TIAM1-RAC1 signalling axis-mediated activation of NADPH oxidase-2 initiates mitochondrial damage in the development of diabetic retinopathy

Diabetologia

Volumn 57, Issue 5, 2014, Pages 1047-1056

  Kowluru, Renu A ^a   Kowluru, Anjaneyulu ^a,b   Veluthakal, Rajakrishnan ^a   Mohammad, Ghulam ^a,c   Syed, Ismail ^a,d   Santos, Julia M ^a   Mishra, Manish ^a  

^a WAYNE STATE UNIVERSITY   (United States)

^b VETERANS AFFAIRS MEDICAL CENTER   (United States)

^c KING SAUD UNIVERSITY   (Saudi Arabia)

^d BETH ISRAEL DEACONESS MEDICAL CENTER   (United States)

Author keywords

Diabetic retinopathy; Mitochondrial dysfunction; NOX2; RAC1; TIAM1

Indexed keywords

4 AMINO 6 [2 [[4 (DIETHYLAMINO) 1 METHYLBUTYL]AMINO] 6 METHYL 4 PYRIMIDINYL] 2 METHYLQUINOLINE; GLUCOSE; GUANINE NUCLEOTIDE EXCHANGE FACTOR; MITOCHONDRIAL DNA; RAC1 PROTEIN; REACTIVE OXYGEN METABOLITE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE 2; T CELL LYMPHOMA INVASION AND METASTASIS PROTEIN; UNCLASSIFIED DRUG; AMINOQUINOLINE DERIVATIVE; CYBB PROTEIN, HUMAN; CYBB PROTEIN, MOUSE; CYBB PROTEIN, RAT; MEMBRANE PROTEIN; NEUROPEPTIDE; PYRIMIDINE DERIVATIVE; RAC1 PROTEIN, HUMAN; RAC1 PROTEIN, MOUSE; RAC1 PROTEIN, RAT; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE; TIAM1 PROTEIN, HUMAN; TIAM1 PROTEIN, MOUSE; TIAM1 PROTEIN, RAT; TUMOR PROTEIN;

ADULT; AGED; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CATTLE; CONTROLLED STUDY; DIABETIC RETINOPATHY; DNA DAMAGE; ENDOTHELIUM CELL; ENZYME ACTIVATION; HUMAN; HUMAN TISSUE; IN VITRO STUDY; IN VIVO STUDY; MALE; MIDDLE AGED; MITOCHONDRION; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; RETINA BLOOD VESSEL; SIGNAL TRANSDUCTION; STREPTOZOTOCIN-INDUCED DIABETES MELLITUS; ANIMAL; BOVINAE; CHEMISTRY; CYTOLOGY; DIABETES MELLITUS; ENZYMOLOGY; EXPERIMENTAL DIABETES MELLITUS; METABOLISM; MICROCIRCULATION; WISTAR RAT;

AGED; AMINOQUINOLINES; ANIMALS; APOPTOSIS; CATTLE; DIABETES MELLITUS; DIABETES MELLITUS, EXPERIMENTAL; DIABETIC RETINOPATHY; ENDOTHELIAL CELLS; ENZYME ACTIVATION; GUANINE NUCLEOTIDE EXCHANGE FACTORS; HUMANS; MALE; MEMBRANE GLYCOPROTEINS; MICE; MICROCIRCULATION; MIDDLE AGED; MITOCHONDRIA; NADPH OXIDASE; NEOPLASM PROTEINS; NEUROPEPTIDES; PYRIMIDINES; RAC1 GTP-BINDING PROTEIN; RATS; RATS, WISTAR; REACTIVE OXYGEN SPECIES; SIGNAL TRANSDUCTION;

EID: 84898598807     PISSN: 0012186X     EISSN: 14320428     Source Type: Journal    
DOI: 10.1007/s00125-014-3194-z     Document Type: Article

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