메뉴 건너뛰기




Volumn 7, Issue 7, 2011, Pages 416-426

Pathogenesis of systemic juvenile idiopathic arthritis: Some answers, more questions

Author keywords

[No Author keywords available]

Indexed keywords

COLONY STIMULATING FACTOR 1; FERRITIN; GAMMA INTERFERON; GRANZYME B; HAPTOGLOBIN; HEMOGLOBIN; INTERLEUKIN 1; INTERLEUKIN 10; INTERLEUKIN 18; INTERLEUKIN 1ALPHA; INTERLEUKIN 1BETA CONVERTING ENZYME; INTERLEUKIN 6; PERFORIN; PROTEIN S 100; RECOMBINANT INTERLEUKIN 1 RECEPTOR BLOCKING AGENT; TOLL LIKE RECEPTOR; TUMOR NECROSIS FACTOR;

EID: 79959963298     PISSN: 17594790     EISSN: 17594804     Source Type: Journal    
DOI: 10.1038/nrrheum.2011.68     Document Type: Review
Times cited : (269)

References (116)
  • 2
    • 33646477692 scopus 로고    scopus 로고
    • Predictors of disease course and remission in systemic juvenile idiopathic arthritis: Significance of early clinical and laboratory features
    • Singh-Grewal, D., Schneider, R., Bayer, N. & Feldman, B. M. Predictors of disease course and remission in systemic juvenile idiopathic arthritis: significance of early clinical and laboratory features. Arthritis Rheum. 54, 1595-1601 (2006).
    • (2006) Arthritis Rheum. , vol.54 , pp. 1595-1601
    • Singh-Grewal, D.1    Schneider, R.2    Bayer, N.3    Feldman, B.M.4
  • 4
    • 0033763981 scopus 로고    scopus 로고
    • Early predictors of poor functional outcome in systemic-onset juvenile rheumatoid arthritis: A multicenter cohort study
    • Spiegel, L. R. et al. Early predictors of poor functional outcome in systemic-onset juvenile rheumatoid arthritis: a multicenter cohort study. Arthritis Rheum. 43, 2402-2409 (2000).
    • (2000) Arthritis Rheum. , vol.43 , pp. 2402-2409
    • Spiegel, L.R.1
  • 6
    • 0030904347 scopus 로고    scopus 로고
    • Clinical analysis of 570 cases with juvenile rheumatoid arthritis: Results of a nationwide retrospective survey in Japan
    • Fujikawa, S. & Okuni, M. Clinical analysis of 570 cases with juvenile rheumatoid arthritis: results of a nationwide retrospective survey in Japan. Acta Paediatr. Jpn 39, 245-249 (1997).
    • (1997) Acta. Paediatr. Jpn. , vol.39 , pp. 245-249
    • Fujikawa, S.1    Okuni, M.2
  • 8
    • 1542283765 scopus 로고    scopus 로고
    • Natural killer cell dysfunction: A common pathway in systemic-onset juvenile rheumatoid arthritis, macrophage activation syndrome, and hemophagocytic lymphohistiocytosis?
    • DOI 10.1002/art.20198
    • Grom, A. Natural killer cell dysfunction: A common pathway in systemic-onset juvenile rheumatoid arthritis, macrophage activation syndrome, and hemophagocytic lymphohistiocytosis? Arthritis Rheum. 50, 689-698 (2004). (Pubitemid 38326166)
    • (2004) Arthritis and Rheumatism , vol.50 , Issue.3 , pp. 689-698
    • Grom, A.A.1
  • 9
    • 0035511981 scopus 로고    scopus 로고
    • Macrophage activation syndrome: A potentially fatal complication of rheumatic disorders
    • DOI 10.1136/adc.85.5.421
    • Sawhney, S., Woo, P. & Murray, K. J. Macrophage activation syndrome: a potentially fatal complication of rheumatic disorders. Arch. Dis. Child. 85, 421-426 (2001). (Pubitemid 33702300)
    • (2001) Archives of Disease in Childhood , vol.85 , Issue.5 , pp. 421-426
    • Sawhney, S.1    Woo, P.2    Murray, K.J.3
  • 10
    • 34248666067 scopus 로고    scopus 로고
    • Occult macrophage activation syndrome in patients with systemic juvenile idiopathic arthritis
    • Behrens, E. M., Beukelman, T., Paessler, M. & Cron, R. Q. Occult macrophage activation syndrome in patients with systemic juvenile idiopathic arthritis. J. Rheumatol. 34, 1133-1138 (2007). (Pubitemid 46774861)
    • (2007) Journal of Rheumatology , vol.34 , Issue.5 , pp. 1133-1138
    • Behrens, E.M.1    Beukelman, T.2    Paessler, M.3    Cron, R.Q.4
  • 12
    • 0023372151 scopus 로고
    • Seasonal variation in systemic onset juvenile rheumatoid arthritis
    • Lindsley, C. B. Seasonal variation in systemic onset juvenile rheumatoid arthritis. Arthritis Rheum. 30, 838-839 (1987).
    • (1987) Arthritis Rheum. , vol.30 , pp. 838-839
    • Lindsley, C.B.1
  • 13
    • 0028918342 scopus 로고
    • Epidemiology of juvenile rheumatoid arthritis in Manitoba Canada 1975-1992: Cycles in incidence
    • Oen, K., Fast, M. & Postl, B. Epidemiology of juvenile rheumatoid arthritis in Manitoba, Canada, 1975-1992: cycles in incidence. J. Rheumatol. 22, 745-750 (1995).
    • (1995) J. Rheumatol. , vol.22 , pp. 745-750
    • Oen, K.1    Fast, M.2    Postl, B.3
  • 15
    • 67650736238 scopus 로고    scopus 로고
    • Horror autoinflammaticus: The molecular pathophysiology of autoinflammatory disease
    • Masters, S., Simon, A., Aksentijevich, I. & Kastner, D. Horror autoinflammaticus: the molecular pathophysiology of autoinflammatory disease. Ann. Rev. Immunol. 27, 621-668 (2009).
    • (2009) Ann. Rev. Immunol. , vol.27 , pp. 621-668
    • Masters, S.1    Simon, A.2    Aksentijevich, I.3    Kastner, D.4
  • 16
    • 33847068680 scopus 로고    scopus 로고
    • First report of macrophage activation syndrome in hyperimmunoglobulinemia D with periodic fever syndrome
    • Rigante, D. et al. First report of macrophage activation syndrome in hyperimmunoglobulinemia D with periodic fever syndrome. Arthritis Rheum. 56, 658-661 (2007).
    • (2007) Arthritis Rheum. , vol.56 , pp. 658-661
    • Rigante, D.1
  • 17
    • 0026843499 scopus 로고
    • Juvenile rheumatoid arthritis and HLA: Report of the park city III workshop
    • Nepom, B. S. & Glass, D. N. Juvenile rheumatoid arthritis and HLA: report of the Park City III workshop. J. Rheumatol. Suppl. 33, 70-74 (1992).
    • (1992) J. Rheumatol. Suppl. , vol.33 , pp. 70-74
    • Nepom, B.S.1    Glass, D.N.2
  • 19
    • 0032189103 scopus 로고    scopus 로고
    • The effect of novel polymorphisms in the interleukin-6 (IL-6) gene on IL-6 transcription and plasma IL-6 levels, and an association with systemic- onset juvenile chronic arthritis
    • Fishman, D. et al. The effect of novel polymorphisms in the interleukin-6 (IL-6) gene on IL-6 transcription and plasma IL-6 levels, and an association with systemic-onset juvenile chronic arthritis. J. Clin. Invest. 102, 1369-1376 (1998). (Pubitemid 28467565)
    • (1998) Journal of Clinical Investigation , vol.102 , Issue.7 , pp. 1369-1376
    • Fishman, D.1    Faulds, G.2    Jeffey, R.3    Mohamed-Ali, V.4    Yudkin, J.S.5    Humphries, S.6    Woo, P.7
  • 21
    • 34547216848 scopus 로고    scopus 로고
    • Novel IL10 gene family associations with systemic juvenile idiopathic arthritis
    • Fife, M. S. et al. Novel IL10 gene family associations with systemic juvenile idiopathic arthritis. Arthritis Res. Ther. 8, R148 (2006).
    • (2006) Arthritis Res. Ther. , vol.8
    • Fife, M.S.1
  • 22
    • 79952652977 scopus 로고    scopus 로고
    • IL10 promoter polymorphisms are associated with systemic onset juvenile idiopathic arthritis sojia
    • Moller, J. et al. IL10 promoter polymorphisms are associated with systemic onset juvenile idiopathic arthritis (SoJIA).Clin. Exp. Rheumatol. 28, 912-918 (2010).
    • (2010) Clin. Exp. Rheumatol. , vol.28 , pp. 912-918
    • Moller, J.1
  • 23
    • 0034742201 scopus 로고    scopus 로고
    • A novel 5′-flanking region polymorphism of macrophage migration inhibitory factor is associated with systemic-onset juvenile idiopathic arthritis
    • DOI 10.1002/1529-0131(200108)44:8<1782::AID-ART314>3.0.CO;2-#
    • Donn, R. P., Shelley, E., Ollier, W. E. & Thomson, W. A novel 5′-flanking region polymorphism of macrophage migration inhibitory factor is associated with systemic-onset juvenile idiopathic arthritis. Arthritis Rheum. 44, 1782-1785 (2001). (Pubitemid 32758224)
    • (2001) Arthritis and Rheumatism , vol.44 , Issue.8 , pp. 1782-1785
    • Donn, R.P.1    Shelley, E.2    Ollier, W.E.R.3    Thomson, W.4
  • 25
    • 44849095175 scopus 로고    scopus 로고
    • Comprehensive association study of genetic variants in the IL-1 gene family in systemic juvenile idiopathic arthritis
    • DOI 10.1038/gene.2008.24, PII GENE200824
    • Stock, C. J. et al. Comprehensive association study of genetic variants in the IL-1 gene family in systemic juvenile idiopathic arthritis. Genes Immun. 9, 349-357 (2008). (Pubitemid 351791491)
    • (2008) Genes and Immunity , vol.9 , Issue.4 , pp. 349-357
    • Stock, C.J.W.1    Ogilvie, E.M.2    Samuel, J.M.3    Fife, M.4    Lewis, C.M.5    Woo, P.6
  • 29
    • 57349147019 scopus 로고    scopus 로고
    • MEFV mutations in systemic onset juvenile idiopathic arthritis
    • Oxford
    • Ayaz, N. A. et al. MEFV mutations in systemic onset juvenile idiopathic arthritis. Rheumatology (Oxford) 48, 23-25 (2009).
    • (2009) Rheumatology , vol.48 , pp. 23-25
    • Ayaz, N.A.1
  • 31
    • 73449117152 scopus 로고    scopus 로고
    • Distribution of circulating cells in systemic juvenile idiopathic arthritis across disease activity states
    • Macaubas, C. et al. Distribution of circulating cells in systemic juvenile idiopathic arthritis across disease activity states. Clin. Immunol. 134, 206-216 (2010).
    • (2010) Clin. Immunol. , vol.134 , pp. 206-216
    • Macaubas, C.1
  • 32
    • 79958276203 scopus 로고    scopus 로고
    • Immature cell populations and an erythropoiesis gene-expression signature in systemic juvenile idiopathic arthritis: Implications for pathogenesis
    • Hinze, C. et al. Immature cell populations and an erythropoiesis gene-expression signature in systemic juvenile idiopathic arthritis: implications for pathogenesis. Arthritis Res. Ther. 12, R123 (2010).
    • (2010) Arthritis Res. Ther. , vol.12
    • Hinze, C.1
  • 33
    • 18644385243 scopus 로고    scopus 로고
    • Role of interleukin-1 (IL-1) in the pathogenesis of systemic onset juvenile idiopathic arthritis and clinical response to IL-1 blockade
    • DOI 10.1084/jem.20050473
    • Pascual, V., Allantaz, F., Arce, E., Punaro, M. & Banchereau, J. Role of interleukin-1 (IL-1) in the pathogenesis of systemic onset juvenile idiopathic arthritis and clinical response to IL-1 blockade. J. Exp. Med. 201, 1479-1486 (2005). (Pubitemid 40664091)
    • (2005) Journal of Experimental Medicine , vol.201 , Issue.9 , pp. 1479-1486
    • Pascual, V.1    Allantaz, F.2    Arce, E.3    Punaro, M.4    Banchereau, J.5
  • 34
    • 34447523762 scopus 로고    scopus 로고
    • Specific gene expression profiles in systemic juvenile idiopathic arthritis
    • DOI 10.1002/art.22644
    • Ogilvie, E. M., Khan, A., Hubank, M., Kellam, P. & Woo, P. Specific gene expression profiles in systemic juvenile idiopathic arthritis. Arthritis Rheum. 56, 1954-1965 (2007). (Pubitemid 47110394)
    • (2007) Arthritis and Rheumatism , vol.56 , Issue.6 , pp. 1954-1965
    • Ogilvie, E.M.1    Khan, A.2    Hubank, M.3    Kellam, P.4    Woo, P.5
  • 35
    • 67650066800 scopus 로고    scopus 로고
    • Subtype-specific peripheral blood gene expression profiles in recent-onset juvenile idiopathic arthritis
    • Barnes, M. et al. Subtype-specific peripheral blood gene expression profiles in recent-onset juvenile idiopathic arthritis. Arthritis Rheum. 60, 2102-2112 (2009).
    • (2009) Arthritis Rheum. , vol.60 , pp. 2102-2112
    • Barnes, M.1
  • 37
    • 79953323633 scopus 로고    scopus 로고
    • A multicentre randomised double-blind placebo-controlled trial with the interleukin-1 receptor antagonist anakinra in patients with systemic-onset juvenile idiopathic arthritis anajis trial
    • Quartier, P. et al. A multicentre, randomised, double-blind, placebo-controlled trial with the interleukin-1 receptor antagonist anakinra in patients with systemic-onset juvenile idiopathic arthritis (ANAJIS trial).Ann. Rheum. Dis. 70, 747-754 (2011).
    • (2011) Ann. Rheum. Dis. , vol.70 , pp. 747-754
    • Quartier, P.1
  • 38
    • 77955357723 scopus 로고    scopus 로고
    • Follistatin-like protein 1 is a mesenchyme-derived inflammatory protein and may represent a biomarker for systemic-onset juvenile rheumatoid arthritis
    • Wilson, D. et al. Follistatin-like protein 1 is a mesenchyme-derived inflammatory protein and may represent a biomarker for systemic-onset juvenile rheumatoid arthritis. Arthritis Rheum. 62, 2510-2516 (2010).
    • (2010) Arthritis Rheum. , vol.62 , pp. 2510-2516
    • Wilson, D.1
  • 39
    • 78649709787 scopus 로고    scopus 로고
    • Plasma profiles in active systemic juvenile idiopathic arthritis: Biomarkers and biological implications
    • Ling, X. et al. Plasma profiles in active systemic juvenile idiopathic arthritis: biomarkers and biological implications. Proteomics 10, 4415-4430 (2010).
    • (2010) Proteomics , vol.10 , pp. 4415-4430
    • Ling, X.1
  • 40
    • 5044223401 scopus 로고    scopus 로고
    • Effective use of the recombinant interleukin 1 receptor antagonist anakinra in therapy resistant systemic onset juvenile rheumatoid arthritis
    • Verbsky, J. & White, A. Effective use of the recombinant interleukin 1 receptor antagonist anakinra in therapy resistant systemic onset juvenile rheumatoid arthritis. J. Rheumatol. 31, 2071-2075 (2004). (Pubitemid 39336738)
    • (2004) Journal of Rheumatology , vol.31 , Issue.10 , pp. 2071-2075
    • Verbsky, J.W.1    White, A.J.2
  • 41
    • 14944387115 scopus 로고    scopus 로고
    • Treatment of systemic onset juvenile rheumatoid arthritis with anakinra
    • Irigoyen, P. I., Olson, J., Hom, C. & Ilowite, N. T. Treatment of systemic onset juvenile rheumatoid arthritis with anakinra. Arthritis Rheum. 50, S437 (2004).
    • (2004) Arthritis Rheum. , vol.50
    • Irigoyen, P.I.1    Olson, J.2    Hom, C.3    Ilowite, N.T.4
  • 42
    • 16244363562 scopus 로고    scopus 로고
    • Efficacy of anakinra in refractory systemic arthritis
    • Henrickson, M. Efficacy of anakinra in refractory systemic arthritis. Arthritis Rheum. 50, S438 (2004).
    • (2004) Arthritis Rheum. , vol.50
    • Henrickson, M.1
  • 43
    • 0036252659 scopus 로고    scopus 로고
    • Differences in the profiles of circulating levels of soluble tumor necrosis factor receptors and interleukin 1 receptor antagonist reflect the heterogeneity of the subgroups of juvenile rheumatoid arthritis
    • Muzaffer, M. A. et al. Differences in the profiles of circulating levels of soluble tumor necrosis factor receptors and interleukin 1 receptor antagonist reflect the heterogeneity of the subgroups of juvenile rheumatoid arthritis. J. Rheumatol. 29, 1071-1078 (2002). (Pubitemid 34493516)
    • (2002) Journal of Rheumatology , vol.29 , Issue.5 , pp. 1071-1078
    • Muzaffer, M.A.1    Dayer, J.-M.2    Feldman, B.M.3    Pruzanski, W.4    Roux-Lombard, P.5    Schneider, R.6    Laxer, R.M.7    Silverman, E.D.8
  • 44
    • 79551654446 scopus 로고    scopus 로고
    • Anakinra as first-line disease modifying therapy in systemic juvenile idiopathic arthritis: Report of forty-six patients from an international multicenter series
    • Nigrovic, P. et al. Anakinra as first-line disease modifying therapy in systemic juvenile idiopathic arthritis: report of forty-six patients from an international multicenter series. Arthritis Rheum. 63, 545-555 (2010).
    • (2010) Arthritis Rheum. , vol.63 , pp. 545-555
    • Nigrovic, P.1
  • 45
    • 77953105116 scopus 로고    scopus 로고
    • Altered redox state of monocytes from cryopyrin-associated periodic syndromes causes accelerated IL-1β secretion
    • USA
    • Tassi, S. et al. Altered redox state of monocytes from cryopyrin-associated periodic syndromes causes accelerated IL-1β secretion. Proc. Natl Acad. Sci. USA 107, 9789-9794 (2010).
    • (2010) Proc. Natl. Acad. Sci. , vol.107 , pp. 9789-9794
    • Tassi, S.1
  • 46
    • 70149102924 scopus 로고    scopus 로고
    • Differential cytokine profiles in juvenile idiopathic arthritis subtypes revealed by cluster analysis
    • Oxford
    • van den Ham, H.-J., de Jager, W., Bijlsma, J. W. J., Prakken, B. J. & de Boer, R. J. Differential cytokine profiles in juvenile idiopathic arthritis subtypes revealed by cluster analysis. Rheumatology (Oxford) 48, 899-905 (2009).
    • (2009) Rheumatology , vol.48 , pp. 899-905
    • Van Den Ham, H.-J.1    De Jager, W.2    Bijlsma, J.W.J.3    Prakken, B.J.4    De Boer, R.J.5
  • 47
    • 73249139175 scopus 로고    scopus 로고
    • Caspase 1-independent activation of interleukin-1β in neutrophil-predominant inflammation
    • Guma, M. et al. Caspase 1-independent activation of interleukin-1β in neutrophil-predominant inflammation. Arthritis Rheum. 60, 3642-3650 (2009).
    • (2009) Arthritis Rheum. , vol.60 , pp. 3642-3650
    • Guma, M.1
  • 48
    • 73249144903 scopus 로고    scopus 로고
    • Inflammatory arthritis in caspase 1 gene-deficient mice: Contribution of proteinase 3 to caspase 1-independent production of bioactive interleukin-1 β
    • Joosten, L. A. B. et al. Inflammatory arthritis in caspase 1 gene-deficient mice: contribution of proteinase 3 to caspase 1-independent production of bioactive interleukin-1 β. Arthritis Rheum. 60, 3651-3662 (2009).
    • (2009) Arthritis Rheum. , vol.60 , pp. 3651-3662
    • Joosten, L.A.B.1
  • 49
    • 55349138368 scopus 로고    scopus 로고
    • Human and mouse granzyme a induce a proinflammatory cytokine response
    • Metkar, S. S. et al. Human and mouse granzyme A induce a proinflammatory cytokine response. Immunity 29, 720-733 (2008).
    • (2008) Immunity , vol.29 , pp. 720-733
    • Metkar, S.S.1
  • 50
    • 61749104104 scopus 로고    scopus 로고
    • The myeloid-related proteins 8 and 14 complex a novel ligand of toll-like receptor 4 and interleukin-1β form a positive feedback mechanism in systemic-onset juvenile idiopathic arthritis
    • Frosch, M. et al. The myeloid-related proteins 8 and 14 complex, a novel ligand of Toll-like receptor 4, and interleukin-1β form a positive feedback mechanism in systemic-onset juvenile idiopathic arthritis. Arthritis Rheum. 60, 883-891 (2009).
    • (2009) Arthritis Rheum. , vol.60 , pp. 883-891
    • Frosch, M.1
  • 51
    • 57349086217 scopus 로고    scopus 로고
    • S100A12 is a novel molecular marker differentiating systemic-onset juvenile idiopathic arthritis from other causes of fever of unknown origin
    • Wittkowski, H. et al. S100A12 is a novel molecular marker differentiating systemic-onset juvenile idiopathic arthritis from other causes of fever of unknown origin. Arthritis Rheum. 58, 3924-3931 (2008).
    • (2008) Arthritis Rheum. , vol.58 , pp. 3924-3931
    • Wittkowski, H.1
  • 52
    • 0026014522 scopus 로고
    • Correlation of serum interleukin-6 levels with joint involvement and thrombocytosis in systemic juvenile rheumatoid arthritis
    • de Benedetti, F. et al. Correlation of serum interleukin-6 levels with joint involvement and thrombocytosis in systemic juvenile rheumatoid arthritis. Arthritis Rheum. 34, 1158-1163 (1991).
    • (1991) Arthritis Rheum. , vol.34 , pp. 1158-1163
    • De Benedetti, F.1
  • 54
    • 0030015099 scopus 로고    scopus 로고
    • Defective iron supply for erythropoiesis and adequate endogenous erythropoietin production in the anemia associated with systemic-onset juvenile chronic arthritis
    • Cazzola, M. et al. Defective iron supply for erythropoiesis and adequate endogenous erythropoietin production in the anemia associated with systemic-onset juvenile chronic arthritis. Blood 87, 4824-4830 (1996). (Pubitemid 26162385)
    • (1996) Blood , vol.87 , Issue.11 , pp. 4824-4830
    • Cazzola, M.1    Ponchio, L.2    De Benedetti, F.3    Ravelli, A.4    Rosti, V.5    Beguin, Y.6    Invernizzi, R.7    Barosi, G.8    Martini, A.9
  • 56
    • 0346340916 scopus 로고    scopus 로고
    • Inflammatory cytokines and cytokine antagonists in whole blood cultures of patients with systemic juvenile chronic arthritis
    • Oxford
    • Muller, K., Herner, E. B., Stagg, A., Bendtzen, K. & Woo, P. Inflammatory cytokines and cytokine antagonists in whole blood cultures of patients with systemic juvenile chronic arthritis. Rheumatology (Oxford) 37, 562-569 (1998).
    • (1998) Rheumatology , vol.37 , pp. 562-569
    • Muller, K.1    Herner, E.B.2    Stagg, A.3    Bendtzen, K.4    Woo, P.5
  • 57
    • 70449704670 scopus 로고    scopus 로고
    • Monocytes from patients with type 1 diabetes spontaneously secrete proinflammatory cytokines inducing TH17 cells
    • Bradshaw, E. M. et al. Monocytes from patients with type 1 diabetes spontaneously secrete proinflammatory cytokines inducing TH17 cells. J. Immunol. 183, 4432-4439 (2009).
    • (2009) J. Immunol. , vol.183 , pp. 4432-4439
    • Bradshaw, E.M.1
  • 59
    • 84869843659 scopus 로고    scopus 로고
    • Tocilizumab in patients with systemic juvenile idiopathic arthritis: Efficacy data from the placebo-controlled 12-week part of the phase 3 TENDER trial
    • De Benedetti, F. et al. Tocilizumab in patients with systemic juvenile idiopathic arthritis: efficacy data from the placebo-controlled 12-week part of the phase 3 TENDER trial. Arthritis Rheum. 62, S596 (2010).
    • (2010) Arthritis Rheum. , vol.62
    • De Benedetti, F.1
  • 60
    • 60149104218 scopus 로고    scopus 로고
    • Improvement of reduced serum cartilage oligomeric matrix protein levels in systemic juvenile idiopathic arthritis patients treated with the anti-interleukin-6 receptor monoclonal antibody tocilizumab
    • Nakajima, S. et al. Improvement of reduced serum cartilage oligomeric matrix protein levels in systemic juvenile idiopathic arthritis patients treated with the anti-interleukin-6 receptor monoclonal antibody tocilizumab. Mod. Rheumatol. 19, 42-46 (2009).
    • (2009) Mod. Rheumatol. , vol.19 , pp. 42-46
    • Nakajima, S.1
  • 61
    • 41949119550 scopus 로고    scopus 로고
    • Elevated serum receptor activator of NF?B ligand RANKL osteoprotegerin OPG matrix metalloproteinase MMP 3 and ProMMP1 in patients with juvenile idiopathic arthritis
    • Sarma, P. K., Misra, R. & Aggarwal, A. Elevated serum receptor activator of NF?B ligand (RANKL), osteoprotegerin (OPG), matrix metalloproteinase (MMP)3, and ProMMP1 in patients with juvenile idiopathic arthritis. Clin. Rheumatol. 27, 289-294 (2008).
    • (2008) Clin. Rheumatol. , vol.27 , pp. 289-294
    • Sarma, P.K.1    Misra, R.2    Aggarwal, A.3
  • 62
    • 0032577453 scopus 로고    scopus 로고
    • Interleukin (IL)-6 and its soluble receptor induce TIMP-1 expression in synoviocytes and chondrocytes, and block IL-1-induced collagenolytic activity
    • DOI 10.1074/jbc.273.22.13625
    • Silacci, P. et al. Interleukin (IL)-6 and its soluble receptor induce TIMP-1 expression in synoviocytes and chondrocytes, and block IL-1-induced collagenolytic activity. J. Biol. Chem. 273, 13625-13629 (1998). (Pubitemid 28268406)
    • (1998) Journal of Biological Chemistry , vol.273 , Issue.22 , pp. 13625-13629
    • Silacci, P.1    Dayer, J.-M.2    Desgeorges, A.3    Peter, R.4    Manueddu, C.5    Guernet, P.-A.6
  • 63
    • 78649693683 scopus 로고    scopus 로고
    • Urine peptidomic and targeted plasma protein analyses in the diagnosis and monitoring of systemic juvenile idiopathic arthritis
    • Ling, X. et al. Urine peptidomic and targeted plasma protein analyses in the diagnosis and monitoring of systemic juvenile idiopathic arthritis. Clin. Proteomics 6, 175-193 (2010).
    • (2010) Clin. Proteomics , vol.6 , pp. 175-193
    • Ling, X.1
  • 66
    • 67349268535 scopus 로고    scopus 로고
    • The role of heme oxygenase-1 in systemic-onset juvenile idiopathic arthritis
    • Takahashi, A. et al. The role of heme oxygenase-1 in systemic-onset juvenile idiopathic arthritis. Mod. Rheumatol. 19, 302-308 (2009).
    • (2009) Mod. Rheumatol. , vol.19 , pp. 302-308
    • Takahashi, A.1
  • 68
    • 71749088821 scopus 로고    scopus 로고
    • + peripheral blood mononuclear cells and induce M2-type macrophage polarization
    • + peripheral blood mononuclear cells and induce M2-type macrophage polarization. J. Biol. Chem. 284, 34342-34354 (2009).
    • (2009) J. Biol. Chem. , vol.284 , pp. 34342-34354
    • Roca, H.1
  • 69
    • 77954309114 scopus 로고    scopus 로고
    • Monocytes are resistant to apoptosis in systemic juvenile idiopathic arthritis
    • Srivastava, S. et al. Monocytes are resistant to apoptosis in systemic juvenile idiopathic arthritis. Clin. Immunol. 136, 257-268 (2010).
    • (2010) Clin. Immunol. , vol.136 , pp. 257-268
    • Srivastava, S.1
  • 70
    • 70349275277 scopus 로고    scopus 로고
    • Tolerance and M2 alternative macrophage polarization are related processes orchestrated by p50 nuclear factor ?B
    • USA
    • Porta, C. et al. Tolerance and M2 (alternative) macrophage polarization are related processes orchestrated by p50 nuclear factor ?B. Proc. Natl Acad. Sci. USA 106, 14978-14983 (2009).
    • (2009) Proc. Natl. Acad. Sci. , vol.106 , pp. 14978-14983
    • Porta, C.1
  • 72
    • 33646841830 scopus 로고    scopus 로고
    • Macrophage activation syndrome as the presenting manifestation of rheumatic diseases in childhood
    • DOI 10.1016/j.jpeds.2005.12.070, PII S0022347605012394
    • Avcin, T., Tse, S. M. L., Schneider, R., Ngan, B. & Silverman, E. Macrophage activation syndrome as the presenting manifestation of rheumatic diseases in childhood. J. Pediatrics 148, 683-686 (2006). (Pubitemid 43776910)
    • (2006) Journal of Pediatrics , vol.148 , Issue.5 , pp. 683-686
    • Avcin, T.1    Tse, S.M.L.2    Schneider, R.3    Ngan, B.4    Silverman, E.D.5
  • 75
    • 40549138745 scopus 로고    scopus 로고
    • Interleukin-17-producing T cells are enriched in the joints of children with arthritis, but have a reciprocal relationship to regulatory T cell numbers
    • DOI 10.1002/art.23291
    • Nistala, K. et al. Interleukin-17-producing T cells are enriched in the joints of children with arthritis, but have a reciprocal relationship to regulatory T cell numbers. Arthritis Rheum. 58, 875-887 (2008). (Pubitemid 351364887)
    • (2008) Arthritis and Rheumatism , vol.58 , Issue.3 , pp. 875-887
    • Nistala, K.1    Moncrieffe, H.2    Newton, K.R.3    Varsani, H.4    Hunter, P.5    Wedderburn, L.R.6
  • 76
    • 70349245581 scopus 로고    scopus 로고
    • TH17 transcription factor RORC2 is inversely correlated with FOXP3 expression in the joints of children with juvenile idiopathic arthritis
    • Olivito, B. et al. TH17 transcription factor RORC2 is inversely correlated with FOXP3 expression in the joints of children with juvenile idiopathic arthritis. J. Rheumatol. 36, 2017-2024 (2009).
    • (2009) J. Rheumatol. , vol.36 , pp. 2017-2024
    • Olivito, B.1
  • 77
    • 40649083317 scopus 로고    scopus 로고
    • Interleukin 17 levels are increased in juvenile idiopathic arthritis synovial fluid and induce synovial fibroblasts to produce proinflammatory cytokines and matrix metalloproteinases
    • Agarwal, S., Misra, R. & Aggarwal, A. Interleukin 17 levels are increased in juvenile idiopathic arthritis synovial fluid and induce synovial fibroblasts to produce proinflammatory cytokines and matrix metalloproteinases. J. Rheumatol. 35, 515-519 (2008). (Pubitemid 351374430)
    • (2008) Journal of Rheumatology , vol.35 , Issue.3 , pp. 515-519
    • Agarwal, S.1    Misra, R.2    Aggarwal, A.3
  • 78
    • 67651175878 scopus 로고    scopus 로고
    • Breaking old paradigms: TH17 cells in autoimmune arthritis
    • Peck, A. & Mellins, E. Breaking old paradigms: TH17 cells in autoimmune arthritis. Clin. Immunol. 132, 295-304 (2009).
    • (2009) Clin. Immunol. , vol.132 , pp. 295-304
    • Peck, A.1    Mellins, E.2
  • 79
    • 44049104564 scopus 로고    scopus 로고
    • H-17 cells requires transforming growth factor-β and induction of the nuclear receptor RORγt
    • DOI 10.1038/ni.1610, PII NI.1610
    • Manel, N., Unutmaz, D. & Littman, D. R. The differentiation of human TH17 cells requires transforming growth factor-β and induction of the nuclear receptor RORγt. Nat. Immunol. 9, 641-649 (2008). (Pubitemid 351714729)
    • (2008) Nature Immunology , vol.9 , Issue.6 , pp. 641-649
    • Manel, N.1    Unutmaz, D.2    Littman, D.R.3
  • 80
    • 78149438748 scopus 로고    scopus 로고
    • Role of interleukin 17 in arthritis chronicity through survival of synoviocytes via regulation of synoviolin expression
    • Toh, M.-L. et al. Role of interleukin 17 in arthritis chronicity through survival of synoviocytes via regulation of synoviolin expression. PLoS ONE 5, e13416 (2010).
    • (2010) PLoS ONE , vol.5
    • Toh, M.-L.1
  • 81
    • 55849150906 scopus 로고    scopus 로고
    • Interleukin-1 drives pathogenic TH17 cells during spontaneous arthritis in interleukin-1 receptor antagonist-deficient mice
    • Koenders, M. et al. Interleukin-1 drives pathogenic TH17 cells during spontaneous arthritis in interleukin-1 receptor antagonist-deficient mice. Arthritis Rheum. 58, 3461-3470 (2008).
    • (2008) Arthritis Rheum. , vol.58 , pp. 3461-3470
    • Koenders, M.1
  • 82
    • 40549125931 scopus 로고    scopus 로고
    • Genetic loci contributing to hemophagocytic lymphohistiocytosis do not confer susceptibility to systemic-onset juvenile idiopathic arthritis
    • DOI 10.1002/art.23270
    • Donn, R. et al. Genetic loci contributing to hemophagocytic lymphohistiocytosis do not confer susceptibility to systemic-onset juvenile idiopathic arthritis. Arthritis Rheum. 58, 869-874 (2008). (Pubitemid 351364886)
    • (2008) Arthritis and Rheumatism , vol.58 , Issue.3 , pp. 869-874
    • Donn, R.1    Ellison, S.2    Lamb, R.3    Day, T.4    Baildam, E.5    Ramanan, A.V.6
  • 83
    • 49749127387 scopus 로고    scopus 로고
    • Macrophage activation syndrome in patients with systemic juvenile idiopathic arthritis is associated with MUNC13-4 polymorphisms
    • Zhang, K. et al. Macrophage activation syndrome in patients with systemic juvenile idiopathic arthritis is associated with MUNC13-4 polymorphisms. Arthritis Rheum. 58, 2892-2896 (2008).
    • (2008) Arthritis Rheum. , vol.58 , pp. 2892-2896
    • Zhang, K.1
  • 84
    • 77950531755 scopus 로고    scopus 로고
    • Mutations in the perforin gene can be linked to macrophage activation syndrome in patients with systemic onset juvenile idiopathic arthritis
    • Oxford
    • Vastert, S. et al. Mutations in the perforin gene can be linked to macrophage activation syndrome in patients with systemic onset juvenile idiopathic arthritis. Rheumatology (Oxford) 49, 441-449 (2010).
    • (2010) Rheumatology , vol.49 , pp. 441-449
    • Vastert, S.1
  • 85
    • 79953301748 scopus 로고    scopus 로고
    • Association of IRF5 polymorphisms with susceptibility to macrophage activation syndrome in patients with juvenile idiopathic arthritis
    • Yanagimachi M. et al. Association of IRF5 polymorphisms with susceptibility to macrophage activation syndrome in patients with juvenile idiopathic arthritis. J. Rheumatol. 38, 769-774 (2011).
    • (2011) J. Rheumatol. , vol.38 , pp. 769-774
    • Yanagimachi, M.1
  • 86
    • 77955751173 scopus 로고    scopus 로고
    • Distinct cytokine profiles of systemic-onset juvenile idiopathic arthritis-associated macrophage activation syndrome with particular emphasis on the role of interleukin-18 in its pathogenesis
    • Oxford
    • Shimizu, M. et al. Distinct cytokine profiles of systemic-onset juvenile idiopathic arthritis-associated macrophage activation syndrome with particular emphasis on the role of interleukin-18 in its pathogenesis. Rheumatology (Oxford) 49, 1645-1653 (2010).
    • (2010) Rheumatology , vol.49 , pp. 1645-1653
    • Shimizu, M.1
  • 87
    • 77955173632 scopus 로고    scopus 로고
    • Differences between systemic onset juvenile idiopathic arthritis and macrophage activation syndrome from the standpoint of the proinflammatory cytokine profiles
    • Imagawa, T. Differences between systemic onset juvenile idiopathic arthritis and macrophage activation syndrome from the standpoint of the proinflammatory cytokine profiles. Arthritis Rheum. 50, S92 (2004).
    • (2004) Arthritis Rheum. , vol.50
    • Imagawa, T.1
  • 88
    • 13544273826 scopus 로고    scopus 로고
    • Macrophage activation syndrome: Characteristic findings on liver biopsy illustrating the key role of activated, IFN-γ-producing lymphocytes and IL-6- and TNF-α-producing macrophages
    • DOI 10.1182/blood-2004-08-2997
    • Billiau, A. D., Roskams, T., Van Damme-Lombaerts, R., Matthys, P. & Wouters, C. Macrophage activation syndrome: characteristic findings on liver biopsy illustrating the key role of activated, IFN-γ-producing lymphocytes and IL-6-and TNF-α-producing macrophages. Blood 105, 1648-1651 (2005). (Pubitemid 40223686)
    • (2005) Blood , vol.105 , Issue.4 , pp. 1648-1651
    • Billiau, A.D.1    Roskams, T.2    Van Damme-Lombaerts, R.3    Matthys, P.4    Wouters, C.5
  • 89
    • 78651365935 scopus 로고    scopus 로고
    • Rapid and sustained remission of systemic juvenile idiopathic arthritis-associated macrophage activation syndrome through treatment with anakinra and corticosteroids
    • Bruck, N. et al. Rapid and sustained remission of systemic juvenile idiopathic arthritis-associated macrophage activation syndrome through treatment with anakinra and corticosteroids. J. Clin. Rheum. 17, 23-27 (2011).
    • (2011) J. Clin. Rheum. , vol.17 , pp. 23-27
    • Bruck, N.1
  • 90
    • 42049086504 scopus 로고    scopus 로고
    • Hemophagocytic lymphohistiocytosis and other hemophagocytic disorders
    • DOI 10.1016/j.iac.2008.01.010, PII S0889856108000222
    • Filipovich, A. Hemophagocytic lymphohistiocytosis and other hemophagocytic disorders. Immunol. Allergy Clin. North Am. 28, 293-313, viii (2008). (Pubitemid 351522416)
    • (2008) Immunology and Allergy Clinics of North America , vol.28 , Issue.2 , pp. 293-313
    • Filipovich, A.H.1
  • 91
    • 33845199637 scopus 로고    scopus 로고
    • Perforin-mediated target-cell death and immune homeostasis
    • DOI 10.1038/nri1983, PII NRI1983
    • Voskoboinik, I., Smyth, M. & Trapani, J. Perforin-mediated target-cell death and immune homeostasis. Nat. Rev. Immunol. 6, 940-952 (2006). (Pubitemid 44851736)
    • (2006) Nature Reviews Immunology , vol.6 , Issue.12 , pp. 940-952
    • Voskoboinik, I.1    Smyth, M.J.2    Trapani, J.A.3
  • 92
    • 0037293064 scopus 로고    scopus 로고
    • Reduced perforin expression in systemic juvenile idiopathic arthritis is restored by autologous stem-cell transplantation
    • DOI 10.1093/rheumatology/keg074
    • Wulffraat, N. M., Rijkers, G. T., Elst, E., Brooimans, R. & Kuis, W. Reduced perforin expression in systemic juvenile idiopathic arthritis is restored by autologous stem-cell transplantation. Rheumatology (Oxford) 42, 375-379 (2003). (Pubitemid 36312936)
    • (2003) Rheumatology , vol.42 , Issue.2 , pp. 375-379
    • Wulffraat, N.M.1    Rijkers, G.T.2    Elst, E.3    Brooimans, R.4    Kuis, W.5
  • 93
    • 0037338925 scopus 로고    scopus 로고
    • Natural killer cell dysfunction in patients with systemic-onset juvenile rheumatoid arthritis and macrophage activation syndrome
    • DOI 10.1067/mpd.2003.110
    • Grom, A. A. et al. Natural killer cell dysfunction in patients with systemic-onset juvenile rheumatoid arthritis and macrophage activation syndrome. J. Pediatrics 142, 292-296 (2003). (Pubitemid 36338013)
    • (2003) Journal of Pediatrics , vol.142 , Issue.3 , pp. 292-296
    • Grom, A.A.1    Villanueva, J.2    Lee, S.3    Goldmuntz, E.A.4    Passo, M.H.5    Filipovich, A.6
  • 94
    • 21744452702 scopus 로고    scopus 로고
    • Natural killer cell dysfunction is a distinguishing feature of systemic onset juvenile rheumatoid arthritis and macrophage activation syndrome
    • Villanueva, J. et al. Natural killer cell dysfunction is a distinguishing feature of systemic onset juvenile rheumatoid arthritis and macrophage activation syndrome. Arthritis Res. Ther. 7, R30-R37 (2005).
    • (2005) Arthritis Res. Ther. , vol.7
    • Villanueva, J.1
  • 95
    • 69449093422 scopus 로고    scopus 로고
    • Defective phosphorylation of interleukin-18 receptor β causes impaired natural killer cell function in systemic-onset juvenile idiopathic arthritis
    • de Jager, W. et al. Defective phosphorylation of interleukin-18 receptor β causes impaired natural killer cell function in systemic-onset juvenile idiopathic arthritis. Arthritis Rheum. 60, 2782-2793 (2009).
    • (2009) Arthritis Rheum. , vol.60 , pp. 2782-2793
    • De Jager, W.1
  • 98
    • 70350004037 scopus 로고    scopus 로고
    • Increased cytokine production in interleukin-18 receptor α-deficient cells is associated with dysregulation of suppressors of cytokine signaling
    • Nold-Petry, C. A. et al. Increased cytokine production in interleukin-18 receptor α-deficient cells is associated with dysregulation of suppressors of cytokine signaling. J. Biol. Chem. 284, 25900-25911 (2009).
    • (2009) J. Biol. Chem. , vol.284 , pp. 25900-25911
    • Nold-Petry, C.A.1
  • 100
    • 2642527912 scopus 로고    scopus 로고
    • Increased interleukin-18 expression in bone marrow of a patient with systemic juvenile idiopathic arthritis and unrecognized macrophage-activation syndrome
    • DOI 10.1002/art.20268
    • Maeno, N. et al. Increased interleukin-18 expression in bone marrow of a patient with systemic juvenile idiopathic arthritis and unrecognized macrophage-activation syndrome. Arthritis Rheum. 50, 1935-1938 (2004). (Pubitemid 38725105)
    • (2004) Arthritis and Rheumatism , vol.50 , Issue.6 , pp. 1935-1938
    • Maeno, N.1    Takei, S.2    Imanaka, H.3    Yamamoto, K.4    Kuriwaki, K.5    Kawano, Y.6    Oda, H.7
  • 102
    • 77749260592 scopus 로고    scopus 로고
    • Differential regulation of iron homeostasis during human macrophage polarized activation
    • Recalcati, S. et al. Differential regulation of iron homeostasis during human macrophage polarized activation. Eur. J. Immunol. 40, 824-835 (2010).
    • (2010) Eur. J. Immunol. , vol.40 , pp. 824-835
    • Recalcati, S.1
  • 103
    • 0027462755 scopus 로고
    • The diagnostic significance of serum ferritin indices in patients with malignant and reactive histiocytosis
    • Lukina, E. A., Levina, A. A., Mokeeva, R. A. & YuN, T. The diagnostic significance of serum ferritin indices in patients with malignant and reactive histiocytosis. Br. J. Haematol. 83, 326-329 (1993). (Pubitemid 23060931)
    • (1993) British Journal of Haematology , vol.83 , Issue.2 , pp. 326-329
    • Lukina, E.A.1    Levina, A.A.2    Mokeeva, R.A.3    Tokarev, Y.N.4
  • 104
    • 79957889288 scopus 로고    scopus 로고
    • Repeated Toll-like receptor 9 stimulation results in macrophage activation syndrome-like disease in mice
    • in press
    • Behrens, E. M. et al. Repeated Toll-like receptor 9 stimulation results in macrophage activation syndrome-like disease in mice. J. Clin. Invest. (in press).
    • J. Clin. Invest.
    • Behrens, E.M.1
  • 105
    • 79953815598 scopus 로고    scopus 로고
    • Serum amyloid A overrides TREG anergy via monocyte-dependent and TREG-intrinsic SOCS3-associated pathways
    • Nguyen, K. D. et al. Serum amyloid A overrides TREG anergy via monocyte-dependent and TREG-intrinsic, SOCS3-associated pathways. Blood 117, 3793-3798 (2011).
    • (2011) Blood , vol.117 , pp. 3793-3798
    • Nguyen, K.D.1
  • 106
    • 69449105914 scopus 로고    scopus 로고
    • Disordered macrophage cytokine secretion underlies impaired acute inflammation and bacterial clearance in crohns disease
    • Smith, A. M. et al. Disordered macrophage cytokine secretion underlies impaired acute inflammation and bacterial clearance in Crohn's disease. J. Exp. Med. 206, 1883-1897 (2009).
    • (2009) J. Exp. Med. , vol.206 , pp. 1883-1897
    • Smith, A.M.1
  • 107
    • 0021954203 scopus 로고
    • Evidence for intravascular coagulation in systemic onset, but not polyarticular, juvenile rheumatoid arthritis
    • DOI 10.1002/art.1780280304
    • Scott, J. P., Gerber, P., Maryjowski, M. C. & Pachman, L. M. Evidence for intravascular coagulation in systemic onset, but not polyarticular, juvenile rheumatoid arthritis. Arthritis Rheum. 28, 256-261 (1985). (Pubitemid 15133569)
    • (1985) Arthritis and Rheumatism , vol.28 , Issue.3 , pp. 256-261
    • Scott, J.P.1    Gerber, P.2    Maryjowski, M.C.3    Pachman, L.M.4
  • 108
    • 34247178468 scopus 로고    scopus 로고
    • Anti-endothelial cell antibodies are prevalent in juvenile idiopathic arthritis: Implications for clinical disease course and pathogenesis
    • DOI 10.1007/s00296-006-0276-3
    • Bloom, B., Toyoda, M., Petrosian, A. & Jordan, S. Anti-endothelial cell antibodies are prevalent in juvenile idiopathic arthritis: implications for clinical disease course and pathogenesis. Rheumatol. Int. 27, 655-660 (2007). (Pubitemid 46625352)
    • (2007) Rheumatology International , vol.27 , Issue.7 , pp. 655-660
    • Bloom, B.J.1    Toyoda, M.2    Petrosian, A.3    Jordan, S.4
  • 109
    • 77950627242 scopus 로고    scopus 로고
    • IL-1 pathways in inflammation and human diseases
    • Gabay, C., Lamacchia, C. & Palmer, G. IL-1 pathways in inflammation and human diseases. Nat. Rev. Rheumatol. 6, 232-241 (2010).
    • (2010) Nat. Rev. Rheumatol. , vol.6 , pp. 232-241
    • Gabay, C.1    Lamacchia, C.2    Palmer, G.3
  • 110
    • 38049083888 scopus 로고    scopus 로고
    • Primer: Inflammasomes and interleukin 1β in inflammatory disorders
    • Church, L., Cook, G. & McDermott, M. Primer: inflammasomes and interleukin 1β in inflammatory disorders. Nat. Clin. Pract. Rheumatol. 4, 34-42 (2008).
    • (2008) Nat. Clin. Pract. Rheumatol. , vol.4 , pp. 34-42
    • Church, L.1    Cook, G.2    McDermott, M.3
  • 112
    • 0035313549 scopus 로고    scopus 로고
    • Two proteins modulating transendothelial migration of leukocytes recognize novel carboxylated glycans on endothelial cells
    • Srikrishna, G. et al. Two proteins modulating transendothelial migration of leukocytes recognize novel carboxylated glycans on endothelial cells. J. Immunol. 166, 4678-4688 (2001). (Pubitemid 32233755)
    • (2001) Journal of Immunology , vol.166 , Issue.7 , pp. 4678-4688
    • Srikrishna, G.1    Panneerselvam, K.2    Westphal, V.3    Abraham, V.4    Varki, A.5    Freeze, H.H.6
  • 113
    • 0031892521 scopus 로고    scopus 로고
    • 2 integrin Mac-1 on neutrophils
    • Newton, R. A. & Hogg, N. The human S100 protein MRP-14 is a novel activator of the β2 integrin Mac-1 on neutrophils. J. Immunol. 160, 1427-1435 (1998). (Pubitemid 28093444)
    • (1998) Journal of Immunology , vol.160 , Issue.3 , pp. 1427-1435
    • Newton, R.A.1    Hogg, N.2
  • 114
    • 67650485985 scopus 로고    scopus 로고
    • Alternative activation of macrophages: An immunologic functional perspective
    • Martinez, F. O., Helming, L. & Gordon, S. Alternative activation of macrophages: an immunologic functional perspective. Ann. Rev. Immunol. 27, 451-483 (2009).
    • (2009) Ann. Rev. Immunol. , vol.27 , pp. 451-483
    • Martinez, F.O.1    Helming, L.2    Gordon, S.3
  • 115
    • 77955426821 scopus 로고    scopus 로고
    • Interleukin-4 induced interferon regulatory factor Irf 4 participates in the regulation of alternative macrophage priming
    • El Chartouni, C., Schwarzfischer, L. & Rehli, M. Interleukin-4 induced interferon regulatory factor (Irf) 4 participates in the regulation of alternative macrophage priming. Immunobiology 215, 821-825 (2010).
    • (2010) Immunobiology , vol.215 , pp. 821-825
    • El Chartouni, C.1    Schwarzfischer, L.2    Rehli, M.3
  • 116
    • 79951671510 scopus 로고    scopus 로고
    • IRF5 promotes inflammatory macrophage polarization and TH1-TH17 responses
    • Krausgruber, T. et al. IRF5 promotes inflammatory macrophage polarization and TH1-TH17 responses. Nat. Immunol. 12, 231-238 (2011).
    • (2011) Nat. Immunol. , vol.12 , pp. 231-238
    • Krausgruber, T.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.