Decreased cardiac L-type Ca 2+channel activity induces hypertrophy and heart failure in mice

Journal of Clinical Investigation

Volumn 122, Issue 1, 2012, Pages 280-290

  Goonasekera, Sanjeewa A ^a   Hammer, Karin ^b   Auger Messier, Mannix ^a   Bodi, Ilona ^a   Chen, Xiongwen ^c   Zhang, Hongyu ^c   Reiken, Steven ^d   Elrod, John W ^a   Correll, Robert N ^a   York, Allen J ^a   Sargent, Michelle A ^a   Hofmann, Franz ^e,f   Moosmang, Sven ^e,f   Marks, Andrew R ^d   Houser, Steven R ^c   Bers, Donald M ^b   Molkentin, Jeffery D ^a  

^a UNIVERSITY OF CINCINNATI COLLEGE OF MEDICINE   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c TEMPLE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^d College of Physicians and Surgeons of Columbia University ^*  (United States)

^e Munich Center for Integrated Protein Science   (Germany)

^f TECHNICAL UNIVERSITY OF MUNICH   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

CALCINEURIN; CALCIUM CHANNEL L TYPE; ISOPRENALINE; NUCLEAR FACTOR;

ALLELE; ALPHA CHAIN; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CALCIUM CURRENT; CALCIUM TRANSPORT; CONTROLLED STUDY; GENE DELETION; GENE TARGETING; GENETIC CODE; HEART DILATATION; HEART FAILURE; HEART FUNCTION; HEART HYPERTROPHY; HEART LEFT VENTRICLE OVERLOAD; HEART LEFT VENTRICLE PERFORMANCE; HEART MUSCLE CELL; HEART MUSCLE CONTRACTILITY; HEART PROTECTION; HEART STIMULATION; HEART STRESS; INTRACELLULAR SIGNALING; LETHALITY; LOXP SITE; MOUSE; NEUROENDOCRINE DISEASE; NONHUMAN; PRIORITY JOURNAL; PROTEIN SUBUNIT; SARCOPLASMIC RETICULUM; SWIMMING; T LYMPHOCYTE ACTIVATION;

ANIMALS; CALCINEURIN; CALCIUM CHANNELS, L-TYPE; CALCIUM SIGNALING; CARDIOMEGALY; GENE KNOCKDOWN TECHNIQUES; HEART FAILURE; HETEROZYGOTE; HOMOZYGOTE; HUMANS; MICE; MICE, KNOCKOUT; MICE, TRANSGENIC; MYOCYTES, CARDIAC; NEUROSECRETORY SYSTEMS; STRESS, PHYSIOLOGICAL;

EID: 84855425877     PISSN: 00219738     EISSN: 15588238     Source Type: Journal    
DOI: 10.1172/JCI58227     Document Type: Article

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