메뉴 건너뛰기




Volumn 1821, Issue 5, 2012, Pages 747-753

Fatty acid synthase and liver triglyceride metabolism: Housekeeper or messenger?

Author keywords

Diabetes; Fatty liver; Lipid signaling; Obesity; Post translational regulation; PPAR

Indexed keywords

CARBOHYDRATE; CARCINOEMBRYONIC ANTIGEN; CYCLIC AMP; FATTY ACID SYNTHASE; FRUCTOSE; GLUCAGON; GLUCOSE; INSULIN; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR ALPHA; TRIACYLGLYCEROL; VERY LOW DENSITY LIPOPROTEIN;

EID: 84859161710     PISSN: 13881981     EISSN: 18792618     Source Type: Journal    
DOI: 10.1016/j.bbalip.2011.09.017     Document Type: Review
Times cited : (311)

References (82)
  • 2
    • 0842277242 scopus 로고    scopus 로고
    • Definition of metabolic syndrome: Report of the National Heart, Lung, and Blood Institute/American Heart Association conference on scientific issues related to definition
    • S.M. Grundy, H.B. Brewer Jr., J.I. Cleeman, S.C. Smith Jr., and C. Lenfant Definition of metabolic syndrome: report of the National Heart, Lung, and Blood Institute/American Heart Association conference on scientific issues related to definition Circulation 109 2004 433 438
    • (2004) Circulation , vol.109 , pp. 433-438
    • Grundy, S.M.1    Brewer, Jr.H.B.2    Cleeman, J.I.3    Smith, Jr.S.C.4    Lenfant, C.5
  • 4
    • 0037116641 scopus 로고    scopus 로고
    • Prevalence of the metabolic syndrome among US adults: Findings from the third National Health and Nutrition Examination Survey
    • E.S. Ford, W.H. Giles, and W.H. Dietz Prevalence of the metabolic syndrome among US adults: findings from the third National Health and Nutrition Examination Survey JAMA 287 2002 356 359
    • (2002) JAMA , vol.287 , pp. 356-359
    • Ford, E.S.1    Giles, W.H.2    Dietz, W.H.3
  • 6
    • 0017384270 scopus 로고
    • High density lipoprotein as a protective factor against coronary heart disease. The Framingham Study
    • T. Gordon, W.P. Castelli, M.C. Hjortland, W.B. Kannel, and T.R. Dawber High density lipoprotein as a protective factor against coronary heart disease. The Framingham Study Am. J. Med. 62 1977 707 714
    • (1977) Am. J. Med. , vol.62 , pp. 707-714
    • Gordon, T.1    Castelli, W.P.2    Hjortland, M.C.3    Kannel, W.B.4    Dawber, T.R.5
  • 7
    • 66149119340 scopus 로고    scopus 로고
    • Fatty liver is associated with insulin resistance, risk of coronary heart disease, and early atherosclerosis in a large European population
    • A. Gastaldelli, M. Kozakova, K. Hojlund, A. Flyvbjerg, A. Favuzzi, A. Mitrakou, and B. Balkau Fatty liver is associated with insulin resistance, risk of coronary heart disease, and early atherosclerosis in a large European population Hepatology 49 2009 1537 1544
    • (2009) Hepatology , vol.49 , pp. 1537-1544
    • Gastaldelli, A.1    Kozakova, M.2    Hojlund, K.3    Flyvbjerg, A.4    Favuzzi, A.5    Mitrakou, A.6    Balkau, B.7
  • 8
    • 0027278522 scopus 로고
    • Positive regulation of the peroxisomal beta-oxidation pathway by fatty acids through activation of peroxisome proliferator-activated receptors (PPAR)
    • C. Dreyer, H. Keller, A. Mahfoudi, V. Laudet, G. Krey, and W. Wahli Positive regulation of the peroxisomal beta-oxidation pathway by fatty acids through activation of peroxisome proliferator-activated receptors (PPAR) Biol. Cell 77 1993 67 76
    • (1993) Biol. Cell , vol.77 , pp. 67-76
    • Dreyer, C.1    Keller, H.2    Mahfoudi, A.3    Laudet, V.4    Krey, G.5    Wahli, W.6
  • 9
    • 0032479423 scopus 로고    scopus 로고
    • Expression of putative fatty acid transporter genes are regulated by peroxisome proliferator-activated receptor alpha and gamma activators in a tissue- and inducer-specific manner
    • K. Motojima, P. Passilly, J.M. Peters, F.J. Gonzalez, and N. Latruffe Expression of putative fatty acid transporter genes are regulated by peroxisome proliferator-activated receptor alpha and gamma activators in a tissue- and inducer-specific manner J. Biol. Chem. 273 1998 16710 16714
    • (1998) J. Biol. Chem. , vol.273 , pp. 16710-16714
    • Motojima, K.1    Passilly, P.2    Peters, J.M.3    Gonzalez, F.J.4    Latruffe, N.5
  • 10
    • 0033594980 scopus 로고    scopus 로고
    • A critical role for the peroxisome proliferator-activated receptor alpha (PPARalpha) in the cellular fasting response: The PPARalpha-null mouse as a model of fatty acid oxidation disorders
    • T.C. Leone, C.J. Weinheimer, and D.P. Kelly A critical role for the peroxisome proliferator-activated receptor alpha (PPARalpha) in the cellular fasting response: the PPARalpha-null mouse as a model of fatty acid oxidation disorders Proc. Natl. Acad. Sci. U.S.A. 96 1999 7473 7478
    • (1999) Proc. Natl. Acad. Sci. U.S.A. , vol.96 , pp. 7473-7478
    • Leone, T.C.1    Weinheimer, C.J.2    Kelly, D.P.3
  • 11
    • 0032489437 scopus 로고    scopus 로고
    • Altered constitutive expression of fatty acid-metabolizing enzymes in mice lacking the peroxisome proliferator-activated receptor alpha (PPARalpha)
    • T. Aoyama, J.M. Peters, N. Iritani, T. Nakajima, K. Furihata, T. Hashimoto, and F.J. Gonzalez Altered constitutive expression of fatty acid-metabolizing enzymes in mice lacking the peroxisome proliferator-activated receptor alpha (PPARalpha) J. Biol. Chem. 273 1998 5678 5684
    • (1998) J. Biol. Chem. , vol.273 , pp. 5678-5684
    • Aoyama, T.1    Peters, J.M.2    Iritani, N.3    Nakajima, T.4    Furihata, K.5    Hashimoto, T.6    Gonzalez, F.J.7
  • 13
    • 0024315871 scopus 로고
    • Fatty acid synthase, a proficient multifunctional enzyme
    • S.J. Wakil Fatty acid synthase, a proficient multifunctional enzyme Biochemistry 28 1989 4523 4530
    • (1989) Biochemistry , vol.28 , pp. 4523-4530
    • Wakil, S.J.1
  • 14
    • 12344283741 scopus 로고    scopus 로고
    • Structure and function of animal fatty acid synthase
    • S.S. Chirala, and S.J. Wakil Structure and function of animal fatty acid synthase Lipids 39 2004 1045 1053
    • (2004) Lipids , vol.39 , pp. 1045-1053
    • Chirala, S.S.1    Wakil, S.J.2
  • 15
    • 0028557012 scopus 로고
    • The animal fatty acid synthase: One gene, one polypeptide, seven enzymes
    • S. Smith The animal fatty acid synthase: one gene, one polypeptide, seven enzymes FASEB J. 8 1994 1248 1259
    • (1994) FASEB J. , vol.8 , pp. 1248-1259
    • Smith, S.1
  • 16
    • 0019888073 scopus 로고
    • Animal fatty acid synthetase. A novel arrangement of the beta-ketoacyl synthetase sites comprising domains of the two subunits
    • J.K. Stoops, and S.J. Wakil Animal fatty acid synthetase. A novel arrangement of the beta-ketoacyl synthetase sites comprising domains of the two subunits J. Biol. Chem. 256 1981 5128 5133
    • (1981) J. Biol. Chem. , vol.256 , pp. 5128-5133
    • Stoops, J.K.1    Wakil, S.J.2
  • 17
    • 0023664701 scopus 로고
    • Small-angle neutron-scattering and electron microscope studies of the chicken liver fatty acid synthase
    • J.K. Stoops, S.J. Wakil, E.C. Uberbacher, and G.J. Bunick Small-angle neutron-scattering and electron microscope studies of the chicken liver fatty acid synthase J. Biol. Chem. 262 1987 10246 10251
    • (1987) J. Biol. Chem. , vol.262 , pp. 10246-10251
    • Stoops, J.K.1    Wakil, S.J.2    Uberbacher, E.C.3    Bunick, G.J.4
  • 18
    • 33644697200 scopus 로고    scopus 로고
    • Architecture of mammalian fatty acid synthase at 4.5 A resolution
    • T. Maier, S. Jenni, and N. Ban Architecture of mammalian fatty acid synthase at 4.5 A resolution Science 311 2006 1258 1262
    • (2006) Science , vol.311 , pp. 1258-1262
    • Maier, T.1    Jenni, S.2    Ban, N.3
  • 19
    • 51149098989 scopus 로고    scopus 로고
    • The crystal structure of a mammalian fatty acid synthase
    • T. Maier, M. Leibundgut, and N. Ban The crystal structure of a mammalian fatty acid synthase Science 321 2008 1315 1322
    • (2008) Science , vol.321 , pp. 1315-1322
    • Maier, T.1    Leibundgut, M.2    Ban, N.3
  • 22
    • 34347237265 scopus 로고    scopus 로고
    • Coupling of the de novo fatty acid biosynthesis and lipoylation pathways in mammalian mitochondria
    • A. Witkowski, A.K. Joshi, and S. Smith Coupling of the de novo fatty acid biosynthesis and lipoylation pathways in mammalian mitochondria J. Biol. Chem. 282 2007 14178 14185
    • (2007) J. Biol. Chem. , vol.282 , pp. 14178-14185
    • Witkowski, A.1    Joshi, A.K.2    Smith, S.3
  • 23
    • 0029130784 scopus 로고
    • Human fatty acid synthase mRNA: Tissue distribution, genetic mapping, and kinetics of decay after glucose deprivation
    • C.F. Semenkovich, T. Coleman, and F.T. Fiedorek Jr. Human fatty acid synthase mRNA: tissue distribution, genetic mapping, and kinetics of decay after glucose deprivation J. Lipid Res. 36 1995 1507 1521
    • (1995) J. Lipid Res. , vol.36 , pp. 1507-1521
    • Semenkovich, C.F.1    Coleman, T.2    Fiedorek, Jr.F.T.3
  • 25
    • 0037637624 scopus 로고    scopus 로고
    • Fatty acid synthesis is essential in embryonic development: Fatty acid synthase null mutants and most of the heterozygotes die in utero
    • S.S. Chirala, H. Chang, M. Matzuk, L. Abu-Elheiga, J. Mao, K. Mahon, M. Finegold, and S.J. Wakil Fatty acid synthesis is essential in embryonic development: fatty acid synthase null mutants and most of the heterozygotes die in utero Proc. Natl. Acad. Sci. U.S.A. 100 2003 6358 6363
    • (2003) Proc. Natl. Acad. Sci. U.S.A. , vol.100 , pp. 6358-6363
    • Chirala, S.S.1    Chang, H.2    Matzuk, M.3    Abu-Elheiga, L.4    Mao, J.5    Mahon, K.6    Finegold, M.7    Wakil, S.J.8
  • 26
    • 0037406445 scopus 로고    scopus 로고
    • Hepatic VLDL production in ob/ob mice is not stimulated by massive de novo lipogenesis but is less sensitive to the suppressive effects of insulin
    • C.H. Wiegman, R.H. Bandsma, M. Ouwens, F.H. van der Sluijs, R. Havinga, T. Boer, D.J. Reijngoud, J.A. Romijn, and F. Kuipers Hepatic VLDL production in ob/ob mice is not stimulated by massive de novo lipogenesis but is less sensitive to the suppressive effects of insulin Diabetes 52 2003 1081 1089
    • (2003) Diabetes , vol.52 , pp. 1081-1089
    • Wiegman, C.H.1    Bandsma, R.H.2    Ouwens, M.3    Van Der Sluijs, F.H.4    Havinga, R.5    Boer, T.6    Reijngoud, D.J.7    Romijn, J.A.8    Kuipers, F.9
  • 28
    • 0029990980 scopus 로고    scopus 로고
    • Human fatty acid synthesis is stimulated by a eucaloric low fat, high carbohydrate diet
    • L.C. Hudgins, M. Hellerstein, C. Seidman, R. Neese, J. Diakun, and J. Hirsch Human fatty acid synthesis is stimulated by a eucaloric low fat, high carbohydrate diet J. Clin. Invest. 97 1996 2081 2091
    • (1996) J. Clin. Invest. , vol.97 , pp. 2081-2091
    • Hudgins, L.C.1    Hellerstein, M.2    Seidman, C.3    Neese, R.4    Diakun, J.5    Hirsch, J.6
  • 29
    • 0033995287 scopus 로고    scopus 로고
    • Relationship between carbohydrate-induced hypertriglyceridemia and fatty acid synthesis in lean and obese subjects
    • L.C. Hudgins, M.K. Hellerstein, C.E. Seidman, R.A. Neese, J.D. Tremaroli, and J. Hirsch Relationship between carbohydrate-induced hypertriglyceridemia and fatty acid synthesis in lean and obese subjects J. Lipid Res. 41 2000 595 604
    • (2000) J. Lipid Res. , vol.41 , pp. 595-604
    • Hudgins, L.C.1    Hellerstein, M.K.2    Seidman, C.E.3    Neese, R.A.4    Tremaroli, J.D.5    Hirsch, J.6
  • 30
    • 0031955070 scopus 로고    scopus 로고
    • Human fatty acid synthesis is reduced after the substitution of dietary starch for sugar
    • L.C. Hudgins, C.E. Seidman, J. Diakun, and J. Hirsch Human fatty acid synthesis is reduced after the substitution of dietary starch for sugar Am. J. Clin. Nutr. 67 1998 631 639
    • (1998) Am. J. Clin. Nutr. , vol.67 , pp. 631-639
    • Hudgins, L.C.1    Seidman, C.E.2    Diakun, J.3    Hirsch, J.4
  • 31
    • 0032726283 scopus 로고    scopus 로고
    • Effects of a low-fat, high-carbohydrate diet on VLDL-triglyceride assembly, production, and clearance
    • E.J. Parks, R.M. Krauss, M.P. Christiansen, R.A. Neese, and M.K. Hellerstein Effects of a low-fat, high-carbohydrate diet on VLDL-triglyceride assembly, production, and clearance J. Clin. Invest. 104 1999 1087 1096
    • (1999) J. Clin. Invest. , vol.104 , pp. 1087-1096
    • Parks, E.J.1    Krauss, R.M.2    Christiansen, M.P.3    Neese, R.A.4    Hellerstein, M.K.5
  • 33
    • 33745896223 scopus 로고    scopus 로고
    • Deficiency of carbohydrate-activated transcription factor ChREBP prevents obesity and improves plasma glucose control in leptin-deficient (ob/ob) mice
    • K. Iizuka, B. Miller, and K. Uyeda Deficiency of carbohydrate-activated transcription factor ChREBP prevents obesity and improves plasma glucose control in leptin-deficient (ob/ob) mice Am. J. Physiol. Endocrinol. Metab. 291 2006 E358 E364
    • (2006) Am. J. Physiol. Endocrinol. Metab. , vol.291
    • Iizuka, K.1    Miller, B.2    Uyeda, K.3
  • 34
    • 18244382304 scopus 로고    scopus 로고
    • Sources of fatty acids stored in liver and secreted via lipoproteins in patients with nonalcoholic fatty liver disease
    • K.L. Donnelly, C.I. Smith, S.J. Schwarzenberg, J. Jessurun, M.D. Boldt, and E.J. Parks Sources of fatty acids stored in liver and secreted via lipoproteins in patients with nonalcoholic fatty liver disease J. Clin. Invest. 115 2005 1343 1351
    • (2005) J. Clin. Invest. , vol.115 , pp. 1343-1351
    • Donnelly, K.L.1    Smith, C.I.2    Schwarzenberg, S.J.3    Jessurun, J.4    Boldt, M.D.5    Parks, E.J.6
  • 36
    • 69449087522 scopus 로고    scopus 로고
    • Hepatic triacylglycerol hydrolysis regulates peroxisome proliferator-activated receptor alpha activity
    • J.M. Sapiro, M.T. Mashek, A.S. Greenberg, and D.G. Mashek Hepatic triacylglycerol hydrolysis regulates peroxisome proliferator-activated receptor alpha activity J. Lipid Res. 50 2009 1621 1629
    • (2009) J. Lipid Res. , vol.50 , pp. 1621-1629
    • Sapiro, J.M.1    Mashek, M.T.2    Greenberg, A.S.3    Mashek, D.G.4
  • 39
  • 40
    • 0037342152 scopus 로고    scopus 로고
    • Gene expression profiles of nondiabetic and diabetic obese mice suggest a role of hepatic lipogenic capacity in diabetes susceptibility
    • H. Lan, M.E. Rabaglia, J.P. Stoehr, S.T. Nadler, K.L. Schueler, F. Zou, B.S. Yandell, and A.D. Attie Gene expression profiles of nondiabetic and diabetic obese mice suggest a role of hepatic lipogenic capacity in diabetes susceptibility Diabetes 52 2003 688 700
    • (2003) Diabetes , vol.52 , pp. 688-700
    • Lan, H.1    Rabaglia, M.E.2    Stoehr, J.P.3    Nadler, S.T.4    Schueler, K.L.5    Zou, F.6    Yandell, B.S.7    Attie, A.D.8
  • 43
    • 0025332564 scopus 로고
    • Nutritional control of rat liver fatty acid synthase and S14 mRNA abundance
    • S.D. Clarke, M.K. Armstrong, and D.B. Jump Nutritional control of rat liver fatty acid synthase and S14 mRNA abundance J. Nutr. 120 1990 218 224
    • (1990) J. Nutr. , vol.120 , pp. 218-224
    • Clarke, S.D.1    Armstrong, M.K.2    Jump, D.B.3
  • 44
    • 0032568557 scopus 로고    scopus 로고
    • Regulation of sterol regulatory element binding proteins in livers of fasted and refed mice
    • J.D. Horton, Y. Bashmakov, I. Shimomura, and H. Shimano Regulation of sterol regulatory element binding proteins in livers of fasted and refed mice Proc. Natl. Acad. Sci. U.S.A. 95 1998 5987 5992
    • (1998) Proc. Natl. Acad. Sci. U.S.A. , vol.95 , pp. 5987-5992
    • Horton, J.D.1    Bashmakov, Y.2    Shimomura, I.3    Shimano, H.4
  • 45
    • 71949094496 scopus 로고    scopus 로고
    • Response to carbohydrate and fat refeeding in the expression of genes involved in nutrient partitioning and metabolism: Striking effects on fibroblast growth factor-21 induction
    • J. Sanchez, A. Palou, and C. Pico Response to carbohydrate and fat refeeding in the expression of genes involved in nutrient partitioning and metabolism: striking effects on fibroblast growth factor-21 induction Endocrinology 150 2009 5341 5350
    • (2009) Endocrinology , vol.150 , pp. 5341-5350
    • Sanchez, J.1    Palou, A.2    Pico, C.3
  • 46
    • 0033607176 scopus 로고    scopus 로고
    • Sterol regulatory element binding protein-1c is a major mediator of insulin action on the hepatic expression of glucokinase and lipogenesis-related genes
    • M. Foretz, C. Guichard, P. Ferre, and F. Foufelle Sterol regulatory element binding protein-1c is a major mediator of insulin action on the hepatic expression of glucokinase and lipogenesis-related genes Proc. Natl. Acad. Sci. U.S.A. 96 1999 12737 12742
    • (1999) Proc. Natl. Acad. Sci. U.S.A. , vol.96 , pp. 12737-12742
    • Foretz, M.1    Guichard, C.2    Ferre, P.3    Foufelle, F.4
  • 47
    • 1842375053 scopus 로고    scopus 로고
    • Upstream stimulatory factor binding to the E-box at - 65 is required for insulin regulation of the fatty acid synthase promoter
    • D. Wang, and H.S. Sul Upstream stimulatory factor binding to the E-box at - 65 is required for insulin regulation of the fatty acid synthase promoter J. Biol. Chem. 272 1997 26367 26374
    • (1997) J. Biol. Chem. , vol.272 , pp. 26367-26374
    • Wang, D.1    Sul, H.S.2
  • 48
    • 0028851735 scopus 로고
    • Upstream stimulatory factors bind to insulin response sequence of the fatty acid synthase promoter. USF1 is regulated
    • D. Wang, and H.S. Sul Upstream stimulatory factors bind to insulin response sequence of the fatty acid synthase promoter. USF1 is regulated J. Biol. Chem. 270 1995 28716 28722
    • (1995) J. Biol. Chem. , vol.270 , pp. 28716-28722
    • Wang, D.1    Sul, H.S.2
  • 49
    • 0015454954 scopus 로고
    • Control of the synthesis of fatty-acid synthetase in rat liver by insulin, glucagon, and adenosine 3′:5′ cyclic monophosphate
    • M.R. Lakshmanan, C.M. Nepokroeff, and J.W. Porter Control of the synthesis of fatty-acid synthetase in rat liver by insulin, glucagon, and adenosine 3′:5′ cyclic monophosphate Proc. Natl. Acad. Sci. U.S.A. 69 1972 3516 3519
    • (1972) Proc. Natl. Acad. Sci. U.S.A. , vol.69 , pp. 3516-3519
    • Lakshmanan, M.R.1    Nepokroeff, C.M.2    Porter, J.W.3
  • 50
    • 0024529257 scopus 로고
    • Hormonal regulation of mouse fatty acid synthase gene transcription in liver
    • J.D. Paulauskis, and H.S. Sul Hormonal regulation of mouse fatty acid synthase gene transcription in liver J. Biol. Chem. 264 1989 574 577
    • (1989) J. Biol. Chem. , vol.264 , pp. 574-577
    • Paulauskis, J.D.1    Sul, H.S.2
  • 52
    • 2942588527 scopus 로고    scopus 로고
    • Stearoyl-CoA desaturase 1 gene expression is necessary for fructose-mediated induction of lipogenic gene expression by sterol regulatory element-binding protein-1c-dependent and -independent mechanisms
    • M. Miyazaki, A. Dobrzyn, W.C. Man, K. Chu, H. Sampath, H.J. Kim, and J.M. Ntambi Stearoyl-CoA desaturase 1 gene expression is necessary for fructose-mediated induction of lipogenic gene expression by sterol regulatory element-binding protein-1c-dependent and -independent mechanisms J. Biol. Chem. 279 2004 25164 25171
    • (2004) J. Biol. Chem. , vol.279 , pp. 25164-25171
    • Miyazaki, M.1    Dobrzyn, A.2    Man, W.C.3    Chu, K.4    Sampath, H.5    Kim, H.J.6    Ntambi, J.M.7
  • 53
    • 8144229872 scopus 로고    scopus 로고
    • Carbohydrate response element binding protein directly promotes lipogenic enzyme gene transcription
    • S. Ishii, K. Iizuka, B.C. Miller, and K. Uyeda Carbohydrate response element binding protein directly promotes lipogenic enzyme gene transcription Proc. Natl. Acad. Sci. U.S.A. 101 2004 15597 15602
    • (2004) Proc. Natl. Acad. Sci. U.S.A. , vol.101 , pp. 15597-15602
    • Ishii, S.1    Iizuka, K.2    Miller, B.C.3    Uyeda, K.4
  • 55
    • 33749407193 scopus 로고    scopus 로고
    • ChREBP-Mlx is the principal mediator of glucose-induced gene expression in the liver
    • L. Ma, L.N. Robinson, and H.C. Towle ChREBP-Mlx is the principal mediator of glucose-induced gene expression in the liver J. Biol. Chem. 281 2006 28721 28730
    • (2006) J. Biol. Chem. , vol.281 , pp. 28721-28730
    • Ma, L.1    Robinson, L.N.2    Towle, H.C.3
  • 58
    • 0036245227 scopus 로고    scopus 로고
    • Suppression of fatty acid synthase promoter by polyunsaturated fatty acids
    • Y.S. Moon, M.J. Latasa, M.J. Griffin, and H.S. Sul Suppression of fatty acid synthase promoter by polyunsaturated fatty acids J. Lipid Res. 43 2002 691 698
    • (2002) J. Lipid Res. , vol.43 , pp. 691-698
    • Moon, Y.S.1    Latasa, M.J.2    Griffin, M.J.3    Sul, H.S.4
  • 59
    • 26444434340 scopus 로고    scopus 로고
    • Polyunsaturated fatty acids suppress glycolytic and lipogenic genes through the inhibition of ChREBP nuclear protein translocation
    • R. Dentin, F. Benhamed, J.P. Pegorier, F. Foufelle, B. Viollet, S. Vaulont, J. Girard, and C. Postic Polyunsaturated fatty acids suppress glycolytic and lipogenic genes through the inhibition of ChREBP nuclear protein translocation J. Clin. Invest. 115 2005 2843 2854
    • (2005) J. Clin. Invest. , vol.115 , pp. 2843-2854
    • Dentin, R.1    Benhamed, F.2    Pegorier, J.P.3    Foufelle, F.4    Viollet, B.5    Vaulont, S.6    Girard, J.7    Postic, C.8
  • 60
    • 4344685089 scopus 로고    scopus 로고
    • Suppression of hepatic fatty acid synthase by feeding alpha-linolenic acid rich perilla oil lowers plasma triacylglycerol level in rats
    • H.K. Kim, S. Choi, and H. Choi Suppression of hepatic fatty acid synthase by feeding alpha-linolenic acid rich perilla oil lowers plasma triacylglycerol level in rats J. Nutr. Biochem. 15 2004 485 492
    • (2004) J. Nutr. Biochem. , vol.15 , pp. 485-492
    • Kim, H.K.1    Choi, S.2    Choi, H.3
  • 61
    • 12644314084 scopus 로고    scopus 로고
    • Two tandem binding sites for sterol regulatory element binding proteins are required for sterol regulation of fatty-acid synthase promoter
    • M.M. Magana, and T.F. Osborne Two tandem binding sites for sterol regulatory element binding proteins are required for sterol regulation of fatty-acid synthase promoter J. Biol. Chem. 271 1996 32689 32694
    • (1996) J. Biol. Chem. , vol.271 , pp. 32689-32694
    • Magana, M.M.1    Osborne, T.F.2
  • 62
    • 12944259150 scopus 로고    scopus 로고
    • Nutritional regulation of the fatty acid synthase promoter in vivo: Sterol regulatory element binding protein functions through an upstream region containing a sterol regulatory element
    • M.J. Latasa, Y.S. Moon, K.H. Kim, and H.S. Sul Nutritional regulation of the fatty acid synthase promoter in vivo: sterol regulatory element binding protein functions through an upstream region containing a sterol regulatory element Proc. Natl. Acad. Sci. U.S.A. 97 2000 10619 10624
    • (2000) Proc. Natl. Acad. Sci. U.S.A. , vol.97 , pp. 10619-10624
    • Latasa, M.J.1    Moon, Y.S.2    Kim, K.H.3    Sul, H.S.4
  • 63
    • 0028875426 scopus 로고
    • Sterol regulation of fatty acid synthase promoter. Coordinate feedback regulation of two major lipid pathways
    • M.K. Bennett, J.M. Lopez, H.B. Sanchez, and T.F. Osborne Sterol regulation of fatty acid synthase promoter. Coordinate feedback regulation of two major lipid pathways J. Biol. Chem. 270 1995 25578 25583
    • (1995) J. Biol. Chem. , vol.270 , pp. 25578-25583
    • Bennett, M.K.1    Lopez, J.M.2    Sanchez, H.B.3    Osborne, T.F.4
  • 64
    • 0030026643 scopus 로고    scopus 로고
    • Identification of an inverted CCAAT box motif in the fatty-acid synthase gene as an essential element for modification of transcriptional regulation by cAMP
    • V.S. Rangan, B. Oskouian, and S. Smith Identification of an inverted CCAAT box motif in the fatty-acid synthase gene as an essential element for modification of transcriptional regulation by cAMP J. Biol. Chem. 271 1996 2307 2312
    • (1996) J. Biol. Chem. , vol.271 , pp. 2307-2312
    • Rangan, V.S.1    Oskouian, B.2    Smith, S.3
  • 65
    • 0031016115 scopus 로고    scopus 로고
    • NF-Y binds to the inverted CCAAT box, an essential element for cAMP-dependent regulation of the rat fatty acid synthase (FAS) gene
    • K. Roder, S.S. Wolf, K.F. Beck, S. Sickinger, and M. Schweizer NF-Y binds to the inverted CCAAT box, an essential element for cAMP-dependent regulation of the rat fatty acid synthase (FAS) gene Gene 184 1997 21 26
    • (1997) Gene , vol.184 , pp. 21-26
    • Roder, K.1    Wolf, S.S.2    Beck, K.F.3    Sickinger, S.4    Schweizer, M.5
  • 66
    • 0032966918 scopus 로고    scopus 로고
    • Interaction between the two ubiquitously expressed transcription factors NF-Y and Sp1
    • K. Roder, S.S. Wolf, K.J. Larkin, and M. Schweizer Interaction between the two ubiquitously expressed transcription factors NF-Y and Sp1 Gene 234 1999 61 69
    • (1999) Gene , vol.234 , pp. 61-69
    • Roder, K.1    Wolf, S.S.2    Larkin, K.J.3    Schweizer, M.4
  • 67
    • 0034636014 scopus 로고    scopus 로고
    • Sterol regulation of human fatty acid synthase promoter i requires nuclear factor-Y- and Sp-1-binding sites
    • S. Xiong, S.S. Chirala, and S.J. Wakil Sterol regulation of human fatty acid synthase promoter I requires nuclear factor-Y- and Sp-1-binding sites Proc. Natl. Acad. Sci. U.S.A. 97 2000 3948 3953
    • (2000) Proc. Natl. Acad. Sci. U.S.A. , vol.97 , pp. 3948-3953
    • Xiong, S.1    Chirala, S.S.2    Wakil, S.J.3
  • 68
    • 79956292356 scopus 로고    scopus 로고
    • Constitutive role for IRE1alpha-XBP1 signaling pathway in the insulin-mediated hepatic lipogenic program
    • J. Ning, T. Hong, A. Ward, J. Pi, Z. Liu, H.Y. Liu, and W. Cao Constitutive role for IRE1alpha-XBP1 signaling pathway in the insulin-mediated hepatic lipogenic program Endocrinology 152 2011 2247 2255
    • (2011) Endocrinology , vol.152 , pp. 2247-2255
    • Ning, J.1    Hong, T.2    Ward, A.3    Pi, J.4    Liu, Z.5    Liu, H.Y.6    Cao, W.7
  • 69
    • 0035923516 scopus 로고    scopus 로고
    • Glucose and cAMP regulate the L-type pyruvate kinase gene by phosphorylation/dephosphorylation of the carbohydrate response element binding protein
    • T. Kawaguchi, M. Takenoshita, T. Kabashima, and K. Uyeda Glucose and cAMP regulate the L-type pyruvate kinase gene by phosphorylation/dephosphorylation of the carbohydrate response element binding protein Proc. Natl. Acad. Sci. U.S.A. 98 2001 13710 13715
    • (2001) Proc. Natl. Acad. Sci. U.S.A. , vol.98 , pp. 13710-13715
    • Kawaguchi, T.1    Takenoshita, M.2    Kabashima, T.3    Uyeda, K.4
  • 70
    • 0035877604 scopus 로고    scopus 로고
    • Involvement of a unique carbohydrate-responsive factor in the glucose regulation of rat liver fatty-acid synthase gene transcription
    • C. Rufo, M. Teran-Garcia, M.T. Nakamura, S.H. Koo, H.C. Towle, and S.D. Clarke Involvement of a unique carbohydrate-responsive factor in the glucose regulation of rat liver fatty-acid synthase gene transcription J. Biol. Chem. 276 2001 21969 21975
    • (2001) J. Biol. Chem. , vol.276 , pp. 21969-21975
    • Rufo, C.1    Teran-Garcia, M.2    Nakamura, M.T.3    Koo, S.H.4    Towle, H.C.5    Clarke, S.D.6
  • 71
    • 70350131993 scopus 로고    scopus 로고
    • Replacing dietary glucose with fructose increases ChREBP activity and SREBP-1 protein in rat liver nucleus
    • H.Y. Koo, M. Miyashita, B.H. Cho, and M.T. Nakamura Replacing dietary glucose with fructose increases ChREBP activity and SREBP-1 protein in rat liver nucleus Biochem. Biophys. Res. Commun. 390 2009 285 289
    • (2009) Biochem. Biophys. Res. Commun. , vol.390 , pp. 285-289
    • Koo, H.Y.1    Miyashita, M.2    Cho, B.H.3    Nakamura, M.T.4
  • 72
    • 33749991421 scopus 로고    scopus 로고
    • Hepatocyte nuclear factor-4alpha contributes to carbohydrate-induced transcriptional activation of hepatic fatty acid synthase
    • A.W. Adamson, G. Suchankova, C. Rufo, M.T. Nakamura, M. Teran-Garcia, S.D. Clarke, and T.W. Gettys Hepatocyte nuclear factor-4alpha contributes to carbohydrate-induced transcriptional activation of hepatic fatty acid synthase Biochem. J. 399 2006 285 295
    • (2006) Biochem. J. , vol.399 , pp. 285-295
    • Adamson, A.W.1    Suchankova, G.2    Rufo, C.3    Nakamura, M.T.4    Teran-Garcia, M.5    Clarke, S.D.6    Gettys, T.W.7
  • 73
    • 3843061127 scopus 로고    scopus 로고
    • Central role for liver X receptor in insulin-mediated activation of Srebp-1c transcription and stimulation of fatty acid synthesis in liver
    • G. Chen, G. Liang, J. Ou, J.L. Goldstein, and M.S. Brown Central role for liver X receptor in insulin-mediated activation of Srebp-1c transcription and stimulation of fatty acid synthesis in liver Proc. Natl. Acad. Sci. U.S.A. 101 2004 11245 11250
    • (2004) Proc. Natl. Acad. Sci. U.S.A. , vol.101 , pp. 11245-11250
    • Chen, G.1    Liang, G.2    Ou, J.3    Goldstein, J.L.4    Brown, M.S.5
  • 74
    • 33847006599 scopus 로고    scopus 로고
    • The liver X receptor (LXR) and hepatic lipogenesis. The carbohydrate-response element-binding protein is a target gene of LXR
    • J.Y. Cha, and J.J. Repa The liver X receptor (LXR) and hepatic lipogenesis. The carbohydrate-response element-binding protein is a target gene of LXR J. Biol. Chem. 282 2007 743 751
    • (2007) J. Biol. Chem. , vol.282 , pp. 743-751
    • Cha, J.Y.1    Repa, J.J.2
  • 76
    • 0027936018 scopus 로고
    • Identification of an insulin response element in the fatty acid synthase promoter
    • N. Moustaid, R.S. Beyer, and H.S. Sul Identification of an insulin response element in the fatty acid synthase promoter J. Biol. Chem. 269 1994 5629 5634
    • (1994) J. Biol. Chem. , vol.269 , pp. 5629-5634
    • Moustaid, N.1    Beyer, R.S.2    Sul, H.S.3
  • 77
    • 34848880141 scopus 로고    scopus 로고
    • Nicotine-induced activation of AMP-activated protein kinase inhibits fatty acid synthase in 3T3L1 adipocytes: A role for oxidant stress
    • Z. An, H. Wang, P. Song, M. Zhang, X. Geng, and M.H. Zou Nicotine-induced activation of AMP-activated protein kinase inhibits fatty acid synthase in 3T3L1 adipocytes: a role for oxidant stress J. Biol. Chem. 282 2007 26793 26801
    • (2007) J. Biol. Chem. , vol.282 , pp. 26793-26801
    • An, Z.1    Wang, H.2    Song, P.3    Zhang, M.4    Geng, X.5    Zou, M.H.6
  • 81
    • 0016708503 scopus 로고
    • Separation of two active forms (holo-a and holo-b) of pigeon liver fatty acid synthetase and their interconversion by phosphorylation and dephosphorylation
    • A.A. Qureshi, R.A. Jenik, M. Kim, F.A. Lornitzo, and J.W. Porter Separation of two active forms (holo-a and holo-b) of pigeon liver fatty acid synthetase and their interconversion by phosphorylation and dephosphorylation Biochem. Biophys. Res. Commun. 66 1975 344 351
    • (1975) Biochem. Biophys. Res. Commun. , vol.66 , pp. 344-351
    • Qureshi, A.A.1    Jenik, R.A.2    Kim, M.3    Lornitzo, F.A.4    Porter, J.W.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.