Phagocyte-like NADPH oxidase promotes cytokine-induced mitochondrial dysfunction in pancreatic β-cells: Evidence for regulation by Rac1

American Journal of Physiology - Regulatory Integrative and Comparative Physiology

Volumn 300, Issue 1, 2011, Pages

  Subasinghe, Wasanthi ^a,b   Syed, Ismail ^a,b   Kowluru, Anjaneyulu ^a,b  

^a WAYNE STATE UNIVERSITY   (United States)

^b VETERANS AFFAIRS MEDICAL CENTER   (United States)

Author keywords

Geranylgeranylation; Metastasis 1; Mitochondrial membrane potential; Pancreatic cell; T lymphoma invasion

Indexed keywords

4 AMINO 6 [2 [[4 (DIETHYLAMINO) 1 METHYLBUTYL]AMINO] 6 METHYL 4 PYRIMIDINYL] 2 METHYLQUINOLINE; APOCYNIN; CASPASE 3; GAMMA INTERFERON; GGTI 2147; INTERLEUKIN 1BETA; PHAGOCYTE LIKE REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE; RAC1 PROTEIN; REACTIVE OXYGEN METABOLITE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE; SMALL INTERFERING RNA; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG;

ARTICLE; CYTOKINE PRODUCTION; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME INDUCTION; GENETIC TRANSFECTION; INSULIN SYNTHESIS; MITOCHONDRIAL MEMBRANE POTENTIAL; MITOCHONDRION; PANCREAS ISLET BETA CELL; PANCREAS ISLET CELL FUNCTION; PHAGOCYTE; PRIORITY JOURNAL; SIGNAL TRANSDUCTION;

AMINOQUINOLINES; ANIMALS; CELL LINE; CYTOKINES; GUANINE NUCLEOTIDE EXCHANGE FACTORS; HUMANS; IMIDAZOLES; INSULIN-SECRETING CELLS; LEUCINE; MITOCHONDRIA; MODELS, ANIMAL; NADPH OXIDASE; NEOPLASM PROTEINS; OXIDATIVE STRESS; PYRIMIDINES; RAC1 GTP-BINDING PROTEIN; RATS; REACTIVE OXYGEN SPECIES; SIGNAL TRANSDUCTION;

EID: 78650665214     PISSN: 03636119     EISSN: 15221490     Source Type: Journal    
DOI: 10.1152/ajpregu.00421.2010     Document Type: Article

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