Alveolar epithelial cells are critical in protection of the respiratory tract by secretion of factors able to modulate the activity of pulmonary macrophages and directly control bacterial growth

Infection and Immunity

Volumn 81, Issue 1, 2013, Pages 381-389

  Chuquimia, Olga D ^a   Petursdottir, Dagbjort H ^a   Periolo, Natalia ^a   Ferńndez, Carmen ^a  

^a STOCKHOLM UNIVERSITY   (Sweden)

Author keywords

[No Author keywords available]

Indexed keywords

BCG VACCINE; LIPOPOLYSACCHARIDE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BACTERIAL GROWTH; BACTERICIDAL ACTIVITY; BOVINE TUBERCULOSIS; CELL PHAGOCYTOSIS; CELL STIMULATION; CELL STRUCTURE; FEMALE; GROWTH REGULATION; IN VITRO STUDY; LUNG ALVEOLUS EPITHELIUM; LUNG ALVEOLUS MACROPHAGE; MACROPHAGE FUNCTION; MACROPHAGE MIGRATION; MOUSE; MYCOBACTERIUM BOVIS; NONHUMAN; PRIORITY JOURNAL;

ANIMALS; BACTERIAL INFECTIONS; CELL COMMUNICATION; CELL MOVEMENT; CELLS, CULTURED; EPITHELIAL CELLS; FEMALE; LIPOPOLYSACCHARIDES; MACROPHAGES, ALVEOLAR; MICE; MICE, INBRED C57BL; PHAGOCYTOSIS; PULMONARY ALVEOLI; RESPIRATORY MUCOSA; RESPIRATORY SYSTEM; WOUND HEALING;

EID: 84871856541     PISSN: 00199567     EISSN: 10985522     Source Type: Journal    
DOI: 10.1128/IAI.00950-12     Document Type: Article

References (58)

1. Bals R. 2000. Epithelial antimicrobial peptides in host defense against infection. Respir. Res. 1:141-150.
2. Ryu JH, Kim CH, Yoon JH. 2010. Innate immune responses of the airway epithelium. Mol. Cells 30:173-183.
3. Williams MC. 2003. Alveolar type I cells: molecular phenotype and development. Annu. Rev. Physiol. 65:669-695.
4. Fereol S, Fodil R, Pelle G, Louis B, Isabey D. 2008. Cell mechanics of alveolar epithelial cells (AECs) and macrophages (AMs). Respir. Physiol. Neurobiol. 163:3-16.
5. Castranova V, Rabovsky J, Tucker JH, Miles PR. 1988. The alveolar type II epithelial cell: a multifunctional pneumocyte. Toxicol. Appl. Pharmacol. 93:472-483.
6. Fehrenbach H. 2001. Alveolar epithelial type II cell: defender of the alveolus revisited. Respir. Res. 2:33-46.
7. Debbabi H, Ghosh S, Kamath AB, Alt J, Demello DE, Dunsmore S, Behar SM. 2005. Primary type II alveolar epithelial cells present microbial antigens to antigen-specific CD4+ T cells. Am. J. Physiol. Lung Cell. Mol. Physiol. 289:L274-L279.
8. Pechkovsky DV, Goldmann T, Ludwig C, Prasse A, Vollmer E, Muller-Quernheim J, Zissel G. 2005. CCR2 and CXCR3 agonistic chemokines are differently expressed and regulated in human alveolar epithelial cells type II. Respir. Res. 6:75.
9. Lo B, Hansen S, Evans K, Heath JK, Wright JR. 2008. Alveolar epithelial type II cells induce T cell tolerance to specific antigen. J. Immunol. 180: 881-888.
10. Witherden IR, Vanden Bon EJ, Goldstraw P, Ratcliffe C, Pastorino U, Tetley TD. 2004. Primary human alveolar type II epithelial cell chemokine release: effects of cigarette smoke and neutrophil elastase. Am. J. Respir. Cell Mol. Biol. 30:500-509.
11. Thorley AJ, Ford PA, Giembycz MA, Goldstraw P, Young A, Tetley TD. 2007. Differential regulation of cytokine release and leukocyte migration by lipopolysaccharide-stimulated primary human lung alveolar type II epithelial cells and macrophages. J. Immunol. 178:463-473.
12. Lohmann-Matthes ML, Steinmuller C, Franke-Ullmann G. 1994. Pulmonary macrophages. Eur. Respir. J. 7:1678-1689.
13. Fathi M, Johansson A, Lundborg M, Orre L, Skold CM, Camner P. 2001. Functional and morphological differences between human alveolar and interstitial macrophages. Exp. Mol. Pathol. 70:77-82.
14. Gordon SB, Read RC. 2002. Macrophage defences against respiratory tract infections. Br. Med. Bull. 61:45-61.
15. Laskin DL, Weinberger B, Laskin LD. 2001. Functional heterogeneity in liver and lung macrophages. J. Leukoc. Biol. 70:163-170.
16. Landsman L, Jung S. 2007. Lung macrophages serve as obligatory intermediate between blood monocytes and alveolar macrophages. J. Immunol. 179:3488-3494.
17. Landsman L, Varol C, Jung S. 2007. Distinct differentiation potential of blood monocyte subsets in the lung. J. Immunol. 178:2000-2007.
18. Hoshino K, Takeuchi O, Kawai T, Sanjo H, Ogawa T, Takeda Y, Takeda K, Akira S. 1999. Cutting edge: Toll-like receptor 4 (TLR4)-deficient mice are hyporesponsive to lipopolysaccharide: evidence for TLR4 as the Lps gene product. J. Immunol. 162:3749 -3752.
19. Humphreys IR, Stewart GR, Turner DJ, Patel J, Karamanou D, Snel-grove RJ, Young DB. 2006. A role for dendritic cells in the dissemination of mycobacterial infection. Microbes Infect. 8:1339-1346.
20. Chuquimia OD, Petursdottir DH, Rahman MJ, Hartl K, Singh M, Fernandez C. 2012. The role of alveolar epithelial cells in initiating and shaping pulmonary immune responses: communication between innate and adaptive immune systems. PLoS One 7:e32125. doi:10.1371/ journal.pone.0032125.
21. Rahman MJ, Chuquimia OD, Petursdottir DH, Periolo N, Singh M, Fernandez C. 2011. Impact of Toll-like receptor 2 deficiency on immune responses to mycobacterial antigens. Infect. Immun. 79:4649-4656.
22. Corti M, Brody AR, Harrison JH. 1996. Isolation and primary culture of murine alveolar type II cells. Am. J. Respir. Cell Mol. Biol. 14:309-315.
23. Migliaccio CT, Hamilton RF, Jr, Holian A. 2005. Increase in a distinct pulmonary macrophage subset possessing an antigen-presenting cell phenotype and in vitro APC activity following silica exposure. Toxicol. Appl. Pharmacol. 205:168-176.
24. Zaslona Z, Wilhelm J, Cakarova L, Marsh LM, Seeger W, Lohmeyer J, von Wulffen W. 2009. Transcriptome profiling of primary murine monocytes, lung macrophages and lung dendritic cells reveals a distinct expression of genes involved in cell trafficking. Respir. Res. 10:2.
25. Kugathasan K, Roediger EK, Small CL, McCormick S, Yang P, Xing Z. 2008. CD11c+ antigen-presenting cells from the alveolar space, lung parenchyma and spleen differ in their phenotype and capabilities to activate naive and antigen-primed T cells. BMC Immunol. 9:48.
26. Rothfuchs A, Gigliotti GD, Palmblad K, Andersson U, Wigzell H, Rottenberg MR. 2001. IFN-alpha beta-dependent, IFN-gamma secretion by bone marrow-derived macrophages controls an intracellular bacterial infection. J. Immunol. 167:6453-6461.
27. Stein M, Keshav S, Harris N, Gordon S. 1992. Interleukin 4 potently enhances murine macrophage mannose receptor activity: a marker of alternative immunologic macrophage activation. J. Exp. Med. 176:287-292.
28. Menzies FM, Henriquez FL, Alexander J, Roberts CW. 2010. Sequential expression of macrophage antimicrobial/inflammatory and wound healing markers following innate, alternative and classical activation. Clin. Exp. Immunol. 160:369-379.
29. Vereyken EJ, Heijnen PD, Baron de Vries EH, Dijkstra CD, Teunissen CE. 2011. Classically and alternatively activated bone marrow derived macrophages differ in cytoskeletal functions and migration towards specific CNS cell types. J. Neuroinflammation 8:58.
30. Kheradmand F, Folkesson HG, Shum L, Derynk R, Pytela R, Matthay MA. 1994. Transforming growth factor-alpha enhances alveolar epithelial cell repair in a new in vitro model. Am. J. Physiol. 267:L728-L738.
31. Munugalavadla V, Borneo J, Ingram DA, Kapur R. 2005. p85alpha subunit of class IA PI-3 kinase is crucial for macrophage growth and migration. Blood 106:103-109.
32. Wright JR. 2005. Immunoregulatory functions of surfactant proteins. Nat. Rev. Immunol. 5:58 - 68.
33. Sever-Chroneos Z, Krupa A, Davis J, Hasan M, Yang CH, Szeliga J, Herrmann M, Hussain M, Geisbrecht BV, Kobzik L, Chroneos ZC. 2011. Surfactant protein A (SP-A)-mediated clearance of Staphylococcus aureus involves binding of SP-A to the staphylococcal adhesin eap and the macrophage receptors SP-A receptor 210 and scavenger receptor class A. J. Biol. Chem. 286:4854-4870.
34. Wu H, Kuzmenko A, Wan S, Schaffer L, Weiss A, Fisher JH, Kim KS, McCormack FX. 2003. Surfactant proteins A and D inhibit the growth of Gram-negative bacteria by increasing membrane permeability. J. Clin. Invest. 111:1589-1602.
35. Bedoret D, Wallemacq H, Marichal T, Desmet C, Quesada Calvo F, Henry E, Closset R, Dewals B, Thielen C, Gustin P, de Leval L, Van Rooijen N, Le Moine A, Vanderplasschen A, Cataldo D, Drion PV, Moser M, Lekeux P, Bureau F. 2009. Lung interstitial macrophages alter dendritic cell functions to prevent airway allergy in mice. J. Clin. Invest. 119:3723-3738.
36. Sanders CJ, Doherty PC, Thomas PG. 2011. Respiratory epithelial cells in innate immunity to influenza virus infection. Cell Tissue Res. 343:13-21.
37. Guth AM, Janssen WJ, Bosio CM, Crouch EC, Henson PM, Dow SW. 2009. Lung environment determines unique phenotype of alveolar macrophages. Am. J. Physiol. Lung Cell. Mol. Physiol. 296:L936 -L946.
38. Sharma AK, Fernandez LG, Awad AS, Kron IL, Laubach VE. 2007. Proinflammatory response of alveolar epithelial cells is enhanced by alveolar macrophage-produced TNF-alpha during pulmonary ischemiareperfusion injury. Am. J. Physiol. Lung Cell. Mol. Physiol. 293:L105-L113.
39. Thorley AJ, Grandolfo D, Lim E, Goldstraw P, Young A, Tetley TD. 2011. Innate immune responses to bacterial ligands in the peripheral human lung-role of alveolar epithelial TLR expression and signalling. PLoS One 6:e21827. doi:10.1371/journal.pone.0021827.
40. Farberman MM, Hoffmann JW, Ryerse JS, Demello DE. 2004. Diffusible signal to murine alveolar macrophages from lipopolysaccharide-and Escherichia coli-stimulated lung type II epithelial cells. Inflamm. Res. 53: 475-483.
41. Rate A, Upham JW, Bosco A, McKenna KL, Holt PG. 2009. Airway epithelial cells regulate the functional phenotype of locally differentiating dendritic cells: implications for the pathogenesis of infectious and allergic airway disease. J. Immunol. 182:72-83.
42. Moldobaeva A, van Rooijen N, Wagner EM. 2011. Effects of ischemia on lung macrophages. PLoS One 6:e26716. doi:10.1371/journal.pone. 0026716.
43. Liang J, Jung Y, Tighe RM, Xie T, Liu N, Leonard M, Gunn MD, Jiang D, Noble PW. 2012. A macrophage subpopulation recruited by CC chemokine ligand-2 clears apoptotic cells in non-infectious lung injury. Am. J. Physiol. Lung Cell. Mol. Physiol. doi:10.1152/ajplung.00256.2011.
44. Herold S, von Wulffen W, Steinmueller M, Pleschka S, Kuziel WA, Mack M, Srivastava M, Seeger W, Maus UA, Lohmeyer J. 2006. Alveolar epithelial cells direct monocyte transepithelial migration upon influenza virus infection: impact of chemokines and adhesion molecules. J. Immunol. 177:1817-1824.
45. Lin KL, Suzuki Y, Nakano H, Ramsburg E, Gunn MD. 2008. CCR2+ monocyte-derived dendritic cells and exudate macrophages produce influenza-induced pulmonary immune pathology and mortality. J. Immunol. 180:2562-2572.
46. Eghtesad M, Jackson HE, Cunningham AC. 2001. Primary human alveolar epithelial cells can elicit the transendothelial migration of CD14+ monocytes and CD3+ lymphocytes. Immunology 102:157-164.
47. Krishnan N, Robertson BD, Thwaites G. 2010. The mechanisms and consequences of the extrapulmonary dissemination of Mycobacterium tuberculosis. Tuberculosis (Edinb.) 90:361-366.
48. Kannan S, Huang H, Seeger D, Audet A, Chen Y, Huang C, Gao H, Li S, Wu M. 2009. Alveolar epithelial type II cells activate alveolar macrophages and mitigate P. aeruginosa infection. PLoS One 4:e4891. doi:10.1371/journal.pone.0004891.
49. Berclaz PY, Zsengeller Z, Shibata Y, Otake K, Strasbaugh S, Whitsett JA, Trapnell JC. 2002. Endocytic internalization of adenovirus, nonspecific phagocytosis, and cytoskeletal organization are coordinately regulated in alveolar macrophages by GM-CSF and PU.1. J. Immunol. 169: 6332-6342.
50. Chroneos ZC, Sever-Chroneos Z, Shepherd VL. 2010. Pulmonary surfactant: an immunological perspective. Cell. Physiol. Biochem. 25:13-26.
51. Singh G, Katyal SL, Brown WE, Collins DL, Mason RJ. 1988. Pulmonary lysozyme-a secretory protein of type II pneumocytes in the rat. Am. Rev. Respir. Dis. 138:1261-1267.
52. Higashimoto Y, Yamagata Y, Iwata T, Ishiguchi T, Okada M, Masuda M, Satoh H, Itoh H. 2005. Adenoviral E1A suppresses secretory leukoprotease inhibitor and elafin secretion in human alveolar epithelial cells and bronchial epithelial cells. Respiration 72:629-635.
53. Hostanska K, Melzer J, Amon A, Saller R. 2011. Suppression of inter-leukin (IL)-8 and human beta defensin-2 secretion in LPS-and/or IL-1beta-stimulated airway epithelial A549 cells by a herbal formulation against respiratory infections (BNO 1030). J. Ethnopharmacol. 134:228 - 233.
54. Li Y, Wang Y, Liu X. 2012. The role of airway epithelial cells in response to mycobacteria infection. Clin. Dev. Immunol. 2012:791392.
55. Rivas-Santiago B, Schwander SK, Sarabia C, Diamond G, Klein-Patel ME, Hernandez-Pando R, Ellner JJ, Sada E. 2005. Human {beta}-defensin 2 is expressed and associated with Mycobacterium tuberculosis during infection of human alveolar epithelial cells. Infect. Immun. 73: 4505-4511.
56. Sonawane A, Santos JC, Mishra BB, Jena P, Progida C, Sorensen OE, Gallo R, Appelberg R, Griffiths G. 2011. Cathelicidin is involved in the intracellular killing of mycobacteria in macrophages. Cell. Microbiol. 13: 1601-1617.
57. Gordon S, Martinez FO. 2010. Alternative activation of macrophages: mechanism and functions. Immunity 32:593-604.
58. Moreira AP, Hogaboam CM. 2011. Macrophages in allergic asthma: fine-tuning their pro and anti-inflammatory actions for disease resolution. J. Interferon Cytokine Res. 31:485-491.