A Ca2+-dependent transgenic model of cardiac hypertrophy: A role for protein kinase Cα

Circulation

Volumn 103, Issue 1, 2001, Pages 140-147

  Muth, James N ^a   Bodi, Ilona ^a   Lewis, William ^b   Varadi, Gyula ^a   Schwartz, Arnold ^a,c  

^a UNIVERSITY OF CINCINNATI COLLEGE OF MEDICINE   (United States)

^b EMORY UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c UNIVERSITY OF CINCINNATI MEDICAL CENTER   (United States)

Author keywords

Calcium; Heart failure; Ion channels

Indexed keywords

CALCIUM CHANNEL; CALCIUM ION; PROTEIN KINASE C;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CARDIOMYOPATHY; CONTROLLED STUDY; ENZYME ACTIVITY; HEART HYPERTROPHY; HEART MUSCLE FIBROSIS; HEART VENTRICLE REMODELING; HISTOPATHOLOGY; MOUSE; NONHUMAN; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; TRANSGENIC MOUSE;

EID: 0035830362     PISSN: 00097322     EISSN: None     Source Type: Journal    
DOI: 10.1161/01.CIR.103.1.140     Document Type: Article

References (35)

1. Contractions induced by calcium-triggered release of calcium from the sarcoplasmic reticulum of single skinned cardiac cells
2. Competition and redistribution among calcium transport systems in rabbit cardiac myocytes
3. Specific inhibitors and promoters of calcium action in the excitation-contraction coupling of heart muscle and their role in the prevention or production of myocardial lesions
4. The cellular and molecular response of cardiac myocytes to mechanical stress
5. Angiotensin II and other hypertrophic stimuli mediated by G protein-coupled receptors activate tyrosine kinase, mitogen-activated protein kinase, and 90-kD S6 kinase in cardiac myocytes
6. 1-adrenergic stimulation
7. Calcium antagonist receptors in cardiomyopathic hamster: Selective increases in heart, muscle, and brain
8. An animal model of dilated cardiomyopathy: Characterization of dihydropyridine receptors and contractile performance
9. Calcium-antagonist receptors in the atrial tissue of patients with hypertrophic cardiomyopathy
10. Expression of calcium channel subunits in the normal and diseased human myocardium
11. Dihydropyridine receptor binding sites in the cardiomyopathic hamster heart are unchanged from control
12. Expression of dihydropyridine receptor and calsequestrin genes in the myocardium of patients with end-stage heart failure
13. The role of action potential prolongation and altered intracellular calcium handling in the pathogenesis of heart failure
14. Increased availability and open probability of single L-type calcium channels from failing compared with nonfailing human ventricle
15. 2+-ATPase increases cardiac contractility in transgenic mouse hearts
16. Overexpression of the sarcolemmal calcium pump in the myocardium of transgenic rats
17. 2-terminal kinase activation in the heart
18. Adverse effects of chronic endogenous sympathetic drive induced by cardiac GS alpha overexpression
19. 2+
20. 2+ content
21. 2+-sensitive isoforms in the failing human heart
22. 2+ channel in transgenic mice
23. Improved patch-clamp techniques for high-resolution current recording from cells and cell-free membrane patches
24. Cardiac dysfunction occurs in the HIV-1 transgenic mouse treated with zidovudine
25. Responses of cardiac protein kinase C isoforms to distinct pathological stimuli are differentially regulated
26. Abnormal intracellular calcium handling in myocardium from patients with end-stage heart failure
27. Apoptosis and heart failure: A critical review of the literature
28. Apoptosis of cardiac myocytes in Gsα transgenic mice
29. q signaling: A common pathway mediates cardiac hypertrophy and apoptotic heart failure
30. Calcineurin-mediated hypertrophy protects cardiomyocytes from apoptosis in vitro and in vivo: An apoptosis-independent model of dilated heart failure
31. Calcium: A life and death signal
32. c-AMP-dependent protein kinase C consensus site mutations of the beta-adrenergic receptor
33. Phosphorylation and activation of β-adrenergic receptor kinase by protein kinase C
34. Defective-adrenergic receptor signaling precedes the development of dilaled cardiomyopathy in transgenic mice with calsequestrin overexpression
35. Preservation of myocardialadrenergic receptor signaling delays the development of heart failure after myocardial infarction