Mutation of the calmodulin binding motif IQ of the L-type Cav1.2 Ca2+ channel to EQ induces dilated cardiomyopathy and death

Journal of Biological Chemistry

Volumn 287, Issue 27, 2012, Pages 22616-22625

  Blaich, Anne ^a   Pahlavan, Sara ^b   Tian, Qinghai ^b   Oberhofer, Martin ^b   Poomvanicha, Montatip ^a   Lenhardt, Peter ^a   Domes, Katrin ^a   Wegener, Jörg W ^a   Moosmang, Sven ^a   Ruppenthal, Sandra ^b   Scholz, Anke ^b   Lipp, Peter ^b   Hofmann, Franz ^a  

^a TECHNICAL UNIVERSITY OF MUNICH   (Germany)

^b SAARLAND UNIVERSITY   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

C TERMINUS; CALCIUM CHANNELS; CALMODULIN BINDING; CARDIAC MYOCYTES; CHANNEL PROTEINS; CRE RECOMBINASE; DILATED CARDIOMYOPATHY; E-C COUPLING; ELECTRICAL EXCITATION; EXCITATION-CONTRACTION COUPLING; METOPROLOL; SARCOPLASMIC RETICULUM; TAMOXIFEN;

CALMODULIN; CAMS; CARDIOLOGY; CELL DEATH; CELL MEMBRANES; HEART; MACHINERY; MAMMALS;

CALCIUM;

CALCIUM CALMODULIN DEPENDENT PROTEIN KINASE II; CALCIUM CHANNEL L TYPE; CALCIUM ION; CALMODULIN BINDING PROTEIN; CRE RECOMBINASE; MITOGEN ACTIVATED PROTEIN KINASE; PROTEIN CAV1.2; UNCLASSIFIED DRUG;

ALLELE; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CALCIUM DEPENDENT FACILITATION; CALCIUM DEPENDENT INACTIVATION; CHEMICAL PARAMETERS; CONGESTIVE CARDIOMYOPATHY; CONTROLLED STUDY; DEATH; ENZYME ACTIVITY; GENE MUTATION; HEART EXCITATION; HEART MUSCLE CELL; HEART MUSCLE CONTRACTILITY; HEART MUSCLE FIBROSIS; HETEROZYGOTE; MOUSE; NEUROENDOCRINE SYSTEM; NONHUMAN; NUCLEOTIDE SEQUENCE; PATHOGENESIS; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; PROTEIN MOTIF; SARCOPLASMIC RETICULUM; UPREGULATION;

AMINO ACID MOTIFS; ANGIOTENSIN-CONVERTING ENZYME INHIBITORS; ANIMALS; ANTI-ARRHYTHMIA AGENTS; BINDING SITES; CALCIUM; CALCIUM CHANNELS, L-TYPE; CALMODULIN; CAPTOPRIL; CARDIOMYOPATHY, DILATED; CELLS, CULTURED; HEART FAILURE; METOPROLOL; MICE; MICE, MUTANT STRAINS; MYOCARDIAL CONTRACTION; MYOCYTES, CARDIAC; PROTEIN STRUCTURE, TERTIARY; SURVIVAL RATE;

MURINAE; MUS;

EID: 84863311484     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M112.357921     Document Type: Article

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