSPHATE; FOCAL ADHESION KINASE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; MITOGEN ACTIVATED PROTEIN KINASE; NCK INTERACTING KINASE; PAXILLIN; PROTEIN KINASE; PROTEIN TYROSINE KINASE; SMAD PROTEIN; THIAZOLE DERIVATIVE; TRANSFORMING GROWTH FACTOR BETA1; TUMOR NECROSIS FACTOR RECEPTOR ASSOCIATED FACTOR 2; UNCLASSIFIED DRUG; WNT PROTEIN; 5-(4-METHYLBENZAMIDO)-2-(PHENYLAMINO)THIAZOLE-4-CARBOXAMIDE; ANILINE DERIVATIVE; ANTINEOPLASTIC AGENT; FOCAL ADHESION KINASE 1; GERMINAL CENTER KINASES; PROTEIN KINASE INHIBITOR; PROTEIN SERINE THREONINE KINASE; PTK2 PROTEIN, HUMAN;

A549 CELL LINE; ARTICLE; CANCER CELL CULTURE; CELL VIABILITY; CONTROLLED STUDY; DRUG BINDING; DRUG EFFICACY; DRUG SYNTHESIS; ENZYME INHIBITION; EPITHELIAL MESENCHYMAL TRANSITION; FOCAL ADHESION; HUMAN; HUMAN CELL; IMMUNOCYTOCHEMISTRY; IMMUNOPRECIPITATION; MOLECULAR DOCKING; REAL TIME POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; WESTERN BLOTTING; ZYMOGRAPHY; ANTAGONISTS AND INHIBITORS; CELL MOTION; DRUG EFFECTS; ENZYMOLOGY; EPITHELIUM CELL; GENE EXPRESSION REGULATION; GENETICS; METABOLISM; PATHOLOGY; RESPIRATORY TRACT MUCOSA; SYNTHESIS; TUMOR CELL LINE;

ANILINE COMPOUNDS; ANTINEOPLASTIC AGENTS; CELL LINE, TUMOR; CELL MOVEMENT; EPITHELIAL CELLS; EPITHELIAL-MESENCHYMAL TRANSITION; EXTRACELLULAR SIGNAL-REGULATED MAP KINASES; FOCAL ADHESION KINASE 1; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; MOLECULAR DOCKING SIMULATION; NF-KAPPA B; PROTEIN KINASE INHIBITORS; PROTEIN-SERINE-THREONINE KINASES; RESPIRATORY MUCOSA; SIGNAL TRANSDUCTION; SMAD PROTEINS; SRC-FAMILY KINASES; THIAZOLES; TRANSFORMING GROWTH FACTOR BETA1; WNT PROTEINS;

EID: 84908295108     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0110180     Document Type: Article

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