-
1
-
-
0034958947
-
Epidemiology of severe sepsis in the United States: Analysis of incidence, outcome, and associated costs of care
-
Angus DC, Linde-Zwirble WT, Lidicker J, Clermont G, Carcillo J, Pinsky MR: Epidemiology of severe sepsis in the United States: analysis of incidence, outcome, and associated costs of care. Crit Care Med 29:1303-1310, 2001.
-
(2001)
Crit Care Med
, vol.29
, pp. 1303-1310
-
-
Angus, D.C.1
Linde-Zwirble, W.T.2
Lidicker, J.3
Clermont, G.4
Carcillo, J.5
Pinsky, M.R.6
-
2
-
-
0027752805
-
The L-arginineYnitric oxide pathway
-
Moncada S, Higgs A: The L-arginineYnitric oxide pathway. N Engl J Med 329:2002-2012, 1993.
-
(1993)
N Engl J Med
, vol.329
, pp. 2002-2012
-
-
Moncada, S.1
Higgs, A.2
-
3
-
-
0034687080
-
Congenital deficiency of nitric oxide synthase 2 protects against endotoxin-induced myocardial dysfunction in mice
-
Ullrich R, Scherrer-Crosbie M, Bloch KD, Ichinose F, Nakajima H, Picard MH, Zapol WM, Quezado ZM: Congenital deficiency of nitric oxide synthase 2 protects against endotoxin-induced myocardial dysfunction in mice. Circulation 102:1440-1446, 2000.
-
(2000)
Circulation
, vol.102
, pp. 1440-1446
-
-
Ullrich, R.1
Scherrer-Crosbie, M.2
Bloch, K.D.3
Ichinose, F.4
Nakajima, H.5
Picard, M.H.6
Zapol, W.M.7
Quezado, Z.M.8
-
4
-
-
4444273012
-
Multiple-center, randomized, placebo-controlled, double-blind study of the nitric oxide synthase inhibitor 546C88: Effect on survival in patients with septic shock
-
Lopez A, Lorente JA, Steingrub J, Bakker J, McLuckie A, Willatts S, Brockway M, Anzueto A, Holzapfel L, Breen D, et al.: Multiple-center, randomized, placebo-controlled, double-blind study of the nitric oxide synthase inhibitor 546C88: effect on survival in patients with septic shock. Crit Care Med 32:21-30, 2004.
-
(2004)
Crit Care Med
, vol.32
, pp. 21-30
-
-
Lopez, A.1
Lorente, J.A.2
Steingrub, J.3
Bakker, J.4
McLuckie, A.5
Willatts, S.6
Brockway, M.7
Anzueto, A.8
Holzapfel, L.9
Breen, D.10
-
5
-
-
0029825613
-
Elevated blood pressures in mice lacking endothelial nitric oxide synthase
-
Shesely EG, Maeda N, Kim HS, Desai KM, Krege JH, Laubach VE, Sherman PA, Sessa WC, Smithies O: Elevated blood pressures in mice lacking endothelial nitric oxide synthase. PNAS 93:13176-13181, 1996.
-
(1996)
PNAS
, vol.93
, pp. 13176-13181
-
-
Shesely, E.G.1
Maeda, N.2
Kim, H.S.3
Desai, K.M.4
Krege, J.H.5
Laubach, V.E.6
Sherman, P.A.7
Sessa, W.C.8
Smithies, O.9
-
6
-
-
15444369648
-
Resistance to endotoxic shock in endo-thelial nitric-oxide synthase (eNOS) knock-out mice: A pro-inflammatory role for eNOS-derived NO in vivo
-
Connelly L, Madhani M, Hobbs AJ: Resistance to endotoxic shock in endo-thelial nitric-oxide synthase (eNOS) knock-out mice: a pro-inflammatory role for eNOS-derived NO in vivo. J Biol Chem 280:10040-10046, 2005.
-
(2005)
J Biol Chem
, vol.280
, pp. 10040-10046
-
-
Connelly, L.1
Madhani, M.2
Hobbs, A.J.3
-
7
-
-
0033994015
-
Resistance to endotoxin shock in transgenic mice overexpressing endothelial nitric oxide synthase
-
Yamashita T, Kawashima S, Ohashi Y, Ozaki M, Ueyama T, Ishida T, Inoue N, Hirata K, Akita H, Yokoyama M: Resistance to endotoxin shock in transgenic mice overexpressing endothelial nitric oxide synthase. Circulation 101:931-937, 2000.
-
(2000)
Circulation
, vol.101
, pp. 931-937
-
-
Yamashita, T.1
Kawashima, S.2
Ohashi, Y.3
Ozaki, M.4
Ueyama, T.5
Ishida, T.6
Inoue, N.7
Hirata, K.8
Akita, H.9
Yokoyama, M.10
-
8
-
-
0025354406
-
Laboratory models of sepsis and septic shock
-
Fink MP, Heard SO: Laboratory models of sepsis and septic shock. J Surg Res 49:186-196, 1990.
-
(1990)
J Surg Res
, vol.49
, pp. 186-196
-
-
Fink, M.P.1
Heard, S.O.2
-
9
-
-
33846116583
-
Cardiomyocyte-specific overexpression of nitric oxide synthase 3 prevents myocardial dysfunction in murine models of septic shock
-
Ichinose F, Buys ES, Neilan TG, Furutani EM, Morgan JG, Jassal DS, Graveline AR, Searles RJ, Lim CC, Kaneki M, et al.: Cardiomyocyte-specific overexpression of nitric oxide synthase 3 prevents myocardial dysfunction in murine models of septic shock. Circ Res 100:130-139, 2007.
-
(2007)
Circ Res
, vol.100
, pp. 130-139
-
-
Ichinose, F.1
Buys, E.S.2
Neilan, T.G.3
Furutani, E.M.4
Morgan, J.G.5
Jassal, D.S.6
Graveline, A.R.7
Searles, R.J.8
Lim, C.C.9
Kaneki, M.10
-
10
-
-
0031924789
-
Essential role of gamma interferon in survival of colon ascendens stent peritonitis, a novel murine model of abdominal sepsis
-
Zantl N, Uebe A, Neumann B, Wagner H, Siewert JR, Holzmann B, Heidecke CD, Pfeffer K: Essential role of gamma interferon in survival of colon ascendens stent peritonitis, a novel murine model of abdominal sepsis. Infect Immun 66:2300-2309, 1998.
-
(1998)
Infect Immun
, vol.66
, pp. 2300-2309
-
-
Zantl, N.1
Uebe, A.2
Neumann, B.3
Wagner, H.4
Siewert, J.R.5
Holzmann, B.6
Heidecke, C.D.7
Pfeffer, K.8
-
11
-
-
0034838078
-
Knockout mice heterozygous for Sod2 show alterations in cardiac mitochondrial function and apoptosis
-
Van Remmen H, Williams MD, Guo Z, Estlack L, Yang H, Carlson EJ, Epstein CJ, Huang TT, Richardson A: Knockout mice heterozygous for Sod2 show alterations in cardiac mitochondrial function and apoptosis. Am J Physiol Heart Circ Physiol 281:H1422-H1432, 2001.
-
(2001)
Am J Physiol Heart Circ Physiol
, vol.281
-
-
Van Remmen, H.1
Williams, M.D.2
Guo, Z.3
Estlack, L.4
Yang, H.5
Carlson, E.J.6
Epstein, C.J.7
Huang, T.T.8
Richardson, A.9
-
13
-
-
33847732229
-
Endothelial nitric oxide synthase (NOS3) knockout decreases NOS2 induction, limiting hyperoxygenation and conferring protection in the postischemic heart
-
Zhao X, Chen YR, He G, Zhang A, Druhan LJ, Strauch AR, Zweier JL: Endothelial nitric oxide synthase (NOS3) knockout decreases NOS2 induction, limiting hyperoxygenation and conferring protection in the postischemic heart. Am J Physiol Heart Circ Physiol 292:H1541-H1550, 2007.
-
(2007)
Am J Physiol Heart Circ Physiol
, vol.292
-
-
Zhao, X.1
Chen, Y.R.2
He, G.3
Zhang, A.4
Druhan, L.J.5
Strauch, A.R.6
Zweier, J.L.7
-
14
-
-
0020522496
-
Inhibition of human platelet aggregation by S-nitrosothiols. Heme-dependent activation of soluble guanylate cyclase and stimulation of cyclic GMP accumulation
-
Mellion BT, Ignarro LJ, Myers CB, Ohlstein EH, Ballot BA, Hyman AL, Kadowitz PJ: Inhibition of human platelet aggregation by S-nitrosothiols. Heme-dependent activation of soluble guanylate cyclase and stimulation of cyclic GMP accumulation. Mol Pharmacol 23:653-664, 1983.
-
(1983)
Mol Pharmacol
, vol.23
, pp. 653-664
-
-
Mellion, B.T.1
Ignarro, L.J.2
Myers, C.B.3
Ohlstein, E.H.4
Ballot, B.A.5
Hyman, A.L.6
Kadowitz, P.J.7
-
15
-
-
0026630603
-
Nitric oxide, an endothelial cell relaxation factor, inhibits neutrophil superoxide anion production via a direct action on the NADPH oxidase
-
Clancy RM, Leszczynska-Piziak J, Abramson SB: Nitric oxide, an endothelial cell relaxation factor, inhibits neutrophil superoxide anion production via a direct action on the NADPH oxidase. J Clin Invest 90:1116-1121, 1992.
-
(1992)
J Clin Invest
, vol.90
, pp. 1116-1121
-
-
Clancy, R.M.1
Leszczynska-Piziak, J.2
Abramson, S.B.3
-
16
-
-
0033843430
-
Molecular mechanisms of innate immunity
-
Ulevitch RJ: Molecular mechanisms of innate immunity. Immunol Res 21:49-54, 2000.
-
(2000)
Immunol Res
, vol.21
, pp. 49-54
-
-
Ulevitch, R.J.1
-
17
-
-
0027159920
-
Clinical detection of LPS and animal models of endotoxemia
-
Redl H, Bahrami S, Schlag G, Traber DL: Clinical detection of LPS and animal models of endotoxemia. Immunobiology 187:330-345, 1993.
-
(1993)
Immunobiology
, vol.187
, pp. 330-345
-
-
Redl, H.1
Bahrami, S.2
Schlag, G.3
Traber, D.L.4
-
18
-
-
33845905763
-
The disconnect between animal models of sepsis and human sepsis
-
Rittirsch D, Hoesel LM, Ward PA: The disconnect between animal models of sepsis and human sepsis. J Leukoc Biol 81:137-143, 2007.
-
(2007)
J Leukoc Biol
, vol.81
, pp. 137-143
-
-
Rittirsch, D.1
Hoesel, L.M.2
Ward, P.A.3
-
19
-
-
16644385124
-
Cecal ligation and puncture versus colon ascendens stent peritonitis: Two distinct animal models for polymicrobial sepsis
-
Maier S, Traeger T, Entleutner M, Westerholt A, Kleist B, Huser N, Holzmann B, Stier A, Pfeffer K, Heidecke CD: Cecal ligation and puncture versus colon ascendens stent peritonitis: two distinct animal models for polymicrobial sepsis. Shock 21:505-511, 2004.
-
(2004)
Shock
, vol.21
, pp. 505-511
-
-
Maier, S.1
Traeger, T.2
Entleutner, M.3
Westerholt, A.4
Kleist, B.5
Huser, N.6
Holzmann, B.7
Stier, A.8
Pfeffer, K.9
Heidecke, C.D.10
-
20
-
-
67649383519
-
Endothelial nitric oxide synthase G894T (GLU298ASP) polymorphism is associated with hypotension in patients with E. coli bacteremia but not in bacteremia caused by a gram-positive organism
-
Huttunen R, Hurme M, Laine J, Eklund C, Vuento R, Aittoniemi J, Huhtala H, Syrjanen J: Endothelial nitric oxide synthase G894T (GLU298ASP) polymorphism is associated with hypotension in patients with E. coli bacteremia but not in bacteremia caused by a gram-positive organism. Shock 31:448-453, 2009.
-
(2009)
Shock
, vol.31
, pp. 448-453
-
-
Huttunen, R.1
Hurme, M.2
Laine, J.3
Eklund, C.4
Vuento, R.5
Aittoniemi, J.6
Huhtala, H.7
Syrjanen, J.8
-
21
-
-
0027920980
-
Pathogenetic mechanisms of septic shock
-
Parrillo JE: Pathogenetic mechanisms of septic shock. N Engl J Med 328: 1471-1477, 1993.
-
(1993)
N Engl J Med
, vol.328
, pp. 1471-1477
-
-
Parrillo, J.E.1
-
22
-
-
0035403179
-
Impairment of the ryanodine-sensitive calcium release channels in the cardiac sarcoplasmic reticulum and its underlying mechanism during the hypodynamic phase of sepsis
-
Dong LW, Wu LL, Ji Y, Liu MS: Impairment of the ryanodine-sensitive calcium release channels in the cardiac sarcoplasmic reticulum and its underlying mechanism during the hypodynamic phase of sepsis. Shock 16:33-39, 2001.
-
(2001)
Shock
, vol.16
, pp. 33-39
-
-
Dong, L.W.1
Wu, L.L.2
Ji, Y.3
Liu, M.S.4
-
23
-
-
0034881125
-
Myocardial dysfunction in septic shock: Part II. Role of cytokines and nitric oxide
-
Kumar A, Krieger A, Symeoneides S, Kumar A, Parrillo JE: Myocardial dysfunction in septic shock: part II. Role of cytokines and nitric oxide. J Cardiothorac Vasc Anesth 15:485-511, 2001.
-
(2001)
J Cardiothorac Vasc Anesth
, vol.15
, pp. 485-511
-
-
Kumar, A.1
Krieger, A.2
Symeoneides, S.3
Kumar, A.4
Parrillo, J.E.5
-
24
-
-
4944254828
-
Immune cell toll-like receptor 4 is required for cardiac myocyte impairment during endotoxemia
-
Tavener SA, Long EM, Robbins SM, McRae KM, Van Remmen H, Kubes P: Immune cell toll-like receptor 4 is required for cardiac myocyte impairment during endotoxemia. Circ Res 95:700-707, 2004.
-
(2004)
Circ Res
, vol.95
, pp. 700-707
-
-
Tavener, S.A.1
Long, E.M.2
Robbins, S.M.3
McRae, K.M.4
Van Remmen, H.5
Kubes, P.6
-
25
-
-
34250733466
-
Mitochondrial dysfunction, bioenergetic impairment, and metabolic down-regulation in sepsis
-
Levy RJ: Mitochondrial dysfunction, bioenergetic impairment, and metabolic down-regulation in sepsis. Shock 28:24-28, 2007.
-
(2007)
Shock
, vol.28
, pp. 24-28
-
-
Levy, R.J.1
-
26
-
-
55349094010
-
Local energetic regulation of sarcoplasmic and myosin ATPase is differently impaired in rats with heart failure
-
Joubert F, Wilding JR, Fortin D, Domergue-Dupont R, Novotova M, Ventura-Clapier Re, Veksler V: Local energetic regulation of sarcoplasmic and myosin ATPase is differently impaired in rats with heart failure. J Physiol 586:5181-5192, 2008.
-
(2008)
J Physiol
, vol.586
, pp. 5181-5192
-
-
Joubert, F.1
Wilding, J.R.2
Fortin, D.3
Domergue-Dupont, R.4
Novotova, M.5
Re, V.6
Veksler, V.7
-
27
-
-
15844375853
-
Loss of cyclophilin D reveals a critical role for mitochondrial permeability transition in cell death
-
Baines CP, Kaiser RA, Purcell NH, Blair NS, Osinska H, Hambleton MA, Brunskill EW, Sayen MR, Gottlieb RA, Dorn GW, et al.: Loss of cyclophilin D reveals a critical role for mitochondrial permeability transition in cell death. Nature 434:658-662, 2005.
-
(2005)
Nature
, vol.434
, pp. 658-662
-
-
Baines, C.P.1
Kaiser, R.A.2
Purcell, N.H.3
Blair, N.S.4
Osinska, H.5
Hambleton, M.A.6
Brunskill, E.W.7
Sayen, M.R.8
Gottlieb, R.A.9
Dorn, G.W.10
-
28
-
-
33745685397
-
Inhibition of mitochondrial permeability transition prevents sepsis-induced myocardial dysfunction and mortality
-
Larche J, Lancel S, Hassoun SM, Favory R, Decoster B, Marchetti P, Chopin C, Neviere R: Inhibition of mitochondrial permeability transition prevents sepsis-induced myocardial dysfunction and mortality. J Am Coll Cardiol 48:377-385, 2006.
-
(2006)
J Am Coll Cardiol
, vol.48
, pp. 377-385
-
-
Larche, J.1
Lancel, S.2
Hassoun, S.M.3
Favory, R.4
Decoster, B.5
Marchetti, P.6
Chopin, C.7
Neviere, R.8
-
29
-
-
34250700076
-
Nitric oxide and mitochondrial respiration in the heart
-
Brown GC, Borutaite V: Nitric oxide and mitochondrial respiration in the heart. Cardiovasc Res 75:283-290, 2007.
-
(2007)
Cardiovasc Res
, vol.75
, pp. 283-290
-
-
Brown, G.C.1
Borutaite, V.2
-
30
-
-
12344335535
-
Hypoxia accelerates nitric oxideY dependent inhibition of mitochondrial complex i in activated macrophages
-
Frost MT, Wang Q, Moncada S, Singer M: Hypoxia accelerates nitric oxideY dependent inhibition of mitochondrial complex I in activated macrophages. Am J Physiol Regul Integr Comp Physiol 288:R394-R400, 2005.
-
(2005)
Am J Physiol Regul Integr Comp Physiol
, vol.288
-
-
Frost, M.T.1
Wang, Q.2
Moncada, S.3
Singer, M.4
-
31
-
-
0034785189
-
2+ release in cardiomyocytes
-
2+ release in cardiomyocytes. Nat Cell Biol 3:867-873, 2001.
-
(2001)
Nat Cell Biol
, vol.3
, pp. 867-873
-
-
Mgv, P.1
Kim, S.H.2
Pepe, S.3
Dessy, C.4
Marban, E.5
Balligand, J.L.6
Sollott, S.J.7
-
32
-
-
58149387380
-
2+ leak in chronic heart failure
-
2+ leak in chronic heart failure. Circ Res 103:1466-1472, 2008.
-
(2008)
Circ Res
, vol.103
, pp. 1466-1472
-
-
Terentyev, D.1
Gyorke, I.2
Belevych, A.E.3
Terentyeva, R.4
Sridhar, A.5
Nishijima, Y.6
Carcache De Blanco, E.7
Khanna, S.8
Sen, C.K.9
Cardounel, A.J.10
-
33
-
-
2342537093
-
Nitric oxide syn-thase activity in rat cardiac mitochondria
-
Zanella B, Giordano E, Muscari C, Zini M, Guarnieri C: Nitric oxide syn-thase activity in rat cardiac mitochondria. Basic Res Cardiol 99:159-164, 2004.
-
(2004)
Basic Res Cardiol
, vol.99
, pp. 159-164
-
-
Zanella, B.1
Giordano, E.2
Muscari, C.3
Zini, M.4
Guarnieri, C.5
-
34
-
-
34548176581
-
Mitochondrial function in sepsis: Acute phase versus multiple organ failure
-
Singer M: Mitochondrial function in sepsis: acute phase versus multiple organ failure. Crit Care Med 35:S441-S448, 2007.
-
(2007)
Crit Care Med
, vol.35
-
-
Singer, M.1
-
35
-
-
0347579845
-
Mitochondrial biogenesis in mammals: The role of endogenous nitric oxide
-
Nisoli E, Clementi E, Paolucci C, Cozzi V, Tonello C, Sciorati C, Bracale R, Valerio A, Francolini M, Moncada S, et al.: Mitochondrial biogenesis in mammals: the role of endogenous nitric oxide. Science 299:896-899, 2003.
-
(2003)
Science
, vol.299
, pp. 896-899
-
-
Nisoli, E.1
Clementi, E.2
Paolucci, C.3
Cozzi, V.4
Tonello, C.5
Sciorati, C.6
Bracale, R.7
Valerio, A.8
Francolini, M.9
Moncada, S.10
|