메뉴 건너뛰기




Volumn 34, Issue 4, 2012, Pages 379-389

Toll-like receptor 4 signaling is involved in PACAP-induced neuroprotection in BV2 microglial cells under OGD/reoxygenation

Author keywords

BV2 microglia; OGD reoxygenation; PACAP; TLR4

Indexed keywords

A 1439; GLUCOSE; HYPOPHYSIS ADENYLATE CYCLASE ACTIVATING POLYPEPTIDE; I KAPPA B; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; MYELOID DIFFERENTIATION FACTOR 88; OXYGEN; TOLL LIKE RECEPTOR 4; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG;

EID: 84863794427     PISSN: 01616412     EISSN: 17431328     Source Type: Journal    
DOI: 10.1179/1743132812Y.0000000028     Document Type: Article
Times cited : (29)

References (54)
  • 1
    • 80053103017 scopus 로고    scopus 로고
    • Role of microglia in the process of inflammation in the hypoxic developing brain
    • Deng YY, Lu J, Ling EA, Kaur C. Role of microglia in the process of inflammation in the hypoxic developing brain. Front Biosci (Schol Ed). 2011;3:884-900.
    • (2011) Front Biosci (Schol Ed) , vol.3 , pp. 884-900
    • Deng, Y.Y.1    Lu, J.2    Ling, E.A.3    Kaur, C.4
  • 2
    • 25444495866 scopus 로고    scopus 로고
    • Microglia in health and disease
    • Kim SU, de Vellis J. Microglia in health and disease. J Neurosci Res. 2005;81(3):302-13.
    • (2005) J Neurosci Res , vol.81 , Issue.3 , pp. 302-313
    • Kim, S.U.1    de Vellis, J.2
  • 3
    • 0031678491 scopus 로고    scopus 로고
    • Perspectives on pituitary adenylate cyclase-activating polypeptide (PACAP) in the neuroendocrine, endocrine, and nervous systems
    • Arimura A. Perspectives on pituitary adenylate cyclase-activating polypeptide (PACAP) in the neuroendocrine, endocrine, and nervous systems. Jpn J Physiol. 1998;48:301-31.
    • (1998) Jpn J Physiol , vol.48 , pp. 301-331
    • Arimura, A.1
  • 4
    • 0034048147 scopus 로고    scopus 로고
    • Pituitary adenylate cyclase activating polypeptide and its receptors: From structure to functions
    • Vaudry D, Gonzalez BJ, Basille M, Yon L, Fournier A, Vaudry H. Pituitary adenylate cyclase activating polypeptide and its receptors: from structure to functions. Pharmacol Rev. 2000; 52:269-324.
    • (2000) Pharmacol Rev , vol.52 , pp. 269-324
    • Vaudry, D.1    Gonzalez, B.J.2    Basille, M.3    Yon, L.4    Fournier, A.5    Vaudry, H.6
  • 5
    • 67651125040 scopus 로고    scopus 로고
    • PACAP and VIP differentially preserve neurovascular reactivity after global cerebral ischemia in newborn pigs
    • Lenti L, Zimmermann A, Kisa D, Oláh O, Tóth GK, Hegyi O, et al. PACAP and VIP differentially preserve neurovascular reactivity after global cerebral ischemia in newborn pigs. Brain Res. 2009;1283:50-7.
    • (2009) Brain Res , vol.1283 , pp. 50-57
    • Lenti, L.1    Zimmermann, A.2    Kisa, D.3    Oláh, O.4    Tóth, G.K.5    Hegyi, O.6
  • 6
    • 77649251477 scopus 로고    scopus 로고
    • Apurinic/apyrimidinic endonuclease APE1 is required for PACAP-induced neuroprotection against global cerebral ischemia
    • Stetler RA, Gao Y, Zukin RS, Vosler PS, Zhang L, Zhang F, et al. Apurinic/apyrimidinic endonuclease APE1 is required for PACAP-induced neuroprotection against global cerebral ischemia. Proc Natl Acad Sci USA. 2010;107(7):3204-9.
    • (2010) Proc Natl Acad Sci USA , vol.107 , Issue.7 , pp. 3204-3209
    • Stetler, R.A.1    Gao, Y.2    Zukin, R.S.3    Vosler, P.S.4    Zhang, L.5    Zhang, F.6
  • 7
    • 79957989551 scopus 로고    scopus 로고
    • PACAP and a novel stable analog protect rat brain from ischemia: Insight into the mechanisms of action
    • Dejda A, Seaborn T, Bourgault S, Touzani O, Fournier A, Vaudry H, et al. PACAP and a novel stable analog protect rat brain from ischemia: insight into the mechanisms of action. Peptides. 2011;32:1207-16.
    • (2011) Peptides , vol.32 , pp. 1207-1216
    • Dejda, A.1    Seaborn, T.2    Bourgault, S.3    Touzani, O.4    Fournier, A.5    Vaudry, H.6
  • 8
    • 0036948319 scopus 로고    scopus 로고
    • Effects of pretreatment with PACAP on the infarct size and functional outcome in rat permanent focal cerebral ischemia
    • Reglodi D, Tamá s A, Somogyvári-Vigh A, Szántó Z, Kertes E, Lénárd L, et al. Effects of pretreatment with PACAP on the infarct size and functional outcome in rat permanent focal cerebral ischemia. Peptides. 2002;23:2227-34.
    • (2002) Peptides , vol.23 , pp. 2227-2234
    • Reglodi, D.1    Tamá s, A.2    Somogyvári-Vigh, A.3    Szántó, Z.4    Kertes, E.5    Lénárd, L.6
  • 9
    • 79958167912 scopus 로고    scopus 로고
    • Review on the protective effects of PACAP in models of neurodegenerative diseases in vitro and in vivo
    • Reglodi D, Kiss P, Lubics A, Tamas A. Review on the protective effects of PACAP in models of neurodegenerative diseases in vitro and in vivo. Curr Pharm Des. 2011;17(10):962-72.
    • (2011) Curr Pharm Des , vol.17 , Issue.10 , pp. 962-972
    • Reglodi, D.1    Kiss, P.2    Lubics, A.3    Tamas, A.4
  • 10
    • 0034700111 scopus 로고    scopus 로고
    • The neuroprotective effect of pituitary adenylate cyclase activating polypeptide on cerebellar granule cells is mediated through inhibition of the CED3-related cysteine protease caspase-3/CPP32
    • Vaudry D, Gonzalez BJ, Basille M, Pamantung TF, Fontaine M, Fournier A, et al. The neuroprotective effect of pituitary adenylate cyclase activating polypeptide on cerebellar granule cells is mediated through inhibition of the CED3-related cysteine protease caspase-3/CPP32. Proc Natl Acad Sci USA. 2000;97:13390-5.
    • (2000) Proc Natl Acad Sci USA , vol.97 , pp. 13390-13395
    • Vaudry, D.1    Gonzalez, B.J.2    Basille, M.3    Pamantung, T.F.4    Fontaine, M.5    Fournier, A.6
  • 11
    • 0037197977 scopus 로고    scopus 로고
    • Pituitary adenylate cyclase-activating polypeptide protects rat cerebellar granule neurons against ethanol-induced apoptotic cell death
    • Vaudry D, Rousselle C, Basille M, Falluel-Morel A, Pamantung TF, Fontaine M, et al. Pituitary adenylate cyclase-activating polypeptide protects rat cerebellar granule neurons against ethanol-induced apoptotic cell death. Proc Natl Acad Sci USA. 2002;99:6398-403.
    • (2002) Proc Natl Acad Sci USA , vol.99 , pp. 6398-6403
    • Vaudry, D.1    Rousselle, C.2    Basille, M.3    Falluel-Morel, A.4    Pamantung, T.F.5    Fontaine, M.6
  • 12
    • 22744432325 scopus 로고    scopus 로고
    • Neuroprotective potential of three neuropeptides PACAP, VIP and PHI
    • Dejda A, Nowak JZ. Neuroprotective potential of three neuropeptides PACAP, VIP and PHI. Pharmocol Reports. 2005;57:307-20.
    • (2005) Pharmocol Reports , vol.57 , pp. 307-320
    • Dejda, A.1    Nowak, J.Z.2
  • 13
    • 5044234125 scopus 로고    scopus 로고
    • Neuropeptide PACAP inhibits hypoxic activation of brain microglia: A protective mechanism against microglial neurotoxicity in ischemia
    • Kyoungho Suk, Park JH, Lee WH. Neuropeptide PACAP inhibits hypoxic activation of brain microglia: a protective mechanism against microglial neurotoxicity in ischemia. Brain Res. 2004;1026:151-6.
    • (2004) Brain Res , vol.1026 , pp. 151-156
    • Kyoungho, S.1    Park, J.H.2    Lee, W.H.3
  • 14
    • 80053504999 scopus 로고    scopus 로고
    • Intermittent hypoxia mobilizes hematopoietic progenitors and augments cellular and humoral elements of innate immunity in adult men
    • Serebrovskaya TV, Nikolsky IS, Nikolska VV, Mallet RT, Ishchuk VA. Intermittent hypoxia mobilizes hematopoietic progenitors and augments cellular and humoral elements of innate immunity in adult men. High Alt Med Biol. 2011; 12(3):243-52.
    • (2011) High Alt Med Biol , vol.12 , Issue.3 , pp. 243-252
    • Serebrovskaya, T.V.1    Nikolsky, I.S.2    Nikolska, V.V.3    Mallet, R.T.4    Ishchuk, V.A.5
  • 15
    • 73349083077 scopus 로고    scopus 로고
    • Lipopolysaccharide sensitizes neonatal hypoxic-ischemic brain injury in a MyD88-dependent manner
    • Wang X, Stridh L, Li W, Dean J, Elmgren A, Gan L, et al. Lipopolysaccharide sensitizes neonatal hypoxic-ischemic brain injury in a MyD88-dependent manner. J Immunol. 2009; 183(11);7471-7.
    • (2009) J Immunol , vol.183 , Issue.11 , pp. 7471-7477
    • Wang, X.1    Stridh, L.2    Li, W.3    Dean, J.4    Elmgren, A.5    Gan, L.6
  • 16
    • 80052706801 scopus 로고    scopus 로고
    • New insights into the immunology of chronic obstructive pulmonary disease
    • Brusselle GG, Joos GF, Bracke KR. New insights into the immunology of chronic obstructive pulmonary disease. Lancet. 2011;378(9795):1015-26.
    • (2011) Lancet , vol.378 , Issue.9795 , pp. 1015-1026
    • Brusselle, G.G.1    Joos, G.F.2    Bracke, K.R.3
  • 17
    • 3142654210 scopus 로고    scopus 로고
    • Inferences, questions and possibilities in Toll-like receptor signaling
    • Beutler B. Inferences, questions and possibilities in Toll-like receptor signaling. Nature. 2004;430:257-63.
    • (2004) Nature , vol.430 , pp. 257-263
    • Beutler, B.1
  • 18
    • 44649161808 scopus 로고    scopus 로고
    • Role of Toll-like receptors in tissue repair and tumorigenesis
    • Rakoff-Nahoum S, Medzhitov R. Role of Toll-like receptors in tissue repair and tumorigenesis. Biochemistry (Mosc). 2008; 73:555-61.
    • (2008) Biochemistry (Mosc) , vol.73 , pp. 555-561
    • Rakoff-Nahoum, S.1    Medzhitov, R.2
  • 19
    • 70849125206 scopus 로고    scopus 로고
    • The TIR/BB-loop mimetic AS-1 protects the myocardium from ischaemia/reperfusion injury
    • Cao Z, Hu Y, Wu W, Ha T, Kelley J, Deng C, et al. The TIR/BB-loop mimetic AS-1 protects the myocardium from ischaemia/reperfusion injury. Cardiovasc Res. 2009;84(3):442-51.
    • (2009) Cardiovasc Res , vol.84 , Issue.3 , pp. 442-451
    • Cao, Z.1    Hu, Y.2    Wu, W.3    Ha, T.4    Kelley, J.5    Deng, C.6
  • 20
    • 12444341944 scopus 로고    scopus 로고
    • Toll-like receptors in innate immunity
    • Takeda K, Akira S. Toll-like receptors in innate immunity. Int Immunol. 2005;17(1):1-14.
    • (2005) Int Immunol , vol.17 , Issue.1 , pp. 1-14
    • Takeda, K.1    Akira, S.2
  • 21
    • 51349104881 scopus 로고    scopus 로고
    • 15-deoxy-delta(12,14)-prostaglandin J(2) and curcumin modulate the expression of Toll-like receptors 4 and 9 in autoimmune T lymphocyte
    • Chearwae W, Bright JJ. 15-deoxy-delta(12,14)-prostaglandin J(2) and curcumin modulate the expression of Toll-like receptors 4 and 9 in autoimmune T lymphocyte. J Clin Immunol. 2008;28:558-70.
    • (2008) J Clin Immunol , vol.28 , pp. 558-570
    • Chearwae, W.1    Bright, J.J.2
  • 22
    • 67649422321 scopus 로고    scopus 로고
    • Therapeutic targeting of toll-like receptors for infectious and inflammatory diseases and cancer
    • O'Neill LA, Bryant CE, Doyle SL. Therapeutic targeting of toll-like receptors for infectious and inflammatory diseases and cancer. Pharmacol Rev. 2009;61:177-97.
    • (2009) Pharmacol Rev , vol.61 , pp. 177-197
    • O'Neill, L.A.1    Bryant, C.E.2    Doyle, S.L.3
  • 23
    • 33747040987 scopus 로고    scopus 로고
    • Critial role of Toll-like receptors and the common TLR adaptor, MyD88, in induction of granulomas and liver injury
    • Velayudham A, Hritz I, Dolganiue A, Mandrekar P, Kurt-Jones E, Szabo G. Critial role of Toll-like receptors and the common TLR adaptor, MyD88, in induction of granulomas and liver injury. J Hepatol. 2006;45(6):813-24.
    • (2006) J Hepatol , vol.45 , Issue.6 , pp. 813-824
    • Velayudham, A.1    Hritz, I.2    Dolganiue, A.3    Mandrekar, P.4    Kurt-Jones, E.5    Szabo, G.6
  • 24
    • 33748781182 scopus 로고    scopus 로고
    • Lipopolysaeeharide (LPS) regulates TLR4 signal transduction in nasopharynx epithelial cell line 5-8F via NF-kappaB and MAPKS signaling pathways
    • Yang YX, Zhou HD, Yang YB, Li W, Zhou M, Zeng Z, et al. Lipopolysaeeharide (LPS) regulates TLR4 signal transduction in nasopharynx epithelial cell line 5-8F via NF-kappaB and MAPKS signaling pathways. Mol Immunol. 2007;44(5):984-92.
    • (2007) Mol Immunol , vol.44 , Issue.5 , pp. 984-992
    • Yang, Y.X.1    Zhou, H.D.2    Yang, Y.B.3    Li, W.4    Zhou, M.5    Zeng, Z.6
  • 25
    • 77949475533 scopus 로고    scopus 로고
    • Toll-like receptor-4 and cytokine cascade in stroke after exercise
    • Zwagerman N, Plumlee C, Guthikonda M, Ding Y. Toll-like receptor-4 and cytokine cascade in stroke after exercise. Neurol Res. 2010;32(2):123-6.
    • (2010) Neurol Res , vol.32 , Issue.2 , pp. 123-126
    • Zwagerman, N.1    Plumlee, C.2    Guthikonda, M.3    Ding, Y.4
  • 26
    • 0036903919 scopus 로고    scopus 로고
    • Huperzine B protects rat pheochromocytoma cells against oxygen-glucose deprivationinduced injury
    • Wang ZF, Zhou J, Tang XC. Huperzine B protects rat pheochromocytoma cells against oxygen-glucose deprivationinduced injury. Acta Pharmacol Sin. 2002;23(12):1193-8.
    • (2002) Acta Pharmacol Sin , vol.23 , Issue.12 , pp. 1193-1198
    • Wang, Z.F.1    Zhou, J.2    Tang, X.C.3
  • 27
    • 70350738626 scopus 로고    scopus 로고
    • Propofol inhibits aquaporin 4 expression through a protein kinase C-dependent pathway in an astrocyte model of cerebral ischemia/reoxygenation
    • Zhu SM, Xiong XX, Zheng YY, Pan CF. Propofol inhibits aquaporin 4 expression through a protein kinase C-dependent pathway in an astrocyte model of cerebral ischemia/reoxygenation. Anesth Analg. 2009;109(5):1493-9.
    • (2009) Anesth Analg , vol.109 , Issue.5 , pp. 1493-1499
    • Zhu, S.M.1    Xiong, X.X.2    Zheng, Y.Y.3    Pan, C.F.4
  • 28
    • 70349942164 scopus 로고    scopus 로고
    • Pituitary adenylate cyclase-activating polypeptide: Focus on structure-activity relationships of a neuroprotective peptide
    • Bourgault S, Vaudry D, Dejda A, Doan ND, Vaudry H, Fournier A. Pituitary adenylate cyclase-activating polypeptide: focus on structure-activity relationships of a neuroprotective peptide. Curr Med Chem. 2009;16(33):4462-80.
    • (2009) Curr Med Chem , vol.16 , Issue.33 , pp. 4462-4480
    • Bourgault, S.1    Vaudry, D.2    Dejda, A.3    Doan, N.D.4    Vaudry, H.5    Fournier, A.6
  • 29
    • 0037928769 scopus 로고    scopus 로고
    • The role of dipeptidyl peptidase IV in the cleavage of glucagon family peptides: In vivo metabolism of pituitary adenylate cyclase activating polypeptide-(1-38)
    • Zhu L, Tamvakopoulos C, Xie D, Dragovic J, Shen X, Fenyk-Melody JE, et al. The role of dipeptidyl peptidase IV in the cleavage of glucagon family peptides: in vivo metabolism of pituitary adenylate cyclase activating polypeptide-(1-38). J Biol Chem. 2003;278(25):22418-23.
    • (2003) J Biol Chem , vol.278 , Issue.25 , pp. 22418-22423
    • Zhu, L.1    Tamvakopoulos, C.2    Xie, D.3    Dragovic, J.4    Shen, X.5    Fenyk-Melody, J.E.6
  • 30
    • 33947251213 scopus 로고    scopus 로고
    • The effect of intravenous PACAP38 on cerebral hemodynamics in healthy volunteers
    • Birk S, Sitarz JT, Petersen KA, Oturai PS, Kruuse C, Fahrenkrug J, et al. The effect of intravenous PACAP38 on cerebral hemodynamics in healthy volunteers. Regul Pept. 2007;140(3):185-91.
    • (2007) Regul Pept , vol.140 , Issue.3 , pp. 185-191
    • Birk, S.1    Sitarz, J.T.2    Petersen, K.A.3    Oturai, P.S.4    Kruuse, C.5    Fahrenkrug, J.6
  • 31
    • 79958845426 scopus 로고    scopus 로고
    • Daxx mediates activation-induced cell death in microglia by triggering MST1 signalling
    • Yun HJ, Yoon JH, Lee JK, Noh KT, Yoon KW, Oh HJ, et al. Daxx mediates activation-induced cell death in microglia by triggering MST1 signalling. EMBO J. 2011;30(12):2465-76.
    • (2011) EMBO J , vol.30 , Issue.12 , pp. 2465-2476
    • Yun, H.J.1    Yoon, J.H.2    Lee, J.K.3    Noh, K.T.4    Yoon, K.W.5    Oh, H.J.6
  • 32
    • 77952362205 scopus 로고    scopus 로고
    • Attenuation of proliferation in oligodendrocyte precursor cells by activated microglia
    • Taylor DL, Pirianov G, Holland S, McGinnity CJ, Norman AL, Reali C, et al. Attenuation of proliferation in oligodendrocyte precursor cells by activated microglia. J Neurosci Res. 2010;88(8):1632-44.
    • (2010) J Neurosci Res , vol.88 , Issue.8 , pp. 1632-1644
    • Taylor, D.L.1    Pirianov, G.2    Holland, S.3    McGinnity, C.J.4    Norman, A.L.5    Reali, C.6
  • 35
    • 0036079049 scopus 로고    scopus 로고
    • Vasoactive intestinal peptide (VIP) and pituitary adenylate cyclase-activating polypeptide (PACAP) as modulators of both innate and adaptive immunity
    • Ganea D, Delgado M. Vasoactive intestinal peptide (VIP) and pituitary adenylate cyclase-activating polypeptide (PACAP) as modulators of both innate and adaptive immunity. Crit Rev Oral Biol Med. 2002;13(3):229-37.
    • (2002) Crit Rev Oral Biol Med , vol.13 , Issue.3 , pp. 229-237
    • Ganea, D.1    Delgado, M.2
  • 36
    • 77958498968 scopus 로고    scopus 로고
    • The effect of PACAP38 on MyD88-mediated signal transduction in ischemia-/hypoxia-induced acute kidney injury
    • Li M, Khan AM, Maderdrut JL, Simon EE, Batuman V. The effect of PACAP38 on MyD88-mediated signal transduction in ischemia-/hypoxia-induced acute kidney injury. Am J Nephrol. 2010;32(6):522-32.
    • (2010) Am J Nephrol , vol.32 , Issue.6 , pp. 522-532
    • Li, M.1    Khan, A.M.2    Maderdrut, J.L.3    Simon, E.E.4    Batuman, V.5
  • 37
    • 77953334827 scopus 로고    scopus 로고
    • Activated microglia in nociception
    • Smith HS. Activated microglia in nociception. Pain Physician. 2010;13(3):295-304.
    • (2010) Pain Physician , vol.13 , Issue.3 , pp. 295-304
    • Smith, H.S.1
  • 38
    • 77955716367 scopus 로고    scopus 로고
    • Heat shock protein gp96 and NAD(P)H oxidase 4 play key roles in Toll-like receptor 4-activated apoptosis during renal ischemia/reperfusion injury
    • Ben Mkaddem S, Pedruzzi E, Werts C, Coant N, Bens M, Cluzeaud F, et al. Heat shock protein gp96 and NAD(P)H oxidase 4 play key roles in Toll-like receptor 4-activated apoptosis during renal ischemia/reperfusion injury. Cell Death Differ. 2010;17:1474-85.
    • (2010) Cell Death Differ , vol.17 , pp. 1474-1485
    • Ben Mkaddem, S.1    Pedruzzi, E.2    Werts, C.3    Coant, N.4    Bens, M.5    Cluzeaud, F.6
  • 39
    • 0037477629 scopus 로고    scopus 로고
    • Activation of innate immunity in the CNS triggers neurodegeneration through a Toll-like receptor 4-dependent pathway
    • Lehnardt SL, Massillon P, Follett FE, Jensen FE, Ratan R, Rosenberg PA, et al. Activation of innate immunity in the CNS triggers neurodegeneration through a Toll-like receptor 4-dependent pathway. Proc Natl Acad Sci USA. 2003;100:8514.-9.
    • (2003) Proc Natl Acad Sci USA , vol.100 , pp. 8514-8519
    • Lehnardt, S.L.1    Massillon, P.2    Follett, F.E.3    Jensen, F.E.4    Ratan, R.5    Rosenberg, P.A.6
  • 40
    • 35348860696 scopus 로고    scopus 로고
    • Pivotal role for neuronal Toll-like receptors in ischemic brain injury and functional deficits
    • Tang SC, Arumugam TV, Xu X, Cheng A, Mughal MR, Jo DG, et al. Pivotal role for neuronal Toll-like receptors in ischemic brain injury and functional deficits. Proc Natl Acad Sci USA. 2007;104(34):13798-803.
    • (2007) Proc Natl Acad Sci USA , vol.104 , Issue.34 , pp. 13798-13803
    • Tang, S.C.1    Arumugam, T.V.2    Xu, X.3    Cheng, A.4    Mughal, M.R.5    Jo, D.G.6
  • 41
    • 34447315562 scopus 로고    scopus 로고
    • Regulation of Toll-like receptor 4 expression and its signaling by hypoxia in cultured microglia
    • Ock J, Jeong J, Choi WS, Lee WH, Kim SH, Kim IK, et al. Regulation of Toll-like receptor 4 expression and its signaling by hypoxia in cultured microglia. J Neurosci Res. 2007; 85(9):1989-95.
    • (2007) J Neurosci Res , vol.85 , Issue.9 , pp. 1989-1995
    • Ock, J.1    Jeong, J.2    Choi, W.S.3    Lee, W.H.4    Kim, S.H.5    Kim, I.K.6
  • 42
    • 77958498968 scopus 로고    scopus 로고
    • The effect of PACAP38 on MyD88-Mediated signal transduction in ischemia-/hypoxia-induced acute kidney injury
    • Li M, Khan AM, Maderdrut JL, Simon EE, Batuman V. The effect of PACAP38 on MyD88-Mediated signal transduction in ischemia-/hypoxia-induced acute kidney injury. Am J Nephrol. 2010;32(6):522-32.
    • (2010) Am J Nephrol , vol.32 , Issue.6 , pp. 522-532
    • Li, M.1    Khan, A.M.2    Maderdrut, J.L.3    Simon, E.E.4    Batuman, V.5
  • 43
    • 38849199203 scopus 로고    scopus 로고
    • Shared principles in NF-kappaB signaling
    • Hayden MS, Ghosh S. Shared principles in NF-kappaB signaling. Cell. 2008;132(3):344-62.
    • (2008) Cell , vol.132 , Issue.3 , pp. 344-362
    • Hayden, M.S.1    Ghosh, S.2
  • 44
    • 67650724069 scopus 로고    scopus 로고
    • Regulation and function of NFkappaB transcription factors in the immune system
    • Vallabhapurapu S, Karin M. Regulation and function of NFkappaB transcription factors in the immune system. Ann Rev Immunol. 2009;27:693-733.
    • (2009) Ann Rev Immunol , vol.27 , pp. 693-733
    • Vallabhapurapu, S.1    Karin, M.2
  • 45
    • 61849127839 scopus 로고    scopus 로고
    • The IkappaB kinase complex: Master regulator of NF-kappaB signaling
    • Solt LA, May MJ. The IkappaB kinase complex: master regulator of NF-kappaB signaling. Immunol Res. 2009;42(1-3):3-18.
    • (2009) Immunol Res , vol.42 , Issue.1-3 , pp. 3-18
    • Solt, L.A.1    May, M.J.2
  • 46
    • 80052024232 scopus 로고    scopus 로고
    • Water extract of Cynanchi atrati Radix regulates inflammation and apoptotic cell death through suppression of IKK-mediated NFkappaB signaling
    • Jeon J, Park KA, Lee H, Shin S, Zhang T, WonM, et al. Water extract of Cynanchi atrati Radix regulates inflammation and apoptotic cell death through suppression of IKK-mediated NFkappaB signaling. J Ethnopharmacol. 2011;137:626-34.
    • (2011) J Ethnopharmacol , vol.137 , pp. 626-634
    • Jeon, J.1    Park, K.A.2    Lee, H.3    Shin, S.4    Zhang, T.5    Won, M.6
  • 47
    • 80052260792 scopus 로고    scopus 로고
    • Curculigoside A attenuates experimental cerebral ischemia injury in vitro and vivo
    • Jiang W, Fu F, Tian J, Zhu H, Hou J. Curculigoside A attenuates experimental cerebral ischemia injury in vitro and vivo. Neuroscience. 2011;192:572-9.
    • (2011) Neuroscience , vol.192 , pp. 572-579
    • Jiang, W.1    Fu, F.2    Tian, J.3    Zhu, H.4    Hou, J.5
  • 48
    • 84862909187 scopus 로고    scopus 로고
    • Pro-apoptotic role of nuclear factor-kappaB in adriamycin-induced acute myocardial injury in rats
    • Wang F, Li H, Shi H, Sun B. Pro-apoptotic role of nuclear factor-kappaB in adriamycin-induced acute myocardial injury in rats. Mol Med Report. 2012;5(2):400-4.
    • (2012) Mol Med Report , vol.5 , Issue.2 , pp. 400-404
    • Wang, F.1    Li, H.2    Shi, H.3    Sun, B.4
  • 49
    • 79954428532 scopus 로고    scopus 로고
    • Effect of NF-kappaB signaling on apoptosis in chronic inflammation-associated carcinogenesis
    • Wang H, Cho CH. Effect of NF-kappaB signaling on apoptosis in chronic inflammation-associated carcinogenesis. Curr Cancer Drug Targets. 2010;10(6):593-9.
    • (2010) Curr Cancer Drug Targets , vol.10 , Issue.6 , pp. 593-599
    • Wang, H.1    Cho, C.H.2
  • 50
    • 80054042211 scopus 로고    scopus 로고
    • Interleukin-1 receptor associated kinases-1/4 inhibition protects against acute hypoxia/ischemia-induced neuronal injury in vivo and in vitro
    • Yang YF, Chen Z, Hu SL, Hu J, Li B, Li JT, et al. Interleukin-1 receptor associated kinases-1/4 inhibition protects against acute hypoxia/ischemia-induced neuronal injury in vivo and in vitro. Neuroscience. 2011;196:25-34.
    • (2011) Neuroscience , vol.196 , pp. 25-34
    • Yang, Y.F.1    Chen, Z.2    Hu, S.L.3    Hu, J.4    Li, B.5    Li, J.T.6
  • 51
    • 79960670510 scopus 로고    scopus 로고
    • TGFBR3, a potential negative regulator of TGF-beta signaling, protects cardiac fibroblasts from hypoxia-induced apoptosis
    • Chu W, Li X, Li C, Wan L, Shi H, Song X, et al. TGFBR3, a potential negative regulator of TGF-beta signaling, protects cardiac fibroblasts from hypoxia-induced apoptosis. J Cell Physiol. 2011;226(10):2586-94.
    • (2011) J Cell Physiol , vol.226 , Issue.10 , pp. 2586-2594
    • Chu, W.1    Li, X.2    Li, C.3    Wan, L.4    Shi, H.5    Song, X.6
  • 52
    • 0024401054 scopus 로고
    • Production of tumornecrosis factor-alpha by microglia and astrocytes in culture
    • Sawada M, Kondo N, Suzumura A, Marunouchi T. Production of tumornecrosis factor-alpha by microglia and astrocytes in culture. Brain Res. 1989;491(2):394-7.
    • (1989) Brain Res , vol.491 , Issue.2 , pp. 394-397
    • Sawada, M.1    Kondo, N.2    Suzumura, A.3    Marunouchi, T.4
  • 53
    • 0036719568 scopus 로고    scopus 로고
    • Mice deficient in TNF receptors are protected against dopaminergic neurotoxicity: Implications for Parkinson's disease
    • Sriram K, Matheson JM, Benkovic SA, Miller DB, Luster MI, O'Callaghan JP. Mice deficient in TNF receptors are protected against dopaminergic neurotoxicity: implications for Parkinson's disease. FASEB J. 2002;16(11):1474-6.
    • (2002) FASEB J , vol.16 , Issue.11 , pp. 1474-1476
    • Sriram, K.1    Matheson, J.M.2    Benkovic, S.A.3    Miller, D.B.4    Luster, M.I.5    O'Callaghan, J.P.6
  • 54
    • 80054909414 scopus 로고    scopus 로고
    • Anti-inflammatory effects of Polygala tenuifolia root through inhibition of NF-kappaB activation in lipopolysaccharide-induced BV2 microglial cells
    • Cheong MH, Lee SR, Yoo HS, Jeong JW, Kim GY, Kim WJ, et al. Anti-inflammatory effects of Polygala tenuifolia root through inhibition of NF-kappaB activation in lipopolysaccharide-induced BV2 microglial cells. J Ethnopharmacol. 2011;137(3):1402-8.
    • (2011) J Ethnopharmacol , vol.137 , Issue.3 , pp. 1402-1408
    • Cheong, M.H.1    Lee, S.R.2    Yoo, H.S.3    Jeong, J.W.4    Kim, G.Y.5    Kim, W.J.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.