Pharmacological stimulation of NADH oxidation ameliorates obesity and related phenotypes in mice

Diabetes

Volumn 58, Issue 4, 2009, Pages 965-974

  Hwang, Jung Hwan ^a   Kim, Dong Wook ^a   Jo, Eun Jin ^b   Kim, Yong Kyung ^a   Jo, Young Suk ^a   Park, Ji Hoon ^a   Yoo, Sang Ku ^b   Park, Myung Kyu ^b   Kwak, Tae Hwan ^b   Kho, Young Lim ^c   Han, Jin ^d   Choi, Hueng Sik ^e   Lee, Sang Hee ^a   Kim, Jin Man ^a   Lee, Inkyu ^f   Kyung, Taeyoon ^g   Jang, Cholsoon ^g   Chung, Jongkyeong ^g   Kweon, Gi Ryang ^a   Shong, Minho ^a  

^a Chungnam National University   (South Korea)

^b Mazence Inc R and D Center   (South Korea)

^c Seoul Health College   (South Korea)

^d Inje University College of Medicine   (South Korea)

^e Chonnam National University   (South Korea)

^f Kyungpook National University School of Medicine   (South Korea)

^g Korea Advanced Institute of Science and Technology (KAIST)   (South Korea)

Author keywords

[No Author keywords available]

Indexed keywords

ACETYL COENZYME A CARBOXYLASE; BETA LAPACHONE; CARNITINE PALMITOYLTRANSFERASE; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE KINASE; NICOTINAMIDE ADENINE DINUCLEOTIDE; NUCLEAR RESPIRATORY FACTOR 1; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA COACTIVATOR 1ALPHA; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE DEHYDROGENASE (QUINONE); SIRTUIN 1;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL ENERGY; CONTROLLED STUDY; DYSLIPIDEMIA; ENERGY EXPENDITURE; ENERGY METABOLISM; ENZYME ACTIVITY; FATTY ACID OXIDATION; FATTY LIVER; GENE EXPRESSION; GLUCOSE INTOLERANCE; IN VITRO STUDY; IN VIVO STUDY; MALE; METABOLIC SYNDROME X; MITOCHONDRION; MOUSE; NONHUMAN; OBESITY; OXIDATION; PHENOTYPE; PRIORITY JOURNAL; RAT; SYMPTOMATOLOGY;

ADENYLATE KINASE; ANIMALS; DISEASE MODELS, ANIMAL; ENERGY METABOLISM; METABOLIC SYNDROME X; MICE; MICE, KNOCKOUT; NAD; NADPH DEHYDROGENASE; NAPHTHOQUINONES; OBESITY; OXIDATION-REDUCTION; PHENOTYPE; SIGNAL TRANSDUCTION;

EID: 64649104153     PISSN: 00121797     EISSN: 1939327X     Source Type: Journal    
DOI: 10.2337/db08-1183     Document Type: Article

References (49)

1. Kahn R, Buse J, Ferrannini E, Stern M: The metabolic syndrome: time for a critical appraisal: joint statement from the American Diabetes Association and the European Association for the Study of Diabetes. Diabetes Care 28:2289-2304, 2005
2. Despres JP, Lemieux I: Abdominal obesity and metabolic syndrome. Nature 444:881-887, 2006
3. Knowler WC, Barrett-Connor E, Fowler SE, Hamman RF, Lachin JM, Walker EA, Nathan DM: Reduction in the incidence of type 2 diabetes with lifestyle intervention or metformin. N Engl J Med 346:393-403, 2002
4. Shklyaev S, Aslanidi G, Tennant M, Prima V, Kohlbrenner E, Kroutov V, Campbell-Thompson M, Crawford J, Shek EW, Scarpace PJ, Zolotukhin S: Sustained peripheral expression of transgene adiponectin offsets the development of diet-induced obesity in rats. Proc Natl Acad SciUSA 100:14217-14222, 2003
5. Guarente L, Picard F: Calorie restriction-the SIR2 connection. Cell 120:473-482, 2005
6. Hardie DG: AMP-activated protein kinase as a drug target. Annu Rev Pharmacol Toxicol 47:185-210, 2007
7. Kahn BB, Alquier T, Carling D, Hardie DG: AMP-activated protein kinase: ancient energy gauge provides clues to modern understanding of metabolism. Cell Metab 1:15-25, 2005
8. Lin J, Handschin C, Spiegelman BM: Metabolic control through the PGC-1 family of transcription coactivators. Cell Metab 1:361-370, 2005
9. Guarente L: Sirtuins as potential targets for metabolic syndrome. Nature 444:868-874, 2006
10. Baur JA, Pearson KJ, Price NL, Jamieson HA, Lerin C, Kalra A, Prabhu VV, Allard JS, Lopez-Lluch G, Lewis K, Pistell PJ, Poosala S, Becker KG, Boss O, Gwinn D, Wang M, Ramaswamy S, Fishbein KW, Spencer RG, Lakatta EG, Le Couteur D, Shaw RJ, Navas P, Puigserver P, Ingram DK, de Cabo R, Sinclair DA: Resveratrol improves health and survival of mice on a high-calorie diet. Nature 444:337-342, 2006
11. Berger F, Ramirez-Hernandez MH, Ziegler M: The new life of a centenarian: signalling functions of NAD(P). Trends Biochem Sci 29:111-118, 2004
12. Pollak N, Dolle C, Ziegler M: The power to reduce: pyridine nucleotides- small molecules with a multitude of functions. Biochem J 402:205-218, 2007
13. Jaiswal AK: Regulation of genes encoding NAD(P)H:quinone oxidoreduc- tases. Free Radic Biol Med 29:254-262, 2000
14. Pink JJ, Planchon SM, Tagliarino C, Varnes ME, Siegel D, Boothman DA: NAD(P)H:Quinone oxidoreductase activity is the principal determinant of beta-lapachone cytotoxicity. J Biol Chem 275:5416-5424, 2000
15. Ni Q, Reid KR, Burant CF, Kennedy RT: Capillary LC-MS for high sensitivity metabolomic analysis of single islets of Langerhans. Anal Chem 80:3539-3546, 2008
16. Lazzarino G, Amorini AM, Fazzina G, Vagnozzi R, Signoretti S, Donzelli S, Di Stasio E, Giardina B, Tavazzi B: Single-sample preparation for simultaneous cellular redox and energy state determination. Anal Biochem 322:51-59, 2003
17. Picard F, Gehin M, Annicotte J, Rocchi S, Champy MF, O'Malley BW, Chambon P, Auwerx J: SRC-1 and TIF2 control energy balance between white and brown adipose tissues. Cell 111:931-941, 2002
18. Hayashi T, Hirshman MF, Fujii N, Habinowski SA, Witters LA, Goodyear LJ: Metabolic stress and altered glucose transport: activation of AMP- activated protein kinase as a unifying coupling mechanism. Diabetes 49:527-531, 2000
19. Dobrzyn P, Dobrzyn A, Miyazaki M, Cohen P, Asilmaz E, Hardie DG, Friedman JM, Ntambi JM: Stearoyl-CoA desaturase 1 deficiency increases fatty acid oxidation by activating AMP-activated protein kinase in liver. Proc Natl Acad SciUSA101:6409-6414, 2004
20. Oh W, Abu-Elheiga L, Kordari P, Gu Z, Shaikenov T, Chirala SS, Wakil SJ: Glucose and fat metabolism in adipose tissue of acetyl-CoA carboxylase 2 knockout mice. Proc Natl Acad SciUSA102:1384-1389, 2005
21. Hosokawa Y, Shimomura Y, Harris RA, Ozawa T: Determination of short-chain acyl-coenzyme A esters by high-performance liquid chroma- tography. Anal Biochem 153:45-49, 1986
22. Zhang X, Xie YW, Nasjletti A, Xu X, Wolin MS, Hintze TH: ACE inhibitors promote nitric oxide accumulation to modulate myocardial oxygen consumption. Circulation 95:176-182, 1997
23. Pajvani UB, Trujillo ME, Combs TP, Iyengar P, Jelicks L, Roth KA, Kitsis RN, Scherer PE: Fat apoptosis through targeted activation of caspase 8: a new mouse model of inducible and reversible lipoatrophy. Nat Med 11:797-803, 2005
24. Nonogaki K, Strack AM, Dallman MF, Tecott LH: Leptin-independent hyperphagia and type 2 diabetes in mice with a mutated serotonin 5-HT2C receptor gene. Nat Med 4:1152-1156, 1998
25. Asselin-Paturel C, Boonstra A, Dalod M, Durand I, Yessaad N, Dezutter- Dambuyant C, Vicari A, O'Garra A, Biron C, Briere F, Trinchieri G: Mouse type I IFN-producing cells are immature APCs with plasmacytoid morphology. Nat Immunol 2:1144-1150, 2001
26. Schaffner-Sabba K, Schmidt-Ruppin KH, Wehrli W, Schuerch AR, Wasley JW: beta-Lapachone: synthesis of derivatives and activities in tumor models. J Med Chem 27:990-994, 1984
27. Ying W: NAD+ and NADH in cellular functions and cell death. Front Biosci 11:3129-3148, 2006
28. Ido Y: Pyridine nucleotide redox abnormalities in diabetes. Antioxid Redox Signal 9:931-942, 2007
29. Lee JH, Koh H, Kim M, Kim Y, Lee SY, Karess RE, Lee SH, Shong M, Kim JM, Kim J, Chung J: Energy-dependent regulation of cell structure by AMP-activated protein kinase. Nature 447:1017-1020, 2007
30. Carling D, Zammit VA, Hardie DG: A common bicyclic protein kinase cascade inactivates the regulatory enzymes of fatty acid and cholesterol biosynthesis. FEBS Lett 223:217-222, 1987
31. Hardie DG, Pan DA: Regulation of fatty acid synthesis and oxidation by the AMP-activated protein kinase. Biochem Soc Trans 30:1064-1070, 2002
32. Ruderman N, Flier JS: Cell biology. Chewing the fat-ACC and energy balance. Science 291:2558-2559, 2001
33. Abu-Elheiga L, Matzuk MM, Abo-Hashema KA, Wakil SJ: Continuous fatty acid oxidation and reduced fat storage in mice lacking acetyl-CoA carboxylase 2. Science 291:2613-2616, 2001
34. Wu Z, Puigserver P, Andersson U, Zhang C, Adelmant G, Mootha V, Troy A, Cinti S, Lowell B, Scarpulla RC, Spiegelman BM: Mechanisms controlling mitochondrial biogenesis and respiration through the thermogenic coacti- vator PGC-1. Cell 98:115-124, 1999
35. Evans MJ, Scarpulla RC: NRF-1: a trans-activator of nuclear-encoded respiratory genes in animal cells. Genes Dev 4:1023-1034, 1990
36. Cohen HY, Miller C, Bitterman KJ, Wall NR, Hekking B, Kessler B, Howitz KT, Gorospe M, de Cabo R, Sinclair DA: Calorie restriction promotes mammalian cell survival by inducing the SIRT1 deacetylase. Science 305:390-392, 2004
37. Shi T, Wang F, Stieren E, Tong Q: SIRT3, a mitochondrial sirtuin deacetylase, regulates mitochondrial function and thermogenesis in brown adipocytes. J Biol Chem 280:13560-13567, 2005
38. Kim JB, Spiegelman BM: ADD1/SREBP1 promotes adipocyte differentiation and gene expression linked to fatty acid metabolism. Genes Dev 10:1096-1107, 1996
39. Lowell BB, Spiegelman BM: Towards a molecular understanding of adaptive thermogenesis. Nature 404:652-660, 2000
40. Reznick RM, Shulman GI: The role of AMP-activated protein kinase in mitochondrial biogenesis. J Physiol 574:33-39, 2006
41. Lin SJ, Ford E, Haigis M, Liszt G, Guarente L: Calorie restriction extends yeast life span by lowering the level of NADH. Genes Dev 18:12-16, 2004
42. Ying W: NAD+-to-NADH and NADP+-to-NADPH in cellular functions and cell death: regulation and biological consequences. Antioxid Redox Signal 10:179-206, 2008
43. Palming J, Sjoholm K, Jernas M, Lystig TC, Gummesson A, Romeo S, Lonn L, Lonn M, Carlsson B, Carlsson LM: The expression of NAD(P)H: quinone oxidoreductase 1 is high in human adipose tissue, reduced by weight loss, and correlates with adiposity, insulin sensitivity, and markers of liver dysfunction. J Clin Endocrinol Metab 92:2346-2352, 2007
44. Hardie DG, Carling D: The AMP-activated protein kinase-fuel gauge of the mammalian cell? Eur J Biochem 246:259-273, 1997
45. Woods A, Dickerson K, Heath R, Hong SP, Momcilovic M, Johnstone SR, Carlson M, Carling D: Ca2+ /calmodulin-dependent protein kinase kinase- beta acts upstream of AMP-activated protein kinase in mammalian cells. Cell Metab 2:21-33, 2005
46. Hawley SA, Pan DA, Mustard KJ, Ross L, Bain J, Edelman AM, Frenguelli BG, Hardie DG: Calmodulin-dependent protein kinase kinase-beta is an alternative upstream kinase for AMP-activated protein kinase. Cell Metab 2:9-19, 2005
47. Pospisilik JA, Knauf C, Joza N, Benit P, Orthofer M, Cani PD, Ebersberger I, Nakashima T, Sarao R, Neely G, Esterbauer H, Kozlov A, Kahn CR, Kroemer G, Rustin P, Burcelin R, Penninger JM: Targeted deletion of AIF decreases mitochondrial oxidative phosphorylation and protects from obesity and diabetes. Cell 131:476-491, 2007
48. Lagouge M, Argmann C, Gerhart-Hines Z, Meziane H, Lerin C, Daussin F, Messadeq N, Milne J, Lambert P, Elliott P, Geny B, Laakso M, Puigserver P, Auwerx J: Resveratrol improves mitochondrial function and protects against metabolic disease by activating SIRT1 and PGC-1alpha. Cell 127:1109-1122, 2006
49. Li Y, Sun X, LaMont JT, Pardee AB, Li CJ: Selective killing of cancer cells by beta-lapachone: direct checkpoint activation as a strategy against cancer. Proc Natl Acad SciUSA100:2674-2678, 2003