Autophagy provides metabolic substrates to maintain energy charge and nucleotide pools in Ras-driven lung cancer cells

Genes and Development

Volumn 30, Issue 15, 2016, Pages 1704-1717

  Guo, Jessie Yanxiang ^a,b,c   Teng, Xin ^d   Laddha, Saurabh V ^a   Ma, Sirui ^a   Van Nostrand, Stephen C ^a   Yang, Yang ^a   Khor, Sinan ^a   Chan, Chang S ^a,b   Rabinowitz, Joshua D ^a,d   White, Eileen ^a,e  

^a RUTGERS CANCER INSTITUTE OF NEW JERSEY   (United States)

^b ROBERT WOOD JOHNSON MEDICAL SCHOOL   (United States)

^c RUTGERS UNIVERSITY   (United States)

^d PRINCETON UNIVERSITY   (United States)

^e RUTGERS UNIVERSITY   (United States)

Author keywords

Amino acid; Autophagy; Energy charge; Mitochondrial metabolism; Nucleotide; Ras driven cancer; ROS

Indexed keywords

ACETYLCYSTEINE; GLUTAMIC ACID; GLUTAMINE; NUCLEOSIDE; NUCLEOTIDE; RAS PROTEIN; REACTIVE OXYGEN METABOLITE; AUTOPHAGY RELATED PROTEIN 7;

ANIMAL CELL; ARTICLE; ATG7 GENE; AUTOPHAGY; BIOENERGY; CELL SURVIVAL; CITRIC ACID CYCLE; CONTROLLED STUDY; ENERGY BALANCE; GENE; GENE DELETION; GENE MUTATION; LUNG CANCER; MITOCHONDRIAL GENOME; MITOCHONDRIAL RESPIRATION; MOUSE; NONHUMAN; NUCLEOTIDE METABOLISM; ONCOGENE K RAS; OXIDATION REDUCTION STATE; PRIORITY JOURNAL; ANIMAL; DRUG EFFECTS; ENERGY METABOLISM; GENETIC VARIATION; GENETICS; LUNG TUMOR; METABOLISM; MITOCHONDRION; OXIDATION REDUCTION REACTION; PATHOPHYSIOLOGY; TUMOR CELL LINE;

ANIMALS; AUTOPHAGY; AUTOPHAGY-RELATED PROTEIN 7; CELL LINE, TUMOR; ENERGY METABOLISM; GENE DELETION; GENETIC VARIATION; GENOME, MITOCHONDRIAL; GLUTAMINE; LUNG NEOPLASMS; MICE; MITOCHONDRIA; NUCLEOSIDES; NUCLEOTIDES; OXIDATION-REDUCTION; RAS PROTEINS;

EID: 84983359562     PISSN: 08909369     EISSN: 15495477     Source Type: Journal    
DOI: 10.1101/gad.283416.116     Document Type: Article

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