VAV2, a guanine nucleotide exchange factor for Rac1, regulates glucose-stimulated insulin secretion in pancreatic beta cells

Diabetologia

Volumn 58, Issue 11, 2015, Pages 2573-2581

  Veluthakal, Rajakrishnan ^a,c   Tunduguru, Ragadeepthi ^c   Arora, Daleep Kumar ^d   Sidarala, Vaibhav ^a,b   Syeda, Khadija ^a,b   Vlaar, Cornelis P ^e   Thurmond, Debbie C ^c   Kowluru, Anjaneyulu ^a,b  

^a VETERANS AFFAIRS MEDICAL CENTER   (United States)

^b WAYNE STATE UNIVERSITY   (United States)

^c INDIANA UNIVERSITY SCHOOL OF MEDICINE   (United States)

^d OKLAHOMA MEDICAL RESEARCH FOUNDATION   (United States)

^e UNIVERSITY OF PUERTO RICO   (Puerto Rico)

Author keywords

Cytoskeleton; Insulin secretion; Pancreatic islet; Rac1; VAV2

Indexed keywords

2,3 DIHYDRO 2 OXO 3 (4,5,6,7 TETRAHYDRO 1H INDOL 2 YLMETHYLENE) 1H INDOLE 5 SULFONIC ACID DIMETHYLAMIDE; GLUCOSE; GUANINE NUCLEOTIDE BINDING PROTEIN; GUANINE NUCLEOTIDE EXCHANGE FACTOR; GUANINE NUCLEOTIDE EXCHANGE FACTOR VAV2; INSULIN; RAC1 PROTEIN; SMALL INTERFERING RNA; TRITON X 114; UNCLASSIFIED DRUG; ACTIN; VAV PROTEIN; VAV2 PROTEIN, HUMAN;

ANIMAL CELL; ARTICLE; CELLS BY BODY ANATOMY; CONFOCAL MICROSCOPY; CONTROLLED STUDY; ENZYME LINKED IMMUNOSORBENT ASSAY; GLUCOSE STIMULATED INSULIN SECRETION; HUMAN; HUMAN CELL; IMMUNOFLUORESCENCE TEST; INSULIN RELEASE; NONHUMAN; PANCREAS ISLET BETA CELL; PHASE PARTITIONING; PRIORITY JOURNAL; PROTEIN LOCALIZATION; PROTEIN PHOSPHORYLATION; RAT; STIMULATION; WESTERN BLOTTING; ANIMAL; CELL LINE; CYTOSKELETON; DRUG EFFECT; GENETICS; MALE; METABOLISM; SPRAGUE DAWLEY RAT;

ACTINS; ANIMALS; CELL LINE; CYTOSKELETON; GLUCOSE; HUMANS; INSULIN; INSULIN SECRETION; INSULIN-SECRETING CELLS; MALE; PROTO-ONCOGENE PROTEINS C-VAV; RAC1 GTP-BINDING PROTEIN; RATS; RATS, SPRAGUE-DAWLEY; RNA, SMALL INTERFERING;

EID: 84942990893     PISSN: 0012186X     EISSN: 14320428     Source Type: Journal    
DOI: 10.1007/s00125-015-3707-4     Document Type: Article

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