Heptaphylline induces apoptosis in human colon adenocarcinoma cells through Bid and Akt/NF-κB (p65) pathways

Asian Pacific Journal of Cancer Prevention

Volumn 15, Issue 23, 2014, Pages 10483-10487

  Boonyarat, Chantana ^a   Yenjai, Chavi ^b   Vajragupta, Opa ^c   Waiwut, Pornthip ^d  

^a KHON KAEN UNIVERSITY   (Thailand)

^b Khon Kaen University   (Thailand)

^c MAHIDOL UNIVERSITY   (Thailand)

^d UBON RATCHATHANI UNIVERSITY   (Thailand)

Author keywords

Akt; Bcl xL; Bid; Colon adenocarcinoma cells; Heptaphylline; p65; XIAP

Indexed keywords

7-METHOXYHEPTAPHYLLINE; BAK1 PROTEIN, HUMAN; BCL2L1 PROTEIN, HUMAN; BID PROTEIN, HUMAN; BIRC5 PROTEIN, HUMAN; CARBAZOLE DERIVATIVE; CASP3 PROTEIN, HUMAN; CASPASE 3; HEPTAPHYLLINE; I KAPPA B KINASE; INHIBITOR OF APOPTOSIS PROTEIN; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE; PARP1 PROTEIN, HUMAN; PROTEIN BAK; PROTEIN BCL X; PROTEIN BID; PROTEIN KINASE B; TRANSCRIPTION FACTOR RELA; X LINKED INHIBITOR OF APOPTOSIS; XIAP PROTEIN, HUMAN;

ADENOCARCINOMA; APOPTOSIS; CELL PROLIFERATION; CELL SURVIVAL; COLON TUMOR; DRUG EFFECTS; HT 29 CELL LINE; HUMAN; METABOLISM; SIGNAL TRANSDUCTION;

ADENOCARCINOMA; APOPTOSIS; BCL-2 HOMOLOGOUS ANTAGONIST-KILLER PROTEIN; BCL-X PROTEIN; BH3 INTERACTING DOMAIN DEATH AGONIST PROTEIN; CARBAZOLES; CASPASE 3; CELL PROLIFERATION; CELL SURVIVAL; COLONIC NEOPLASMS; HT29 CELLS; HUMANS; I-KAPPA B KINASE; INHIBITOR OF APOPTOSIS PROTEINS; POLY(ADP-RIBOSE) POLYMERASES; PROTO-ONCOGENE PROTEINS C-AKT; SIGNAL TRANSDUCTION; TRANSCRIPTION FACTOR RELA; X-LINKED INHIBITOR OF APOPTOSIS PROTEIN;

EID: 84921752255     PISSN: 15137368     EISSN: None     Source Type: Journal    
DOI: 10.7314/APJCP.2014.15.23.10483     Document Type: Article

References (29)

1. Aouacheria A, Neel B, Bouaziz ZR, et al (2002). Carbazolequinone induction of caspase-dependent cell death in Src-overexpressing cells. Biochem Pharmacol, 64, 1605-16.
2. Chen X, Ding WX, Ni HM, et al (2006). Bid-independent mitochondrial activation in tumor necrosis factor alpha-induced apoptosis and liver injury. Mol Cell Biol, 27, 541-53.
3. Dai Y, Rahmani M, Dent P, et al (2005). Kinase 1 Activation Downregulation, and c-Jun N-terminal mediated by oxidative damage, XIAP leukemia cells through a process NF-kB activation potentiates apoptosis in inhibitor-induced RelA/p65 acetylation and blockade. Mol Cell Biol, 25, 5429.
4. Debatin KM, Krammer PH (2004). Death receptors in chemotherapy and cancer. Oncogene, 23, 2950-66.
5. Evan GI, Vousden KH (2001). Proliferation, cell cycle and apoptosis in cancer. Nature, 411, 342-8.
6. Ghobrial IM, Witzig TE, Adjei AA (2005). Targeting apoptosis pathways in cancer therapy. CA Cancer J Clin, 55, 178-94.
7. Hanahan D and Weinberg RA (2011). Hallmarks of cancer: the next generation. Cell, 144, 646-74.
8. Hanahan D, Weinberg RA (2000) The hallmarks of cancer. Cell, 100, 57-70.
9. Ip SW, Lan SH, Lu HF, et al (2012). Capsaicin mediates apoptosis in human nasopharyngeal carcinoma NPC-TW 039 cells through mitochondrial depolarization and endoplasmic reticulum stress. Hum Exp Toxicol, 31, 539-49.
10. Ito C, Itoigawa M, Katsuno S, et al (2000). Chemical constituents of Clausena excavata: isolation and structure elucidation of novel furanone-coumarins with inhibitory effects for tumor-promotion. J Nat Prod, 63, 1218-24.
11. Kantari C, Walczak H (2011) Caspase-8 and Bid: caught in the act between death receptors and mitochondria. Biochim Biophys Acta, 1813, 558-63.
12. Kim JH, Choi YW, Park C, et al (2010). Apoptosis induction of human leukemia U937 cells by gomisin N, a dibenzocyclooctadiene lignan, isolated from Schizandra chinensis Baill. Food Chem Toxicol, 48, 807-13.
13. Korsmeyer SJ, Wei MC, Saito M, et al (2000). Pro-apoptotic cascade activates BID, which oligomerizes BAK or BAX into pores that result in the release of cytochrome C. Cell Death Differ, 7, 1166-73.
14. Liu J, Uematsu H, Tsuchida N, et al (2011). Essential role of caspase-8 in p53/p73-dependent apoptosis induced by etoposide in head and neck carcinoma cells. Mol Cancer, 31, 95.
15. Mendoza FJ, Espino PS, Cann KL, et al (2005). Anti-tumor chemotherapy utilizing peptide-based approaches-apoptotic pathways, kinases, and proteasome as targets. Arch Immunol Ther Exp, 53, 47-60.
16. Millimouno FM, Dong J, Yang L, Li J, Li X (2014). Targeting apoptosis pathways in cancer and perspectives with natural compounds from mother nature. Cancer Prev Res, 7, 1081-107.
17. Namba H, Saenko V, Yamashita S (2007). Nuclear factor-κB in thyroid carcinogenesis and progression: a novel therapeutic target for advanced thyroid cancer. Arq Bras Endocrinol Metab, 51, 843-51.
18. Okada H, Mak TW (2004). Pathways of apoptotic and non-apoptotic death in tumour cells. Nat Rev Cancer, 4, 592-603.
19. Pei Y, Xing D, Gao X, Liu L, Chen T (2007) Real-time monitoring full length bid interacting with Bax during TNF-alpha-induced apoptosis. Apoptosis, 12, 1681-90.
20. Perez D, White E (2000). TNF-alpha signals apoptosis through a bid-dependent conformational change in Bax that is inhibited by E1B 19K. Mol Cell, 6, 53-63.
21. Shukla S, MacLennan GT, Fu P, et al (2004). Nuclear factor-kappaB/p65 (Rel A) is constitutively activated in human prostate adenocarcinoma and correlates with disease progression. Neoplasia, 6, 390-400.
22. Songsiang U, Thongthoom T, Boonyarat C, Yenjai C (2011). Claurailas A-D, cytotoxic carbazole alkaloids from the roots of Clausena harmandiana. J Nat Prod, 74, 208-12.
23. Stevenson HS, Fu SW, Pinzone JJ, et al (2007). BP1 transcriptionally activates bcl-2 and inhibits TNF-alpha-induced cell death in MCF7 breast cancer cells. Breast Cancer Res, 9, 60.
24. Thongthoom T, Songsiang U, Phaosiri C, Yenjai C (2010). Biological activity of chemical constituents from Clausena harmandiana. Arch Pharm Res, 33, 675-80.
25. Thongthoom T, Promsuwan P, Yenjai C (2011). Synthesis and cytotoxic activity of the heptaphylline and 7-methoxyheptaphylline series. Eur J Med Chem, 9, 3755-61.
26. Thorburn A, Behbakht K, Ford H (2008). TRAIL receptor-targeted therapeu-tics: resistance mechanisms and strategies to avoid them. Drug Resist Updat, 11, 17-24.
27. Wangboonskul J, Yenjai C (2012). Antioxidant activity and cytotoxicity against cholangiocarcinoma of carbazoles and coumarins from Clausena harmandiana. Science Asia, 38, 75-81.
28. Wong RS (2011). Apoptosis in cancer: from pathogenesis to treatment 1-14. J Exp Clin Cancer Res, 30, 87.
29. Yenjai C, Sripontan S, Sriprajun P, et al (2000). Coumarins and carbazoles with antiplasmodial activity from Clausena harmandiana. Planta Med, 66, 277-9.