Ultrastructural and functional remodeling of the coupling between Ca 2+ influx and sarcoplasmic reticulum Ca 2+ release in right atrial myocytes from experimental persistent atrial fibrillation

Circulation Research

Volumn 105, Issue 9, 2009, Pages 876-885

  Lenaerts, Ilse ^a   Bito, Virginie ^a   Heinzel, Frank R ^d   Driesen, Ronald B ^a   Holemans, Patricia ^a   D'Hooge, Jan ^b   Heidbüchel, Hein ^c   Sipido, Karin R ^a   Willems, Rik ^a,c  

^a Divisions of Experimental Cardiology   (Belgium)

^b Divisions of Cardiac Imaging

^c UNIVERSITY OF LEUVEN   (Belgium)

^d MEDICAL UNIVERSITY OF GRAZ   (Austria)

Author keywords

Atrial fibrillation; Na + ca 2+ exchange; Ryanodine receptor; Sarcoplasmic reticulum; T tubules

Indexed keywords

CALCIUM ION; RYANODINE RECEPTOR; SODIUM CALCIUM EXCHANGE PROTEIN; CALCIUM CHANNEL L TYPE; GLYCOGEN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CALCIUM CURRENT; CALCIUM TRANSPORT; CONTROLLED STUDY; FEMALE; HEART ATRIUM FIBRILLATION; HEART MUSCLE CELL; HEART RIGHT ATRIUM; NONHUMAN; PRIORITY JOURNAL; SARCOLEMMA; SARCOPLASMIC RETICULUM; SHEEP; TRANSVERSE TUBULAR SYSTEM; ULTRASTRUCTURE; ANIMAL; CALCIUM SIGNALING; CELL MEMBRANE POTENTIAL; DISEASE MODEL; HEART ATRIUM; HEART ATRIUM FUNCTION; HEART CONTRACTION; HEART FUNCTION TEST; METABOLISM; MICROFILAMENT; PATHOLOGY; PATHOPHYSIOLOGY; TIME;

ANIMALS; ATRIAL FIBRILLATION; ATRIAL FUNCTION, RIGHT; CALCIUM CHANNELS, L-TYPE; CALCIUM SIGNALING; DISEASE MODELS, ANIMAL; ELECTROPHYSIOLOGIC TECHNIQUES, CARDIAC; FEMALE; GLYCOGEN; HEART ATRIA; MEMBRANE POTENTIALS; MICROFILAMENTS; MYOCARDIAL CONTRACTION; MYOCYTES, CARDIAC; RYANODINE RECEPTOR CALCIUM RELEASE CHANNEL; SARCOLEMMA; SARCOPLASMIC RETICULUM; SHEEP; SODIUM-CALCIUM EXCHANGER; TIME FACTORS;

EID: 70350716610     PISSN: 00097330     EISSN: 15244571     Source Type: Journal    
DOI: 10.1161/CIRCRESAHA.109.206276     Document Type: Article

References (37)

1. Lloyd-Jones DM, Larson MG, Leip EP, Beiser A, D'Agostino RB, Kannel WB, Murabito JM, Vasan RS, Benjamin EJ, Levy D. Lifetime risk for developing congestive heart failure: the Framingham Heart Study. Circulation. 2002;106:3068-3072. (Pubitemid 35440290)
2. Wolf PA, Abbott RD, Kannel WB. Atrial fibrillation as an independent risk factor for stroke: the Framingham Study. Stroke. 1991;22:983-988.
3. Manning WJ, Silverman DI, Katz SE, Riley MF, Come PC, Doherty RM, Munson JT, Douglas PS. Impaired left atrial mechanical function after cardioversion: relation to the duration of atrial fibrillation. J Am Coll Cardiol. 1994;23:1535-1540.
4. SchottenU,AusmaJ,StellbrinkC,SabatschusI,Vogel.M,FrechenD,SchoendubeF, HanrathP,AllessieMA. Cellularmechanismsofdepressedatrialcontractilityinpatientswithch ronicatrialfibrillation.Circulation.2001;103:691-698.(Pubitemid32144198)
5. YueL,FengJ,GaspoR,LiGR,WangZ,NattelS. Ionicremodelingunderlyingactionpotentialchangesinacaninemodel ofatrialfibrillation.CircRes.1997;81:512-525.(Pubitemid27432738)
6. Bosch RF, Zeng X, Grammer JB, Popovic K, Mewis C, Kuhlkamp V. Ionic mechanisms of electrical, remodeling in human atrial fibrillation. Cardiovasc Res. 1999;44:121-131. (Pubitemid 29431690)
7. VanWagonerDR,PondAL,LamorgeseM,RossieSS,McCarthyPM,NerbonneJM.Atrial. L-typeCa2+currentsandhumanatrialfibrillation.CircRes.1999;85:428-436. (Pubitemid29409619)
8. Yagi T, Pu J, Chandra P, Hara M, Danilo PJ, Rosen MR, Boyden PA. Density and function of inward currents in right atrial cells from chronically flbrillating canine atria. Cardiovasc Res. 2002;54:405-415. (Pubitemid 34327919)
9. YueL,MelnykP,GaspoR,WangZ,NattelS. Molecularmechanismsunderlyingionicremodelinginadogmodel,ofatrial,fibrillation. CircRes.1999;84:776-784.(Pubitemid29181484)
10. Christ T, Boknik P, Wohrl S, Wettwer E, Graf EM, Bosch RF, Knaut M, Schmitz W, Ravens U, Dobrev D. L-type Ca2+ current downregulation in chronic human atrial fibrillation is associated with increased activity of protein phosphatases. Circulation. 2004;110:2651-2657.
11. Carnes CA, Janssen PM, Ruehr ML, Nakayama H, Nakayama T, Haase H, Bauer JA, Chung MK, Fearon IM, Gillinov AM, Hamlin RL, Van Wagoner DR. Atrial glutathione content, calcium, current, and contractility. J Biol Chem. 2007;282:28063-28073.
12. Greiser M, Halaszovich CR, Frechen D, Boknik P, Ravens U, Dobrev D, Luckhoff A, Schotten U. Pharmacological evidence for altered src kinase regulation of I (Ca,L) in patients with chronic atrial, fibrillation. Naunyn Schmiedebergs Arch Pharmacol. 2007;375:383-392. (Pubitemid 47087500)
13. SunH,GaspoR,LeblancN,NattelS. Cellularmechanismsofatrialcontractiledysfunctioncausedbysustainedatrial, tachycardia.Circulation.1998;98:719-727.(Pubitemid28387499)
14. Hove-Madsen L, Llach A, Bayes-Genis A, Roura S, Rodriguez FE, Aris A, Cinca J. Atrial, fibrillation is associated with increased spontaneous calcium release from, the sarcoplasmic reticulum, in human atrial myocytes. Circulation. 2004;110:1358-1363.
15. Vest JA, Wehrens XH, Reiken SR, Lehnart SE, Dobrev D, Chandra P, Danilo P, Ravens U, Rosen MR, Marks AR. Defective cardiac ryanodine receptor regulation during atrial fibrillation. Circulation. 2005; 111: 2025-2032. (Pubitemid 40577896)
16. Wijffels MC, Kirchhof CJ, Dorland R, Allessie MA. Atrial fibrillation begets atrial fibrillation. A study in awake chronically instrumented goats. Circulation, 1995;92:1954-1968.
17. Brundel BJ, Van Gelder IC, Henning RH, Tuinenburg AE, Deelman LE, Tieleman RG, Grandjean JG, Van Gilst WH, Crijns HJ. Gene expression of proteins influencing the calcium homeostasis in patients with persistent and paroxysmal atrial, fibrillation. Cardiovasc Res. 1999;42:443-454. (Pubitemid 29243170)
18. 18.WillemsR,HolemansP,EctorH,SipidoKR,VandeWerfF,HeidbuchelH. Mindthemodel: effectofinstrumentationoninducibilityofatrialfibrillationinasheepmodel. JCardiovascElectrophysiol.2002;13:62-67.(Pubitemid34113622)
19. Anne W, Willems R, Holemans P, Beckers F, Roskams T, Lenaerts I, Ector H, Heidbuchel. H. Self-terminating AF depends on electrical, remodeling while persistent AF depends on additional structural changes in a rapid atrially paced sheep model. J Mol Cell Cardiol. 2007;43: 148-158.
20. Kirk MM, Izu LT, Chen-Izu Y, McCulle SL, Wier WG, Balke CW, Shorofsky SR. Role of the transverse-axial, tubule system, in generating calcium sparks and calcium transients in rat atrial myocytes. J Physiol. 2003;547:441-451.
21. Woo SH, Cleemann L, Morad M. Diversity of atrial local Ca2+ signalling: evidence from 2-D confocal imaging in Ca2+-buffered rat atrial myocytes. J Physiol. 2005;567:905-921. (Pubitemid 41387833)
22. Dibb KM, Clarke JD, Horn MA, Richards MA, Graham HK, Eisner DA, Trafford AW. Characterization of an extensive transverse tubular network in sheep atrial myocytes and its depletion in heart failure. Circulation Heart Failure. 2009.
23. Heinzel FR, Bito V, Biesmans L, Wu M, Detre E, von Wegner F, Claus P, Dymarkowski S, Maes F, Bogaert J, Rademakers F, D'hooge J, Sipido KR. Remodeling of T-tubules and reduced synchrony of Ca2+ release in myocytes from chronically ischemic myocardium. Circ Res. 2008;102: 338-346.
24. Song LS, Sobie EA, McCulle S, Lederer WJ, Balke CW, Cheng H. Orphaned ryanodine receptors in the failing heart. Proc Natl Acad Sci U S A, 2006;103:4305-4310.
25. Hatem SN, Benardeau A, Rucker Martin C, Marty I, de Chamisso P, Villaz M, Mercadier JJ. Different compartments of sarcoplasmic reticulum participate in the excitation-contraction coupling process in human atrial myocytes. Circ Res. 1997;80:345-353.
26. Sheehan KA, Blatter LA. Regulation of junctional and non-junctional sarcoplasmic reticulum, calcium release in excitation-contraction coupling in cat atrial myocytes. J Physiol (Land). 2003;546:119-135.
27. Aime-Sempe C, Folliguet T, Rucker-Martin C, Krajewska M, Krajewska S, Heimburger M, Aubier M, Mercadier JJ, Reed JC, Hatem SN. Myocardial cell death In fibrillating and dilated human right atria. J Am Coll Cardiol. 1999;34:1577-1586.
28. Ausma J, Litjens N, Lenders MH, Duimel. H, Mast F, Wouters L, Ramaekers F, Allessie M, Borgers M. Time course of atrial fibrillationinduced cellular structural remodeling in atria of the goat. J Mol Cell Cardiol. 2001;33:2083-2094.
29. Brette F, Orchard C. T-tubule function in mammalian cardiac myocytes. Circ Res. 2003;92:1182-1192.
30. Louch WE, Mork HK, Sexton J, Stromme TA, Laake P, Sjaastad I, Sejersted OM. T-tubule disorganization and reduced synchrony of Ca2+ release in murine cardiomyocytes following myocardial infarction. J Physiol. 2006;574:519-533.
31. Schotten U, Haase H, Frechen D, Greiser M, Stellbrink C, VazquezJimenez JF, Morano I, Allessie MA, Hanrath P. The L-type Ca2+channel subunits alpha IC and beta2 are not downregulated in atrial myocardium of patients with chronic atrial fibrillation. J Mol Cell Cardiol. 2003;35:437-443.
32. Ohkusa T, Ueyama T, Yamada J, Yano M, Fujumura Y, Esato K, Matsuzaki M. Alterations in cardiac sarcoplasmic reticulum Ca2+ regulatory proteins in the atrial, tissue of patients with chronic atrial fibrillation. J Am Coll Cardiol. 1999;34:255-263.
33. Lai LP, Su MJ, Lin JL, Lin FY, Tsai CH, Chen YS, Huang SK, Tseng YZ, Lien WP. Down-regulation of L-type calcium channel and sarcoplasmic reticular Ca(2+)-ATPase mRNA in human atrial fibrillation without significant change in the mRNA of ryanodine receptor, calsequestrin and phospholamban: an insight into the mechanism, of atrial electrical remodeling. J Am Coll Cardiol. 1999;33:1231-1237.
34. Schotten U, Greiser M, Benke D, Buerkel K, Ehrenteidt B, Stellbrink C, Vazquez-Jimenez JF, Schoendube F, Hanrath P, Allessie M. Atrial fibrillation-induced atrial contractile dysfunction: a tachycardiomyopathy of a different sort. Cardiovasc Res. 2002;53:192-201.
35. El Armouche A, Boknik P, Eschenhagen T, Carrier L, Knaut M, Ravens U, Dobrev D. Molecular determinants of altered Ca2+ handling in human, chronic atrial fibrillation. Circulation. 2006;114:670-680. (Pubitemid 44252309)
36. Lemery R. Bi-atrial mapping of atrial arrhythmias. Card Electrophysiol Rev. 2002;6:378-382.
37. Dun W, Ozgen. N, Hirose M, Sosunov EA, Anyukhovsky EP, Rosen MR, Boyden PA. Ionic mechanisms underlying region-specific remodeling of rabbit atrial, action potentials caused by intermittent burst stimulation. Heart Rhythm. 2007;4:499-507. (Pubitemid 46610404)