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Volumn 17, Issue 9, 2016, Pages 1046-1056

C13orf31 (FAMIN) is a central regulator of immunometabolic function

Author keywords

[No Author keywords available]

Indexed keywords

ADENOSINE TRIPHOSPHATE; FATTY ACID METABOLISM IMMUNITY NEXUS PROTEIN; FATTY ACID SYNTHASE; INFLAMMASOME; NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE; PROTEIN; REACTIVE OXYGEN METABOLITE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE; UNCLASSIFIED DRUG; FASN PROTEIN, HUMAN; LACC1 PROTEIN, HUMAN;

EID: 84980390288     PISSN: 15292908     EISSN: 15292916     Source Type: Journal    
DOI: 10.1038/ni.3532     Document Type: Article
Times cited : (126)

References (50)
  • 1
    • 84919946933 scopus 로고    scopus 로고
    • Association of a mutation in LACC1 with a monogenic form of systemic juvenile idiopathic arthritis
    • Wakil, S.M. et al. Association of a mutation in LACC1 with a monogenic form of systemic juvenile idiopathic arthritis. Arthritis Rheumatol. 67, 288-295 (2015
    • (2015) Arthritis Rheumatol , vol.67 , pp. 288-295
    • Wakil, S.M.1
  • 2
    • 84907696889 scopus 로고    scopus 로고
    • Study of Mendelian forms of Crohn?s disease in Saudi Arabia reveals novel risk loci and alleles
    • Patel, N. et al. Study of Mendelian forms of Crohn?s disease in Saudi Arabia reveals novel risk loci and alleles. Gut 63, 1831-1832 (2014
    • (2014) Gut , vol.63 , pp. 1831-1832
    • Patel, N.1
  • 3
    • 84924041476 scopus 로고    scopus 로고
    • Discovery of six new susceptibility loci and analysis of pleiotropic effects in leprosy
    • Liu, H. et al. Discovery of six new susceptibility loci and analysis of pleiotropic effects in leprosy. Nat. Genet. 47, 267-271 (2015
    • (2015) Nat. Genet , vol.47 , pp. 267-271
    • Liu, H.1
  • 4
    • 84868336049 scopus 로고    scopus 로고
    • Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease
    • Jostins, L. et al. Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease. Nature 491, 119-124 (2012
    • (2012) Nature , vol.491 , pp. 119-124
    • Jostins, L.1
  • 5
    • 58749109023 scopus 로고    scopus 로고
    • Genevestigator v3: A reference expression database for the meta-Analysis of transcriptomes
    • Hruz, T. et al. Genevestigator v3: a reference expression database for the meta-Analysis of transcriptomes. Adv. Bioinformatics 2008, 420747 (2008
    • (2008) Adv. Bioinformatics 2008 , pp. 420747
    • Hruz, T.1
  • 6
    • 52649097448 scopus 로고    scopus 로고
    • The Immunological Genome Project: Networks of gene expression in immune cells
    • Heng, T.S., & Painter, M.W. The Immunological Genome Project: networks of gene expression in immune cells. Nat. Immunol. 9, 1091-1094 (2008
    • (2008) Nat. Immunol , vol.9 , pp. 1091-1094
    • Heng, T.S.1    Painter, M.W.2
  • 7
    • 84859161710 scopus 로고    scopus 로고
    • Fatty acid synthase and liver triglyceride metabolism: Housekeeper or messenger?. Biochim
    • Jensen-Urstad, A.P., & Semenkovich, C.F. Fatty acid synthase and liver triglyceride metabolism: housekeeper or messenger?. Biochim. Biophys. Acta 1821, 747-753 (2012
    • (2012) Biophys. Acta , vol.1821 , pp. 747-753
    • Jensen-Urstad, A.P.1    Semenkovich, C.F.2
  • 8
    • 84878980483 scopus 로고    scopus 로고
    • Nutrient-dependent phosphorylation channels lipid synthesis to regulate PPAR?
    • Jensen-Urstad, A.P. et al. Nutrient-dependent phosphorylation channels lipid synthesis to regulate PPAR?. J. Lipid Res. 54, 1848-1859 (2013
    • (2013) J. Lipid Res , vol.54 , pp. 1848-1859
    • Jensen-Urstad, A.P.1
  • 9
    • 84896731135 scopus 로고    scopus 로고
    • Peroxisomes a nexus for lipid metabolism and cellular signaling
    • Lodhi, I.J., & Semenkovich, C.F. Peroxisomes: a nexus for lipid metabolism and cellular signaling. Cell Metab. 19, 380-392 (2014
    • (2014) Cell Metab , vol.19 , pp. 380-392
    • Lodhi, I.J.1    Semenkovich, C.F.2
  • 10
    • 84904394690 scopus 로고    scopus 로고
    • Macrophage activation and polarization: Nomenclature and experimental guidelines
    • Murray, P.J. et al. Macrophage activation and polarization: nomenclature and experimental guidelines. Immunity 41, 14-20 (2014
    • (2014) Immunity , vol.41 , pp. 14-20
    • Murray, P.J.1
  • 11
    • 84876285741 scopus 로고    scopus 로고
    • Succinate is an inflammatory signal that induces IL-1β through HIF-1?.
    • Tannahill, G.M. et al. Succinate is an inflammatory signal that induces IL-1β through HIF-1?. Nature 496, 238-242 (2013
    • (2013) Nature , vol.496 , pp. 238-242
    • Tannahill, G.M.1
  • 12
    • 84906319549 scopus 로고    scopus 로고
    • Cell-intrinsic lysosomal lipolysis is essential for alternative activation of macrophages
    • Huang, S.C. et al. Cell-intrinsic lysosomal lipolysis is essential for alternative activation of macrophages. Nat. Immunol. 15, 846-855 (2014
    • (2014) Nat. Immunol , vol.15 , pp. 846-855
    • Huang, S.C.1
  • 13
    • 79959210305 scopus 로고    scopus 로고
    • A conditional knockout resource for the genome-wide study of mouse gene function
    • Skarnes, W.C. et al. A conditional knockout resource for the genome-wide study of mouse gene function. Nature 474, 337-342 (2011
    • (2011) Nature , vol.474 , pp. 337-342
    • Skarnes, W.C.1
  • 14
    • 84855255300 scopus 로고    scopus 로고
    • Identification of a new fatty acid synthesis-Transport machinery at the peroxisomal membrane
    • Hillebrand, M. et al. Identification of a new fatty acid synthesis-Transport machinery at the peroxisomal membrane. J. Biol. Chem. 287, 210-221 (2012
    • (2012) J. Biol. Chem , vol.287 , pp. 210-221
    • Hillebrand, M.1
  • 15
    • 0030931047 scopus 로고    scopus 로고
    • Regulation of fatty acid synthase (FAS
    • Semenkovich, C.F. Regulation of fatty acid synthase (FAS). Prog. Lipid Res. 36, 43-53 (1997
    • (1997) Prog. Lipid Res , vol.36 , pp. 43-53
    • Semenkovich, C.F.1
  • 16
    • 84924935721 scopus 로고    scopus 로고
    • Network integration of parallel metabolic and transcriptional data reveals metabolic modules that regulate macrophage polarization
    • Jha, A.K. et al. Network integration of parallel metabolic and transcriptional data reveals metabolic modules that regulate macrophage polarization. Immunity 42, 419-430 (2015
    • (2015) Immunity , vol.42 , pp. 419-430
    • Jha, A.K.1
  • 18
    • 84875465199 scopus 로고    scopus 로고
    • Cancer metabolism: Fatty acid oxidation in the limelight
    • Carracedo, A., Cantley, L.C., & Pandolfi, P.P. Cancer metabolism: fatty acid oxidation in the limelight. Nat. Rev. Cancer 13, 227-232 (2013
    • (2013) Nat. Rev. Cancer , vol.13 , pp. 227-232
    • Carracedo, A.1    Cantley, L.C.2    Pandolfi, P.P.3
  • 19
    • 33846317064 scopus 로고    scopus 로고
    • Multiparameter metabolic analysis reveals a close link between attenuated mitochondrial bioenergetic function and enhanced glycolysis dependency in human tumor cells
    • Wu, M. et al. Multiparameter metabolic analysis reveals a close link between attenuated mitochondrial bioenergetic function and enhanced glycolysis dependency in human tumor cells. Am. J. Physiol. Cell Physiol. 292, C125-C136 (2007
    • (2007) Am. J. Physiol. Cell Physiol , vol.292 , pp. C125-C136
    • Wu, M.1
  • 20
    • 77951250700 scopus 로고    scopus 로고
    • Oligomycin-induced bioenergetic adaptation in cancer cells with heterogeneous bioenergetic organization
    • Hao, W., Chang, C.P., Tsao, C.C., & Xu, J. Oligomycin-induced bioenergetic adaptation in cancer cells with heterogeneous bioenergetic organization. J. Biol. Chem. 285, 12647-12654 (2010
    • (2010) J. Biol. Chem , vol.285 , pp. 12647-12654
    • Hao, W.1    Chang, C.P.2    Tsao, C.C.3    Xu, J.4
  • 21
    • 0017375420 scopus 로고
    • Effect of citrate on the activities of 6-phosphofructokinase from nervous and muscle tissues from different animals and its relationships to the regulation of glycolysis
    • Newsholme, E.A., Sugden, P.H., & Williams, T. Effect of citrate on the activities of 6-phosphofructokinase from nervous and muscle tissues from different animals and its relationships to the regulation of glycolysis. Biochem. J. 166, 123-129 (1977
    • (1977) Biochem. J. , vol.166 , pp. 123-129
    • Newsholme, E.A.1    Sugden, P.H.2    Williams, T.3
  • 22
    • 33744783432 scopus 로고    scopus 로고
    • Attenuation of LDH-A expression uncovers a link between glycolysis, mitochondrial physiology, and tumor maintenance
    • Fantin, V.R., St-Pierre, J., & Leder, P. Attenuation of LDH-A expression uncovers a link between glycolysis, mitochondrial physiology, and tumor maintenance. Cancer Cell 9, 425-434 (2006
    • (2006) Cancer Cell , vol.9 , pp. 425-434
    • Fantin, V.R.1    St-Pierre, J.2    Leder, P.3
  • 23
    • 33745428666 scopus 로고    scopus 로고
    • Oxidative metabolism and PGC-1β attenuate macrophage-mediated inflammation
    • Vats, D. et al. Oxidative metabolism and PGC-1β attenuate macrophage-mediated inflammation. Cell Metab. 4, 13-24 (2006
    • (2006) Cell Metab , vol.4 , pp. 13-24
    • Vats, D.1
  • 24
    • 9144219529 scopus 로고    scopus 로고
    • C75, a fatty acid synthase inhibitor, modulates AMP-Activated protein kinase to alter neuronal energy metabolism
    • Landree, L.E. et al. C75, a fatty acid synthase inhibitor, modulates AMP-Activated protein kinase to alter neuronal energy metabolism. J. Biol. Chem. 279, 3817-3827 (2004
    • (2004) J. Biol. Chem , vol.279 , pp. 3817-3827
    • Landree, L.E.1
  • 25
    • 84875906572 scopus 로고    scopus 로고
    • Mitochondrial dynamics in the regulation of nutrient utilization and energy expenditure
    • Liesa, M., & Shirihai, O.S. Mitochondrial dynamics in the regulation of nutrient utilization and energy expenditure. Cell Metab. 17, 491-506 (2013
    • (2013) Cell Metab , vol.17 , pp. 491-506
    • Liesa, M.1    Shirihai, O.S.2
  • 26
    • 58249093939 scopus 로고    scopus 로고
    • How mitochondria produce reactive oxygen species
    • Murphy, M.P. How mitochondria produce reactive oxygen species. Biochem. J. 417, 1-13 (2009
    • (2009) Biochem. J. , vol.417 , pp. 1-13
    • Murphy, M.P.1
  • 27
    • 0032493445 scopus 로고    scopus 로고
    • Gp91phox is the heme binding subunit of the superoxide-generating NADPH oxidase
    • Yu, L., Quinn, M.T., Cross, A.R., & Dinauer, M.C. Gp91phox is the heme binding subunit of the superoxide-generating NADPH oxidase. Proc. Natl. Acad. Sci. USA 95, 7993-7998 (1998
    • (1998) Proc. Natl. Acad. Sci. USA , vol.95 , pp. 7993-7998
    • Yu, L.1    Quinn, M.T.2    Cross, A.R.3    Dinauer, M.C.4
  • 28
    • 84887010498 scopus 로고    scopus 로고
    • Genome engineering using the CRISPR-Cas9 system
    • Ran, F.A. et al. Genome engineering using the CRISPR-Cas9 system. Nat. Protoc. 8, 2281-2308 (2013
    • (2013) Nat. Protoc , vol.8 , pp. 2281-2308
    • Ran, F.A.1
  • 29
    • 79955532516 scopus 로고    scopus 로고
    • TLR signalling augments macrophage bactericidal activity through mitochondrial ROS
    • West, A.P. et al. TLR signalling augments macrophage bactericidal activity through mitochondrial ROS. Nature 472, 476-480 (2011
    • (2011) Nature , vol.472 , pp. 476-480
    • West, A.P.1
  • 30
    • 0033823535 scopus 로고    scopus 로고
    • Evaluation of human antimycobacterial immunity using recombinant reporter mycobacteria
    • Kampmann, B. et al. Evaluation of human antimycobacterial immunity using recombinant reporter mycobacteria. J. Infect. Dis. 182, 895-901 (2000
    • (2000) J. Infect. Dis , vol.182 , pp. 895-901
    • Kampmann, B.1
  • 31
    • 78651393239 scopus 로고    scopus 로고
    • A role for mitochondria in NLRP3 inflammasome activation
    • Zhou, R., Yazdi, A.S., Menu, P., & Tschopp, J. A role for mitochondria in NLRP3 inflammasome activation. Nature 469, 221-225 (2011
    • (2011) Nature , vol.469 , pp. 221-225
    • Zhou, R.1    Yazdi, A.S.2    Menu, P.3    Tschopp, J.4
  • 32
    • 43949116263 scopus 로고    scopus 로고
    • The pattern of response to anti-interleukin-1 treatment distinguishes two subsets of patients with systemic-onset juvenile idiopathic arthritis
    • Gattorno, M. et al. The pattern of response to anti-interleukin-1 treatment distinguishes two subsets of patients with systemic-onset juvenile idiopathic arthritis. Arthritis Rheum. 58, 1505-1515 (2008
    • (2008) Arthritis Rheum , vol.58 , pp. 1505-1515
    • Gattorno, M.1
  • 33
    • 79959963298 scopus 로고    scopus 로고
    • Pathogenesis of systemic juvenile idiopathic arthritis: Some answers, more questions
    • Mellins, E.D., Macaubas, C., & Grom, A.A. Pathogenesis of systemic juvenile idiopathic arthritis: some answers, more questions. Nat. Rev. Rheumatol. 7, 416-426 (2011
    • (2011) Nat. Rev. Rheumatol , vol.7 , pp. 416-426
    • Mellins, E.D.1    Macaubas, C.2    Grom, A.A.3
  • 34
    • 79953323633 scopus 로고    scopus 로고
    • A multicentre, randomised, double-blind, placebo-controlled trial with the interleukin-1 receptor antagonist anakinra in patients with systemic-onset juvenile idiopathic arthritis (ANAJIS trial)
    • Quartier, P. et al. A multicentre, randomised, double-blind, placebo-controlled trial with the interleukin-1 receptor antagonist anakinra in patients with systemic-onset juvenile idiopathic arthritis (ANAJIS trial). Ann. Rheum. Dis. 70, 747-754 (2011
    • (2011) Ann. Rheum. Dis , vol.70 , pp. 747-754
    • Quartier, P.1
  • 35
    • 18644385243 scopus 로고    scopus 로고
    • Role of interleukin-1 (IL-1) in the pathogenesis of systemic onset juvenile idiopathic arthritis and clinical response to IL-1 blockade
    • Pascual, V., Allantaz, F., Arce, E., Punaro, M., & Banchereau, J. Role of interleukin-1 (IL-1) in the pathogenesis of systemic onset juvenile idiopathic arthritis and clinical response to IL-1 blockade. J. Exp. Med. 201, 1479-1486 (2005
    • (2005) J. Exp. Med , vol.201 , pp. 1479-1486
    • Pascual, V.1    Allantaz, F.2    Arce, E.3    Punaro, M.4    Banchereau, J.5
  • 36
    • 0030900980 scopus 로고    scopus 로고
    • Intracellular adenosine triphosphate (ATP) concentration: A switch in the decision between apoptosis and necrosis
    • Leist, M., Single, B., Castoldi, A.F., Kühnle, S., & Nicotera, P. Intracellular adenosine triphosphate (ATP) concentration: a switch in the decision between apoptosis and necrosis. J. Exp. Med. 185, 1481-1486 (1997
    • (1997) J. Exp. Med , vol.185 , pp. 1481-1486
    • Leist, M.1    Single, B.2    Castoldi, A.F.3    Kühnle, S.4    Nicotera, P.5
  • 37
    • 69049098306 scopus 로고    scopus 로고
    • The Randle cycle revisited: A new head for an old hat
    • Hue, L., & Taegtmeyer, H. The Randle cycle revisited: a new head for an old hat. Am. J. Physiol. Endocrinol. Metab. 297, E578-E591 (2009
    • (2009) Am. J. Physiol. Endocrinol. Metab , vol.297 , pp. E578-E591
    • Hue, L.1    Taegtmeyer, H.2
  • 38
    • 0036797450 scopus 로고    scopus 로고
    • A futile metabolic cycle activated in adipocytes by antidiabetic agents
    • Guan, H.P. et al. A futile metabolic cycle activated in adipocytes by antidiabetic agents. Nat. Med. 8, 1122-1128 (2002
    • (2002) Nat. Med , vol.8 , pp. 1122-1128
    • Guan, H.P.1
  • 39
    • 84904392273 scopus 로고    scopus 로고
    • Memory CD8+ T cells use cell-intrinsic lipolysis to support the metabolic programming necessary for development
    • O?Sullivan, D. et al. Memory CD8+ T cells use cell-intrinsic lipolysis to support the metabolic programming necessary for development. Immunity 41, 75-88 (2014
    • (2014) Immunity , vol.41 , pp. 75-88
    • O'Sullivan, D.1
  • 40
    • 84883423963 scopus 로고    scopus 로고
    • CD8 memory T cells have a bioenergetic advantage that underlies their rapid recall ability
    • Van der Windt, G.J. et al. CD8 memory T cells have a bioenergetic advantage that underlies their rapid recall ability. Proc. Natl. Acad. Sci. USA 110, 14336-14341 (2013
    • (2013) Proc. Natl. Acad. Sci. USA , vol.110 , pp. 14336-14341
    • Van Der Windt, G.J.1
  • 41
    • 33747340215 scopus 로고    scopus 로고
    • Novel polyphenol oxidase mined from a metagenome expression library of bovine rumen: Biochemical properties, structural analysis, and phylogenetic relationships
    • Beloqui, A. et al. Novel polyphenol oxidase mined from a metagenome expression library of bovine rumen: biochemical properties, structural analysis, and phylogenetic relationships. J. Biol. Chem. 281, 22933-22942 (2006
    • (2006) J. Biol. Chem , vol.281 , pp. 22933-22942
    • Beloqui, A.1
  • 42
    • 33646782548 scopus 로고    scopus 로고
    • Crystal structure of hypothetical protein YfiH from Shigella flexneri at 2 A resolution
    • Kim, Y. et al. Crystal structure of hypothetical protein YfiH from Shigella flexneri at 2 A resolution. Proteins 63, 1097-1101 (2006
    • (2006) Proteins , vol.63 , pp. 1097-1101
    • Kim, Y.1
  • 43
    • 74949089659 scopus 로고    scopus 로고
    • Pharmacologic inhibition of fatty acid oxidation sensitizes human leukemia cells to apoptosis induction
    • Samudio, I. et al. Pharmacologic inhibition of fatty acid oxidation sensitizes human leukemia cells to apoptosis induction. J. Clin. Invest. 120, 142-156 (2010
    • (2010) J. Clin. Invest , vol.120 , pp. 142-156
    • Samudio, I.1
  • 44
    • 84922080059 scopus 로고    scopus 로고
    • De novo fatty acid synthesis controls the fate between regulatory T and T helper 17 cells
    • Berod, L. et al. De novo fatty acid synthesis controls the fate between regulatory T and T helper 17 cells. Nat. Med. 20, 1327-1333 (2014
    • (2014) Nat. Med , vol.20 , pp. 1327-1333
    • Berod, L.1
  • 45
    • 84881331109 scopus 로고    scopus 로고
    • Immunoresponsive gene 1 augments bactericidal activity of macrophage-lineage cells by regulating β-oxidation-dependent mitochondrial ROS production
    • Hall, C.J. et al. Immunoresponsive gene 1 augments bactericidal activity of macrophage-lineage cells by regulating β-oxidation-dependent mitochondrial ROS production. Cell Metab. 18, 265-278 (2013
    • (2013) Cell Metab , vol.18 , pp. 265-278
    • Hall, C.J.1
  • 46
    • 84960399221 scopus 로고    scopus 로고
    • Immunometabolism governs dendritic cell and macrophage function
    • O?Neill, L.A., & Pearce, E.J. Immunometabolism governs dendritic cell and macrophage function. J. Exp. Med. 213, 15-23 (2016
    • (2016) J. Exp. Med , vol.213 , pp. 15-23
    • O'Neill, L.A.1    Pearce, E.J.2
  • 47
    • 84943452673 scopus 로고    scopus 로고
    • Hyper-IgD syndrome/mevalonate kinase deficiency: What is new?. Semin
    • Mulders-Manders, C.M., & Simon, A. Hyper-IgD syndrome/mevalonate kinase deficiency: what is new?. Semin. Immunopathol. 37, 371-376 (2015
    • (2015) Immunopathol , vol.37 , pp. 371-376
    • Mulders-Manders, C.M.1    Simon, A.2
  • 48
    • 84873729095 scopus 로고    scopus 로고
    • Multiplex genome engineering using CRISPR/Cas systems
    • Cong, L. et al. Multiplex genome engineering using CRISPR/Cas systems. Science 339, 819-823 (2013
    • (2013) Science , vol.339 , pp. 819-823
    • Cong, L.1
  • 50
    • 77955970985 scopus 로고    scopus 로고
    • Nos3 protects against systemic inflammation and myocardial dysfunction in murine polymicrobial sepsis
    • Bougaki, M. et al. Nos3 protects against systemic inflammation and myocardial dysfunction in murine polymicrobial sepsis. Shock 34, 281-290 (2010
    • (2010) Shock , vol.34 , pp. 281-290
    • Bougaki, M.1


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