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Volumn 21, Issue 6, 2016, Pages 1037-1053

Ginkgolides and bilobalide protect BV2 microglia cells against OGD/reoxygenation injury by inhibiting TLR2/4 signaling pathways

Author keywords

Bilobalide; BV2 microglia cells; Cerebral ischemia; Ginkgolides; Inflammatory; NF B; TLRs

Indexed keywords

BILOBALIDE; CASPASE 3; GINKGOLIDE; GINKGOLIDE A; GINKGOLIDE B; GINKGOLIDE K; I KAPPA B ALPHA; I KAPPA B KINASE ALPHA; I KAPPA B KINASE BETA; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 10; INTERLEUKIN 1BETA; INTERLEUKIN 6; INTERLEUKIN 8; MYELOID DIFFERENTIATION FACTOR 88; NEUROPROTECTIVE AGENT; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE 1; PROTEIN BAK; PROTEIN BAX; PROTEIN BCL 2; TOLL LIKE RECEPTOR 2; TOLL LIKE RECEPTOR 4; TRANSCRIPTION FACTOR RELA; TRANSFORMING GROWTH FACTOR BETA ACTIVATED KINASE 1; TUMOR NECROSIS FACTOR; UNCLASSIFIED DRUG; CYCLOPENTANE DERIVATIVE; CYTOKINE; FURAN DERIVATIVE; GLUCOSE; MYD88 PROTEIN, MOUSE; RELA PROTEIN, MOUSE;

EID: 84983418165     PISSN: 13558145     EISSN: 14661268     Source Type: Journal    
DOI: 10.1007/s12192-016-0728-y     Document Type: Article
Times cited : (72)

References (96)
  • 1
    • 0141749421 scopus 로고    scopus 로고
    • Neuroprotective effects of Ginkgo biloba extract
    • COI: 1:CAS:528:DC%2BD3sXotF2jt70%3D, PID: 14523543
    • Ahlemeyer B, Krieglstein J (2003) Neuroprotective effects of Ginkgo biloba extract. Cell Mol Life Sci: CMLS 60:1779–1792
    • (2003) Cell Mol Life Sci: CMLS , vol.60 , pp. 1779-1792
    • Ahlemeyer, B.1    Krieglstein, J.2
  • 2
    • 84904369534 scopus 로고    scopus 로고
    • Pathogen recognition by innate immunity and its signaling
    • COI: 1:CAS:528:DC%2BD1MXmtlajtb4%3D
    • Akira S (2009) Pathogen recognition by innate immunity and its signaling. Proc Jpn Acad Ser B, Phys Biol Sci 85:143–156
    • (2009) Proc Jpn Acad Ser B, Phys Biol Sci , vol.85 , pp. 143-156
    • Akira, S.1
  • 3
    • 3142724031 scopus 로고    scopus 로고
    • Toll-like receptor signalling
    • COI: 1:CAS:528:DC%2BD2cXlt1Cqur0%3D, PID: 15229469
    • Akira S, Takeda K (2004) Toll-like receptor signalling. Nat Rev Immunol 4:499–511
    • (2004) Nat Rev Immunol , vol.4 , pp. 499-511
    • Akira, S.1    Takeda, K.2
  • 4
    • 48749105650 scopus 로고    scopus 로고
    • GuidAge study: a 5-year double blind, randomised trial of EGb 761 for the prevention of Alzheimer’s disease in elderly subjects with memory complaints. I. Rationale, design and baseline data
    • COI: 1:CAS:528:DC%2BD1cXpsVylsLc%3D, PID: 18690838
    • Andrieu S, Ousset PJ, Coley N, Ouzid M, Mathiex-Fortunet H, Vellas B, G. Guid Age study (2008) GuidAge study: a 5-year double blind, randomised trial of EGb 761 for the prevention of Alzheimer’s disease in elderly subjects with memory complaints. I. Rationale, design and baseline data. Curr Alzheimer Res 5:406–415
    • (2008) Curr Alzheimer Res , vol.5 , pp. 406-415
    • Andrieu, S.1    Ousset, P.J.2    Coley, N.3    Ouzid, M.4    Mathiex-Fortunet, H.5    Vellas, B.6    G. Guid Age study7
  • 5
    • 0030271387 scopus 로고    scopus 로고
    • NF-kappa B: ten years after
    • COI: 1:CAS:528:DyaK28XmtFeit7g%3D, PID: 8858144
    • Baeuerle PA, Baltimore D (1996) NF-kappa B: ten years after. Cell 87:13–20
    • (1996) Cell , vol.87 , pp. 13-20
    • Baeuerle, P.A.1    Baltimore, D.2
  • 6
    • 84921752255 scopus 로고    scopus 로고
    • Heptaphylline induces apoptosis in human colon adenocarcinoma cells through bid and Akt/NF-kappaB (p65) pathways
    • PID: 25556496
    • Boonyarat C, Yenjai C, Vajragupta O, Waiwut P (2014) Heptaphylline induces apoptosis in human colon adenocarcinoma cells through bid and Akt/NF-kappaB (p65) pathways. Asian Pac J Cancer Prev: APJCP 15:10483–10487
    • (2014) Asian Pac J Cancer Prev: APJCP , vol.15 , pp. 10483-10487
    • Boonyarat, C.1    Yenjai, C.2    Vajragupta, O.3    Waiwut, P.4
  • 7
    • 0022958875 scopus 로고
    • Proofs of involvement of PAF-acether in various immune disorders using BN 52021 (ginkgolide B): a powerful PAF-acether antagonist isolated from Ginkgo biloba L
    • COI: 1:CAS:528:DyaL2sXot1Klsg%3D%3D, PID: 2949548
    • Braquet P (1986) Proofs of involvement of PAF-acether in various immune disorders using BN 52021 (ginkgolide B): a powerful PAF-acether antagonist isolated from Ginkgo biloba L. Adv Prostaglandin Thromboxane Leukot Res 16:179–198
    • (1986) Adv Prostaglandin Thromboxane Leukot Res , vol.16 , pp. 179-198
    • Braquet, P.1
  • 9
    • 0041825196 scopus 로고    scopus 로고
    • Neuroprotective effects of bilobalide, a component of Ginkgo biloba extract (EGb 761) in global brain ischemia and in excitotoxicity-induced neuronal death
    • COI: 1:CAS:528:DC%2BD3sXnvVSlt78%3D, PID: 13130395
    • Chandrasekaran K, Mehrabian Z, Spinnewyn B, Chinopoulos C, Drieu K, Fiskum G (2003) Neuroprotective effects of bilobalide, a component of Ginkgo biloba extract (EGb 761) in global brain ischemia and in excitotoxicity-induced neuronal death. Pharmacopsychiatry 36(Suppl 1):S89–S94
    • (2003) Pharmacopsychiatry , vol.36 , pp. S89-S94
    • Chandrasekaran, K.1    Mehrabian, Z.2    Spinnewyn, B.3    Chinopoulos, C.4    Drieu, K.5    Fiskum, G.6
  • 10
    • 0033979832 scopus 로고    scopus 로고
    • Lipopolysaccharide activates nuclear factor kappaB in rat intestine: role of endogenous platelet-activating factor and tumour necrosis factor
    • COI: 1:CAS:528:DC%2BD3cXpslyrsg%3D%3D, PID: 10694237
    • De Plaen IG, Tan XD, Chang H, Wang L, Remick DG, Hsueh W (2000) Lipopolysaccharide activates nuclear factor kappaB in rat intestine: role of endogenous platelet-activating factor and tumour necrosis factor. Br J Pharmacol 129:307–314
    • (2000) Br J Pharmacol , vol.129 , pp. 307-314
    • De Plaen, I.G.1    Tan, X.D.2    Chang, H.3    Wang, L.4    Remick, D.G.5    Hsueh, W.6
  • 11
    • 0036451982 scopus 로고    scopus 로고
    • Bilobalide and neuroprotection
    • COI: 1:CAS:528:DC%2BD38XovVyhtLw%3D, PID: 12457632
    • Defeudis FV (2002) Bilobalide and neuroprotection. Pharmacol Res 46:565–568
    • (2002) Pharmacol Res , vol.46 , pp. 565-568
    • Defeudis, F.V.1
  • 13
    • 34248392684 scopus 로고    scopus 로고
    • Microglial activation and its implications in the brain diseases
    • COI: 1:CAS:528:DC%2BD2sXltFejsro%3D, PID: 17504139
    • Dheen ST, Kaur C, Ling EA (2007) Microglial activation and its implications in the brain diseases. Curr Med Chem 14:1189–1197
    • (2007) Curr Med Chem , vol.14 , pp. 1189-1197
    • Dheen, S.T.1    Kaur, C.2    Ling, E.A.3
  • 14
    • 46349090692 scopus 로고    scopus 로고
    • Mechanisms of ischemic brain damage
    • COI: 1:CAS:528:DC%2BD1cXhtVSit77L, PID: 18308346
    • Doyle KP, Simon RP, Stenzel-Poore MP (2008) Mechanisms of ischemic brain damage. Neuropharmacology 55:310–318
    • (2008) Neuropharmacology , vol.55 , pp. 310-318
    • Doyle, K.P.1    Simon, R.P.2    Stenzel-Poore, M.P.3
  • 15
    • 81255195550 scopus 로고    scopus 로고
    • Ischemia and reperfusion—from mechanism to translation
    • COI: 1:CAS:528:DC%2BC3MXhsVOisLnJ, PID: 22064429
    • Eltzschig HK, Eckle T (2011) Ischemia and reperfusion—from mechanism to translation. Nat Med 17:1391–1401
    • (2011) Nat Med , vol.17 , pp. 1391-1401
    • Eltzschig, H.K.1    Eckle, T.2
  • 16
    • 84865166402 scopus 로고    scopus 로고
    • Downstream toll-like receptor signaling mediates adaptor-specific cytokine expression following focal cerebral ischemia
    • COI: 1:CAS:528:DC%2BC38Xhsl2jt77E, PID: 22799573
    • Famakin B, Mou Y, Spatz M, Lawal M, Hallenbeck J (2012) Downstream toll-like receptor signaling mediates adaptor-specific cytokine expression following focal cerebral ischemia. J Neuroinflammation 9:174
    • (2012) J Neuroinflammation , vol.9 , pp. 174
    • Famakin, B.1    Mou, Y.2    Spatz, M.3    Lawal, M.4    Hallenbeck, J.5
  • 19
    • 84866125550 scopus 로고    scopus 로고
    • Inhibition of NF-kappaB activation is associated with anti-inflammatory and anti-apoptotic effects of ginkgolide B in a mouse model of cerebral ischemia/reperfusion injury
    • COI: 1:CAS:528:DC%2BC38Xhs1agtr7J
    • Gu JH, Ge JB, Li M, Wu F, Zhang W, Qin ZH (2012) Inhibition of NF-kappaB activation is associated with anti-inflammatory and anti-apoptotic effects of ginkgolide B in a mouse model of cerebral ischemia/reperfusion injury. Eur J Pharm Sci: off J Eur Fed Pharm Sci 47:652–660
    • (2012) Eur J Pharm Sci: off J Eur Fed Pharm Sci , vol.47 , pp. 652-660
    • Gu, J.H.1    Ge, J.B.2    Li, M.3    Wu, F.4    Zhang, W.5    Qin, Z.H.6
  • 20
    • 38849199203 scopus 로고    scopus 로고
    • Shared principles in NF-kappaB signaling
    • COI: 1:CAS:528:DC%2BD1cXivVahtbY%3D, PID: 18267068
    • Hayden MS, Ghosh S (2008) Shared principles in NF-kappaB signaling. Cell 132:344–362
    • (2008) Cell , vol.132 , pp. 344-362
    • Hayden, M.S.1    Ghosh, S.2
  • 21
    • 84868509136 scopus 로고    scopus 로고
    • Baicalin attenuates proinflammatory cytokine production in oxygen-glucose deprived challenged rat microglial cells by inhibiting TLR4 signaling pathway
    • COI: 1:CAS:528:DC%2BC38XhslOku7vI, PID: 23116637
    • Hou J, Wang J, Zhang P, Li D, Zhang C, Zhao H, Fu J, Wang B, Liu J (2012) Baicalin attenuates proinflammatory cytokine production in oxygen-glucose deprived challenged rat microglial cells by inhibiting TLR4 signaling pathway. Int Immunopharmacol 14:749–757
    • (2012) Int Immunopharmacol , vol.14 , pp. 749-757
    • Hou, J.1    Wang, J.2    Zhang, P.3    Li, D.4    Zhang, C.5    Zhao, H.6    Fu, J.7    Wang, B.8    Liu, J.9
  • 23
    • 77957858212 scopus 로고    scopus 로고
    • Toll-like receptor 4 (TLR4), but not TLR3 or TLR9, knock-out mice have neuroprotective effects against focal cerebral ischemia
    • COI: 1:CAS:528:DC%2BC3cXhtlShtL7L, PID: 20804821
    • Hyakkoku K, Hamanaka J, Tsuruma K, Shimazawa M, Tanaka H, Uematsu S, Akira S, Inagaki N, Nagai H, Hara H (2010) Toll-like receptor 4 (TLR4), but not TLR3 or TLR9, knock-out mice have neuroprotective effects against focal cerebral ischemia. Neuroscience 171:258–267
    • (2010) Neuroscience , vol.171 , pp. 258-267
    • Hyakkoku, K.1    Hamanaka, J.2    Tsuruma, K.3    Shimazawa, M.4    Tanaka, H.5    Uematsu, S.6    Akira, S.7    Inagaki, N.8    Nagai, H.9    Hara, H.10
  • 24
    • 0035143182 scopus 로고    scopus 로고
    • Cerebral ischemia and inflammation
    • COI: 1:STN:280:DC%2BD3M7psVCguw%3D%3D, PID: 11176223
    • Iadecola C, Alexander M (2001) Cerebral ischemia and inflammation. Curr Opin Neurol 14:89–94
    • (2001) Curr Opin Neurol , vol.14 , pp. 89-94
    • Iadecola, C.1    Alexander, M.2
  • 25
    • 79960141471 scopus 로고    scopus 로고
    • The immunology of stroke: from mechanisms to translation
    • COI: 1:CAS:528:DC%2BC3MXos1Srsrw%3D, PID: 21738161
    • Iadecola C, Anrather J (2011) The immunology of stroke: from mechanisms to translation. Nat Med 17:796–808
    • (2011) Nat Med , vol.17 , pp. 796-808
    • Iadecola, C.1    Anrather, J.2
  • 26
    • 14344256045 scopus 로고    scopus 로고
    • Isolation of ginkgolides a, B, C, J and bilobalide from G. biloba extracts
    • COI: 1:CAS:528:DC%2BD2cXovVKnsr8%3D, PID: 15501258
    • Jaracz S, Malik S, Nakanishi K (2004) Isolation of ginkgolides a, B, C, J and bilobalide from G. biloba extracts. Phytochemistry 65:2897–2902
    • (2004) Phytochemistry , vol.65 , pp. 2897-2902
    • Jaracz, S.1    Malik, S.2    Nakanishi, K.3
  • 27
    • 84876231902 scopus 로고    scopus 로고
    • Guidelines for the early management of patients with acute ischemic stroke: a guideline for healthcare professionals from the American Heart Association/American Stroke Association
    • C. American Heart Association Stroke, N. Council on Cardiovascular, D. Council on Peripheral Vascular and C. Council on Clinical
    • Jauch EC, Saver JL, Adams HP Jr, Bruno A, Connors JJ, Demaerschalk BM, Khatri P, McMullan PW Jr, Qureshi AI, Rosenfield K, Scott PA, Summers DR, Wang DZ, Wintermark M, Yonas H, C. American Heart Association Stroke, N. Council on Cardiovascular, D. Council on Peripheral Vascular and C. Council on Clinical (2013) Guidelines for the early management of patients with acute ischemic stroke: a guideline for healthcare professionals from the American Heart Association/American Stroke Association. Stroke J Cereb Cir 44:870–947
    • (2013) Stroke J Cereb Cir , vol.44 , pp. 870-947
    • Jauch, E.C.1    Saver, J.L.2    Adams, H.P.3    Bruno, A.4    Connors, J.J.5    Demaerschalk, B.M.6    Khatri, P.7    McMullan, P.W.8    Qureshi, A.I.9    Rosenfield, K.10    Scott, P.A.11    Summers, D.R.12    Wang, D.Z.13    Wintermark, M.14    Yonas, H.15
  • 28
    • 84908068614 scopus 로고    scopus 로고
    • Neuroprotective effects of bilobalide on cerebral ischemia and reperfusion injury are associated with inhibition of pro-inflammatory mediator production and down-regulation of JNK1/2 and p38 MAPK activation
    • PID: 25256700
    • Jiang M, Li J, Peng Q, Liu Y, Liu W, Luo C, Peng J, Li J, Yung KK, Mo Z (2014) Neuroprotective effects of bilobalide on cerebral ischemia and reperfusion injury are associated with inhibition of pro-inflammatory mediator production and down-regulation of JNK1/2 and p38 MAPK activation. J Neuroinflammation 11:167
    • (2014) J Neuroinflammation , vol.11 , pp. 167
    • Jiang, M.1    Li, J.2    Peng, Q.3    Liu, Y.4    Liu, W.5    Luo, C.6    Peng, J.7    Li, J.8    Yung, K.K.9    Mo, Z.10
  • 29
    • 0037318720 scopus 로고    scopus 로고
    • Adaptors as central mediators of signal transduction in immune cells
    • COI: 1:CAS:528:DC%2BD3sXmslGqug%3D%3D, PID: 12555096
    • Jordan MS, Singer AL, Koretzky GA (2003) Adaptors as central mediators of signal transduction in immune cells. Nat Immunol 4:110–116
    • (2003) Nat Immunol , vol.4 , pp. 110-116
    • Jordan, M.S.1    Singer, A.L.2    Koretzky, G.A.3
  • 30
    • 79952318766 scopus 로고    scopus 로고
    • Endotoxin-activated microglia injure brain derived endothelial cells via NF-kappaB, JAK-STAT and JNK stress kinase pathways
    • COI: 1:CAS:528:DC%2BC3MXjvVClurY%3D
    • Kacimi R, Giffard RG, Yenari MA (2011) Endotoxin-activated microglia injure brain derived endothelial cells via NF-kappaB, JAK-STAT and JNK stress kinase pathways. J Inflamm 8:7
    • (2011) J Inflamm , vol.8 , pp. 7
    • Kacimi, R.1    Giffard, R.G.2    Yenari, M.A.3
  • 31
    • 33745298519 scopus 로고    scopus 로고
    • Nuclear factor-kappaB in cancer development and progression
    • COI: 1:CAS:528:DC%2BD28XkvVyrsrw%3D, PID: 16724054
    • Karin M (2006) Nuclear factor-kappaB in cancer development and progression. Nature 441:431–436
    • (2006) Nature , vol.441 , pp. 431-436
    • Karin, M.1
  • 32
    • 39849083520 scopus 로고    scopus 로고
    • Mechanisms of microglia-mediated neurotoxicity in a new model of the stroke penumbra
    • COI: 1:CAS:528:DC%2BD1cXjt1Cqu7k%3D
    • Kaushal V, Schlichter LC (2008) Mechanisms of microglia-mediated neurotoxicity in a new model of the stroke penumbra. J Neurosci: Off J Soc Neurosci 28:2221–2230
    • (2008) J Neurosci: Off J Soc Neurosci , vol.28 , pp. 2221-2230
    • Kaushal, V.1    Schlichter, L.C.2
  • 33
    • 0033166472 scopus 로고    scopus 로고
    • Unresponsiveness of MyD88-deficient mice to endotoxin
    • COI: 1:CAS:528:DyaK1MXltFCgt7w%3D, PID: 10435584
    • Kawai T, Adachi O, Ogawa T, Takeda K, Akira S (1999) Unresponsiveness of MyD88-deficient mice to endotoxin. Immunity 11:115–122
    • (1999) Immunity , vol.11 , pp. 115-122
    • Kawai, T.1    Adachi, O.2    Ogawa, T.3    Takeda, K.4    Akira, S.5
  • 34
    • 0026489096 scopus 로고
    • Ginkgo biloba
    • COI: 1:STN:280:DyaK3s%2FmtFGguw%3D%3D, PID: 1359218
    • Kleijnen J, Knipschild P (1992) Ginkgo biloba. Lancet 340:1136–1139
    • (1992) Lancet , vol.340 , pp. 1136-1139
    • Kleijnen, J.1    Knipschild, P.2
  • 35
    • 33646587342 scopus 로고    scopus 로고
    • Platelet-activating factor-induced NF-kappaB activation enhances VEGF expression through a decrease in p53 activity
    • COI: 1:CAS:528:DC%2BD28XltVKntbg%3D, PID: 16684540
    • Ko HM, Jung HH, Seo KH, Kang YR, Kim HA, Park SJ, Lee HK, Im SY (2006) Platelet-activating factor-induced NF-kappaB activation enhances VEGF expression through a decrease in p53 activity. FEBS Lett 580:3006–3012
    • (2006) FEBS Lett , vol.580 , pp. 3006-3012
    • Ko, H.M.1    Jung, H.H.2    Seo, K.H.3    Kang, Y.R.4    Kim, H.A.5    Park, S.J.6    Lee, H.K.7    Im, S.Y.8
  • 37
    • 79952276409 scopus 로고    scopus 로고
    • [Effects of ginkgolide B on inflammation induced by cerebral ischemia-reperfusion in rats]. Zhong yao cai Zhongyaocai
    • COI: 1:CAS:528:DC%2BC3cXhtlGhs73J
    • Liu YG, Li FJ, Wang J, Wang XD (2010) [Effects of ginkgolide B on inflammation induced by cerebral ischemia-reperfusion in rats]. Zhong yao cai Zhongyaocai. J Chin Med Mater 33:578–580
    • (2010) J Chin Med Mater , vol.33 , pp. 578-580
    • Liu, Y.G.1    Li, F.J.2    Wang, J.3    Wang, X.D.4
  • 38
    • 84873738685 scopus 로고    scopus 로고
    • Rosmarinic acid protects against experimental diabetes with cerebral ischemia: relation to inflammation response
    • COI: 1:CAS:528:DC%2BC3sXotFCktL8%3D, PID: 23414442
    • Luan H, Kan Z, Xu Y, Lv C, Jiang W (2013) Rosmarinic acid protects against experimental diabetes with cerebral ischemia: relation to inflammation response. J Neuroinflammation 10:28
    • (2013) J Neuroinflammation , vol.10 , pp. 28
    • Luan, H.1    Kan, Z.2    Xu, Y.3    Lv, C.4    Jiang, W.5
  • 39
    • 79851515594 scopus 로고    scopus 로고
    • Roles of inflammation response in microglia cell through toll-like receptors 2/interleukin-23/interleukin-17 pathway in cerebral ischemia/reperfusion injury
    • COI: 1:CAS:528:DC%2BC3MXhvFKjsrk%3D, PID: 21182899
    • Lv M, Liu Y, Zhang J, Sun L, Liu Z, Zhang S, Wang B, Su D, Su Z (2011a) Roles of inflammation response in microglia cell through toll-like receptors 2/interleukin-23/interleukin-17 pathway in cerebral ischemia/reperfusion injury. Neuroscience 176:162–172
    • (2011) Neuroscience , vol.176 , pp. 162-172
    • Lv, M.1    Liu, Y.2    Zhang, J.3    Sun, L.4    Liu, Z.5    Zhang, S.6    Wang, B.7    Su, D.8    Su, Z.9
  • 40
    • 80053911882 scopus 로고    scopus 로고
    • Therapeutic neuroprotective effects of ginkgolide B on cortex and basal ganglia in a rat model of transient focal ischemia
    • COI: 1:CAS:528:DC%2BC3MXht12rt7nP
    • Lv P, Fang W, Geng X, Yang Q, Li Y, Sha L (2011b) Therapeutic neuroprotective effects of ginkgolide B on cortex and basal ganglia in a rat model of transient focal ischemia. Eur J Pharm Sci: Off J Eur Fed Pharm Sci 44:235–240
    • (2011) Eur J Pharm Sci: Off J Eur Fed Pharm Sci , vol.44 , pp. 235-240
    • Lv, P.1    Fang, W.2    Geng, X.3    Yang, Q.4    Li, Y.5    Sha, L.6
  • 41
    • 83455217337 scopus 로고    scopus 로고
    • Neuroprotective effect of ginkgolide K on glutamate-induced cytotoxicity in PC 12 cells via inhibition of ROS generation and Ca (2+) influx
    • COI: 1:CAS:528:DC%2BC38XitVCgur0%3D, PID: 22120026
    • Ma S, Liu H, Jiao H, Wang L, Chen L, Liang J, Zhao M, Zhang X (2012) Neuroprotective effect of ginkgolide K on glutamate-induced cytotoxicity in PC 12 cells via inhibition of ROS generation and Ca (2+) influx. Neurotoxicology 33:59–69
    • (2012) Neurotoxicology , vol.33 , pp. 59-69
    • Ma, S.1    Liu, H.2    Jiao, H.3    Wang, L.4    Chen, L.5    Liang, J.6    Zhao, M.7    Zhang, X.8
  • 42
    • 0036343060 scopus 로고    scopus 로고
    • The CNS effects of Ginkgo biloba extracts and ginkgolide B
    • COI: 1:CAS:528:DC%2BD38XmtVSksLg%3D, PID: 12169298
    • Maclennan KM, Darlington CL, Smith PF (2002) The CNS effects of Ginkgo biloba extracts and ginkgolide B. Prog Neurobiol 67:235–257
    • (2002) Prog Neurobiol , vol.67 , pp. 235-257
    • Maclennan, K.M.1    Darlington, C.L.2    Smith, P.F.3
  • 43
    • 0037040883 scopus 로고    scopus 로고
    • Ras participates in the activation of p38 MAPK by interleukin-1 by associating with IRAK, IRAK2, TRAF6, and TAK-1
    • COI: 1:CAS:528:DC%2BD38XitFynu70%3D, PID: 11744690
    • McDermott EP, O’Neill LA (2002) Ras participates in the activation of p38 MAPK by interleukin-1 by associating with IRAK, IRAK2, TRAF6, and TAK-1. J Biol Chem 277:7808–7815
    • (2002) J Biol Chem , vol.277 , pp. 7808-7815
    • McDermott, E.P.1    O’Neill, L.A.2
  • 45
    • 0030983708 scopus 로고    scopus 로고
    • Mortality by cause for eight regions of the world: global burden of disease study
    • COI: 1:STN:280:DyaK2s3os12lug%3D%3D, PID: 9142060
    • Murray CJ, Lopez AD (1997) Mortality by cause for eight regions of the world: global burden of disease study. Lancet 349:1269–1276
    • (1997) Lancet , vol.349 , pp. 1269-1276
    • Murray, C.J.1    Lopez, A.D.2
  • 46
    • 0030694108 scopus 로고    scopus 로고
    • Pillars article: IRAK (Pelle) family member IRAK-2 and MyD88 as proximal mediators of IL-1 signaling
    • Journal of immunology, 190, 16–19
    • Muzio M, Ni J, Feng P, Dixit VM (2013) Pillars article: IRAK (Pelle) family member IRAK-2 and MyD88 as proximal mediators of IL-1 signaling. Science. 1997 278:1612–1615 Journal of immunology, 190, 16–19
    • (2013) Science. 1997 , vol.278 , pp. 1612-1615
    • Muzio, M.1    Ni, J.2    Feng, P.3    Dixit, V.M.4
  • 47
    • 33644654686 scopus 로고    scopus 로고
    • Ischemic preconditioning in the brain
    • PID: 16252891
    • Nagy K, Domoki F, Bari F (2005) Ischemic preconditioning in the brain. Ideggyogyaszati szemle 58:305–313
    • (2005) Ideggyogyaszati szemle , vol.58 , pp. 305-313
    • Nagy, K.1    Domoki, F.2    Bari, F.3
  • 48
    • 80051798126 scopus 로고    scopus 로고
    • Acute inhibition of TAK1 protects against neuronal death in cerebral ischemia
    • COI: 1:CAS:528:DC%2BC3MXhtVWnt7rP, PID: 21475303
    • Neubert M, Ridder DA, Bargiotas P, Akira S, Schwaninger M (2011) Acute inhibition of TAK1 protects against neuronal death in cerebral ischemia. Cell Death Differ 18:1521–1530
    • (2011) Cell Death Differ , vol.18 , pp. 1521-1530
    • Neubert, M.1    Ridder, D.A.2    Bargiotas, P.3    Akira, S.4    Schwaninger, M.5
  • 49
    • 84855192013 scopus 로고    scopus 로고
    • Addition of NMDA-receptor antagonist MK801 during oxygen/glucose deprivation moderately attenuates the upregulation of glucose uptake after subsequent reoxygenation in brain endothelial cells
    • COI: 1:CAS:528:DC%2BC3MXhs1OrurrE, PID: 22040671
    • Neuhaus W, Burek M, Djuzenova CS, Thal SC, Koepsell H, Roewer N, Forster CY (2012) Addition of NMDA-receptor antagonist MK801 during oxygen/glucose deprivation moderately attenuates the upregulation of glucose uptake after subsequent reoxygenation in brain endothelial cells. Neurosci Lett 506:44–49
    • (2012) Neurosci Lett , vol.506 , pp. 44-49
    • Neuhaus, W.1    Burek, M.2    Djuzenova, C.S.3    Thal, S.C.4    Koepsell, H.5    Roewer, N.6    Forster, C.Y.7
  • 50
    • 79952555514 scopus 로고    scopus 로고
    • Study on the protective effect of the mixture of Shengmai powder and Danshen decoction on the myocardium of diabetic cardiomyopathy in the rat model
    • PID: 21390578
    • Ni Q, Wang J, Li EQ, Zhao AB, Yu B, Wang M, Huang CR (2011) Study on the protective effect of the mixture of Shengmai powder and Danshen decoction on the myocardium of diabetic cardiomyopathy in the rat model. Chin J Integr Med 17:116–125
    • (2011) Chin J Integr Med , vol.17 , pp. 116-125
    • Ni, Q.1    Wang, J.2    Li, E.Q.3    Zhao, A.B.4    Yu, B.5    Wang, M.6    Huang, C.R.7
  • 51
    • 25144494690 scopus 로고    scopus 로고
    • Superoxide dismutase 1 overexpression reduces MCP-1 and MIP-1 alpha expression after transient focal cerebral ischemia
    • COI: 1:CAS:528:DC%2BD2MXhtFGlt77L
    • Nishi T, Maier CM, Hayashi T, Saito A, Chan PH (2005) Superoxide dismutase 1 overexpression reduces MCP-1 and MIP-1 alpha expression after transient focal cerebral ischemia. J Cereb Blood Flow Metab: Off J Int Soc Cereb Blood Flow Metab 25:1312–1324
    • (2005) J Cereb Blood Flow Metab: Off J Int Soc Cereb Blood Flow Metab , vol.25 , pp. 1312-1324
    • Nishi, T.1    Maier, C.M.2    Hayashi, T.3    Saito, A.4    Chan, P.H.5
  • 52
    • 0036607441 scopus 로고    scopus 로고
    • Toll-like receptor signal transduction and the tailoring of innate immunity: a role for Mal?
    • PID: 12072368
    • O’Neill LA (2002) Toll-like receptor signal transduction and the tailoring of innate immunity: a role for Mal? Trends Immunol 23:296–300
    • (2002) Trends Immunol , vol.23 , pp. 296-300
    • O’Neill, L.A.1
  • 53
    • 0038540887 scopus 로고    scopus 로고
    • The role of MyD88-like adapters in toll-like receptor signal transduction
    • PID: 12773173
    • O’Neill LA (2003) The role of MyD88-like adapters in toll-like receptor signal transduction. Biochem Soc Trans 31:643–647
    • (2003) Biochem Soc Trans , vol.31 , pp. 643-647
    • O’Neill, L.A.1
  • 55
    • 78349300284 scopus 로고    scopus 로고
    • [effect of ginkgolide B on the production of NO, IL-6 and RANTES from astrocytes]. Yao xue xue bao
    • COI: 1:CAS:528:DC%2BC3MXhsVagu78%3D
    • Peng SY, Liao WH, Nie ZG, Liu Y, Wang L, Wang F, Wang WJ (2010) [effect of ginkgolide B on the production of NO, IL-6 and RANTES from astrocytes]. Yao xue xue bao. Acta Pharm Sin 45:1103–1108
    • (2010) Acta Pharm Sin , vol.45 , pp. 1103-1108
    • Peng, S.Y.1    Liao, W.H.2    Nie, Z.G.3    Liu, Y.4    Wang, L.5    Wang, F.6    Wang, W.J.7
  • 57
    • 84863794427 scopus 로고    scopus 로고
    • Toll-like receptor 4 signaling is involved in PACAP-induced neuroprotection in BV2 microglial cells under OGD/reoxygenation
    • COI: 1:CAS:528:DC%2BC38Xhs1ynt7zP, PID: 22643083
    • Qin X, Sun ZQ, Dai XJ, Mao SS, Zhang JL, Jia MX, Zhang YM (2012) Toll-like receptor 4 signaling is involved in PACAP-induced neuroprotection in BV2 microglial cells under OGD/reoxygenation. Neurol Res 34:379–389
    • (2012) Neurol Res , vol.34 , pp. 379-389
    • Qin, X.1    Sun, Z.Q.2    Dai, X.J.3    Mao, S.S.4    Zhang, J.L.5    Jia, M.X.6    Zhang, Y.M.7
  • 58
    • 84888432562 scopus 로고    scopus 로고
    • TLR4 signaling is involved in the protective effect of propofol in BV2 microglia against OGD/reoxygenation
    • COI: 1:CAS:528:DC%2BC3sXhslymsrbP, PID: 23512249
    • Qin X, Sun ZQ, Zhang XW, Dai XJ, Mao SS, Zhang YM (2013) TLR4 signaling is involved in the protective effect of propofol in BV2 microglia against OGD/reoxygenation. J Physiol Biochem 69:707–718
    • (2013) J Physiol Biochem , vol.69 , pp. 707-718
    • Qin, X.1    Sun, Z.Q.2    Zhang, X.W.3    Dai, X.J.4    Mao, S.S.5    Zhang, Y.M.6
  • 59
    • 59349107204 scopus 로고    scopus 로고
    • NF-kappaB signaling in cerebral ischemia
    • COI: 1:CAS:528:DC%2BD1MXhsFKrur4%3D, PID: 18675321
    • Ridder DA, Schwaninger M (2009) NF-kappaB signaling in cerebral ischemia. Neuroscience 158:995–1006
    • (2009) Neuroscience , vol.158 , pp. 995-1006
    • Ridder, D.A.1    Schwaninger, M.2
  • 61
    • 1842586172 scopus 로고    scopus 로고
    • Cerebral ischemia and reperfusion: the pathophysiologic concept as a basis for clinical therapy
    • Schaller B, Graf R (2004) Cerebral ischemia and reperfusion: the pathophysiologic concept as a basis for clinical therapy. J Cereb Blood Flow Metab: Off J Int Soc Cereb Blood Flow Metab 24:351–371
    • (2004) J Cereb Blood Flow Metab: Off J Int Soc Cereb Blood Flow Metab , vol.24 , pp. 351-371
    • Schaller, B.1    Graf, R.2
  • 62
    • 84882664441 scopus 로고    scopus 로고
    • Neurodegeneration after transient brain ischemia in aged mice: beneficial effects of bilobalide
    • COI: 1:CAS:528:DC%2BC3sXht1Wns7rF, PID: 23850645
    • Schwarzkopf TM, Koch KA, Klein J (2013) Neurodegeneration after transient brain ischemia in aged mice: beneficial effects of bilobalide. Brain Res 1529:178–187
    • (2013) Brain Res , vol.1529 , pp. 178-187
    • Schwarzkopf, T.M.1    Koch, K.A.2    Klein, J.3
  • 64
    • 84155162481 scopus 로고    scopus 로고
    • Role of pro-inflammatory cytokines released from microglia in neurodegenerative diseases
    • COI: 1:CAS:528:DC%2BC3MXhs12gsr3P, PID: 22024597
    • Smith JA, Das A, Ray SK, Banik NL (2012) Role of pro-inflammatory cytokines released from microglia in neurodegenerative diseases. Brain Res Bull 87:10–20
    • (2012) Brain Res Bull , vol.87 , pp. 10-20
    • Smith, J.A.1    Das, A.2    Ray, S.K.3    Banik, N.L.4
  • 65
    • 67249152098 scopus 로고    scopus 로고
    • Panax notoginseng attenuates the infarct volume in rat ischemic brain and the inflammatory response of microglia
    • COI: 1:CAS:528:DC%2BD1MXktVSqu78%3D, PID: 19305121
    • Son HY, Han HS, Jung HW, Park YK (2009) Panax notoginseng attenuates the infarct volume in rat ischemic brain and the inflammatory response of microglia. J Pharmacol Sci 109:368–379
    • (2009) J Pharmacol Sci , vol.109 , pp. 368-379
    • Son, H.Y.1    Han, H.S.2    Jung, H.W.3    Park, Y.K.4
  • 67
    • 12444341944 scopus 로고    scopus 로고
    • Toll-like receptors in innate immunity
    • COI: 1:CAS:528:DC%2BD2cXhtVKru77P, PID: 15585605
    • Takeda K, Akira S (2005) Toll-like receptors in innate immunity. Int Immunol 17:1–14
    • (2005) Int Immunol , vol.17 , pp. 1-14
    • Takeda, K.1    Akira, S.2
  • 69
    • 0035903158 scopus 로고    scopus 로고
    • Endocytosed HSP60s use toll-like receptor 2 (TLR2) and TLR4 to activate the toll/interleukin-1 receptor signaling pathway in innate immune cells
    • COI: 1:CAS:528:DC%2BD3MXmsVejsb4%3D, PID: 11402040
    • Vabulas RM, Ahmad-Nejad P, da Costa C, Miethke T, Kirschning CJ, Hacker H, Wagner H (2001) Endocytosed HSP60s use toll-like receptor 2 (TLR2) and TLR4 to activate the toll/interleukin-1 receptor signaling pathway in innate immune cells. J Biol Chem 276:31332–31339
    • (2001) J Biol Chem , vol.276 , pp. 31332-31339
    • Vabulas, R.M.1    Ahmad-Nejad, P.2    da Costa, C.3    Miethke, T.4    Kirschning, C.J.5    Hacker, H.6    Wagner, H.7
  • 70
    • 67650724069 scopus 로고    scopus 로고
    • Regulation and function of NF-kappaB transcription factors in the immune system
    • COI: 1:CAS:528:DC%2BD1MXlsFSlt7o%3D, PID: 19302050
    • Vallabhapurapu S, Karin M (2009) Regulation and function of NF-kappaB transcription factors in the immune system. Annu Rev Immunol 27:693–733
    • (2009) Annu Rev Immunol , vol.27 , pp. 693-733
    • Vallabhapurapu, S.1    Karin, M.2
  • 71
    • 0033785945 scopus 로고    scopus 로고
    • The efficacy of ginkgo for elderly people with dementia and age-associated memory impairment: new results of a randomized clinical trial
    • PID: 11037003
    • van Dongen MC, van Rossum E, Kessels AG, Sielhorst HJ, Knipschild PG (2000) The efficacy of ginkgo for elderly people with dementia and age-associated memory impairment: new results of a randomized clinical trial. J Am Geriatr Soc 48:1183–1194
    • (2000) J Am Geriatr Soc , vol.48 , pp. 1183-1194
    • van Dongen, M.C.1    van Rossum, E.2    Kessels, A.G.3    Sielhorst, H.J.4    Knipschild, P.G.5
  • 73
    • 4644308783 scopus 로고    scopus 로고
    • Microglia: phagocyte and glia cell
    • COI: 1:CAS:528:DC%2BD2cXnslKgsrY%3D, PID: 15381143
    • Vilhardt F (2005) Microglia: phagocyte and glia cell. Int J Biochem Cell Biol 37:17–21
    • (2005) Int J Biochem Cell Biol , vol.37 , pp. 17-21
    • Vilhardt, F.1
  • 74
    • 79954428532 scopus 로고    scopus 로고
    • Effect of NF-kappaB signaling on apoptosis in chronic inflammation-associated carcinogenesis
    • PID: 20482486
    • Wang H, Cho CH (2010) Effect of NF-kappaB signaling on apoptosis in chronic inflammation-associated carcinogenesis. Curr Cancer Drug Targets 10:593–599
    • (2010) Curr Cancer Drug Targets , vol.10 , pp. 593-599
    • Wang, H.1    Cho, C.H.2
  • 75
    • 10644282097 scopus 로고    scopus 로고
    • [Effects of Ginkgo biloba extract on number and activity of endothelial progenitor cells from peripheral blood]
    • COI: 1:CAS:528:DC%2BD2MXhtVynsL7K
    • Wang XX, Shang YP, Chen JZ, Zhu JH, Guo XG, Sun J (2004) [Effects of Ginkgo biloba extract on number and activity of endothelial progenitor cells from peripheral blood]. Yao xue xue bao = Acta Pharm Sin 39:656–660
    • (2004) Yao xue xue bao = Acta Pharm Sin , vol.39 , pp. 656-660
    • Wang, X.X.1    Shang, Y.P.2    Chen, J.Z.3    Zhu, J.H.4    Guo, X.G.5    Sun, J.6
  • 76
    • 33847644971 scopus 로고    scopus 로고
    • The inflammatory response in stroke
    • COI: 1:CAS:528:DC%2BD2sXislejtL0%3D, PID: 17188755
    • Wang Q, Tang XN, Yenari MA (2007) The inflammatory response in stroke. J Neuroimmunol 184:53–68
    • (2007) J Neuroimmunol , vol.184 , pp. 53-68
    • Wang, Q.1    Tang, X.N.2    Yenari, M.A.3
  • 77
    • 52049093687 scopus 로고    scopus 로고
    • Protective effect of Ginkgolids (A + B) is associated with inhibition of NIK/IKK/IkappaB/NF-kappaB signaling pathway in a rat model of permanent focal cerebral ischemia
    • COI: 1:CAS:528:DC%2BD1cXhtFektrbF, PID: 18722355
    • Wang X, Qin ZH, Shi H, Savitz SI, Qin AP, Jiang Y, Zhang HL (2008) Protective effect of Ginkgolids (A + B) is associated with inhibition of NIK/IKK/IkappaB/NF-kappaB signaling pathway in a rat model of permanent focal cerebral ischemia. Brain Res 1234:8–15
    • (2008) Brain Res , vol.1234 , pp. 8-15
    • Wang, X.1    Qin, Z.H.2    Shi, H.3    Savitz, S.I.4    Qin, A.P.5    Jiang, Y.6    Zhang, H.L.7
  • 78
    • 84862909187 scopus 로고    scopus 로고
    • Pro-apoptotic role of nuclear factor-kappaB in adriamycin-induced acute myocardial injury in rats
    • COI: 1:CAS:528:DC%2BC38XkvFeksw%3D%3D, PID: 22011862
    • Wang F, Li H, Shi H, Sun B (2012a) Pro-apoptotic role of nuclear factor-kappaB in adriamycin-induced acute myocardial injury in rats. Mol Med Rep 5:400–404
    • (2012) Mol Med Rep , vol.5 , pp. 400-404
    • Wang, F.1    Li, H.2    Shi, H.3    Sun, B.4
  • 79
    • 84866735550 scopus 로고    scopus 로고
    • Geniposide reduces inflammatory responses of oxygen-glucose deprived rat microglial cells via inhibition of the TLR4 signaling pathway
    • COI: 1:CAS:528:DC%2BC38XhtFCrt7bI, PID: 22869019
    • Wang J, Hou J, Zhang P, Li D, Zhang C, Liu J (2012b) Geniposide reduces inflammatory responses of oxygen-glucose deprived rat microglial cells via inhibition of the TLR4 signaling pathway. Neurochem Res 37:2235–2248
    • (2012) Neurochem Res , vol.37 , pp. 2235-2248
    • Wang, J.1    Hou, J.2    Zhang, P.3    Li, D.4    Zhang, C.5    Liu, J.6
  • 80
    • 77949342162 scopus 로고    scopus 로고
    • Microglia in ischemic brain injury
    • COI: 1:CAS:528:DC%2BC3cXivVCjtL0%3D, PID: 20401171
    • Weinstein JR, Koerner IP, Moller T (2010) Microglia in ischemic brain injury. Future Neurol 5:227–246
    • (2010) Future Neurol , vol.5 , pp. 227-246
    • Weinstein, J.R.1    Koerner, I.P.2    Moller, T.3
  • 82
    • 84875112049 scopus 로고    scopus 로고
    • Expression analysis of genes involved in TLR2-related signaling pathway: inflammation and apoptosis after ischemic brain injury
    • COI: 1:CAS:528:DC%2BC3sXlsFChsr0%3D, PID: 23402853
    • Winters L, Winters T, Gorup D, Mitrecic D, Curlin M, Kriz J, Gajovic S (2013) Expression analysis of genes involved in TLR2-related signaling pathway: inflammation and apoptosis after ischemic brain injury. Neuroscience 238:87–96
    • (2013) Neuroscience , vol.238 , pp. 87-96
    • Winters, L.1    Winters, T.2    Gorup, D.3    Mitrecic, D.4    Curlin, M.5    Kriz, J.6    Gajovic, S.7
  • 83
    • 65549164068 scopus 로고    scopus 로고
    • Roles of NF-kappaB in health and disease: mechanisms and therapeutic potential
    • COI: 1:CAS:528:DC%2BD1MXhslSit7g%3D, PID: 19200055
    • Wong ET, Tergaonkar V (2009) Roles of NF-kappaB in health and disease: mechanisms and therapeutic potential. Clin Sci 116:451–465
    • (2009) Clin Sci , vol.116 , pp. 451-465
    • Wong, E.T.1    Tergaonkar, V.2
  • 84
    • 77951173483 scopus 로고    scopus 로고
    • Ginkgolide B preconditioning protects neurons against ischaemia-induced apoptosis
    • COI: 1:CAS:528:DC%2BC3cXkvFGjsLg%3D, PID: 19602048
    • Wu X, Qian Z, Ke Y, Du F, Zhu L (2009) Ginkgolide B preconditioning protects neurons against ischaemia-induced apoptosis. J Cell Mol Med 13:4474–4483
    • (2009) J Cell Mol Med , vol.13 , pp. 4474-4483
    • Wu, X.1    Qian, Z.2    Ke, Y.3    Du, F.4    Zhu, L.5
  • 85
    • 34249780094 scopus 로고    scopus 로고
    • Pharmacological action and mechanisms of ginkgolide B
    • COI: 1:CAS:528:DC%2BD2sXntFehtb4%3D, PID: 17543184
    • Xia SH, Fang DC (2007) Pharmacological action and mechanisms of ginkgolide B. Chin Med J 120:922–928
    • (2007) Chin Med J , vol.120 , pp. 922-928
    • Xia, S.H.1    Fang, D.C.2
  • 86
    • 84955611654 scopus 로고    scopus 로고
    • Protective mechanisms of CA074-me (other than cathepsin-B inhibition) against programmed necrosis induced by global cerebral ischemia/reperfusion injury in rats
    • COI: 1:CAS:528:DC%2BC2MXhvVyrsrfE, PID: 26562519
    • Xu Y, Wang J, Song X, Wei R, He F, Peng G, Luo B (2016) Protective mechanisms of CA074-me (other than cathepsin-B inhibition) against programmed necrosis induced by global cerebral ischemia/reperfusion injury in rats. Brain Res Bull 120:97–105
    • (2016) Brain Res Bull , vol.120 , pp. 97-105
    • Xu, Y.1    Wang, J.2    Song, X.3    Wei, R.4    He, F.5    Peng, G.6    Luo, B.7
  • 87
    • 0029551805 scopus 로고
    • Identification of a member of the MAPKKK family as a potential mediator of TGF-beta signal transduction
    • COI: 1:CAS:528:DyaK28XltlSl, PID: 8533096
    • Yamaguchi K, K. S, Shibuya H, Irie K, Oishi I, Ueno N, et al. (1995) Identification of a member of the MAPKKK family as a potential mediator of TGF-beta signal transduction. Science 270:2008–2011
    • (1995) Science , vol.270 , pp. 2008-2011
    • Yamaguchi, K.S.1    Shibuya, H.2    Irie, K.3    Oishi, I.4    Ueno, N.5
  • 88
    • 84933036444 scopus 로고    scopus 로고
    • Inhibition of receptor-interacting protein 3 upregulation and nuclear translocation involved in Necrostatin-1 protection against hippocampal neuronal programmed necrosis induced by ischemia/reperfusion injury
    • COI: 1:CAS:528:DC%2BC2MXlt1anu7Y%3D, PID: 25801119
    • Yin B, Xu Y, Wei RL, He F, Luo BY, Wang JY (2015) Inhibition of receptor-interacting protein 3 upregulation and nuclear translocation involved in Necrostatin-1 protection against hippocampal neuronal programmed necrosis induced by ischemia/reperfusion injury. Brain Res 1609:63–71
    • (2015) Brain Res , vol.1609 , pp. 63-71
    • Yin, B.1    Xu, Y.2    Wei, R.L.3    He, F.4    Luo, B.Y.5    Wang, J.Y.6
  • 91
    • 68949145035 scopus 로고    scopus 로고
    • Cutting edge: cardiac myosin activates innate immune responses through TLRs
    • COI: 1:CAS:528:DC%2BD1MXnsVOrurg%3D, PID: 19535635
    • Zhang P, Cox CJ, Alvarez KM, Cunningham MW (2009a) Cutting edge: cardiac myosin activates innate immune responses through TLRs. J Immunol 183:27–31
    • (2009) J Immunol , vol.183 , pp. 27-31
    • Zhang, P.1    Cox, C.J.2    Alvarez, K.M.3    Cunningham, M.W.4
  • 92
    • 67650000915 scopus 로고    scopus 로고
    • Cell cycle inhibition attenuates microglial proliferation and production of IL-1beta, MIP-1alpha, and NO after focal cerebral ischemia in the rat
    • PID: 19115378
    • Zhang Q, Chen C, Lu J, Xie M, Pan D, Luo X, Yu Z, Dong Q, Wang W (2009b) Cell cycle inhibition attenuates microglial proliferation and production of IL-1beta, MIP-1alpha, and NO after focal cerebral ischemia in the rat. Glia 57:908–920
    • (2009) Glia , vol.57 , pp. 908-920
    • Zhang, Q.1    Chen, C.2    Lu, J.3    Xie, M.4    Pan, D.5    Luo, X.6    Yu, Z.7    Dong, Q.8    Wang, W.9
  • 94
    • 22344457163 scopus 로고    scopus 로고
    • [Change of peripheral blood monocytes derived macrophage scavenger receptors activity in patients with coronary heart disease, and the intervention effect of Ginkgo biloba extract]. Zhongguo Zhong xi yi jie he za zhi Zhongguo Zhongxiyi jiehe zazhi = Chinese journal of integrated traditional and Western medicine / Zhongguo Zhong xi yi jie he xue hui
    • Zhu GY, Zhu XL, Geng QX, Zhang X, Shao J (2004) [Change of peripheral blood monocytes derived macrophage scavenger receptors activity in patients with coronary heart disease, and the intervention effect of Ginkgo biloba extract]. Zhongguo Zhong xi yi jie he za zhi Zhongguo Zhongxiyi jiehe zazhi = Chinese journal of integrated traditional and Western medicine / Zhongguo Zhong xi yi jie he xue hui. Zhongguo Zhong yi yan jiu yuan zhu ban 24:1069–1072
    • (2004) Zhongguo Zhong yi yan jiu yuan zhu ban , vol.24 , pp. 1069-1072
    • Zhu, G.Y.1    Zhu, X.L.2    Geng, Q.X.3    Zhang, X.4    Shao, J.5
  • 96
    • 77949475533 scopus 로고    scopus 로고
    • Toll-like receptor-4 and cytokine cascade in stroke after exercise
    • PID: 19726014
    • Zwagerman N, Plumlee C, Guthikonda M, Ding Y (2010) Toll-like receptor-4 and cytokine cascade in stroke after exercise. Neurol Res 32:123–126
    • (2010) Neurol Res , vol.32 , pp. 123-126
    • Zwagerman, N.1    Plumlee, C.2    Guthikonda, M.3    Ding, Y.4


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