Phagocyte-like NADPH oxidase (Nox2) promotes activation of p38MAPK in pancreatic β-cells under glucotoxic conditions: Evidence for a requisite role of Ras-related C3 botulinum toxin substrate 1 (Rac1)

Biochemical Pharmacology

Volumn 95, Issue 4, 2015, Pages 301-310

  Sidarala, Vaibhav ^a   Veluthakal, Rajakrishnan ^a   Syeda, Khadija ^a   Vlaar, Cornelis ^b   Newsholme, Philip ^c   Kowluru, Anjaneyulu ^a  

^a WAYNE STATE UNIVERSITY   (United States)

^b UNIVERSITY OF PUERTO RICO SCHOOL OF MEDICINE   (Puerto Rico)

^c CURTIN UNIVERSITY   (Australia)

Author keywords

Diabetes; Glucotoxicity; p38MAPK; Pancreatic islet cell; Rac1

Indexed keywords

2 BROMOPALMITIC ACID; 4 AMINO 6 [2 [[4 (DIETHYLAMINO) 1 METHYLBUTYL]AMINO] 6 METHYL 4 PYRIMIDINYL] 2 METHYLQUINOLINE; EHOP 016; EHT 1864; GGTI 2147; GLUCOSE; MITOGEN ACTIVATED PROTEIN KINASE P38; OXIDOREDUCTASE INHIBITOR; PEPTIDE; PROTEIN INHIBITOR; RAC1 PROTEIN; REACTIVE OXYGEN METABOLITE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE 2; UNCLASSIFIED DRUG; CYBB PROTEIN, RAT; GUANOSINE DIPHOSPHATE; GUANOSINE TRIPHOSPHATE; MEMBRANE PROTEIN; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE;

ANIMAL CELL; ARTICLE; CONTROLLED STUDY; DIABETOGENESIS; ENZYME ACTIVATION; ENZYME INHIBITION; ENZYME PHOSPHORYLATION; EXPERIMENTAL MODEL; GLUCOTOXICITY; INSULIN RELEASE; MALE; NONHUMAN; PALMITOYLATION; PANCREAS ISLET BETA CELL; PRIORITY JOURNAL; RAT; REGULATORY MECHANISM; SIGNAL TRANSDUCTION; ANIMAL; ANTAGONISTS AND INHIBITORS; APOPTOSIS; CELL LINE; CYTOLOGY; DRUG EFFECTS; METABOLISM; PROTEIN PRENYLATION; SPRAGUE DAWLEY RAT;

ANIMALS; APOPTOSIS; CELL LINE; ENZYME ACTIVATION; GLUCOSE; GUANOSINE DIPHOSPHATE; GUANOSINE TRIPHOSPHATE; INSULIN-SECRETING CELLS; MALE; MEMBRANE GLYCOPROTEINS; NADPH OXIDASE; P38 MITOGEN-ACTIVATED PROTEIN KINASES; PROTEIN PRENYLATION; RAC1 GTP-BINDING PROTEIN; RATS, SPRAGUE-DAWLEY; REACTIVE OXYGEN SPECIES; SIGNAL TRANSDUCTION;

EID: 84929712201     PISSN: 00062952     EISSN: 18732968     Source Type: Journal    
DOI: 10.1016/j.bcp.2015.04.001     Document Type: Article

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