Cyclopentenone isoprostanes are novel bioactive products of lipid oxidation which enhance neurodegeneration

Journal of Neurochemistry

Volumn 97, Issue 5, 2006, Pages 1301-1313

  Musiek, Erik S ^a   Breeding, Rebecca S ^a,b   Milne, Ginger L ^a   Zanoni, Giuseppe ^c   Morrow, Jason D ^a   McLaughlin, Bethann ^a,b,d  

^a VANDERBILT UNIVERSITY   (United States)

^b VANDERBILT UNIVERSITY MEDICAL CENTER   (United States)

^c UNIVERSITY OF PAVIA   (Italy)

^d VANDERBILT UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

12 lipoxygenase; Apoptosis; Isoprostane; Lipid peroxidation; Oxidative stress; p66shc

Indexed keywords

ARACHIDONATE 12 LIPOXYGENASE; CASPASE 3; CYCLOPENTENONE; ISOPROSTANE DERIVATIVE; PROSTAGLANDIN DERIVATIVE; PROTEIN P66; REACTIVE OXYGEN METABOLITE;

ANIMAL TISSUE; APOPTOSIS; ARTICLE; CELL DEATH; ENZYME ACTIVATION; ENZYME PHOSPHORYLATION; LIPID OXIDATION; LIPID PEROXIDATION; MOLECULAR MECHANICS; NERVE CELL CULTURE; NERVE DEGENERATION; NEUROPROTECTION; NONHUMAN; OXIDATION REDUCTION REACTION; OXIDATIVE STRESS; PATHOGENESIS; PHOSPHOLIPID MEMBRANE; PRIORITY JOURNAL; RAT; STROKE;

ADAPTOR PROTEINS, SIGNAL TRANSDUCING; ANIMALS; ARACHIDONATE 12-LIPOXYGENASE; CELLS, CULTURED; CYCLOPENTANES; DOSE-RESPONSE RELATIONSHIP, DRUG; EXCITATORY AMINO ACID AGONISTS; GLUTAMIC ACID; GLUTATHIONE; ISOPROSTANES; LIPID PEROXIDATION; MITOGEN-ACTIVATED PROTEIN KINASE 3; MODELS, NEUROLOGICAL; MOLECULAR STRUCTURE; NERVE DEGENERATION; NEURONS; OXIDATIVE STRESS; PHOSPHORYLATION; PROSTAGLANDINS A; RATS; RATS, SPRAGUE-DAWLEY; REACTIVE OXYGEN SPECIES;

EID: 33646549564     PISSN: 00223042     EISSN: 14714159     Source Type: Journal    
DOI: 10.1111/j.1471-4159.2006.03797.x     Document Type: Article

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