메뉴 건너뛰기




Volumn 37, Issue 9, 2016, Pages 768-778

Targeting Oxidative Stress in Central Nervous System Disorders

Author keywords

[No Author keywords available]

Indexed keywords

ANTIOXIDANT; DISUFENTON SODIUM; MITOQUINONE MESYLATE; PLACEBO; REACTIVE NITROGEN SPECIES; REACTIVE OXYGEN METABOLITE; UNCLASSIFIED DRUG; VERDIPERSTAT;

EID: 84982225556     PISSN: 01656147     EISSN: 18733735     Source Type: Journal    
DOI: 10.1016/j.tips.2016.06.007     Document Type: Review
Times cited : (233)

References (65)
  • 1
    • 84943639915 scopus 로고    scopus 로고
    • Antioxidants can increase melanoma metastasis in mice
    • 1 Le Gal, K., et al. Antioxidants can increase melanoma metastasis in mice. Sci. Transl. Med., 7, 2015, 308re8.
    • (2015) Sci. Transl. Med. , vol.7 , pp. 308re8
    • Le Gal, K.1
  • 2
    • 84962309568 scopus 로고    scopus 로고
    • Antioxidants accelerate lung cancer progression
    • 2 Sayin, V.I., et al. Antioxidants accelerate lung cancer progression. Sci. Transl. Med., 6, 2014, 221ra15.
    • (2014) Sci. Transl. Med. , vol.6 , pp. 221ra15
    • Sayin, V.I.1
  • 3
    • 33750469522 scopus 로고    scopus 로고
    • The mystery of sleep function: current perspectives and future directions
    • 3 Frank, M.G., The mystery of sleep function: current perspectives and future directions. Rev. Neurosci. 17 (2006), 375–392.
    • (2006) Rev. Neurosci. , vol.17 , pp. 375-392
    • Frank, M.G.1
  • 4
    • 0002549698 scopus 로고
    • Oxidative stress: introductory remarks
    • Academic Press
    • 4 Sies, H., Oxidative stress: introductory remarks. Oxidative Stress, 1985, Academic Press, 1–8.
    • (1985) Oxidative Stress , pp. 1-8
    • Sies, H.1
  • 5
    • 33744962865 scopus 로고    scopus 로고
    • Redefining oxidative stress
    • 5 Jones, D.P., Redefining oxidative stress. Antioxid. Redox Signal. 8 (2006), 1865–1879.
    • (2006) Antioxid. Redox Signal. , vol.8 , pp. 1865-1879
    • Jones, D.P.1
  • 6
    • 0024848034 scopus 로고
    • Abnormalities of the electron transport chain in idiopathic Parkinson's disease
    • 6 Parker, W.D. Jr, et al. Abnormalities of the electron transport chain in idiopathic Parkinson's disease. Ann. Neurol. 26 (1989), 719–723.
    • (1989) Ann. Neurol. , vol.26 , pp. 719-723
    • Parker, W.D.1
  • 7
    • 0026754574 scopus 로고
    • Reactive oxygen species and the central nervous system
    • 7 Halliwell, B., Reactive oxygen species and the central nervous system. J. Neurochem. 59 (1992), 1609–1623.
    • (1992) J. Neurochem. , vol.59 , pp. 1609-1623
    • Halliwell, B.1
  • 8
    • 84956877036 scopus 로고    scopus 로고
    • Crosstalk of mitochondria with NADPH oxidase via reactive oxygen and nitrogen species signalling and its role for vascular function
    • Published online December 9
    • 8 Daiber, A., et al. Crosstalk of mitochondria with NADPH oxidase via reactive oxygen and nitrogen species signalling and its role for vascular function. Br. J. Pharmacol., 2015, 10.1111/bph.13403 Published online December 9.
    • (2015) Br. J. Pharmacol.
    • Daiber, A.1
  • 9
    • 84891767145 scopus 로고    scopus 로고
    • Mitochondrial redox signaling: interaction of mitochondrial reactive oxygen species with other sources of oxidative stress
    • 9 Schulz, E., et al. Mitochondrial redox signaling: interaction of mitochondrial reactive oxygen species with other sources of oxidative stress. Antioxid. Redox Signal. 20 (2014), 308–324.
    • (2014) Antioxid. Redox Signal. , vol.20 , pp. 308-324
    • Schulz, E.1
  • 10
    • 4544226082 scopus 로고    scopus 로고
    • Generation of reactive oxygen species in the reaction catalyzed by alpha-ketoglutarate dehydrogenase
    • 10 Tretter, L., Adam-Vizi, V., Generation of reactive oxygen species in the reaction catalyzed by alpha-ketoglutarate dehydrogenase. J. Neurosci. 24 (2004), 7771–7778.
    • (2004) J. Neurosci. , vol.24 , pp. 7771-7778
    • Tretter, L.1    Adam-Vizi, V.2
  • 11
    • 77956250065 scopus 로고    scopus 로고
    • 2 removal in brain mitochondria via the thioredoxin/peroxiredoxin system
    • 2 removal in brain mitochondria via the thioredoxin/peroxiredoxin system. J. Biol. Chem. 285 (2010), 27850–27858.
    • (2010) J. Biol. Chem. , vol.285 , pp. 27850-27858
    • Drechsel, D.A.1    Patel, M.2
  • 12
    • 58249093939 scopus 로고    scopus 로고
    • How mitochondria produce reactive oxygen species
    • 12 Murphy, M.P., How mitochondria produce reactive oxygen species. Biochem. J. 417 (2009), 1–13.
    • (2009) Biochem. J. , vol.417 , pp. 1-13
    • Murphy, M.P.1
  • 13
    • 84891767145 scopus 로고    scopus 로고
    • Mitochondrial redox signaling: interaction of mitochondrial reactive oxygen species with other sources of oxidative stress
    • 13 Schulz, E., et al. Mitochondrial redox signaling: interaction of mitochondrial reactive oxygen species with other sources of oxidative stress. Antioxid. Redox Signal. 20 (2014), 308–324.
    • (2014) Antioxid. Redox Signal. , vol.20 , pp. 308-324
    • Schulz, E.1
  • 14
    • 0028342913 scopus 로고
    • Regulation of the transcription factors NF-κB and AP-1 by redox changes
    • 14 Meyer, M., et al. Regulation of the transcription factors NF-κB and AP-1 by redox changes. Chem. Biol. Interact. 91 (1994), 91–100.
    • (1994) Chem. Biol. Interact. , vol.91 , pp. 91-100
    • Meyer, M.1
  • 15
    • 0030993117 scopus 로고    scopus 로고
    • Superoxide-driven aconitase Fe–S center cycling
    • 15 Gardner, P.R., Superoxide-driven aconitase Fe–S center cycling. Biosci. Res. 17 (1997), 33–42.
    • (1997) Biosci. Res. , vol.17 , pp. 33-42
    • Gardner, P.R.1
  • 16
    • 4444360218 scopus 로고    scopus 로고
    • Iron–sulfur enzyme mediated mitochondrial superoxide toxicity in experimental Parkinson's disease
    • 16 Liang, L.P., Patel, M., Iron–sulfur enzyme mediated mitochondrial superoxide toxicity in experimental Parkinson's disease. J. Neurochem. 90 (2004), 1076–1084.
    • (2004) J. Neurochem. , vol.90 , pp. 1076-1084
    • Liang, L.P.1    Patel, M.2
  • 19
    • 84940598646 scopus 로고    scopus 로고
    • Sulfhydryl-mediated redox signaling in inflammation: role in neurodegenerative diseases
    • 19 Gorelenkova Miller, O., Mieyal, J.J., Sulfhydryl-mediated redox signaling in inflammation: role in neurodegenerative diseases. Arch. Toxicol. 89 (2015), 1439–1467.
    • (2015) Arch. Toxicol. , vol.89 , pp. 1439-1467
    • Gorelenkova Miller, O.1    Mieyal, J.J.2
  • 20
    • 84925725817 scopus 로고    scopus 로고
    • Aberrant protein S-nitrosylation contributes to the pathophysiology of neurodegenerative diseases
    • 20 Nakamura, T., et al. Aberrant protein S-nitrosylation contributes to the pathophysiology of neurodegenerative diseases. Neurobiol. Dis. 84 (2015), 99–108.
    • (2015) Neurobiol. Dis. , vol.84 , pp. 99-108
    • Nakamura, T.1
  • 21
    • 17444403972 scopus 로고    scopus 로고
    • The biochemistry of the isoprostane, neuroprostane, and isofuran pathways of lipid peroxidation
    • 21 Roberts, L.J. II, et al. The biochemistry of the isoprostane, neuroprostane, and isofuran pathways of lipid peroxidation. Brain Pathol. 15 (2005), 143–148.
    • (2005) Brain Pathol. , vol.15 , pp. 143-148
    • Roberts, L.J.1
  • 22
    • 33646549564 scopus 로고    scopus 로고
    • Cyclopentenone isoprostanes are novel bioactive products of lipid oxidation which enhance neurodegeneration
    • 22 Musiek, E.S., et al. Cyclopentenone isoprostanes are novel bioactive products of lipid oxidation which enhance neurodegeneration. J. Neurochem. 97 (2006), 1301–1313.
    • (2006) J. Neurochem. , vol.97 , pp. 1301-1313
    • Musiek, E.S.1
  • 23
    • 44649118752 scopus 로고    scopus 로고
    • Thromboxane receptor activation mediates isoprostane-induced increases in amyloid pathology in Tg2576 mice
    • 23 Shineman, D.W., et al. Thromboxane receptor activation mediates isoprostane-induced increases in amyloid pathology in Tg2576 mice. J. Neurosci. 28 (2008), 4785–4794.
    • (2008) J. Neurosci. , vol.28 , pp. 4785-4794
    • Shineman, D.W.1
  • 24
    • 0036583274 scopus 로고    scopus 로고
    • Effects of reactive gamma-ketoaldehydes formed by the isoprostane pathway (isoketals) and cyclooxygenase pathway (levuglandins) on proteasome function
    • 24 Davies, S.S., et al. Effects of reactive gamma-ketoaldehydes formed by the isoprostane pathway (isoketals) and cyclooxygenase pathway (levuglandins) on proteasome function. Faseb. J. 16 (2002), 715–717.
    • (2002) Faseb. J. , vol.16 , pp. 715-717
    • Davies, S.S.1
  • 25
    • 34247156564 scopus 로고    scopus 로고
    • DNA repair, mitochondria, and neurodegeneration
    • 25 Weissman, L., et al. DNA repair, mitochondria, and neurodegeneration. Neuroscience 145 (2007), 1318–1329.
    • (2007) Neuroscience , vol.145 , pp. 1318-1329
    • Weissman, L.1
  • 26
    • 0029194750 scopus 로고
    • The definition and measurement of antioxidants in biological systems
    • 26 Halliwell, B., Gutteridge, J.M., The definition and measurement of antioxidants in biological systems. Free Radic. Biol. Med. 18 (1995), 125–126.
    • (1995) Free Radic. Biol. Med. , vol.18 , pp. 125-126
    • Halliwell, B.1    Gutteridge, J.M.2
  • 27
    • 79952851690 scopus 로고    scopus 로고
    • OH radical scavenging activity of edaravone: mechanism and kinetics
    • 27 Perez-Gonzalez, A., Galano, A., OH radical scavenging activity of edaravone: mechanism and kinetics. J. Phys. Chem. B 115 (2011), 1306–1314.
    • (2011) J. Phys. Chem. B , vol.115 , pp. 1306-1314
    • Perez-Gonzalez, A.1    Galano, A.2
  • 28
    • 0035992622 scopus 로고    scopus 로고
    • Melatonin's unique radical scavenging properties – roles of its functional substituents as revealed by a comparison with its structural analogs
    • 28 Poeggeler, B., et al. Melatonin's unique radical scavenging properties – roles of its functional substituents as revealed by a comparison with its structural analogs. J. Pineal Res. 33 (2002), 20–30.
    • (2002) J. Pineal Res. , vol.33 , pp. 20-30
    • Poeggeler, B.1
  • 29
    • 2942623947 scopus 로고    scopus 로고
    • Catalytic antioxidants: a radical approach to new therapeutics
    • 29 Day, B.J., Catalytic antioxidants: a radical approach to new therapeutics. Drug Discov. Today 9 (2004), 557–566.
    • (2004) Drug Discov. Today , vol.9 , pp. 557-566
    • Day, B.J.1
  • 30
    • 0026636515 scopus 로고
    • Antioxidant effect of ebselen (PZ 51): peroxidase mimetic activity on phospholipid and cholesterol hydroperoxides vs free radical scavenger activity
    • 30 Maiorino, M., et al. Antioxidant effect of ebselen (PZ 51): peroxidase mimetic activity on phospholipid and cholesterol hydroperoxides vs free radical scavenger activity. Arch. Biochem. Biophys. 295 (1992), 404–409.
    • (1992) Arch. Biochem. Biophys. , vol.295 , pp. 404-409
    • Maiorino, M.1
  • 31
    • 0002296980 scopus 로고    scopus 로고
    • Salen–manganese complexes: combined superoxide dismutase/catalase mimics with broad pharmacological efficacy
    • 31 Doctrow, S.R., et al. Salen–manganese complexes: combined superoxide dismutase/catalase mimics with broad pharmacological efficacy. Adv. Pharmacol. 38 (1997), 247–269.
    • (1997) Adv. Pharmacol. , vol.38 , pp. 247-269
    • Doctrow, S.R.1
  • 32
    • 0031573475 scopus 로고    scopus 로고
    • Manganic porphyrins possess catalase activity and protect endothelial cells against hydrogen peroxide-mediated injury
    • 32 Day, B.J., et al. Manganic porphyrins possess catalase activity and protect endothelial cells against hydrogen peroxide-mediated injury. Arch. Biochem. Biophys. 347 (1997), 256–262.
    • (1997) Arch. Biochem. Biophys. , vol.347 , pp. 256-262
    • Day, B.J.1
  • 33
    • 0002296980 scopus 로고    scopus 로고
    • Salen–manganese complexes: combined superoxide dismutase/catalase mimics with broad pharmacological efficacy
    • 33 Doctrow, S.R., et al. Salen–manganese complexes: combined superoxide dismutase/catalase mimics with broad pharmacological efficacy. Adv. Pharmacol. 38 (1997), 247–269.
    • (1997) Adv. Pharmacol. , vol.38 , pp. 247-269
    • Doctrow, S.R.1
  • 34
    • 46149113117 scopus 로고    scopus 로고
    • Medicinal applications of fullerenes
    • 34 Bakry, R., et al. Medicinal applications of fullerenes. Int. J. Nanomedicine 2 (2007), 639–649.
    • (2007) Int. J. Nanomedicine , vol.2 , pp. 639-649
    • Bakry, R.1
  • 35
    • 84884903879 scopus 로고    scopus 로고
    • Nitrone-based therapeutics for neurodegenerative diseases: their use alone or in combination with lanthionines
    • 35 Floyd, R.A., et al. Nitrone-based therapeutics for neurodegenerative diseases: their use alone or in combination with lanthionines. Free Radic. Biol. Med. 62 (2013), 145–156.
    • (2013) Free Radic. Biol. Med. , vol.62 , pp. 145-156
    • Floyd, R.A.1
  • 36
    • 0035004114 scopus 로고    scopus 로고
    • Flavonoid antioxidants
    • 36 Rice-Evans, C., Flavonoid antioxidants. Curr. Med. Chem. 8 (2001), 797–807.
    • (2001) Curr. Med. Chem. , vol.8 , pp. 797-807
    • Rice-Evans, C.1
  • 37
    • 0025004502 scopus 로고
    • Flavonoids as antioxidants: determination of radical-scavenging efficiencies
    • 37 Bors, W., et al. Flavonoids as antioxidants: determination of radical-scavenging efficiencies. Methods Enzymol. 186 (1990), 343–355.
    • (1990) Methods Enzymol. , vol.186 , pp. 343-355
    • Bors, W.1
  • 38
    • 84892369382 scopus 로고    scopus 로고
    • How do nutritional antioxidants really work: nucleophilic tone and para-hormesis versus free radical scavenging in vivo
    • 38 Forman, H.J., et al. How do nutritional antioxidants really work: nucleophilic tone and para-hormesis versus free radical scavenging in vivo. Free Radic. Biol. Med. 66 (2014), 24–35.
    • (2014) Free Radic. Biol. Med. , vol.66 , pp. 24-35
    • Forman, H.J.1
  • 39
    • 84892371857 scopus 로고    scopus 로고
    • Antioxidant therapeutics: Pandora's box
    • 39 Day, B.J., Antioxidant therapeutics: Pandora's box. Free Radic. Biol. Med. 66 (2014), 58–64.
    • (2014) Free Radic. Biol. Med. , vol.66 , pp. 58-64
    • Day, B.J.1
  • 40
    • 84940753656 scopus 로고    scopus 로고
    • Effect of the myeloperoxidase inhibitor AZD3241 on microglia: a PET study in Parkinson's disease
    • 40 Jucaite, A., et al. Effect of the myeloperoxidase inhibitor AZD3241 on microglia: a PET study in Parkinson's disease. Brain 138 (2015), 2687–2700.
    • (2015) Brain , vol.138 , pp. 2687-2700
    • Jucaite, A.1
  • 41
    • 48749112603 scopus 로고    scopus 로고
    • N-acetyl cysteine as a glutathione precursor for schizophrenia – a double-blind, randomized, placebo-controlled trial
    • 41 Berk, M., et al. N-acetyl cysteine as a glutathione precursor for schizophrenia – a double-blind, randomized, placebo-controlled trial. Biol. Psychiatry 64 (2008), 361–368.
    • (2008) Biol. Psychiatry , vol.64 , pp. 361-368
    • Berk, M.1
  • 42
    • 84874652458 scopus 로고    scopus 로고
    • The promise of N-acetylcysteine in neuropsychiatry
    • 42 Berk, M., et al. The promise of N-acetylcysteine in neuropsychiatry. Trends Pharmacol. Sci. 34 (2013), 167–177.
    • (2013) Trends Pharmacol. Sci. , vol.34 , pp. 167-177
    • Berk, M.1
  • 43
    • 0035895888 scopus 로고    scopus 로고
    • Selective targeting of a redox-active ubiquinone to mitochondria within cells: antioxidant and antiapoptotic properties
    • 43 Kelso, G.F., et al. Selective targeting of a redox-active ubiquinone to mitochondria within cells: antioxidant and antiapoptotic properties. J. Biol. Chem. 276 (2001), 4588–4596.
    • (2001) J. Biol. Chem. , vol.276 , pp. 4588-4596
    • Kelso, G.F.1
  • 44
    • 0348136710 scopus 로고    scopus 로고
    • Mitochondria-targeted antioxidants protect Friedreich ataxia fibroblasts from endogenous oxidative stress more effectively than untargeted antioxidants
    • 44 Jauslin, M.L., et al. Mitochondria-targeted antioxidants protect Friedreich ataxia fibroblasts from endogenous oxidative stress more effectively than untargeted antioxidants. FASEB J. 17 (2003), 1972–1974.
    • (2003) FASEB J. , vol.17 , pp. 1972-1974
    • Jauslin, M.L.1
  • 45
    • 33344479169 scopus 로고    scopus 로고
    • The effects of exogenous antioxidants on lifespan and oxidative stress resistance in Drosophila melanogaster
    • 45 Magwere, T., et al. The effects of exogenous antioxidants on lifespan and oxidative stress resistance in Drosophila melanogaster. Mech. Ageing Dev. 127 (2006), 356–370.
    • (2006) Mech. Ageing Dev. , vol.127 , pp. 356-370
    • Magwere, T.1
  • 46
    • 77956207531 scopus 로고    scopus 로고
    • Mitochondria-targeted antioxidants protect against amyloid-beta toxicity in Alzheimer's disease neurons
    • 46 Manczak, M., et al. Mitochondria-targeted antioxidants protect against amyloid-beta toxicity in Alzheimer's disease neurons. J. Alzheimers Dis. 20:Suppl. 2 (2010), S609–S631.
    • (2010) J. Alzheimers Dis. , vol.20 , pp. S609-S631
    • Manczak, M.1
  • 47
    • 77955283395 scopus 로고    scopus 로고
    • Animal and human studies with the mitochondria-targeted antioxidant MitoQ
    • 47 Smith, R.A., Murphy, M.P., Animal and human studies with the mitochondria-targeted antioxidant MitoQ. Ann. N. Y. Acad. Sci. 1201 (2010), 96–103.
    • (2010) Ann. N. Y. Acad. Sci. , vol.1201 , pp. 96-103
    • Smith, R.A.1    Murphy, M.P.2
  • 48
    • 84942836209 scopus 로고    scopus 로고
    • Synthesis of triphenylphosphonium vitamin E derivatives as mitochondria-targeted antioxidants
    • 48 Jameson, V.J., et al. Synthesis of triphenylphosphonium vitamin E derivatives as mitochondria-targeted antioxidants. Tetrahedron 71 (2015), 8444–8453.
    • (2015) Tetrahedron , vol.71 , pp. 8444-8453
    • Jameson, V.J.1
  • 49
    • 84928996827 scopus 로고    scopus 로고
    • Mitochondria-targeted plastoquinone antioxidant SkQR1 has positive effect on memory of rats
    • 49 Stelmashook, E.V., et al. Mitochondria-targeted plastoquinone antioxidant SkQR1 has positive effect on memory of rats. Biochemistry (Mosc.) 80 (2015), 592–595.
    • (2015) Biochemistry (Mosc.) , vol.80 , pp. 592-595
    • Stelmashook, E.V.1
  • 50
    • 84928164175 scopus 로고    scopus 로고
    • Mitochondria-targeted antioxidant SkQT1 decreases trauma-induced neurological deficit in rat and prevents amyloid-beta-induced impairment of long-term potentiation in rat hippocampal slices
    • 50 Genrikhs, E.E., et al. Mitochondria-targeted antioxidant SkQT1 decreases trauma-induced neurological deficit in rat and prevents amyloid-beta-induced impairment of long-term potentiation in rat hippocampal slices. J. Drug Target. 23 (2015), 347–352.
    • (2015) J. Drug Target. , vol.23 , pp. 347-352
    • Genrikhs, E.E.1
  • 51
    • 4544370680 scopus 로고    scopus 로고
    • Cell-permeable peptide antioxidants targeted to inner mitochondrial membrane inhibit mitochondrial swelling, oxidative cell death, and reperfusion injury
    • 51 Zhao, K., et al. Cell-permeable peptide antioxidants targeted to inner mitochondrial membrane inhibit mitochondrial swelling, oxidative cell death, and reperfusion injury. J. Biol. Chem. 279 (2004), 34682–34690.
    • (2004) J. Biol. Chem. , vol.279 , pp. 34682-34690
    • Zhao, K.1
  • 52
    • 77952548782 scopus 로고    scopus 로고
    • How increased oxidative stress promotes longevity and metabolic health: the concept of mitochondrial hormesis (mitohormesis)
    • 52 Ristow, M., Zarse, K., How increased oxidative stress promotes longevity and metabolic health: the concept of mitochondrial hormesis (mitohormesis). Exp. Gerontol. 45 (2010), 410–418.
    • (2010) Exp. Gerontol. , vol.45 , pp. 410-418
    • Ristow, M.1    Zarse, K.2
  • 53
    • 80051669923 scopus 로고    scopus 로고
    • Translational research involving oxidative stress and diseases of aging
    • 53 Floyd, R.A., et al. Translational research involving oxidative stress and diseases of aging. Free Radic. Biol. Med. 51 (2011), 931–941.
    • (2011) Free Radic. Biol. Med. , vol.51 , pp. 931-941
    • Floyd, R.A.1
  • 54
    • 0031742961 scopus 로고    scopus 로고
    • Manganese superoxide dismutase overexpression attenuates MPTP toxicity
    • 54 Klivenyi, P., et al. Manganese superoxide dismutase overexpression attenuates MPTP toxicity. Neurobiol. Dis. 5 (1998), 253–258.
    • (1998) Neurobiol. Dis. , vol.5 , pp. 253-258
    • Klivenyi, P.1
  • 55
    • 24044455008 scopus 로고    scopus 로고
    • Manganese superoxide dismutase protects against 6-hydroxydopamine injury in mouse brains
    • 55 Callio, J., et al. Manganese superoxide dismutase protects against 6-hydroxydopamine injury in mouse brains. J. Biol. Chem. 280 (2005), 18536–18542.
    • (2005) J. Biol. Chem. , vol.280 , pp. 18536-18542
    • Callio, J.1
  • 56
    • 84919343950 scopus 로고    scopus 로고
    • Targeted overexpression of mitochondrial catalase prevents radiation-induced cognitive dysfunction
    • 56 Parihar, V.K., et al. Targeted overexpression of mitochondrial catalase prevents radiation-induced cognitive dysfunction. Antioxid. Redox Signal. 22 (2015), 78–91.
    • (2015) Antioxid. Redox Signal. , vol.22 , pp. 78-91
    • Parihar, V.K.1
  • 57
    • 0026583465 scopus 로고
    • Transgenic mice with increased Cu/Zn-superoxide dismutase activity are resistant to N-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced neurotoxicity
    • 57 Przedborski, S., et al. Transgenic mice with increased Cu/Zn-superoxide dismutase activity are resistant to N-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced neurotoxicity. J. Neurosci. 12 (1992), 1658–1667.
    • (1992) J. Neurosci. , vol.12 , pp. 1658-1667
    • Przedborski, S.1
  • 58
    • 0034669186 scopus 로고    scopus 로고
    • Mitochondrial superoxide production in kainate-induced hippocampal damage
    • 58 Liang, L.P., et al. Mitochondrial superoxide production in kainate-induced hippocampal damage. Neuroscience 101 (2000), 563–570.
    • (2000) Neuroscience , vol.101 , pp. 563-570
    • Liang, L.P.1
  • 59
    • 15844393658 scopus 로고    scopus 로고
    • Motor neurons in Cu/Zn superoxide dismutase-deficient mice develop normally but exhibit enhanced cell death after axonal injury
    • 59 Reaume, A.G., et al. Motor neurons in Cu/Zn superoxide dismutase-deficient mice develop normally but exhibit enhanced cell death after axonal injury. Nat. Genet. 13 (1996), 43–47.
    • (1996) Nat. Genet. , vol.13 , pp. 43-47
    • Reaume, A.G.1
  • 60
    • 0035503501 scopus 로고    scopus 로고
    • Lifespan extension and rescue of spongiform encephalopathy in superoxide dismutase 2 nullizygous mice treated with superoxide dismutase-catalase mimetics
    • 60 Melov, S., et al. Lifespan extension and rescue of spongiform encephalopathy in superoxide dismutase 2 nullizygous mice treated with superoxide dismutase-catalase mimetics. J. Neurosci. 21 (2001), 8348–8353.
    • (2001) J. Neurosci. , vol.21 , pp. 8348-8353
    • Melov, S.1
  • 61
    • 77955792985 scopus 로고    scopus 로고
    • A double-blind, placebo-controlled study to assess the mitochondria-targeted antioxidant MitoQ as a disease-modifying therapy in Parkinson's disease
    • 61 Snow, B.J., et al. A double-blind, placebo-controlled study to assess the mitochondria-targeted antioxidant MitoQ as a disease-modifying therapy in Parkinson's disease. Mov. Disord. 25 (2010), 1670–1674.
    • (2010) Mov. Disord. , vol.25 , pp. 1670-1674
    • Snow, B.J.1
  • 62
    • 34249780840 scopus 로고    scopus 로고
    • Life after cerovive: a personal perspective on ischemic neuroprotection in the post-NXY-059 era
    • 62 Ginsberg, M.D., Life after cerovive: a personal perspective on ischemic neuroprotection in the post-NXY-059 era. Stroke 38 (2007), 1967–1972.
    • (2007) Stroke , vol.38 , pp. 1967-1972
    • Ginsberg, M.D.1
  • 64
    • 34948814624 scopus 로고    scopus 로고
    • The relationship between dose of vitamin E and suppression of oxidative stress in humans
    • 64 Roberts, L.J. II, et al. The relationship between dose of vitamin E and suppression of oxidative stress in humans. Free Radic. Biol. Med. 43 (2007), 1388–1393.
    • (2007) Free Radic. Biol. Med. , vol.43 , pp. 1388-1393
    • Roberts, L.J.1
  • 65
    • 84877134982 scopus 로고    scopus 로고
    • RIGOR guidelines: escalating STAIR and STEPS for effective translational research
    • 65 Lapchak, P.A., et al. RIGOR guidelines: escalating STAIR and STEPS for effective translational research. Transl. Stroke Res. 4 (2013), 279–285.
    • (2013) Transl. Stroke Res. , vol.4 , pp. 279-285
    • Lapchak, P.A.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.