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Volumn 64, Issue 5, 2008, Pages 361-368

N-Acetyl Cysteine as a Glutathione Precursor for Schizophrenia-A Double-Blind, Randomized, Placebo-Controlled Trial

Author keywords

Adjunct therapy; clinical trials; glutathione; n acetyl cysteine; schizophrenia

Indexed keywords

ACETYLCYSTEINE; ARIPIPRAZOLE; CLOZAPINE; GLUTATHIONE; NEUROLEPTIC AGENT; OLANZAPINE; PLACEBO; QUETIAPINE; RISPERIDONE;

EID: 48749112603     PISSN: 00063223     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.biopsych.2008.03.004     Document Type: Article
Times cited : (479)

References (44)
  • 2
    • 0033787297 scopus 로고    scopus 로고
    • Schizophrenia: Glutathione deficit in cerebrospinal fluid and prefrontal cortex in vivo
    • Do K.Q., Trabensinger M.K., Lauer C.J., Dydak U., Hell D., Holsboer F., et al. Schizophrenia: Glutathione deficit in cerebrospinal fluid and prefrontal cortex in vivo. Eur J Neurosci 12 (2000) 3721-3728
    • (2000) Eur J Neurosci , vol.12 , pp. 3721-3728
    • Do, K.Q.1    Trabensinger, M.K.2    Lauer, C.J.3    Dydak, U.4    Hell, D.5    Holsboer, F.6
  • 3
    • 29244464827 scopus 로고    scopus 로고
    • Altered glutathione redox state in schizophrenia
    • Yao J.K., Leonard S., and Reddy R. Altered glutathione redox state in schizophrenia. Dis Markers 22 (2006) 83-93
    • (2006) Dis Markers , vol.22 , pp. 83-93
    • Yao, J.K.1    Leonard, S.2    Reddy, R.3
  • 4
    • 33748676111 scopus 로고    scopus 로고
    • Schizophrenia and oxidative stress: Glutamate cysteine ligase modifier as a susceptibility gene
    • Tosic M., Ott J., Barral S., Bovet P., Deppen P., Gheorghita F., et al. Schizophrenia and oxidative stress: Glutamate cysteine ligase modifier as a susceptibility gene. Am J Hum Genet 79 (2006) 586-592
    • (2006) Am J Hum Genet , vol.79 , pp. 586-592
    • Tosic, M.1    Ott, J.2    Barral, S.3    Bovet, P.4    Deppen, P.5    Gheorghita, F.6
  • 5
    • 36749104268 scopus 로고    scopus 로고
    • Impaired glutathione synthesis in schizophrenia: Convergent genetic and functional evidence
    • Gysin R., Kraftsik R., Sandell J., Bovet P., Chappuis C., Conus P., et al. Impaired glutathione synthesis in schizophrenia: Convergent genetic and functional evidence. Proc Natl Acad Sci U S A 104 (2007) 16621-16626
    • (2007) Proc Natl Acad Sci U S A , vol.104 , pp. 16621-16626
    • Gysin, R.1    Kraftsik, R.2    Sandell, J.3    Bovet, P.4    Chappuis, C.5    Conus, P.6
  • 6
    • 0030933056 scopus 로고    scopus 로고
    • Oxidative reactions and schizophrenia: A review-discussion
    • Smythies J.R. Oxidative reactions and schizophrenia: A review-discussion. Schizophr Res 24 (1997) 357-364
    • (1997) Schizophr Res , vol.24 , pp. 357-364
    • Smythies, J.R.1
  • 7
    • 0028850552 scopus 로고
    • Glutamate receptor dysfunction and schizophrenia
    • Olney J.W., and Farber N.B. Glutamate receptor dysfunction and schizophrenia. Arch Gen Psychiatry 52 (1995) 998-1007
    • (1995) Arch Gen Psychiatry , vol.52 , pp. 998-1007
    • Olney, J.W.1    Farber, N.B.2
  • 8
    • 1642497596 scopus 로고    scopus 로고
    • Low brain glutathione and ascorbic acid associated with dopamine uptake inhibition during rat's development induce long-term cognitive deficit: Relevance to schizophrenia
    • Castagne V., Rougemont M., Cuenod M., and Do K.Q. Low brain glutathione and ascorbic acid associated with dopamine uptake inhibition during rat's development induce long-term cognitive deficit: Relevance to schizophrenia. Neurobiol Dis 15 (2004) 93-105
    • (2004) Neurobiol Dis , vol.15 , pp. 93-105
    • Castagne, V.1    Rougemont, M.2    Cuenod, M.3    Do, K.Q.4
  • 9
    • 30144435733 scopus 로고    scopus 로고
    • Synpatic plasticity impairment and hypofunction of NMDA receptors induced by glutathione deficit: Relevance to schizophrenia
    • Steullet P., Neijt H.C., Cuenod M., and Do K.Q. Synpatic plasticity impairment and hypofunction of NMDA receptors induced by glutathione deficit: Relevance to schizophrenia. Neuroscience 137 (2006) 807-819
    • (2006) Neuroscience , vol.137 , pp. 807-819
    • Steullet, P.1    Neijt, H.C.2    Cuenod, M.3    Do, K.Q.4
  • 10
    • 0024331933 scopus 로고
    • Metabolism of N-acetyl-L-cysteine. Some structural requirements for the deacetylation and consequences for the oral bioavailability
    • Sjodin K., Nilsson E., Hallberg A., and Tunek A. Metabolism of N-acetyl-L-cysteine. Some structural requirements for the deacetylation and consequences for the oral bioavailability. Biochem Pharmacol 38 (1989) 3981-3985
    • (1989) Biochem Pharmacol , vol.38 , pp. 3981-3985
    • Sjodin, K.1    Nilsson, E.2    Hallberg, A.3    Tunek, A.4
  • 11
    • 0025288044 scopus 로고
    • Dose dependent pharmacokinetics of N-acetylcysteine after oral doing to man
    • Borgstrom L., and Kagedal B. Dose dependent pharmacokinetics of N-acetylcysteine after oral doing to man. Biopharm Drug Dispos 11 (1990) 131-136
    • (1990) Biopharm Drug Dispos , vol.11 , pp. 131-136
    • Borgstrom, L.1    Kagedal, B.2
  • 12
    • 0025959339 scopus 로고
    • Clinical pharmokinetics of N-acetylcysteine
    • Holdiness M.R. Clinical pharmokinetics of N-acetylcysteine. Clin Pharmacokinet 20 (1991) 123-134
    • (1991) Clin Pharmacokinet , vol.20 , pp. 123-134
    • Holdiness, M.R.1
  • 13
    • 0037342554 scopus 로고    scopus 로고
    • The antioxidants alpha-lipoic acid and N-acetylcysteine reverse memory impairment and brain oxidative stress in aged SAMP8 mice
    • Farr S.A., Poon H.F., Dogrukol-Ak D., Drake J., Banks W.A., Eyerman E., et al. The antioxidants alpha-lipoic acid and N-acetylcysteine reverse memory impairment and brain oxidative stress in aged SAMP8 mice. J Neurochem 84 (2003) 1173-1183
    • (2003) J Neurochem , vol.84 , pp. 1173-1183
    • Farr, S.A.1    Poon, H.F.2    Dogrukol-Ak, D.3    Drake, J.4    Banks, W.A.5    Eyerman, E.6
  • 14
    • 12244307208 scopus 로고    scopus 로고
    • N-acetylcysteine reduced the effect of ethanol on antioxidant system in rat plasma and brain tissue
    • Aydin S., Ozaras R., Uzun H., Belce A., Uslu E., Tahan V., et al. N-acetylcysteine reduced the effect of ethanol on antioxidant system in rat plasma and brain tissue. Tohoku J Exp Med 198 (2002) 71-77
    • (2002) Tohoku J Exp Med , vol.198 , pp. 71-77
    • Aydin, S.1    Ozaras, R.2    Uzun, H.3    Belce, A.4    Uslu, E.5    Tahan, V.6
  • 15
    • 0142185297 scopus 로고    scopus 로고
    • Reversal of cadmium induced oxidative stress by chelating agent, antioxidant or their combination in rat
    • Tandon S.K., Singh S., Prasad S., Khandekar K., Dwivedi V.K., Chatterjee M., et al. Reversal of cadmium induced oxidative stress by chelating agent, antioxidant or their combination in rat. Toxicol Lett 145 (2003) 211-217
    • (2003) Toxicol Lett , vol.145 , pp. 211-217
    • Tandon, S.K.1    Singh, S.2    Prasad, S.3    Khandekar, K.4    Dwivedi, V.K.5    Chatterjee, M.6
  • 16
    • 0029996841 scopus 로고    scopus 로고
    • In vivo indices of oxidative stress in lead-exposed C57BL/6 mice are reduced by treatment with meso-2,3-dimercaptosuccinic acid or N-acetylcysteine
    • Ercal N., Treeratphan P., Hammond T.C., Matthews R.H., Grannemann N.H., and Spitz D.R. In vivo indices of oxidative stress in lead-exposed C57BL/6 mice are reduced by treatment with meso-2,3-dimercaptosuccinic acid or N-acetylcysteine. Free Radic Biol Med 21 (1996) 157-161
    • (1996) Free Radic Biol Med , vol.21 , pp. 157-161
    • Ercal, N.1    Treeratphan, P.2    Hammond, T.C.3    Matthews, R.H.4    Grannemann, N.H.5    Spitz, D.R.6
  • 17
    • 0032693563 scopus 로고    scopus 로고
    • Arsenic-induced oxidative stress and its reversibility following combined administration of N-acetylcysteine and meso 2,3-dimercaptosuccinic acid in rats
    • Flora S.J. Arsenic-induced oxidative stress and its reversibility following combined administration of N-acetylcysteine and meso 2,3-dimercaptosuccinic acid in rats. Clin Exp Pharmacol Physiol 26 (1999) 865-869
    • (1999) Clin Exp Pharmacol Physiol , vol.26 , pp. 865-869
    • Flora, S.J.1
  • 18
    • 33645709875 scopus 로고    scopus 로고
    • Carbofuran-induced neurochemical and neurobehavioral alterations in rats: Attenuation by N-acetylcysteine
    • Kamboj A., Kiran R., and Sandhir R. Carbofuran-induced neurochemical and neurobehavioral alterations in rats: Attenuation by N-acetylcysteine. Exp Brain Res 170 (2006) 567-575
    • (2006) Exp Brain Res , vol.170 , pp. 567-575
    • Kamboj, A.1    Kiran, R.2    Sandhir, R.3
  • 19
    • 0034601439 scopus 로고    scopus 로고
    • N-acetyl-L-cysteine improves survival and preserves motor performance in an animal model of familial amyotrophic lateral sclerosis
    • Andreassen O.A., Dedeoglu A., Klivenyi P., Beal M.F., and Bush A.I. N-acetyl-L-cysteine improves survival and preserves motor performance in an animal model of familial amyotrophic lateral sclerosis. Neuroreport 11 (2000) 2491-2493
    • (2000) Neuroreport , vol.11 , pp. 2491-2493
    • Andreassen, O.A.1    Dedeoglu, A.2    Klivenyi, P.3    Beal, M.F.4    Bush, A.I.5
  • 20
    • 0028916027 scopus 로고
    • N-acetylcysteine (D- and L-stereoisomers) prevents apoptotic death of neuronal cells
    • Ferrari G., Yan C.Y., and Greene L.A. N-acetylcysteine (D- and L-stereoisomers) prevents apoptotic death of neuronal cells. J Neurosci 15 (1995) 2857-2866
    • (1995) J Neurosci , vol.15 , pp. 2857-2866
    • Ferrari, G.1    Yan, C.Y.2    Greene, L.A.3
  • 21
    • 0033043959 scopus 로고    scopus 로고
    • In vivo modulation of rodent glutathione and its role in peroxynitrite-induced neocortical synaptosomal membrane protein damage
    • Koppal T., Drake J., and Butterfield D.A. In vivo modulation of rodent glutathione and its role in peroxynitrite-induced neocortical synaptosomal membrane protein damage. Biochim Biophys Acta 1453 (1999) 407-411
    • (1999) Biochim Biophys Acta , vol.1453 , pp. 407-411
    • Koppal, T.1    Drake, J.2    Butterfield, D.A.3
  • 22
    • 0028169881 scopus 로고
    • N-acetyl-L-cysteine is a pluripotent protector against cell death and enhancer of trophic factor-mediated cell survival in vitro
    • Mayer M., and Noble M. N-acetyl-L-cysteine is a pluripotent protector against cell death and enhancer of trophic factor-mediated cell survival in vitro. Proc Natl Acad Sci U S A 91 (1994) 7496-7500
    • (1994) Proc Natl Acad Sci U S A , vol.91 , pp. 7496-7500
    • Mayer, M.1    Noble, M.2
  • 23
    • 0029175712 scopus 로고
    • Redox regulation of activation of NF-kappa B transcription factor complex: Effects of N-acetylcysteine
    • Staal F.J., Anderson M.T., and Herzenberg L.A. Redox regulation of activation of NF-kappa B transcription factor complex: Effects of N-acetylcysteine. Meth Enzymol 252 (1995) 168-174
    • (1995) Meth Enzymol , vol.252 , pp. 168-174
    • Staal, F.J.1    Anderson, M.T.2    Herzenberg, L.A.3
  • 24
    • 0037132035 scopus 로고    scopus 로고
    • Randomisation in clinical trials
    • Beller E.M., Gebski V., and Keech A.C. Randomisation in clinical trials. Med J Aust 177 (2002) 565-567
    • (2002) Med J Aust , vol.177 , pp. 565-567
    • Beller, E.M.1    Gebski, V.2    Keech, A.C.3
  • 27
    • 0036014536 scopus 로고    scopus 로고
    • Intracellular glutathione and bronchoalveolar cells in fibrosing alveolitis: Effects of N-acetylcysteine
    • Behr J., Degenkolb B., Krombach F., and Vogelmeier C. Intracellular glutathione and bronchoalveolar cells in fibrosing alveolitis: Effects of N-acetylcysteine. Eur Respir J 19 (2002) 906-911
    • (2002) Eur Respir J , vol.19 , pp. 906-911
    • Behr, J.1    Degenkolb, B.2    Krombach, F.3    Vogelmeier, C.4
  • 28
    • 0035940625 scopus 로고    scopus 로고
    • Controlled trial of N-acetylcysteine for patients with probable Alzheimer's disease
    • Adair J.C., Knoefel J.E., and Morgan N. Controlled trial of N-acetylcysteine for patients with probable Alzheimer's disease. Neurology 57 (2001) 1515-1517
    • (2001) Neurology , vol.57 , pp. 1515-1517
    • Adair, J.C.1    Knoefel, J.E.2    Morgan, N.3
  • 29
    • 0004235298 scopus 로고
    • American Psychiatric Association, American Psychiatric Association, Washington, DC
    • American Psychiatric Association. Diagnostic and Statistical Manual of Mental Disorders. 4th ed. (1994), American Psychiatric Association, Washington, DC
    • (1994) Diagnostic and Statistical Manual of Mental Disorders. 4th ed.
  • 30
    • 0035146030 scopus 로고    scopus 로고
    • Risk factors in the development of adverse reactions to N-acetylcysteine in patients with paracetamol poisoning
    • Schmidt L.E., and Dalhoff K. Risk factors in the development of adverse reactions to N-acetylcysteine in patients with paracetamol poisoning. Br J Clin Pharmacol 51 (2001) 87-91
    • (2001) Br J Clin Pharmacol , vol.51 , pp. 87-91
    • Schmidt, L.E.1    Dalhoff, K.2
  • 31
    • 48949117907 scopus 로고    scopus 로고
    • Glutathione precursor, N-acetyl-cysteine, improves mismatch negativity in schizophrenia patients
    • [published online ahead of print November 14, 2007]
    • Lavoie S., Murray M.M., Deppen P., Knyazeva M.G., Berk M., Boulat O., et al. Glutathione precursor, N-acetyl-cysteine, improves mismatch negativity in schizophrenia patients. [published online ahead of print November 14, 2007]. Neuropsychopharmacology (2007)
    • (2007) Neuropsychopharmacology
    • Lavoie, S.1    Murray, M.M.2    Deppen, P.3    Knyazeva, M.G.4    Berk, M.5    Boulat, O.6
  • 32
  • 33
    • 0038266756 scopus 로고    scopus 로고
    • Chlorpromazine equivalent doses for the newer atypical antipsychotics
    • Woods S.W. Chlorpromazine equivalent doses for the newer atypical antipsychotics. J Clin Psychiatry 64 (2003) 663-667
    • (2003) J Clin Psychiatry , vol.64 , pp. 663-667
    • Woods, S.W.1
  • 34
    • 50849139232 scopus 로고    scopus 로고
    • Oxidative stress in psychiatric disorders: Evidence base and therapeutic implications
    • [published online ahead of print January 21, 2008]
    • Ng F., Berk M., Dean O., and Bush A.I. Oxidative stress in psychiatric disorders: Evidence base and therapeutic implications. [published online ahead of print January 21, 2008]. Int J Neuropsychopharmacol (2008)
    • (2008) Int J Neuropsychopharmacol
    • Ng, F.1    Berk, M.2    Dean, O.3    Bush, A.I.4
  • 36
    • 33646479818 scopus 로고    scopus 로고
    • Elevated serum superoxide dismutase and thiobarbituric acid reactive substances in schizophrenia: A study of patients treated with haloperidol or clozapine
    • Gama C.S., Salvador M., Andreazza A.C., Kapczinski F., and Silva Belmonte-de-Abreu P. Elevated serum superoxide dismutase and thiobarbituric acid reactive substances in schizophrenia: A study of patients treated with haloperidol or clozapine. Prog Neuropsychopharmacol Biol Psychiatry 30 (2006) 512-515
    • (2006) Prog Neuropsychopharmacol Biol Psychiatry , vol.30 , pp. 512-515
    • Gama, C.S.1    Salvador, M.2    Andreazza, A.C.3    Kapczinski, F.4    Silva Belmonte-de-Abreu, P.5
  • 37
    • 38949159129 scopus 로고    scopus 로고
    • Effect of chronic N-acetylcysteine administration on oxidative status in the presence and absence of induced oxidative stress in rat striatum
    • Harvey B.H., Joubert C., du Preez J.L., and Berk M. Effect of chronic N-acetylcysteine administration on oxidative status in the presence and absence of induced oxidative stress in rat striatum. Neurochem Res 33 (2008) 508-517
    • (2008) Neurochem Res , vol.33 , pp. 508-517
    • Harvey, B.H.1    Joubert, C.2    du Preez, J.L.3    Berk, M.4
  • 38
    • 36848999339 scopus 로고    scopus 로고
    • Ketamine-induced loss of phenotype of fast-spiking interneurons is mediated by NADPH-oxidase
    • Behrens M.M., Ali S.S., Dao D.N., Lucero J., Shekhtman G., Quick K.L., et al. Ketamine-induced loss of phenotype of fast-spiking interneurons is mediated by NADPH-oxidase. Science 318 (2007) 1645-1647
    • (2007) Science , vol.318 , pp. 1645-1647
    • Behrens, M.M.1    Ali, S.S.2    Dao, D.N.3    Lucero, J.4    Shekhtman, G.5    Quick, K.L.6
  • 39
    • 0034672943 scopus 로고    scopus 로고
    • Metabolism and functions of glutathione in brain
    • Dringen R. Metabolism and functions of glutathione in brain. Prog Neurobiol 62 (2000) 649-671
    • (2000) Prog Neurobiol , vol.62 , pp. 649-671
    • Dringen, R.1
  • 40
    • 48749083778 scopus 로고    scopus 로고
    • Contribution of cystine-glutamate antiporters to the psychotomimetic effects of phencyclidine
    • [published online ahead of print August 29, 2007]
    • Baker D.A., Madayag A., Kristiansen L.V., Meador-Woodruff J.H., Haroutunian V., and Raju I. Contribution of cystine-glutamate antiporters to the psychotomimetic effects of phencyclidine. [published online ahead of print August 29, 2007]. Neuropsychopharmacology (2007)
    • (2007) Neuropsychopharmacology
    • Baker, D.A.1    Madayag, A.2    Kristiansen, L.V.3    Meador-Woodruff, J.H.4    Haroutunian, V.5    Raju, I.6
  • 41
    • 0037783989 scopus 로고    scopus 로고
    • Supplementation with a combination of omega-3 fatty acids and antioxidants (vitamins E and C) improves the outcome of schizophrenia
    • Arvindakshan M., Ghate M., Ranjekar P.K., Evans D.R., and Mahadik S.P. Supplementation with a combination of omega-3 fatty acids and antioxidants (vitamins E and C) improves the outcome of schizophrenia. Schizophr Res 62 (2003) 195-204
    • (2003) Schizophr Res , vol.62 , pp. 195-204
    • Arvindakshan, M.1    Ghate, M.2    Ranjekar, P.K.3    Evans, D.R.4    Mahadik, S.P.5
  • 42
    • 26844535408 scopus 로고    scopus 로고
    • Supplementation of vitamin C with atypical antipsychotics reduces oxidative stress and improves the outcome of schizophrenia
    • Dakhale G.N., Khanzode S.D., Khanzode S.S., and Saoji A. Supplementation of vitamin C with atypical antipsychotics reduces oxidative stress and improves the outcome of schizophrenia. Psychopharmacology (Berl) 182 (2005) 494-498
    • (2005) Psychopharmacology (Berl) , vol.182 , pp. 494-498
    • Dakhale, G.N.1    Khanzode, S.D.2    Khanzode, S.S.3    Saoji, A.4
  • 43
    • 0038636003 scopus 로고    scopus 로고
    • Glutathione pathways in the brain
    • Dringen R., and Hirrlinger J. Glutathione pathways in the brain. Biol Chem 384 (2003) 505-516
    • (2003) Biol Chem , vol.384 , pp. 505-516
    • Dringen, R.1    Hirrlinger, J.2
  • 44
    • 0033787297 scopus 로고    scopus 로고
    • Schizophrenia: Glutathione deficit in cerebrospinal fluid and prefrontal cortex in vivo
    • Do K.Q., Trabensinger M.K., Lauer C.J., Dydak U., Hell D., Holsboer F., et al. Schizophrenia: Glutathione deficit in cerebrospinal fluid and prefrontal cortex in vivo. Eur J Neurosci 12 (2000) 3721-3728
    • (2000) Eur J Neurosci , vol.12 , pp. 3721-3728
    • Do, K.Q.1    Trabensinger, M.K.2    Lauer, C.J.3    Dydak, U.4    Hell, D.5    Holsboer, F.6


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