Evaluation of the Catalytic Contribution from a Positioned General Base in Ketosteroid Isomerase

Journal of the American Chemical Society

Volumn 138, Issue 31, 2016, Pages 9902-9909

  Lamba, Vandana ^a   Yabukarski, Filip ^a   Pinney, Margaux ^a   Herschlag, Daniel ^a,b  

^a STANFORD UNIVERSITY   (United States)

^b Stanford University   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BACTERIA; BINDING ENERGY; CARBOXYLATION; PROTON TRANSFER;

ACTIVE SITE RESIDUES; CATALYTIC MECHANISMS; COMAMONAS TESTOSTERONI; KETOSTEROID ISOMERASE; PROTON TRANSFER REACTIONS; SITE DIRECTED MUTAGENESIS; STRUCTURAL REARRANGEMENT; X RAY CRYSTAL STRUCTURES;

CRYSTAL STRUCTURE;

BASE; CARBOXYLIC ACID; STEROID DELTA ISOMERASE; ASPARTIC ACID; CARBON; ISOMERASE; OXOSTEROID;

ARTICLE; CATALYST; COMAMONAS TESTOSTERONI; CONSENSUS; CRYSTAL STRUCTURE; EVALUATION STUDY; PSEUDOMONAS PUTIDA; STEREOSPECIFICITY; BINDING SITE; CATALYSIS; CHEMISTRY; ENZYME ACTIVE SITE; ENZYMOLOGY; HYDROGEN BOND; KINETICS; METABOLISM; MUTATION; PH; SITE DIRECTED MUTAGENESIS; X RAY CRYSTALLOGRAPHY;

ASPARTIC ACID; BINDING SITES; CARBON; CATALYSIS; CATALYTIC DOMAIN; COMAMONAS TESTOSTERONI; CRYSTALLOGRAPHY, X-RAY; HYDROGEN BONDING; HYDROGEN-ION CONCENTRATION; ISOMERASES; KETOSTEROIDS; KINETICS; MUTAGENESIS, SITE-DIRECTED; MUTATION; PSEUDOMONAS PUTIDA; STEROID ISOMERASES;

EID: 84981516779     PISSN: 00027863     EISSN: 15205126     Source Type: Journal    
DOI: 10.1021/jacs.6b04796     Document Type: Article

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