Effect of Intestinal Flora on Protein Expression of Drug-Metabolizing Enzymes and Transporters in the Liver and Kidney of Germ-Free and Antibiotics-Treated Mice

Molecular Pharmaceutics

Volumn 13, Issue 8, 2016, Pages 2691-2701

  Kuno, Takuya ^a,b   Hirayama Kurogi, Mio ^a,c   Ito, Shingo ^a,c   Ohtsuki, Sumio ^a,c  

^a KUMAMOTO UNIVERSITY   (Japan)

^b OTSUKA PHARMACEUTICAL CO LTD   (Japan)

^c JAPAN AGENCY FOR MEDICAL RESEARCH AND DEVELOPMENT   (Japan)

Author keywords

antibiotics; drug metabolizing enzyme; intestinal flora; quantitative proteomics; targeted proteomics; transporter

Indexed keywords

ABC TRANSPORTER; ADENOSINE 3' PHOSPHATE 5' PHOSPHOSULFATE; BILE SALT EXPORT PUMP; CARBOXYLESTERASE; CARBOXYLESTERASE BCRP1; CYTOCHROME CYP2B10; CYTOCHROME CYP3A25; CYTOCHROME CYP51A1; CYTOCHROME P450; CYTOCHROME P450 2B; CYTOCHROME P450 3A11; DRUG METABOLIZING ENZYME; GLUCURONOSYLTRANSFERASE; GLUTATHIONE TRANSFERASE; GLUTATHIONE TRANSFERASE P1; MITOCHONDRIAL PROTEIN; ORGANIC CATION TRANSPORTER 1; POLYMYXIN B; SULFOTRANSFERASE; SULFOTRANSFERASE 1A1; UNCLASSIFIED DRUG; VANCOMYCIN; ANTIINFECTIVE AGENT;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIBIOTIC THERAPY; ARTICLE; CONTROLLED STUDY; DYSBIOSIS; ENZYME ACTIVITY; GERMFREE MOUSE; INTESTINE FLORA; KIDNEY; LIVER; LIVER MICROSOME; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEOMICS; QUANTITATIVE ANALYSIS; SHORT COURSE THERAPY; TREATMENT DURATION; ANIMAL; DRUG EFFECTS; GERMFREE ANIMAL; METABOLISM;

ANIMALS; ANTI-BACTERIAL AGENTS; GASTROINTESTINAL MICROBIOME; KIDNEY; LIVER; MALE; MICE; PROTEOMICS; SPECIFIC PATHOGEN-FREE ORGANISMS;

EID: 84980010090     PISSN: 15438384     EISSN: 15438392     Source Type: Journal    
DOI: 10.1021/acs.molpharmaceut.6b00259     Document Type: Article

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