Synthesis of triphenylphosphonium Vitamin E derivatives as mitochondria-targeted antioxidants

Tetrahedron

Volumn 71, Issue 44, 2015, Pages 8444-8453

  Jameson, Victoria J A ^a   Cochemé, Helena M ^b,c   Logan, Angela ^c   Hanton, Lyall R ^a   Smith, Robin A J ^a   Murphy, Michael P ^c  

^a UNIVERSITY OF OTAGO   (New Zealand)

^b IMPERIAL COLLEGE LONDON   (United Kingdom)

^c UNIVERSITY OF CAMBRIDGE   (United Kingdom)

Author keywords

Lipid peroxidation; Mitochondria; Mitochondria targeted antioxidant; MitoE; Vitamin E

Indexed keywords

(10 (6 HYDROXY 2,5,7,8 TETRAMETHYL CHROMAN 2 YL) DECYL)TRIPHENYLPHOSPHONIUM METHANESULFONATE; (11 (6 HYDROXY 2,5,7,8 TETRAMETHYL CHROMAN 2 YL) UNDECYL)TRIPHENYLPHOSPHONIUM METHANESULFONATE; (2 (6 (METHANESULFONYLOXY) 2,5,7,8 TETRAMETHYL 2H CHROMEN 2 YL)ETHYL)TRIPHENYL PHOSPHONIUM; (2 (6 HYDROXY 2,5,7,8 TETRAMETHYL CHROMEN 2 YL)ETHYL)TRIPHENYLPHOSPHONIUM METHANESULFONATE; (4 (6 HYDROXY 2,5,7,8 TETRAMETHYL CHROMAN 2 YL) BUTYL)TRIPHENYLPHOSPHONIUM METHANESULFONATE; (4 (6 METHANESULFONYLOXY 2,5,7,8 TETRAMETHYL CHROMEN 2 YL)BUTYL)TRIPHENYL PHOSPHONIUM METHANESULFONATE; (6 (6 HYDROXY 2,5,7,8 TETRAMETHYL CHROMAN 2 YL) HEXYL)TRIPHENYL PHOSPHONIUM METHANESULFONATE; (6 (6 METHANESULFONYLOXY 2,5,7,8 TETRAMETHYL CHROMEN 2 YL)HEXYL)TRIPHENYLSPHOSPHONIUM METHANESULFONATE; 2 (4 HYDROXYBUTYL) 2,5,7,8 TETRAMETHYL CHROMEN 6 OL; 2 (6 (METHANESULFONYLOXY) 2,5,7,8 TETRAMETHYLCHROMEN 2 YL)ETHYL METHANESULFONATE; 2 (6 HYDROXYHEXYL) 2,5,7,8 TETRAMETHYL CHROMEN 6 OL; 3,7 DIHYDROXY 3 METHYL HEPT 1 ENE; 4 (6 METHANESULFONYLOXY 2,5,7,8 TETRAMETHYL CHROMEN 2 YL)BUTYL METHANESULFONATE; 4 (6 METHANESULFONYLOXY 2,5,7,8 TETRAMETHYL CHROMEN 2 YL)HEXYL METHANESULFONATE; 5 (TETRAHYDRO 2H PYRAN 2 YLOXY) 3 HYDROXY 3 METHYL PENT 1 ENE; 9 (TETRAHYDRO 2H PYRAN 2 YLOXY) 3 HYDROXY 3 METHYL NON 1 ENE; ALKYL GROUP; ALPHA TOCOPHEROL DERIVATIVE; ANTIOXIDANT; TRIPHENYLPHOSPHONIUM VITAMIN E DERIVATIVE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ANTIOXIDANT ACTIVITY; ARTICLE; BRAIN HOMOGENATE; CARBON NUCLEAR MAGNETIC RESONANCE; DRUG STRUCTURE; DRUG SYNTHESIS; HYDROPHOBICITY; LIPID PEROXIDATION; LIVER MITOCHONDRION; MITOCHONDRION; NONHUMAN; PRIORITY JOURNAL; PROTON NUCLEAR MAGNETIC RESONANCE; RAT; THIN LAYER CHROMATOGRAPHY; X RAY DIFFRACTION;

EID: 84942836209     PISSN: 00404020     EISSN: 14645416     Source Type: Journal    
DOI: 10.1016/j.tet.2015.09.014     Document Type: Article

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