NSC23766, a known inhibitor of Tiam1-Rac1 signaling module, prevents the onset of type 1 diabetes in the NOD mouse model

Cellular Physiology and Biochemistry

Volumn 39, Issue 2, 2016, Pages 760-767

  Veluthakal, Rajakrishnan ^a   Sidarala, Vaibhav ^b   Kowluru, Anjaneyulu ^b  

^a CITY OF HOPE NATIONAL MEDICAL CENTER   (United States)

^b WAYNE STATE UNIVERSITY   (United States)

Author keywords

Diabetes; ER stress; NOD mice; Nox2; Pancreatic islet; Rac1

Indexed keywords

4 AMINO 6 [2 [[4 (DIETHYLAMINO) 1 METHYLBUTYL]AMINO] 6 METHYL 4 PYRIMIDINYL] 2 METHYLQUINOLINE; GLUCOSE; GROWTH ARREST AND DNA DAMAGE INDUCIBLE PROTEIN 153; RAC1 PROTEIN; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE 2; AMINOQUINOLINE DERIVATIVE; CYBB PROTEIN, MOUSE; DDIT3 PROTEIN, MOUSE; GLUCOSE BLOOD LEVEL; GUANINE NUCLEOTIDE EXCHANGE FACTOR; MEMBRANE PROTEIN; NEUROPEPTIDE; PYRIMIDINE DERIVATIVE; RAC1 PROTEIN, MOUSE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE; TIAM1 PROTEIN, MOUSE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIDIABETIC ACTIVITY; ARTICLE; BLOOD GLUCOSE MONITORING; BODY WEIGHT; CONTROLLED STUDY; ENDOPLASMIC RETICULUM STRESS; GLUCOSE BLOOD LEVEL; IN VITRO STUDY; INSULIN DEPENDENT DIABETES MELLITUS; MOUSE; NONHUMAN; NONOBESE DIABETIC MOUSE; OXIDATIVE STRESS; PANCREAS ISLET; PANCREAS ISLET BETA CELL; PRIORITY JOURNAL; PROTEIN EXPRESSION; ANIMAL; BAGG ALBINO MOUSE; BLOOD; DIABETES MELLITUS, TYPE 1; DISEASE MODEL; DRUG EFFECTS; METABOLISM; SIGNAL TRANSDUCTION; SPECIES DIFFERENCE; WESTERN BLOTTING;

AMINOQUINOLINES; ANIMALS; BLOOD GLUCOSE; BLOTTING, WESTERN; BODY WEIGHT; DIABETES MELLITUS, TYPE 1; DISEASE MODELS, ANIMAL; GUANINE NUCLEOTIDE EXCHANGE FACTORS; ISLETS OF LANGERHANS; MEMBRANE GLYCOPROTEINS; MICE, INBRED BALB C; MICE, INBRED NOD; NADPH OXIDASE; NEUROPEPTIDES; PYRIMIDINES; RAC1 GTP-BINDING PROTEIN; SIGNAL TRANSDUCTION; SPECIES SPECIFICITY; TRANSCRIPTION FACTOR CHOP;

EID: 84981333217     PISSN: 10158987     EISSN: 14219778     Source Type: Journal    
DOI: 10.1159/000445666     Document Type: Article

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