Deletion of P2X7 attenuates hyperoxia-induced acute lung injury via inflammasome suppression

American Journal of Physiology - Lung Cellular and Molecular Physiology

Volumn 310, Issue 6, 2016, Pages L572-L581

  Galam, Lakshmi ^a   Rajan, Ashna ^a   Failla, Athena ^a   Soundararajan, Ramani ^a   Lockey, Richard F ^a   Kolliputi, Narasaiah ^a  

^a UNIVERSITY OF SOUTH FLORIDA   (United States)

Author keywords

Acute lung injury; Hyperoxia; Inflammasome; NLRP3; P2X7

Indexed keywords

EPITHELIAL SODIUM CHANNEL; INFLAMMASOME; INTERLEUKIN 1BETA; INTERLEUKIN 6; MONOCYTE CHEMOTACTIC PROTEIN 1; OXYGEN; PURINERGIC P2X7 RECEPTOR; TUMOR NECROSIS FACTOR; INTERLEUKIN 1BETA CONVERTING ENZYME;

ACUTE LUNG INJURY; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CELL PERMEABILIZATION; COCULTURE; CONTROLLED STUDY; CYTOKINE RELEASE; FEMALE; GENE DELETION; HYPEROXIA; INFLAMMATORY CELL; LUNG ALVEOLUS EPITHELIUM CELL; LUNG ALVEOLUS MACROPHAGE; LUNG CLEARANCE; LUNG EDEMA; MALE; MONOLAYER CULTURE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN CONTENT; PROTEIN EXPRESSION; SURVIVAL RATE; ANIMAL; BIOSYNTHESIS; C57BL MOUSE; CELL CULTURE; COMPLICATION; GENETICS; IMMUNOLOGY; KNOCKOUT MOUSE; LIPID PEROXIDATION; MEMBRANE POTENTIAL; METABOLISM; NEUTROPHIL CHEMOTAXIS; PROTECTION;

ACUTE LUNG INJURY; ALVEOLAR EPITHELIAL CELLS; ANIMALS; CASPASE 1; CELLS, CULTURED; COCULTURE TECHNIQUES; FEMALE; HYPEROXIA; INFLAMMASOMES; INTERLEUKIN-1BETA; LIPID PEROXIDATION; MALE; MEMBRANE POTENTIALS; MICE, INBRED C57BL; MICE, KNOCKOUT; NEUTROPHIL INFILTRATION; PROTECTIVE FACTORS; RECEPTORS, PURINERGIC P2X7;

EID: 84984601434     PISSN: 10400605     EISSN: 15221504     Source Type: Journal    
DOI: 10.1152/ajplung.00417.2015     Document Type: Article

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