Tiam1-rac1 axis promotes activation of p38 MAP kinase in the development of diabetic retinopathy: Evidence for a requisite role for protein palmitoylation

Cellular Physiology and Biochemistry

Volumn 36, Issue 1, 2015, Pages 208-220

  Veluthakal, Rajakrishnan ^a   Kumar, Binit ^a   Mohammad, Ghulam ^a   Kowluru, Anjaneyulu ^b,c   Kowluru, Renu A ^a  

^a Ophthalmology   (United States)

^b WAYNE STATE UNIVERSITY   (United States)

^c VETERANS AFFAIRS MEDICAL CENTER   (United States)

Author keywords

2 bromopalmitate; Nox2; NSC23766; p38 MAP kinase; Rac1; Retinopathy; Tiam1 and Diabetic

Indexed keywords

2 BROMOPALMITIC ACID; 4 AMINO 6 [2 [[4 (DIETHYLAMINO) 1 METHYLBUTYL]AMINO] 6 METHYL 4 PYRIMIDINYL] 2 METHYLQUINOLINE; GUANINE NUCLEOTIDE BINDING PROTEIN; MITOCHONDRIAL DNA; MITOGEN ACTIVATED PROTEIN KINASE P38; PROTEIN; RAC1 PROTEIN; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE 2; TIAM1 PROTEIN; UNCLASSIFIED DRUG; 2-BROMOPALMITATE; AMINOQUINOLINE DERIVATIVE; GLUCOSE; GUANINE NUCLEOTIDE EXCHANGE FACTOR; NEUROPEPTIDE; PALMITIC ACID DERIVATIVE; PYRIMIDINE DERIVATIVE; RAC1 PROTEIN, MOUSE; TIAM1 PROTEIN, MOUSE;

ANIMAL EXPERIMENT; ANIMAL MODEL; APOPTOSIS; ARTICLE; COMPARATIVE STUDY; CONTROLLED STUDY; DIABETIC RETINOPATHY; DNA DAMAGE; ENDOTHELIUM CELL; ENZYME ACTIVATION; HYPERGLYCEMIA; IMMUNOHISTOCHEMISTRY; MALE; METABOLIC STRESS; MOLECULAR WEIGHT; MOUSE; NONHUMAN; PALMITOYLATION; PRIORITY JOURNAL; PROTEIN MODIFICATION; PROTEIN PROCESSING; RETINA CELL; SIGNAL TRANSDUCTION; WESTERN BLOTTING; ANIMAL; BOVINE; CELL CULTURE; COMPLICATION; CYTOLOGY; DRUG EFFECTS; EXPERIMENTAL DIABETES MELLITUS; LIPOYLATION; METABOLISM; PATHOLOGY; RETINA;

MUS;

AMINOQUINOLINES; ANIMALS; APOPTOSIS; CATTLE; CELLS, CULTURED; DIABETES MELLITUS, EXPERIMENTAL; DIABETIC RETINOPATHY; ENDOTHELIAL CELLS; GLUCOSE; GUANINE NUCLEOTIDE EXCHANGE FACTORS; LIPOYLATION; MALE; MICE; NEUROPEPTIDES; P38 MITOGEN-ACTIVATED PROTEIN KINASES; PALMITATES; PYRIMIDINES; RAC1 GTP-BINDING PROTEIN; RETINA; SIGNAL TRANSDUCTION;

EID: 84929931841     PISSN: 10158987     EISSN: 14219778     Source Type: Journal    
DOI: 10.1159/000374065     Document Type: Article

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